科研论文

  1. Deng Huan, Lin Xue, Xiang Rongqi, Bao Miaoye, Qiao Lichun, Liu Haobiao, He Huifang, Wen Xinyue, Han Jing*. Low selenium and T-2 toxin may be involved in the pathogenesis of Kashin-Beck disease by affecting AMPK/mTOR/ULK1 pathway mediated autophagy. Ecotoxicology and Environmental Safety. 2024.

  2. Lin Xue#, Qiao Lichun#, Liu Haobiao#, Bao Miaoye, Deng Huan, Jia Lianxu, Wen Xinyue, Deng Feidan, Wan Ping, LyuYizhen, Han Jing*. An untargeted metabolomics study of cardiac pathology damage in rats caused by low selenium alone or in combination with T-2 toxin. Food and Chemical Toxicology. 2024.

  3. Xue Lin#, Haobiao Liu#, Lichun Qiao#, Huan Deng, Miaoye Bao, Zhihao Yang, Yujie He, Rongqi Xiang, Huifang He, Jing Han*. Chondrocyte autophagy mediated by T-2 toxin via AKT/TSC/Rheb/mTOR signaling pathway and protective effect of CSA-SeNP. Osteoarthritis and Cartilage. 2024.

  4. Yan Zhao#, Zhaoyang Li#, Xinyue Wen#, Hongqiu Li, Huifang He, Jing Han*. The association between metal exposure and body mass index of preschool children of Shaanxi, China. Hygiene and Environmental Health Advances. 2024.

  5. Qiao Lichun#, Lin Xue#, Liu Haobiao#, Xiang Rongqi, Zhan Jingming, Deng Feidan, Bao Miaoye, He Huifang, Wen Xinyue, Deng Huan, Wang Xining, He Yujie, Yang Zhihao, Han Jing*. T-2 toxin induces cardiac fibrosis by causing metabolic disorders and up-regulating Sirt3/FoxO3α/MnSOD signaling pathway-mediated oxidative stress. Journal of Environmental Sciences. 2025, 150:532-544.

  6. Liu Haobiao#, Lin Xue#, Qiao Lichun, Liu Min, Bai Zhenbo, Han Jing*. Secular Trends in Type 2 Diabetes Mellitus Attributable to PM2.5 Exposure in China from 1990 to 2019: an Age-Period-Cohort Analysis. International Journal of Environmental Health Research. 2024, 1-13.

  7. Xiang Rongqi#, Xiao Xiang#, Liu Jiaxin, Guo Ziwei, He Huifang, Wang Xining, Wen Xinyue, Angelo Viscardi, Han Jing*. Protective effects of functional Nano-Se supplementation on spleen injury through regulation of p38 MAPK and NF-κB protein expression. International Immunopharmacology. 2024, 130:111574.

  8. Liu Haobiao#, Bao Miaoye#, Liu Min#, Deng Feidan, Wen Xinyue, Wan Ping, Lin Xue, Dong Guoqiang, Li Zhaoyang*, Han Jing*. The Association between Serum Copper and Bone Mineral Density among Adolescents Aged 12 to 19 in the United States. Nutrients. 2024,16(3):453.

  9. Liu Haobiao#, Liu Min#, Qiao Lichun, Yang Zhihao, He Yujie, Bao Miaoye, Lin Xue, Han Jing*. Association of Blood Cadmium Levels and All-cause Mortality among Adults with Rheumatoid Arthritis: the NHANES Cohort Study. Journal of Trace Elements in Medicine and Biology. 2024, 83:127406.

  10. Liu Jiaxin#, Li Hongqiu#, Guo Ziwei, Xiao Xiang, Angelo Viscardi, Xiang Rongqi, Liu Haobiao, Lin Xue, Han Jing*. The Changes and Correlation of IL-6 and Oxidative Stress Levels in RAW264.7 Macrophage Cells Induced by PAHs in PM2.5. Environmental Geochemistry and Health. 2024, 46(2), 61.

  11. Liu Haobiao#, Lin Xue#, Chilufya Mumba Mulutula#, Qiao Lichun, Bao Miaoye, Wen Xinyue, Xiang Rongqi, He Huifang, Li Miaoqian, Han Jing*. Synergistic effects of T-2 toxin and selenium deficiency exacerbate renal  fibrosis through modulation of the ERα/PI3K/Akt signaling pathway. Ecotoxicology and Environmental Safety. 2024, 269:115748.

