(1.)Basic Information

 

Curriculum Vitae

PERSONAL

Name:                         Dong-Yuan Cao

Gender:       Male

        Nationality:   Chinese

EDUCATION BACKGROUND

2000-2003  Ph.D. in Physiological Science, Department of Physiology, Xi’an Jiaotong University School of Medicine, Shaanxi, China.

1996-1999  Master in Physiological Science, Department of Physiology, Xi’an Medical University, China.

1990-1993  Clinical Medicine, Xi’an Medical University, China.

HONORS AND AWARDS

2009 Trainee Travel Award, North American Research Conference on Complementary & Integrative Medicine, Minneapolis, MN.

2005 Award of Science & Technology (Grade A) sponsored by Shaanxi Province Education Office, China (the 3rd contributor).

2005 Award of Science & Technology (Grade C) sponsored by the Government of Shaanxi Province, China (the 3rd contributor).

2002 Award of Science & Technology (Grade B) sponsored by Ministry of Education of China (3rd contributor).

2002 Second Grade Award of Science & Technology (Grade B) sponsored by Shaanxi Province Education Office, China (2nd contributor).

2002 Award of Natural Science & Technology (Grade A) sponsored by Xi’an Jiaotong University, China (3rd contributor).

2003 Excellent graduate award of Xi’an Jiaotong University, Xi’an, China.

PROFESSIONAL EXPERIENCE

April 2015-present, Research Professor, Research Center of Stomatology, Stomatological Hospital, Xi’an Jiaotong University Health Science Center. Research on the mechanisms of stress-induced pain and comorbidity of temporomandibular joint disorder (TMD)- Fibromyalgia syndrome (FMS).

Aug. 2012-March 2015, Research Associate, Department of Neural and Pain Sciences, University of Maryland School of Dentistry. Research on the epigenetic modulation on visceral pain and mechanisms of Temporomandibular joint disorder (TMD)-Irritable bowel syndrome (IBS) comorbidity.

June 2010-July. 2012 Post-doctoral Fellow; Department of Neural and Pain Sciences, University of Maryland School of Dentistry. Research on the modulation of estrogen receptor beta on visceral pain.

Oct. 2006-May 2010  Post-doctoral Research Associate, Palmer Center for Chiropractic Research, Palmer College of Chiropractic. Research on sensory mechanisms that contribute to spinal column function and the effects of spinal manipulation on sensory nerve endings in paraspinal tissues.

Oct. 2004-Sept. 2006  Post-doctoral Research Associate, Department of Biomedicine, Medical School, State University of New York at Stony Brook. Research on mechanism of spinal manipulation on low back pain treatment, observing facet joint capsule strain using biomechanical methods while recording unitary nerve activity of muscle spindles simultaneously from the dorsal root.

Jul. 1999-Oct. 2004  Research Associate, Department of Physiology & Neurobiology, School of Medicine, Xi’an Jiaotong University, China. Research on the mechanisms of glutamate involved in peripheral sensitization of pain.

Sept. 1996-Jul. 1999 Teaching Assistant, Department of Physiology, Xi’an Medical University. Research on the relationship of substance P and neurogenic inflammation.

Jul. 1988-Aug. 1996  Research Assistant, Department of Brain & Nerve, Xi’an Medical University. Research on electromyography, the receptive character of sensory nerves, and the mechanisms of diabetic hyperalgesia and the mechanisms of acupuncture.

ACADEMIC EXPERIENCE AND MEMBERSHIP

Member of Editorial Board:

BioMed Research International

Journal of Alternative and Complementary Medicine (2009-2016）

Ad hoc Journal Reviewer:  

Neuropsychopharmacology

Brain Behavior and Immunity

Neuroscience Bulletin

Life Sciences

Frontiers in Neuroscience

Pharmacology

European Journal of Pharmacology

Brain Research

Clinical and Experimental Physiology and Pharmacology

Evidence Based Complementary and Alternative Medicine

International Journal of Clinical Acupuncture

Journal of Acupuncture and Tuina Science

Acupuncture in Medicine

Neuroscience Letters

Membership:     

2005~  Society for Neuroscience, US

2012~  International Associate for the Study of Pain

RESEARCH SUPPORT

1.       National Natural Science Foundation of China (No.81971049): The mechanism of somatic hyperalgesia and visceral hypersensitivity induced by orofacial inflammation combined with different patterns of stress. Principal Investigator. Jan 2020-Dec 2023, ￥550,000 ($79,000)

2.       National Natural Science Foundation of China (No.81671097): The inhibitory of epigenetic modulation on histone acetylation of neurons in the spinal cord and the central nucleus of amygdala in stress-induced visceral pain. Principal Investigator. Jan 2017-Dec 2020, ￥520,000 ($75,000)

3.       The Organized Research Center on Persistent Pain grant, University of Maryland: The role of neurochemical markers in TMD-IBS comorbidity. Principal Investigator. Oct 2011-Oct 2012, $10,000.

