Basic Information

Hong-Mei Zhang , PhD

Professor of Biomedical Information Engineering

Key Laboratory of Biomedical Information Engineering, Ministry of Education

Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University

28 Xian Ning West Avenue, 710049

P. R. China

Tel: (029)82665901; Fax: (029)82668668-801

Mobile: 15353563571

Email: claramei@mail.xjtu.edu.cn

 

Hongmei Zhang received her PhD degree in Biomedical Science and Technology from Xi’an Jiaotong University, in 2004. She is currently a Professor in the Key Laboratory of Biomedical Information Engineering, Ministry of Education, the Department of Biomedical Engineering, Xi’an Jiaotong University. Her research work is to develop novel methods to characterize the viscoelastic property of the soft tissue. Her multidisciplinary broad research interests include fractional derivative model based viscoelastic biomarkers for early disease; Machine learning of multi-mode medical imaging data on early diagnosis of major disease. She has more than 30 publications. She is the editorial board member of  《Measurement Science and Technology》. She is an IEEE member and a member of the Chinese Institute of Electronics.

 

EDUCATION:

Visiting Scholar: University of Illinois at Urbana-Champaign. (2014.9-2015.9)

Ph.D. Biomedical Engineering, Xi’an Jiaotong University, P.R. China, (2000-2004)

M.S. Material Science, Xi’an Jiaotong University, P.R. China, (1997-2000)

B.S. Material Science, Nanjing University of Science and Technology, P. R. China (1992-1996)

Research Interests

►Nanoindentation of soft tissue based on Fractional derivative models.

►Fractional derivative model based viscoelastic imaging and deep learning of imaging parameters.

►Machine learning of multi-mode medical imaging data on early diagnosis of major disease (Vulnerability evaluation for Carotid plaque, breast cancer and other clinic symptom)​​​​​​​​​​​​​​​​​​​​​​​

Teaching Activity

Medical image processing,  2 credit hours/semester ( for undergraduate student)

Medical image information Analysis,  2 credit hours/semester ( for postgraduate student)

Funding

(1) Project Title: “Multi source data set deep reinforcement learning and fractional viscoelastic flow ultrasound for early breast screening”

PI: Hong-Mei Zhang

Funding support: National Natural Science Fundation of China under Grant (No. 62171366)

Research Time:  01/01/2022-12/31/2025

Total cost: RMB:560,000 

 

 

(2) Project Title: “Ultrasound Viscoelasticity and fluidity biomarkers for vulnerability of carotid plaque by Fractional derivative model”

PI: Hong-Mei Zhang

Funding support: National Natural Science Fundation of China under Grant (No. 61871316)

Research Time:  01/01/2019-12/31/2022

Total cost: RMB:630,000 

 

 

 (3) Project Title: “Super-resolution ultrasound elasticity imaging on carotid plaque-Theroetical methods and experiments”

PI: Hong-Mei Zhang

Funding support: National Natural Science Fundation of China under Grant (No.60801057)

Research Time:  01/01/2009-12/31/2011

Total cost: RMB:200,000

 

 

 (4) Project Title: “Carotid strain estimation and elasticity imaging”

PI: Hong-Mei Zhang

Funding support: President Science Fundation of Xi an Jiaotong University under Grant (No.xjj2008027)

Research Time:  10/01/2008-9/31/2010

Total cost: RMB:10,000

 

 

(5) Project Title: “Fractional based model for Viscoelastic imaging and application on early sifting of breast cancer”

PI: Hong-Mei Zhang

Funding support: Major and Cultivation Project of Xi’an JiaoTong University(No: zdyf2017011).

Research Time:  10/01/2017-9/31/2019.

Total cost: RMB:150,000

 

 

 (6) Project Title: “Super-resolution strain estimation and elasticity imaging to evaluate the risk of vulnerability of Carotid plaque”

PI: Hong-Mei Zhang

Funding support: International cooperation Science Fundation of Xi an Jiaotong University under Grant (No. 2012jdhz50)

Research Time:  10/01/2010-9/31/2012.