  12. Han Jing#,*, Deng Huan#, Li Yang#, Qiao Lichun, Jia Hongrui, Zhang Lan, Wang Linghang, Qu Chengjuan. Nano-elemental selenium particle developed via supramolecular self-assembly of chondroitin sulfate A and Na2SeO3 to repair cartilage lesions. Carbohydrate Polymers, 2023, 316:121047.

  13. Xiao Xiang, Deng Huan, Lin Xue, Ali Ahmed Sameir Mohamed, Viscardi Angelo, Guo Ziwei, Qiao Lichun, He Yujie, Han Jing*. Selenium nanoparticles: Properties, preparation methods, and therapeutic applications. Chemico-Biological Interactions. 2023, 378:110483.

  14. Guo Ziwei#, Chilufya Mumba Mulutula#, Deng Huan, Qiao Lichun, Liu Jiaxin, Xiao Xiang, Zhao Yan, Lin Xue, Liu Haobiao, Xiang Rongqi, Han Jing*. Single and Combined Efects of Short-Term Selenium Defciency and T-2 Toxin-Induced Kidney Pathological Injury Through the MMPs/TIMPs System. Biological Trace Element Research. 2023,201(10):4850-4860.

  15. Qiao Lichun#, Lin Xue#, Zhao Yan, Wang Qingfeng, Liu Haobiao, You Mei, Yuan Qian, Yang Zhihao, Bian Wenming, Liu Jiaxin, Guo Ziwei, Han Jing*. Short-term dietary selenium deficiency induced liver fibrosis by inhibiting the Akt/mTOR signaling pathway in rats. Biological Trace Element Research. 2023,201(8):3825-3833.

  16. Zhou Jieting#, Guo Ziwei#, Liu Jiaxin#, Gao Min, Sun Xiaoxia, Sheng Yun, Zhang Yue, Lv Yizhen, Zhang Zhenwen, Han Jing*. PM2.5-bound polycyclic aromatic hydrocarbons (PAHs) from the atmosphere of Xi’an, China: Seasonal variation, sources, and health risk assessments. Hygiene and Environmental Health Advances. 2023, 5:100041.

  17. Han Jing#*, Deng Huan#, Lyu Yizhen, Xiao Xiang, Zhao Yan, Liu Jiaxin, Guo Ziwei, Liu Xuan, Qiao Lichun, Lammi Mikko Juhani*. Identification of N-Glycoproteins of knee cartilage from adult osteoarthritis and Kashin-Beck disease based on quantitative glycoproteomics, compared with normal control cartilage. Cells. 2022,11(16):2513.

  18. Lyu Yizhen#, Zhou Jieting#, Li Jin, Li Jianjun, Hu Guocheng, Wang Liyun, Wang Liang, Han Jing*, Wang Dong*. Alterations of IL-1beta and TNF-alpha expression in RAW264.7 cell damage induced by two samples of PM2.5 with different compositions. Science Progress. 2022,105(3):368504221113709.

  19. Qiao Lichun#, Guo Ziwei#, Liu Haobiao#, Liu Jiaxin, Lin Xue, Deng Huan, Liu Xuan, Zhao Yan, Xiao Xiang, Lei Jian, Han Jing*. Protective effect of mitophagy regulated by mTOR signaling pathway in liver fibrosis associated with selenium. Nutrients. 2022,14(12):2410.

  20. Lyu Yizhen#, Deng Huan#, Qu chengjuan#, Qiao Lichun, Liu Xuan, Xiao Xiang, Liu Jiaxin, Guo Ziwei, Zhao Yan, Han Jing*, Lammi Mikko Juhani. Identification of proteins and N-glycosylation sites of knee cartilage in Kashin-Beck Disease compared with osteoarthritis. International Journal of Biological Macromolecules. 2022, 210:128-138.

  21. Deng Huan#, Xiao Xiang#, Chilufya Mumba Mulutula#, Qiao Lichun, Lv Yizhen, Guo Ziwei, Lei Jian, Liu Jiaxin, Zhang Jiaheng, Wang Wenyue, Han Jing*, Qu Chengjuan. Altered expression of the Hedgehog pathway proteins BMP2, BMP4, SHH and IHH involved in knee cartilage damage of patients with osteoarthritis and Kashin-Beck disease. Cartilage. 2022, 13(1):19476035221087706.