4.       National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH) (No. 5R01NS037424-09): Neurochemical mechanism of visceral pain. Main participator. June 2010-present. PI: Richard J. Traub, $1,600,000

5.       National Center for Complementary and Alternative Medicine, National Institutes of Health (NIH) (No. 3U19AT004137): Developmental Center to Study Mechanisms and Effects of Chiropractic Manipulation. Main participator. July 2007-Jun 2010, PI: Joel G. Pickar, $3,800,000

6.       National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH) (No. 5R01NS046818): Vertebral Position alters muscle spindle sensitivity. Main participator. Nov 2004-Sept 2008, PI: Joel G. Pickar, $1,400,000

7.       National Center for Complementary and Alternative Medicine, National Institutes of Health (NIH) (No. 3U19AT002006): Mechanisms and effects of chiropractic manipulation. Main participator. Nov 2004-Sept 2007, PI: William C. Meeker

8.       National Natural Science Foundation of China (No.30400131): The mechanism of excitation transmission between sensory peripheral terminals involved in peripheral sensitization of pain. Principal Investigator. Jan 2005-Dec 2007, ￥210,000 ($30,000)

9.       National Natural Science Foundation of China (No.30600219): The Molecular Base of Difference React to Nociceptive Stimulation in DA and DA.1U Rats and Definition the Pain Related Genes in MHC ClassⅡ. Secondary Investigator. Jan 2007-Dec 2009, ￥220,000 ($31,400)

10.    Natural Science Foundation of Shaanxi Province (No.2004C225): The study on mechanisms of peripheral sensitization and central sensitization of pain. Principal Investigator. Jan 2005-Dec 2006, ￥15,000 ($2,100)

11.    Ph.D. Foundation of Xi’an Jiaotong University (2004): The study on mechanism of information transmission across spinal segments and peripheral sensitization of pain. Principal Investigator. Jan 2005-Dec 2006, ￥10,000 ($1,400)

12.    Natural Science Foundation of Xi’an Jiaotong University (2003): The role of signal transduction between NMDA receptor and D2 receptor in morphine withdrawal. Principal Investigator. Jan 2004-Dec 2005, ￥15,000 ($2,100)

13.    Natural Science Foundation of Medical School, Xi’an Jiaotong University (No.2001-7): The ion mechanism of local effector activation. Principal Investigator. June 2001-May 2003 ￥10,000 ($1,400)

14.    Ph.D. Program Foundation supported by the Ministry of Education of China (20040698022): The mechanism of transmitters and receptors on acupuncture information. Co-Investigator. PI: Yan Zhao, Jan 2005-Dec 2007, ￥50,000 ($7,100)

15.    National Natural Science Foundation of China (No.30371729): The transmitters and receptors involved in the information transmission along “Pangguang Meridian of Foot-Taiyang”. Co-Investigator. PI: Yan Zhao, Jan 2004-Dec 2004, ￥70,000 ($10,000)

16.    Ph.D. Program Foundation supported by the Ministry of Education of China (20020698033): The transmitters and their receptors involved in axonal reflex related to meridian activity. Co-Investigator. PI: Yan Zhao, Jan 2003-Dec 2005, ￥75,000 ($10,700)

PUBLICATIONS

1. Li JH, Yang JL, Wei SQ, Li ZL, Collins AA, Zou M, Wei F, Cao DY. Contribution of central sensitization to stress-induced spreading hyperalgesia in rats with orofacial inflammation. Mol Brain, 2020;13(1):106 (IF 4.686) (correspondence author）

2. Xue Y, Wei SQ, Wang PX, Wang WY, Liu EQ, Traub RJ, Cao DY. Down-regulation of spinal 5-HT2A and 5-HT2C receptors contributes to somatic hyperalgesia induced by orofacial inflammation combined with stress. Neuroscience, 2020;440:196-209 (IF 3.056) (correspondence author）.

3. Xu GZ*, Xue Y*, Wei SQ, Li JH, Traub RJ, Wang MD, Cao DY. Valproate reverses stress-induced somatic hyperalgesia and visceral hypersensitivity by up-regulating spinal 5-HT2C receptor expression in female rats. Neuropharmacology, 2020;165:107926 (IF 4.367) (correspondence author）

4. Li YX, An H, Wen Z, Tao ZY, Cao DY. Can oxytocin inhibit stress-induced hyperalgesia? Neuropeptides, 2020;79:101996 (IF 2.407) (correspondence author）

5. Tao ZY, Wang PX, Wei SQ, Traub RJ, Li JF, Cao DY. The role of descending pain modulation in chronic primary pain: potential application of drugs targeting serotonergic system. Neural Plast, 2019:1389296 (IF 3.591) (correspondence author）

6. Li ZL, Xue Y, Tao ZY, Du WZ, Jiang YG, Cao DY. Spinal 5-HT3 Receptor Contributes to Somatic Hyperalgesia Induced by Sub-chronic Stress. Mol Pain, 2019: 1744806919859723. doi: 10.1177/1744806919859723 [PubMed: 31184246](IF 2.746)( correspondence author）

7. Li JH, He PY, Fan DN, Alemujiang D, Huo FQ, Zhao Y, Cao DY. Peripheral ionotropic glutamate receptors contribute to Fos expression increase in the spinal cord through antidromic electrical stimulation of sensory nerves. Neurosci Lett. 2018; 678:1-7. [PubMed 29705538] (IF 2.173) (correspondence author).

