| 论文简介 |
Abstract: A crystal of chlorohydrate alkaloid (1) was isolated by extraction and acidifying from Sophora flavescens in the Qin mountain. Two new matrines of diastereoisomers exist in the molecular structure of 1, named cis-neomatrine and trans-neomatrine. The absolute configurations of cis-neomatrine and trans-neomatrine are 1S, 5S, 6S, 7R, 11R, 16S, and 1S, 5S, 6S, 7R,11R, 16R, respectively. The crystal of 1 (C15H24N2O.C15H24N2O.2HCl.5H(2)O) crystallized in the Orthorhombic space group P2(1)2(1)2(1) with cell parameters a = 0.8053(2) rim, b = 1.3464 (5) rim, c = 3.0971(9) ran, V = 3.3580 (18) nm(3), Z = 4, mu = 0.244 mm(-1), F(000) = 1432, R = 0.0467, wR = 0.1129. In the structures of cis-neomatrine and trans-neomatrine, rings A, B, C have the chair form and D the half-chair form. Rings A and B, B and C, A and C have the trans type of linkage. Two stereoisomers differ from each other in the type of linkage between rings C and D. The rings C and D of cis-neomatrine have the cis type of linkage and that of trans-neomatrine have the trans type of linkage.
IDS Number: 715TM |
(创新港)