Total cost: RMB:40,000  

 

 

(7) Project Title: “APP of smart making friends”

PI: Hong-Mei Zhang

Funding support: Transverse project (No: 20210228).

Research Time:  01/22/2021-03/01/2024.

Total cost: RMB:30,000

 

 

 

(8) Project Title: “System construction of major lung diseases based on Knowledge Engineering”

PI: Hong-Mei Zhang

Funding support: Transverse project (No: 20210227).

Research Time:  01/18/2021-01/18/2024.

Total cost: RMB:30,000

 

 

(9) Project Title: “Machine learning and knowledge map construction of major lung diseases”

PI: Hong-Mei Zhang

Funding support: Transverse project (No: 202112106).

Research Time:  12/01/2021-12/01/2024.

Total cost: RMB:150,000

Publications

  1. Hongmei Zhang, Tongqing Lu, Qingzhe Zhang, Yan Zhou, Hongrui Zhu, Joseph Harms, Xiaofeng Yang, Mingxi Wan*, Michael F. Insana*, Solutions to ramp-hold dynamic oscillation indentation tests for assessing the viscoelasticity of hydrogel by Kelvin-Voigt fractional derivative modeling, Mechanics of Materials, 2020, 148 (103431):1-15. DOI: 10.1016/j.mechmat.2020.103431
  2. HONGMEI ZHANG, LEI XU, ZHIHUI LIU, SHUKUAN LU, JICHAO YIN, SIBO TIAN, XIAOFENG YANG, MINGXI WAN*. Statistical and Texture Descriptors of Symptomatic Plantar Fasciitis Using Ultrasound Shear Wave Elastography. IEEE Access. 2020:8,120146-120159. DOI: 1-1. 10.1109/ACCESS.2020.3005829.
  3. Hongmei Zhang , Ying Guo , Yan Zhou, Hongrui Zhu, Manman Song, Kai Wang, Meili Gao, Litao Ruan, Mingxi Wan, Michael F. Insana*, Fluidity and elasticity form a concise set of viscoelastic biomarkers for breast cancer diagnosis based on Kelvin–Voigt fractional derivative modeling, Biomechanics and Modeling in Mechanobiology , Biomechanics and Modeling in Mechanobiology, 2020,19:19:2163–2177 (DOI:10.1007/s10237-020-01330-7)
  4. HONGMEI ZHANG, MANMAN SONG,LITAO RUAN,FURONG ZHANG, AIFENG ZHANG, ANDREW M. SIEDLECKI, MINGXI WAN. Von Mises Strain as a Risk Marker for Vulnerability of Carotid Plaque: Preliminary Clinical Evaluation of Cerebral Infarction. Ultrasound Med Biol 2019, 45:1221-1233. DOI: 10.1016/j.ultrasmedbio.2019.01.007
  5. Hongmei Zhang, Qingzhe Zhang，Litao Ruan, Mingxi Wan, Michael F.Insana. Modeling Ramp-hold Indentation Measurements based on Kelvin-Voigt Fractional Derivative Model. Measurement Science and Technology. 2018, 29(3), 1-16. DOI: 10.1088/1361-6501/aa9daf.
  6. Hongmei Zhang, Yue Wang, Mostafa Fatemi , Michael Insana. Assessing composition and structure of soft biphasic media from Kelvin-Voigt fractional derivative model parameters", Measurement Science and Technology. 2017, 28 (2017) 035703 (12pp) doi:10.1088/1361-6501/aa5531.
  7. HongMei Zhang1,2, Yue Wang2, Michael F. Insana2, Ramp-hold relaxation solutions for the KVFD model applied to soft viscoelastic media. Measurement Science and Technology, 27 (2016) :1-11.
  8. Zhang HM, Song MM, Yang M, Ruan LT, Wan MX. Fast Von Mises Strain Imaging on Ultrasound Carotid Vessel Wall by Flow Driven Diffusion Method, AUSTRALAS PHYS ENG S 2018: 1-18.
  9. HongMeiZhang, Yue Wang, LiTao Ruan, Junbo Duan, MingXi Wan ,Non-invasive Von Mises Strain imaging for Longitudinal Artery Wall. Journal of Medical Imaging and Health Informatics, 2016,6(4):906-915.