8. Tao ZY, Xue Y, Li JF, Traub TJ, Cao DY. Do microRNAs modulate visceral pain? BioMed Res Intern, 2018: 5406973 (IF 2.583) (correspondence author)

9. Xu GZ, Jia J, Jin L, Li JH, Wang ZY, Cao DY. Low-level laser therapy for temporomandibular disorders: a systematic review with meta-analysis. Pain Res Manag. 2018: 4230583 [PMID 29861802] (IF 1.701) (correspondence author)

10. Zhao YJ, Li JH, Hu B, Wang Y, Chang XF, Traub RJ, Cao DY. Extracellular signal-regulated kinase activation in the spinal cord contributes to visceral hypersensitivity induced by craniofacial injury followed by stress. Neurogastroenterol Motil. 2018; 30(2). doi: 10.1111/nmo. 13161. [PubMed 28730748] (IF 3.842) (correspondence author).

11. Xu GZ, Li YF, Wang MD, Cao DY. Complementary and alternative interventions for fatigue management after traumatic brain injury: a systematic review. Ther Adv Neurol Disord. 2017; 10(5):229-239. [PubMed 28529544] (IF 4.192) (correspondence author).

12. Cao DY, Bai G, Ji Y, Karpowicz J, Traub RJ. Histone hyperacetylation modulates spinal type II metabotropic glutamate receptor alleviating stress-induced visceral hypersensitivity in female rats. Mol Pain, 2016; 12 [PubMed: 27385724] (IF 3.533).

13. Cao DY, Bai G, Ji Y, Traub RJ. Epigenetic upregulation of metabotropic glutamate receptor 2 in the spinal cord attenuates oestrogen-induced visceral hypersensitivity. Gut, 2015; 64 (12): 1913-20 [PubMed 25378524].

14. Cao DY, Pickar JG. Effect of spinal manipulation on the development of history-dependent responsiveness of lumbar paraspinal muscle spindles in the cat. J. Can. Chiropr. Assoc., 2014, 58(2):149-59 [PubMed 24932019].

15. Cao DY, Reed W, Long CR, Kawchuk GN, Pickar JG. Effects of thrust amplitude and duration of high-velocity, low-amplitude spinal manipulation on lumbar muscle spindle responses to vertebral position and movement. J. Manipulative. Physiol. Ther., 2013;36(2):68-77 [PubMed 23499141].

​​​​​​​16. Reed W*, Cao DY*, Long CR, Kawchuk GN, Pickar JG. Relationship between Biomechanical Characteristics of Spinal Manipulation and Neural Responses in an Animal Model: Effect of Linear Control of Thrust Displacement versus Force, Thrust Amplitude, Thrust Duration, and Thrust Rate. Evid. Based Complement. Alternat. Med., 2013, 492039., *co-first author [PubMed 23401713].

17. Cao DY, Ji Y, Tang B, Traub RJ. Estrogen Receptor β Activation is Antinociceptive in a Model of Visceral Pain in the Rat. J Pain, 2012, 13(7): 685-694 [PubMed 22698981].

18. Cao DY, Pickar JG. Lengthening but not shortening history of paraspinal muscle spindles in the low back alters their dynamic sensitivity. J Neurophysiol. 2011;105(1):434-41 [PubMed 21047939]

19. Ge W*, Cao DY*, Long CR, Pickar JG. Plane of vertebral movement eliciting muscle lengthening history in the low back influences the decrease in muscle spindle responsiveness of the cat. J Appl Physiol. 2011;111(6):1735-1743. [PubMed 21960662]  *co-first author.

20. Cao DY, Pickar JG, Ge W, Ianuzzi A, Khalsa PS. Position Sensitivity of Feline Paraspinal Muscle Spindles to Vertebral Movement in the Lumbar Spine. J. Neurophysiol., 2009; 101(4): 1722-1729 [PubMed 19164108]

21. Cao DY, Khalsa PS, Pickar JG. Dynamic Responsiveness of Lumbar Paraspinal Muscle Spindles during Vertebral Movement in the Cat. Exp. Brain Res., 2009; 197(4): 369-377 [PubMed 19590861]

22. Cao DY, Pickar JG. Thoracolumbar Fascia does not Influence Proprioceptive Signaling from Lumbar Paraspinal Muscle Spindles in the Cat. J. Anat., 2009; 215(4):417-424 [PubMed 19627391]

23. Wang J, Guo Y, Cao DY, Luo R, Ma SJ, Wang HS, Pickar JG, Zhao Y. Tonic Inhibition of Somatostatin on C and Adelta Afferent Fibers in Rat Dorsal Skin in vivo. Brain Res., 2009; 1288: 50-59 [PubMed 19590861] * Co-corresponding author