  22. Zhao Yan#, Sheng Yun#, Zhou Jieting#, Wang Hao, Chilufya Mumba Mulutula, Liu Xuan, Mohamed Alaa Osman, Han Jing*, Qu Chenjuan. Influencing factors of residents' environmental health literacy in Shaanxi province, China: a cross-sectional study. BMC Public Health. 2022, 22(1):114.

  23. Deng Huan#, Liu Haobiao#, Yang Zhihao#, Bao Miaoye, Lin Xue, Han Jing*, Qu Chengjuan. Progress of selenium deficiency in the pathogenesis of arthropathies and selenium supplement for their treatment. Biological Trace Element Research. 2022, 200(10):4238-4249.

  24. Xiao Xiang#, Deng Huang#, Chilufya Mumba Mulutula, Lv Yizhen, Zhao Yan, Liu Jiaxin, Guo Ziwei, Qiao Lichun, Han Jing*, Wang Dong*, Qu Chengjuan. Chondroitin sulfate and hyaluronic acid perfusion for interstitial cystitis/bladder pain syndrome: a systematic review and meta-analysis. Science Insights. 2021, 39(4):361-373.

  25. Qiao Lichun#, Liu Xuan#, He Yujie#, Zhang Jiaheng, Huang Hao, Bian Wenming, Chilufya Mumba Mulutula, Zhao Yan, Han Jing*. Progress of signaling pathways, stress pathways, and epigenetics in the pathogenesis of skeletal fluorosis. International Journal of Molecular Sciences. 2021, 21(22): 11932.

  26. Deng Huan#, Chilufya Mumba Mulutula#, Liu Jiaxin#, Qiao Lichun, Xiao Xiang, Zhao Yan, Guo Ziwei, Lv Yizhen, Wang Wenyue, Zhang Jiaheng, Han Jing*. Effect of low nutrition and T-2 toxin on C28/I2 chondrocytes cell line and chondroitin sulfate-modifying sulfotransferases. Cartilage. 2021, 13(2_suppl): 818S-825S.

  27. Qiao Lichun#, Amhare Abebe Feyissa#, Deng Huan#, Lv Yizhen, Zhao Yan, Liu Jiaxin, Lei Jian, Wang Liyun, Chilufya Mumba Mulutula, Han Jing*. Protective effect of chondroitin sulfate nano-selenium on chondrocyte of patients with Kashin-Beck disease. Journal of biomaterials applications. 2021, 35(10):1347-1354.

  28. Amhare Abebe Feyissa, Lei Jian, Deng Huan, Lv Yizhen, Han Jing*, Zhang Lei. Biomedical application of chondroitin sulfate with nanoparticles in drug delivery systems: systematic review. Journal of Drug Targeting. 2021, 29(3):259-268.

  29. Lei Jian, Deng Huan, Ran Yan, Lv Yizhen, Amhare Abebe Feyissa, Wang Liyun, Guo Xiong, Han Jing*, Lammi Mikko J. Altered expression of aggrecan, FAM20B, B3GALT6, and EXTL2 in patients with osteoarthritis and Kashin-Beck disease. Cartilage. 2021, 13(1_suppl):818S-828S.

  30. Amhare Abebe Feyissa, Lei Jian, Wagaw Lealem Minwuyelet, Qu Chenjuan, Han Jing*. Magnitude and associated factors of perceived stress and its consequence among undergraduate students of Salale University, Ethiopia: cross-sectional study. Psychology Health & Medince. 2021, 26(10):1230-1240.

  31. Woldetsadik Abebe Belete#, Amhare Abebe Feyissa#, Bitew Sintayehu Tsegaye, Pei Leilei, Lei Jian, Han Jing*. Socio-demographic characteristics and associated factors influencing cervical cancer screening among women attending in St. Paul's Teaching and Referral Hospital, Ethiopia. BMC Womens Health. 2020, 20(1):70.

  32. Wang Liyun, Yin Jiafeng, Yang Bo, Qu Chenjuan, Lei Jian, Han Jing*, Guo Xiong. Serious Selenium Deficiency in the Serum of Patients with Kashin-Beck disease and the effect of nano-selenium on their chondrocytes. Biological Trace Element Research. 2020, 194(1):96-104.