  10. HongMei Zhang, HuiE Zhang, JunFeng Wu, et al. "Detection of thin structure defects in radiographic images using an improved Gabor filter." Insight - Non-Destructive Testing and Condition Monitoring 59.10(2017):531-536.
  11. Zhang Hongmei, Wan Mingxi, Bian Zhengzhong. Complementary tensor-driven image coherence diffusion for oriented structure enhancement. EURASIP Journal on Advances in Signal Processing 2011, 2011:70http://asp.eurasipjournals.com/content/2011/1/70.
  12. HongMei Zhang, MingXi Wan, JinJin Wan,XuLei Qin. Super-Resolution Reconstruction of Deformable Tissue from Temporal Sequence of Ultrasound Images, 2010 International conference on artificial Intelligence and Computational Intelligence. Vol. 1, pp.337-342.
  13. Hongmei Zhang，Mingxi Wan, Bo Shen, Xiaodong Wang, Mingzhu Lu. Volume estimation in a sequence of freehand ultrasound images. Measurement Science and Technology. 2006, 17 (11): 2927-2937.
  14. Zhang Hongmei，Wan Mingxi. Improved Mumford-Shah Functional for Coupled Edge-Preserving Regularization and Image Segmentation. EURASIP Journal on Applied Signal Processing. 2006 Art. No. 37129 : 1-9
  15. Zhang Hongmei，Bian Zhengzhong, Guo Youmin, Ye Min, Miao Yalin. Region information-based ROI extraction by multi-initial fast marching algorithm.  EURASIP Journal on Applied Signal Processing，2004,11:1739-1749.
  16. Zhang Hongmei, Bian Zhengzhong, Yuan Zejian, Ye Min, Ji Feng. A novel multiresolution fuzzy segmentation method on MR image. Journal of Computer Science and Technology, 2003, 18(5): 659-666.
  17. Zhang Hong-mei，Bian Zheng-zhong ,Guo You-min, Ye Min. Efficient approach to extraction of region of interest, Journal of Software, 2005, 16(1): 77-88.
  18. Zhang Hongmei, Bian Zhengzhong, Jiang Dazong, Yuan Zejian, Ye Min. Level set method for pulmonary vessels extraction. IEEE International Conference on Image Processing, Barcelona, Spain, 14-17 September 2003, 2:1105-1108.
  19. Hongmei Zhang, Zhengzhong Bian, Youmin Guo, Baowei Fei, Min Ye. An efficient multiscale approach to level set evolution. The 25th Silver Anniversary International conference of the IEEE Engineering in Medicine and Biology Society, Cancun, Mexico, 17-21 Sept. 2003, 694-697.
  20. Zhang Hong-mei, Yuan Ze-jian, Cai Zhong-min, Bian Zheng-zhong. Segmentation of MRI Using Hierarchical Markov Random Field. Journal of Software, 2002, 13(9): 1779-1786.
  21. Zhang Hong-mei, Bian Zheng-zhong, Guo You-min, Yuan Ze-jian. An Efficient Approach to Pulmonary Vessels Extraction Based on Curve Evolution. Chinese Journal of Biomedical Engineering (English edition), 2004, 13(1): 39-46.
  22. Hongmei Zhang, Yalin Miao, Youmin Guo, Jiang Yang, Zhengzhong Bian, Vascular enhancement by anisotropic diffusion-reaction PDE. Microellectronics & Computer, 2004,21(3):25-27.(In Chinese)
  23. Hongmei Zhang, Donglang Chai, Zhengzhong Bian, a fast subdivision method for grid of composite material. Journal of Applied Mechanics, 2002,19(4):147-149. (In Chinese)

(Chinese National Invention patent)

  1. Zhang Hongmei, Ruan Litao, Zhang qingzhe, Guo Youmin, Wan Mingxi, Shan Baowen. A novel and high accuracy noninvasive elastic imaging of vascular wall. Authorized, ZL 2016012710027191.

  2. Zhang Hongmei, Wang Kai, Liu Zhihui, Zhang Kehao, Zhou Yan, Yang Fan, Wang Jiong, Wan Mingxi. Machine learning optimization method of fractional order KVFD parameters for Viscoelastic characterization of soft matter, CN 202010598527.4 (publicizing)

  3. Zhang Hongmei, Zhou Yan, Wang Kai, Li Wenbin, Zhang Kehao, Wang Jiong, Wan Mingxi. Global optimization method and system for KVFD model mechanical parameters based on deep reinforcement learning with double losses value network, CN 2021103682572 (publicizing)

Book  Chapter (In Chinese)

  1. Hongmei Zhang, Chapter  7  Elasticity reconstruction of Vascular (Mingxi Wan et al, Computational Ultrasonic imaging), 2019-01, 978-7-03-059103-6 Chinese Science Press.
  2. Hongmei Zhang, Chapter  8  Fractional derivative model based viscoelastic measurement of biological tissue (Mingxi Wan et al, Computational Ultrasonic imaging ) 2010-05,978-7-03-027204-1 Chinese Science Press
  3. Hongmei Zhang, Chapter 10 Ultrasound medical image processing (Mingxi Wan et al, Biomedical Ultrasonics),  2010-05,978-7-03-027204-1, Chinese Science Press.

 (Software Copyright)

  1. Hongmei Zhang ,Litao Ruan, Zhengzhong Bian, Youmin Guo, Mingxi Wan, Variational and d PDE base evolution methods  for image analysis.  (corpyright No. 2014SR080747)
  2. Hongmei Zhang , Mingxi Wan, Litao Ruan, Volume measurement from free hand Ultrasound images (copyright 2014SR080401)

( Publication as co-corresponding author )

  1. Jianjun Yu, Hao Guo, Meng Han, Fan Wang, Ayache Bouakaz, Hongmei Zhang*, Mingxi Wan*. Transcranial ultrasound estimation of viscoelasticity and fluidity of the soft matter, Physical Review Applied. 2022, 17: 024001.
  2. Yan Song, Ying Dang, Jichang Wang, Hui Cai, Jun Feng, Hongmei Zhang*, Litao Ruan*. Carotid intraplaque neovascularization predicts Ischemic Stroke Recurrence in Patients with Carotid Atherosclerosis. Gerontology. 2021, 67(2):1-8.

 ( Publication as co-author )

  1. Jinjin Wan, Fangli He, Yongfeng Zhao, Hongmei Zhang, Xiaodong Zhou, Mingxi Wan. Non-invasive Vascular Radial/Circumferential Strain Imaging and Wall Shear Rate Estimation Using Video Images of Diagnostic Ultrasound. Ultrasound in Medicine & Biology, 2014,40(3), 622-636.
  2. Hongrui Zhu, Dui Qin, Youshen Wu,  Bowen Jing,  Jiajun Liu,  David Hazlewood,  Hongmei Zhang,  Yi Feng,  Xinmai Yang, Mingxi Wan,* , and Daocheng Wu*  Laser-Activated Bioprobes with High Photothermal Conversion Efficiency for Sensitive Photoacoustic/Ultrasound Imaging and Photothermal Sensing. ACS Appl. Mater. Inter 2018, 10:29251-29259.
  3. Zhu, H., Gan, Z., Li, D., Qin, J., Zhang, H., Wan, M., & Wu, D. (2019). Sensitive detection of dopamine with ultrasound cavitation-enhanced fluorescence method. Microchemical Journal, 150, 104199.
  4. D.F. Luo, P. Ning, F. Zhang, Y. Zhou, H.M. Zhang, T. Fu. Hydrothermal calcification surface modification of biomedical tantalum. Rare Metals. 2021, 40(4), 928-933.