24. Cao DY, Pickar JG. The Effect of Spinal Manipulative Thrusts on the Development of Muscle History-dependent Responsiveness of Lumbar Paraspinal Muscle Spindles. Altern. Ther. Health Med. 2009; 15: S81

25. Cao DY, You HJ, Zhao Y, Guo Y, Wang HS, Arendt-Nielsen L, Wang HL, Zhang Q. Involvement of Peripheral Ionotropic Glutamate Receptors in Activation of Cutaneous Branches of Spinal Dorsal Rami following Antidromic Electrical Stimulation of Adjacent Afferent Nerves in Rats. Brain Res. Bull., 2007; 72 (1): 10-17 [PubMed 17303502]

26. Cao DY, Pickar JG, Ge W, Ianuzzi A, Khalsa PS. Relationship between Lumbar Facet Joint Capsule Strain and Paraspinal Muscle Spindle Discharge during Vertebral Movement. J. Chiropr. Educ., 2007; 21(1): 48-49

27. Cao DY, Zhao Y, Niu HZ. Release of Substance P Induced by Electrical Stimulation of Acupoint “Zusanli”. International Journal of Clinical Acupuncture, 2006; 17(1): 35-43

28. Cao DY, Guo Y, Zhang Q, Tian YL, Wang HS, Zhao Y. Effects of Glutamate on the Afferent Discharges of Dorsal Cutaneous Sensory Nerves in Rats. Neurosci. Bull., 2005; 21(2): 111-116

29. Cao DY，Zhao Y，Guo Y，Du JH，Wang HS. Effects of Glutamate on the Discharges Rate in Rat Primary Afferent Nerve. Chinese Science and Technology Magazine Online, 2004 (Chinese, with English Abstract)

30. Cao DY, Niu HZ, Zhao Y, Du JQ, Zhu ZL. Stimulation of Acupoint Induces Release of Substance P through Primary Afferent Reflex. Chinese Acupuncture and Moxibustion, 2001;21(10): 623-625 (Chinese, with English Abstract)

31. Cao DY, Niu HZ, Zhao Y, Zhu ZL, Du JQ. Neurogenic Inflammation of the Visceral Organ Evoked by Electrical Stimulation of Acupoint in Rats. Chinese Acupuncture and Moxibustion, 2001;21(11): 662-664 (Chinese, with English Abstract)

32. Cao DY, Niu HZ, Tang XD, Li Q. Dorsal Root Reflex from Aδ and C Afferent Fibers Induced by Electrical Stimulation of the Sural Nerve in Rats. Acta Physiol. Sinica, 2003; 55(1): 105-109. [PubMed 12598945] (Chinese, with English Abstract)

33. Cao DY, Zhao Y. Role of Glutamate in Primary Sensory Transduction. Prog. Physiol. Sci., 2003; 34(4): 361-364. [PubMed 14992025] (Chinese Review)

34. Cao DY, Niu HZ, Zhao Y, Xu JT. Neurogenic Inflammation on the Skin following Electrical Stimulation at Zusanli (ST36) Acupoint. Shanghai J. Acupuncture and Moxibustion, 2003; 22 (1): 7-10 (Chinese, with English Abstract)

35. Cao DY, Niu HZ, Zhao Y, Zhang SH, Wang Y. Plasma Extravasation in the Visceral Organs Caused by Electrical Stimulation of Acupoint “Zusanli” in Rats. J. Xi’an Med. Univ. (English Edition), 2002; 14(1): 43-45

36. Cao DY, Niu HZ, Du JQ, Zhu ZL. Acupoint Electrical Stimulation Initiates Visceral Neurogenic Inflammation Reaction via Primary Afferent Reflex in the Rat. Acupuncture Research, 2002; 27(1): 45-49 (Chinese, with English Abstract)

37. Cao DY, Niu HZ. Neurogenic Inflammation of Somatic and Visceral Tissues through Primary Afferent Reflex. J. Xi’an Med. Univ., 2000;21(1):87-89 (Chinese review)

38. Guo Y, Cao DY, Zhang ZJ, Yao FR, Wang HS, Zhao Y. Electrical signal propagated across acupoints along Foot Taiyang Bladder Meridian in rats. Chin. J. Integr. Med., 2016 [PubMed 26631142].

39. Guo Y, Yao FR, Cao DY, Li L, Wang HS, Xie W, Zhao Y. The major histocompatibility complex genes impact pain response in DA and DA.1U rats. Physiol. Behav., 2015;147:30-37 [PubMed 25861730].

40. Ji Y, Bai G, Cao DY, Traub RJ. Estradiol modulates visceral hyperalgesia by increasing thoracolumbar spinal GluN2B subunit activity in female rats. Neurogastroenter. Motility., 2015;27(6):775-86 [PubMed 25810326] .

41. Traub RJ, Cao DY, Karpowicz J, Pandya S, Ji Y, Dorsey S, Dessem D. A clinically relevant animal model of temporomandibular disorder and irritable bowel syndrome comorbidity. J. Pain, 2014; 15(9): 955-966. [PubMed 24981128]

42. Li L, Luo R, Guo Y, Yao F, Cao D, Ma S, Wang J, Wang H, Zhao Y. The inhibitory effect of somatostatin receptor activation on bee venom-evoked nociceptive behavior and pCREB expression in rats. Biomed. Res. Int., 2014;2014:251785 [PubMed 24895558]

43. Wang J, Cao DY, Guo Y, Ma SJ, Zhao Y. Inhibitory effect of octreotide on the cross excitation of adjacent segment of spinal nerve in rat. Acta Physiol. Sinica, 2013; 65(6):593-599 [PubMed 24343716]. (Chinese, with English Abstract) * Co-corresponding author.

44. Reed W, Cao DY, Ge W, Pickar JG. Using vertebral movement and intact paraspinal muscles to determine the distribution of intrafusal fiber innervation of muscle spindle afferents in the anesthetized cat. Exp Brain Res, 2013;225(2): 205-215 [PubMed 23229776].

45. Ji Y, Tang B, Cao DY, Wang G, Traub RJ. Sex differences in spinal processing of transient and inflammatory colorectal stimuli in the rat. Pain, 2012; 153(9):1965-1973 [PubMed 22819535]

46. Wang J, Cao DY, Guo Y, Ma SJ, Luo R, Pickar JG, Zhao Y. Octreotide inhibits capsaicin-induced activation of C and Aδ afferent fibres in rat hairy skin in vivo. Clin Exp Pharmacol Physiol. 2011;38(8):521-7 [PubMed 21595740]

47. Luo R, Guo Y, Cao DY, Pickar JG, Li L, Wang J, Zhao Y. Local Effects of Octreotide on Glutamate-evoked Activation of Adelta and C Afferent Fibers in Rat Hairy Skin. Brain Res. 2010, 1322: 50-58 [PubMed 20117102]

48. Guo Y, Yao FR, Lu SM, Cao DY, Reed W, Zhao Y. The Major Histocompatibility Complex Genes are Associated with Basal Pain Sensitivity Differences between Dark-Agouti and Novel Congenic DA.1U rats. 1U rats. Life Sci., 2010, 86: 972-978 [PubMed 20471989]

49. Guo Y, Yao FR, Cao DY, Pickar JG, Zhang Q, Wang HS, Zhao Y. Somatostatin Inhibits Activation of Dorsal Cutaneous Primary Afferents Induced by Antidromic Stimulation of Primary Afferents from an Adjacent Thoracic Segment in the Rat. Brain Res., 2008; 1229(1):61-71 [PubMed 18640104]

50. Zhang SH, Sun QX, Seltzer Z, Cao DY, Wang HS, Chen Z, Zhao Y. Paracrine-like Excitation of Low-threshold Mechanoceptive C-fibers Innervating Rat Hairy Skin is Mediated by Substance P via NK-1 Receptors. Brain Res. Bull., 2008; 75(1): 238-245 [PubMed 18158108]

51. You HJ, Cao DY, Yuan B, Arendt-Nielsen L. Sex Differences in the Responses of Spinal Wide-dynamic Range Neurons to Subcutaneous Formalin and in the Effects of Different Frequencies of Conditioning Electrical Stimulation. Neuroscience, 2006; 138(4): 1299-1307 [PubMed 16426769]

52. Yao FR, Cao DY, Zhao Y. Cyclic AMP Response Element-binding Protein (CREB) and Pain Modulation. Prog Physiol Sci, 2006; 37(2):125-128 [PubMed 16850616] (Chinese Review)

53. Zhang Q, Zhao Y, Guo Y, Cao DY, Tang XD, Tian YL, Yao FR, Wang HS. Activation and Sensitization of C and A delta Afferent Fibers Mediated by P2X Receptors in Rat Dorsal Skin. Brain Res., 2006; 1102(1): 78-85 [PubMed 16784725]

54. Zhang Q, Zhao Y, Guo Y, Cao DY, Tian YL, Yao FR, Wang HS. Electrophysiological Evidence for the Interaction of Substance P and Glutamate on Adelta and C Afferent Fibers in Rat Hairy Skin. Clin. Exp. Pharmacol. Physiol., 2006; 33(12): 1128–1133 [PubMed 17184490]

55. Xiang XH, Wang HL, Wu WR, Guo Y, Cao DY, Wang HS, Zhao Y. Ethological Analysis of Scopolamine Treatment or Pretreatment in Morphine Dependent Rats. Physiol Behav., 2006; 88(1,2): 183-190 [PubMed 16690091]

56. Tian YL, Guo Y, Cao DY, Zhang Q, Wang HS, Zhao Y. Local Application of Morphine Suppresses Glutamate-evoked Activities of C and Adelta Afferent Fibers in Rat Hairy Skin. Brain Res., 2005; 1059(1):28-34 [PubMed 16168967]

57. Wang HL, Xiang XH, Guo Y, Wu WR, Cao DY, Wang HS, Zhao Y. Ionotropic Glutamatergic Neurotransmission in the Ventral Tegmental Area Modulates DeltaFosB Expression in the Nucleus Accumbens and Abstinence Syndrome in Morphine Withdrawal Rats. Eur. J. Pharmacol., 2005; 527(1-3): 94-104 [PubMed 16303124]

58. Zhang Q, Zhao Y, Tian YL, Guo Y, Cao DY, Wang HS. Local Injection of Alpha, Beta-Methylene ATP Induces Excitation of Primary Afferent Fibers in Rats. J. First Military Med. Univ., 2005; 25 (10): 1256-1260 [PubMed 16234102] (Chinese, with English Abstract)

59. Zhang Q, Zhao Y, Guo Y, Cao DY, Tian YL, Yao FR, Wang HS. Substance P Potentiates Glutamate-evoked Activities of Adelta and C Affrent Fibers in Rat’s Hairy Skin. Chinese Science and Technology Magazine Online, 2005 (Chinese, with English Abstract)

60. Xiang XH, Zhao Y, Wang HL, Wang HS, Cao DY. Effect of Scopolamine on Food Intake, Water Intake and Urine Volumes in Morphine Dependent Rats. J. Fourth Military Med. Univ., 2004; 25(7): 615 (Chinese, with English Abstract)

61. Zhan SQ, Zhao Y, Guo XK, Wang HS, Cao DY. Influence of Electroacupuncture on the Expression of Preprotachykinin A mRNA in the Brain of Rat. Chinese Journal of Clinical Rehabilitation (English Edition), 2004; 8(16): 3204-3205

62. Liu J, Zhang QJ, Guo BC, Cao DY, Wang KM. α2 Adrenoreceptor Influences Afferent Activities of C and Aδ Units of Caudal Nerve in Diabetic Hyperalgesic Rats. Chin. J. Neurosci., 2003; 19(1): 27-31 (Chinese, with English Abstract)

63. Jia H, Du JQ, Cao DY, et al. Effects of Skin-arrangement Treatment on Skin Temperature, Pain Threshold, Heart Rate and Conduction Velocity of Peripheral Nerves. J. Xi’an Med. Univ., 2002; 23(3): 274-276 (Chinese, with English Abstract)

64. Liu J, Zhang QJ, Guo BC, Cao DY, Wang KM. Prostaglandin Inhibitor Indomethacin Inhibits Afferent Activities of Aδ and C Units in the Saphenous Nerve of Diabetic Hyperalgesic Rats.  Acta Physiol. Sinica, 2002; 54(4):379-384 [PubMed 12399816 ] (Chinese, with English Abstract)

65. Zhan SQ, Zhao Y, Wang HS, Cao DY, Guo XK. Influence of Electroacupuncture on Cerebral Substance P Expression in the Rat. Acupuncture Res., 2002; 27(1): 33-35 (Chinese, with English Abstract)

66.   Zhao Y, Sun QX, Zhang SH, Jia J, Cao DY, Guo Y. Multiple Neuropeptides Participate in the Peripheral Information Transmission across Dermatomes. Acupuncture Res., 2002; 27(4): 298-302 (Chinese, with English Abstract)

67.   Liu J, Wang KM, Zhang QJ, Cao DY. Responses of Afferent Unit of the Caudal Nerve of Diabetic  Hyperalgesic Rats to Sympathetic Efferent Stimulation. Acta Physiol. Sinica, 2001;53(6):456-460 [PubMed 11930225] (Chinese, with English Abstract)

68. Liu J, Wang KM, Cao DY, He LZ. Responsive Properties of Afferent Units of the Superficial Branch of Radial Nerve in Diabetic Neuropathic Patients. Acta Physiol. Sinica, 1996; 48(4): 355-360 [PubMed 9389198] (Chinese, with English Abstract)

69. Liu J, Wang KM, Cao DY, He LZ. Responsive Property of Afferent Units in the Caudal Nerve of Streptozotocin-Diabetic Rats. Acta Physiol. Sinica, 1996;48(4):395-400 [PubMed 9389204] (Chinese, with English Abstract)

70. Liu J, Wang KM, He LZ, Cao DY. Effects of Sympathetic Efferent in Diabetic Hyperalgesia in Rat. Acta Physiol. Sinica, 1996; 48(6):536-542 [PubMed 9389151] (Chinese, with English Abstract)

71. Liu J, Wang KM, Cao DY, He LZ. Effects of Prostaglandins on the Diabetic Hyperalgesia of Rats. J. Xi’an Med. Univ., 1996;17(4):418-421 (Chinese, with English Abstract)

72. Liu J, Wang KM, Cao DY, He LZ. Effects of Chemical Sympathectomy on the Diabetic Hyperalgesia of Rats. J. Xi’an Med. Univ., 1996;17(3):288-291 (Chinese, with English Abstract)

73. Liu J, Wang KM, Cao DY, He LZ. The Setting up of a Model of Diabetic Hyperalgesia. J. Xi’an Med. Univ., 1996;17(2):136-139 (Chinese, with English Abstract)

74. Wang KM, Cao DY. The Relation between the Latency of H Reflex of 100 Subjects and Physiological Variables. J. Xi’an Med. Univ., 1994;15(4):362-364 (Chinese, with English Abstract)

75. Liu J, Wang KM, Cao DY, He LZ. Physiological Properties of Aδ and C Fibers of Superficial Branch of Radial Nerve in Human. Acta Physiol. Sinica, 1993;45(3):223-230 [PubMed 8235722] (Chinese, with English Abstract)

76. Liu J, Wang KM, Cao DY, He LZ. Physiological Characteristics of Superficial Branch of the Radial Nerve Innervating Mechanoreceptive units in the Human Body. J. Xi’an Med. Univ., 1993; 14(1):25-29 (Chinese, with English Abstract)

77. Wang KM, Liu J, Cao DY. Study on the Peripheral Apparatuses of the Acupoints Innervated by the Tibial Nerve and Their Needling Sensations. Acupuncture Res., 1991;16(3,4):211-212 (Chinese, with English Abstract)

BOOK CHAPTERS

1. Wei SQ, Xue Y, Tao ZY, Cao DY. Peripheral sensitization (Book Chapter). In: Peripheral Nerves-injuries, Disorders and Treatment. Turker H (Ed). IntechOpen, 2019

2. Tao ZY, Traub RJ, Cao DY. Epigenetic modulation of visceral Pain (Book Chapter). In: Epigenetics of Chronic Pain. Bai G & Ren K (Eds). Elsevier, 2018, 141-156

3. Cao DY, Zhao Y, Guo Y, Pickar JG. Glutamate receptors involved in interaction between peripheral nerve terminals. In: Amino Acid Receptor Research. NOVA press, 2008, 309-327

4. Cao DY, Yan JQ. Excitatory Amino Acids and Inhibitory Amino Acids. In: Essentials of Neurobiology (Chinese edition). Yan JQ & Zhao Y (eds), Xi’an Jiaotong University Press, 2007: pp. 73-92

5. Cao DY, Zhao Y. Tachykinins. In: Essentials of Neurobiology (Chinese edition). Yan JQ & Zhao Y (eds), Xi’an Jiaotong University Press, 2007: pp. 116-123

6. Cao DY, Zhao Y. The Role of Neurotransmitters in Pain Modulation. In: Essentials of Neurobiology (Chinese edition). Yan JQ & Zhao Y (eds), Xi’an Jiaotong University Press, 2007: pp. 252-258

ABSTRACT

1.     Xue Y, Wei SQ, Wang PX, Li JH, Liu EQ, Traub RJ, Cao DY. Orofacial inflammation with stress induces hyperalgesia through down-regulation of 5-HT2 receptors. Society of Neuroscience 49th Annual Meeting, Chicago, IL, No. 2019-S-4571, 2019

2.     Xu GZ, Xue Y, Wei SQ, Li JH, Traub RJ, Wang MD, Cao DY. Valproate inhibits stress-induced somatic and visceral pain through up-regulation of 5-HT2C receptor. Society of Neuroscience 49th Annual Meeting, Chicago, IL, No. 2019-S-4576, 2019

3.     Li JH, Li ZL, Tao ZY, Xue Y, Cao DY. NMDA receptor in the spinal cord contributes to somatic hyperalgesia induced by craniofacial inflammatory pain combined with repeated forced swim stress. The 17th World Congress on Pain, Boston, MA, USA. Sept., 2018

4.     Cao DY, Bai G, Ji Y, Traub RJ. Stress epigenetically regulates spinal NMDA and mGluR3 expression modulating visceral sensitivity in female rats. Society of Neuroscience 45th Annual Meeting, Chicago, IL, No. 238.04, 2015

5.     Li A, Cao DY, Guo Y, Zhao Y. Peripheral glutamate receptors contribute to Fos expression in the spinal dorsal horn through interaction between peripheral nerve terminals. Society of Neuroscience 45th Annual Meeting, Chicago, IL, No. 704.08, 2015

6.     Cao DY, Bai G, Ji Y, Traub RJ. Stress-induced visceral hypersensitivity involves epigenetic modulation of spinal NMDA and mGluR2/3 expression modulating viseral sensitivity. The 6th Asian Pain Symposium, Suzhou, China, 2015

7.     Cao DY, Bai G, Karpowicz J, Ji Y, Traub RJ. Epigenetic modulation on stress-induced visceral hypersensitivity. Society of Neuroscience 44rd Annual Meeting, Washington DC, No. 628.07, 2014.

8.     Ji Y, Karpowicz J, Pandya S, Cao DY, Traub RJ. Estrogen receptor alpha and beta differentially mediate MAPK signaling pathway activation in the female rat spinal cord. Society of Neuroscience 44rd Annual Meeting, Washington DC, No. 628.17, 2014.

 

9.     Cao DY, Guang B, Ji Y, Traub RJ. Epigenetic modulation of estrogen-induced facilitation of visceral pain. Society for Neuroscience 43rd Annual Meeting, San Diego, CA, No. 643.04, November 2013.

10.   Traub RJ, Cao DY, Dorsey S, Dessem D. Stress and estrogen induce persistent visceral hypersensitivity following masseter muscle inflammation: A new model of overlapping pain conditions. Society for Neuroscience 43rd Annual Meeting, San Diego, CA, No. 369.02, November 2013.

11.   Cao DY, Ji Y, Tang B, Traub RJ. Activation of estrogen receptor beta inhibits visceral pain. The 14th World Congress on Pain, Milan, Italy. No.107935, August 2012.

12.   Cao DY, Ji Y, Tang B, Traub RJ. Effect of estrogen receptor beta activation on the response of dorsal horn neurons to colorectal distention. Society for Neuroscience 41th Annual Meeting, Washington DC, No. 494.04, November 2011.

13.   Pickar JG, Reed WR, Cao DY, Kawchuk GN. Effect of the mechanical characteristics (magnitude and duration) of a spinal manipulative thrust on lumbar paraspinal muscle spindle discharge. 2011 ACC RAC conference, Las Vegas, Nevada, March 2011.

14.   Cao DY, Reed WR, Kawchuk GN, Pickar JG. Effects of thrust displacement simulating a spinal manipulation on the response of lumbar paraspinal muscle spindles to ramp and hold movement. Society for Neuroscience 40th Annual Meeting, San Diego, CA, No. 182.1, November 2010.

15.   Reed WR, Cao DY, Kawchuk GN, Pickar JG. Effects of spinal manipulation's mechanical characteristics (magnitude and duration) on paraspinal muscle spindle discharge. Society for Neuroscience 40th Annual Meeting, San Diego, CA, No. 182.17, November 2010.

16.   Cao DY, Pickar JG. The effect of muscle history on the velocity sensitivity of lumbar paraspinal muscle spindles. Society for Neuroscience 39th Annual Meeting, Chicago, IL, No. 80.4, October 2009.

17.   Cao DY, Pickar JG. Lumbodorsal fascia does not affect passive signaling properties of lumbar paraspinal muscle spindles. The 2nd International Fascia Research Congress, Amsterdam, The Netherlands, October 2009.

18.   Cao DY, Pickar JG. The effect of spinal manipulative thrusts on the development of muscle history-dependent responsiveness of lumbar paraspinal muscle spindles. Oral Presentation at 2nd North American Research Conference on Complementary & Integrative Medicine, No. 2869, Minneapolis, MN, May 2009.

19.   Reed WR, Cao DY, Pickar JG. An in vivo spinal joint hypo- and hypermobility model for investigating paraspinal afferent feedback. Society for Neuroscience 39th Annual Meeting, Chicago, IL, No. 80.3, October 2009.

20.   Cao DY, Pickar JG. Removing lumbodorsal fascia does not affect the development of muscle history-dependent responsiveness in lumbar paraspinal muscle spindles. Society for Neuroscience 38th Annual Meeting, No. 181.10, Washington DC, November 2008.

21.   Pickar JG, Cao DY, Ge W. The responsiveness of lumbar paraspinal muscle spindles is affected by the history of vertebral position along 3 orthogonal axes of vertebral motion. Society for Neuroscience 38th Annual Meeting, No. 181.11, Washington DC, November 2008.

22.   Cao DY, Pickar JG, Ge W, Ianuzzi A, Khalsa PS. Sensitivity of paraspinal muscle spindles to intervertebral movement in the cat lumbar spine. Society for Neuroscience 37th Annual Meeting, No. 410.10, San Diego, November 2007.

23.   Ge W, Cao DY, Pickar JG. Resting discharge of paraspinal muscle spindles is stable under deep anesthesia using sodium pentobarbital. Society for Neuroscience 37th Annual Meeting, No. 410.12, San Diego, November 2007.

24.   Pickar JG, Cao DY, Ge W, Ianuzzi A, Khalsa PS. Sensitivity of paraspinal muscle spindles to intervertebral position in the cat lumbar spine. Society for Neuroscience 37th Annual Meeting, No. 410.11, San Diego, CA, November 2007.

25.   Cao DY, Pickar JG, Ge W, Ianuzzi A, Khalsa PS. Changes in lumbar facet joint capsule strain and paraspinal muscle spindle discharge during vertebral movement in the anesthetized cat. Society for Neuroscience 36th Annual Meeting, No. 650.1, Atlanta, GA, October 2006.

26.   Ge W, Cao DY, Pickar JG. Very small changes in vertebral position evoke muscle history dependent changes in paraspinal muscle spindle discharge of the anesthetized cat. Society for Neuroscience 36th Annual Meeting, No. 650.2, Atlanta, GA, October 2006.

27.   Cao DY, Zhao Y, Guo Y, Wang HS. Antidromic electrical stimulation of sensory nerve sensitizes adjacent primary afferent terminal: the role of glutamate ionotropic receptors. Oral Presentation at Society for Neuroscience 35th Annual Meeting, No. 364.10, Washington DC, November 2005.

CORRESPONDENCE ADDRESS:

              Dong-Yuan Cao

              Research Center of Stomatology

              Stomatological Hospital

              Xi’an Jiaotong University Health Science Center

              Xi’an, Shaanxi 710004, China

              Tel: 18291885396(Cell)  

              E-mail: Dongyuan_cao@hotmail.com；caody1@xjtu.edu.cn