  33. Lei Jian, Amhare Abebe Feyissa, Wang Liyun, Lv Yizhen, Deng Huan, Gao Hang, Guo Xiong, Han Jing*, Lammi Mikko J. Proteomic analysis of knee cartilage reveals potential signaling pathways in pathological mechanism of Kashin-Beck disease compared with osteoarthritis. Scientific Reports. 2020, 10(1):6824.

  34. Lei Jian, Yan Siqi, Zhou Yuan, Wang Liyun, Zhang Jinghua, Guo Xiong, Lammi Mikko J, Han Jing*, Qu Chenjuan. Abnormal expression of chondroitin sulfate sulfotransferases in the articular cartilage of pediatric patients with Kashin-Beck disease. Histochemistry and Cell Biology. 2020, 153(3):153-164.

  35. Guo Yijie, Zhou Yuan, Yan Siqi, Qu Chenjuan, Wang Liyun, Guo Xiong, Han Jing*. Decreased expression of CHST-12, CHST-13, and UST in the proximal interphalangeal joint cartilage of school-age children with Kashin-Beck disease: an endemic osteoarthritis in China caused by selenium deficiency. Biological Trace Element Research. 2019, 191(2):276-285.

  36. Wang Liyun, Guo Xiong, Yi Jianhua, Qu Chenjuan, Lei Jian, Guo Qingquan, Han Jing*. The effects of long-term low selenium diet on the expression of CHST-3, CHST-12 and UST in knee cartilage of growing rats. Journal of Trace Elements In Medicine and Biology. 2018, 50:123-129.

  37. Guo Yijie, Xun Meng, Han Jing*. A bovine myeloid antimicrobial peptide (BMAP-28) and its analogs kill pan-drug-resistant Acinetobacter baumannii by interacting with outer membrane protein A (OmpA). Medicine. 2018, 97(42):e12832.

  38. Han Jing#, Liang Hua#, Yi Jianhua, Tan Wuhong, He Sshulan, Wang Sen, Li Feng, Wu Xiaofang, Ma Jing, Shi Xiaowei, Guo Xiong, Bai Chuanyi. Long-term selenium-deficient diet induces liver damage by altering hepatocyte ultrastructure and MMP1/3 and TIMP1/3 expression in growing rats. Biological Trace Element Research. 2017, 175(2):396-404.

  39. Han Jing, Li Danyang, Qu Chenjuan, Wang Dong, Wang Liyun, Guo Xiong, Lammi Mikko J. Altered expression of chondroitin sulfate structure modifying sulfotransferases in the articular cartilage from adult osteoarthritis and Kashin-Beck disease. Osteoarthritis and Cartilage. 2017, 25(8):1372-1375.

  40. Li Danyang#, Han Jing#,*, Guo Xiong, Qu Chenjuan, Yu Fangfang, Wu Xiaofang. The effects of T-2 toxin on the prevalence and development of Kashin-Beck disease in China: a meta-analysis and systematic review. Toxicol Research. 2016, 5(3):731-751.

  41. Han Jing#, Liang Hua#, Yi Jianhua, Tan Wuhong, He Shulan, Wu Xiaofang, Shi Xiaowei, Ma Jing, Guo Xiong. Selenium deficiency induced damages and altered expressions of metalloproteinases and their inhibitors (MMP1/3, TIMP1/3) in the kidneys of growing rats. Journal of Trace Elements In Medicine and Biology. 2016, 34:1-9.

  42. Yu Fangfang#, Han Jing#, Wang Xi, Fang Hua, Liu Huan, Guo Xiong*. Salt-rich selenium for prevention and control children with Kashin-Beck disease: a meta-analysis of community-based trial. Biological Trace Element Research. 2016, 170(1):25-32.

  43. Wu Xiaofang, Yi Jianhua, Qu Chenjuan, Lei Jian, Wang Liyun, Guo Xiong, Han Jing*. A review of the surgical treatment methods of Kashin-Beck disease, an endemic osteoarthritis in China. International Journal of Orthopaedic Studies. 2017, 1(1).

  44. Wu Xiaofang#, Han Jing#,*, Yi Jianhua, Wang Zuyong, Qu Chenjuan, Li Danyang, Yu Fangfang, Guo Xiong. The effects of chondroitin and/or glucosamine on patients with Kashin-Beck disease. