- National Natural Science Foundation of China 2020-2023
Title: “Enhanced cancer immunotherapy by combining microbubble-mediated low frequency ultrasound and hyperthermia: mechanical and thermal mechanisms”
Total Award Amount: ¥2,000,000
Tasks: To develop a useful protocol of potential immunotherapy with high intensity focused ultrasound and increased cavitation with targeted microbubble; to evaluate the microbubble vibration mode under low frequency focused ultrasound and its cavitation effects; to evaluate the activation of immunotherapy with HIFU, cavitation and anti-PD-1 and their combined effects with different protocol; to prove the anti-tumor effects of combined immunotherapy in vitro and in vivo..
- National Natural Science Foundation of China 2017-2020
Title: “Photoacoustic Cavitation Targeted Damage on Micro-Vessel: Mechanical Mechanism, In Situ Experiments and In Vivo Monitoring Imaging”
Total Award Amount: ¥630,000
Tasks: To develop a useful protocol of photoacoustic cavitation damage on micro-vessel in localized drug delivery; to evaluate the photoacoustic cavitation nucleation/ bubble dynamics via simulation, high speed microscopic imaging, passive cavitation detection; to build up the image-guided photoacoustic cavitation experimental/ pre-clinic system in an in situ micro-vessel model and the nude mice spine tumor model in vivo.
- National Natural Science Foundation of Shaanxi Province 2014-2016
Title: “Multi-mode ultrasound contrast agents assisted ultrasound induced angiogenesis regression and its cavitation mechanobiological study”
Total Award Amount: ¥20,000
Tasks: To produce an effective way inducing angiogenesis regression by ultrasound and multi-mode UCA; to evaluate the influence of cavitation on the above process and its molecular mechanism.
- The Fundamental Research Funds for the Central Universities 2014-2016
Title: “In situ micro-vessel damage by photoacoustic cavitation and its mechanism”
Total Award Amount: ¥120,000
Tasks: To design and realize the targeted micro-vessel damage by photoacoustic cavitation in an in situ microscopic system; to evaluate the transient process and analyze the characteristics of acoustic signals from the photoacoustic cavitation.
- National Natural Science Foundation of China 2013-2015
Title: “Antiangiogenic therapy based on targeted microbubble assistant low intensity focused ultrasound: transient cavitation and its molecular mechanism”
Total Award Amount: ¥230,000
Tasks: To develop a novel antiangiogenic therapeutic protocol with LIFU and targeted microbubbles; to design and construct A single cell-single bubble-LIFU-acoustic and light confocal/ high speed/ fluorescent microscopic system and illustrate the mechanism of above process; to test and verify the tumor growth inhibition in vivo.
- Research Fund for the Doctoral Program of Higher Education of China 2012-2014
Title: “Inhibition of tumor growth via low intensity focused ultrasound and targeted microbubbles on angiogenesis”
Total Award Amount: ¥40,000
Tasks: To test the inhibition of tumor growth with low intensity focused ultrasound and microbubbles targeted to angiogenesis; to analyze the gene and protein profile contributing to the effects; to provide an effective protocol of assistant cancer therapy via above mechanism.
- The Fundamental Research Funds for the Central Universities 2012-2014
Title: “The evaluation, effects and molecular mechanism of artery hemodynamics on vascular remodeling”
Total Award Amount: ¥80,000
Tasks: To produce a method of echo-PIV to evaluate the artery hemodynamics; to examine its effects on vascular remodeling; to analyze its potential molecular mechanism via the gene and protein analysis.