My research focuses on the role of calcium-activated potassium channels in cardiovascular diseases. I have presided over 6 projects from National Natural Science Foundation, 1 Special Scientific Research Fund for Doctoral Programs in Colleges and Universities, 1 Natural Science Foundation of Shaanxi Province and 10 Founds from pharmaceutical company or university. I have published 130 papers, including 50 papers in SCI, and got 1 patent.
Paper
1. Galectin-3 and KCa3.1 mediate heterogenous cell coupling and myocardial fibrogenesis driven by b-adrenoceptor activation. Hypertension 2020
2. KCa3.1 channel mediates inflammatory signaling of pancreatic β-cells and progression of type 2 diabetes mellitus. FASEB J 2019
3. Oxidative stress induced by palmitic acid modulates KCa2.3 channels in vascular endothelium. Exp Cell Res 2019
4. KCa3.1 channels promote cardiac fibrosis through mediating inflammation and differentiation of monocyte into myofibroblast in angiotensin II treated rats. J Am Heart Assoc 2019
5. The role and mechanism of KCa3.1 channels in human monocyte migration induced by palmitic acid. Exp Cell Res 2018
6. Tyrphostin AG556 increases the activity of large conductance Ca2+-activated K+ channels by inhibiting EGFR tyrosine kinase. J Cell Mol Med 2017
7. Effects of equol on multiple K+ channels stably expressed in HEK 293 cells. PLoS One 2017
8. Equol increases cerebral blood flow in rats via activation of large-conductance Ca2+-activated K+ channels in vascular smooth muscle cells. Pharmacol Res 2016
9. The role of KCa3.1 channels in cardiac fibrosis induced by pressure overload in rats. Pflugers Arch 2015
10. Metformin restores IKCa- and SKCa-mediated vasodilatation impaired by advanced glycation end products in rat mesenteric artery. Mol Pharmacol 2014
11. Advanced glycation endproducts impair KCa3.1- and KCa2.3-mediated vasodilatation via oxidative stress in rat mesenteric arteries. Pflug Arch 2014
12. Equol is neuroprotective during focal cerebral ischemia and reperfusion that involves p-Src and gp91phox. Curr Neurovas Res 2014
13. KCa3.1 channels mediate the increase of cell migration and proliferation by advanced glycation end products in cultured rat vascular smooth muscle cells. Lab Invest 2013
14. Angiotensin II upregulates KCa3.1 channels and stimulates cell proliferation in rat cardiac fibroblasts. Biochem Pharmcol 2013
15. EGFR Tyrosine kinase regulates small conductance Ca2+-activated K+ (hSKCa1) channels expressed in HEK 293 cells. Biochem J 2013
16. Cholesterol down-regulates BK channels stably expressed in HEK 293 cells. PLoS One 2013
17. Advanced glycation end products promote proliferation of cardiac fibroblasts by upregulation of KCa3.1 channels. Pflugers Arch 2012
18. Insulin-mediated upregulation of KCa3.1 channels promotes cell migration and proliferation in rat vascular smooth muscle. J Mol Cell Cardiol 2011
19. Functional ion channels in stem cells. World J Stem Cells 2011
20. Genistein and tyrphostin AG556 inhibit inwardly-rectifying Kir2.1 channels expressed in HEK 293 cells via protein tyrosine kinase inhibition. BBA-Biomembranes 2011
21. Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases. Cardiovasc Res 2012
22. Experimental diabetes mellitus down-regulates large-conductance Ca2+-activated K+ channels in cerebral vascular smooth muscle and alters functional conductance. Curr Neurovas Res 2010
23. Daidzein relaxes rat cerebral basilar artery via activation of large-conductance Ca2+-activated K+ channels in vascular smooth muscle cells. Eur J Pharmacol 2010
24. Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs. Circulation 2008
25. Cell cycle-dependent expression of potassium channels and cell proliferation in rat mesenchymal stem cells from bone marrow. Cell Prolif 2007
26. A non-steroidal anti-inflammatory agent provides significant protection during focal ischemic stroke with decreased expression of matrix metalloproteinases. Curr Neurovase Res 2007
27. Comparison of alpha1-adrenergic receptors cell membrane stationary phases prepared from expressed cell line and from rabbit hepatocytes. Anal Bioanal Chem 2006
28. Properties of ion channels in rabbit mesenchymal stem cells from bone marrow. Biochem Bioph Res Co 2006
29. Ion channels in mesenchymal stem cells from rat bone marrow. Stem Cells 2006
30. Characterization of ionic currents in human mesenchymal stem cells from bone marrow. Stem Cells 2005
课题组主持的项目
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项目号/主持人
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项目来源
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项目名称
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支助额
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执行年限
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81870223
邓秀玲
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国家自然科学基金面上项目
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AMPK调节血管内皮钙激活钾离子通道的作用与机制
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56万
（直接经费）
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2019.01～2022.12
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2017JQ8004
庞正达
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陕西省自然科学基础研究计划-青年项目
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核因子κB调节胰腺β细胞KCa3.1参与2型糖尿病发病的研究
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5.0万元
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2017.01～2018. 12
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81600656
庞正达
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国家自然科学基金青年项目
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胰腺β细胞KCa3.1在2型糖尿病发病中的作用与调节机制
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17.0万
（直接经费）
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2017.01～2019. 12
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2015M580857
庞正达
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第58批中国博士后科学基金面上项目
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中电导钙激活钾通道在2型糖尿病发病中的作用与机制
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8.0万
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2016. 01～2018. 12
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81570214
邓秀玲
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国家自然科学基金面上项目
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KCa3.1在压力超负荷所致心脏纤维化中的作用与机制
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52.0万
（直接经费）
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2016. 01～2019. 12
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81370191
赵丽梅
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国家自然科学基金面上项目
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血管紧张素II调控钙激活钾通道参与心房纤颤的作用与机制
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65.0万
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2014. 01～2017. 12
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81200097
王燕
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国家自然科学基金青年项目
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IKCa通道对人成体心脏干细胞迁移、分化的调控作用及其在心肌缺血损伤修复中的意义
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24.0万
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2013. 01～2015. 12
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81170137
邓秀玲
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国家自然科学基金面上项目
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c-Src激酶在2型糖尿病脑动脉BKCa通道功能障碍中的作用
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60.0万
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2012. 01～2015. 12
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81100231
赵丽梅
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国家自然科学基金青年项目
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钙激活钾通道在糖尿病血管内皮舒张功能障碍中的作用及机制
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14.0万
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2012. 01～2012. 12
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2011JQ4021
赵丽梅
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陕西省自然科学青年人才项目
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AGEs在糖尿病血管内皮舒张功能障碍中的作用及机制
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2.0万
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2011. 01～2012. 12
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81070129
邓秀玲
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国家自然科学基金面上项目
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KCa3.1在糖尿病血管平滑肌细胞上的调控作用及机制
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33.0万
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2011. 01～2013. 12
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20100481335
赵丽梅
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第48批中国博士后科学基金面上项目
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糖基化终产物在糖尿病血管内皮超极化因子介导的舒张功能障碍中的作用及机制
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3.0万
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2011. 01～2012.12
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200806980032
邓秀玲
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博士学科点导师基金
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血管平滑肌细胞IKCa在糖尿病血管并发症中的作用
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6.0万
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2009. 01～2011. 12
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30572184
邓秀玲
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国家自然科学基金面上项目
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血管平滑肌BKCa表达和调控改变在糖尿病血管病变中的作用
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25.0万
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2006. 01～2008. 12
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(创新港)
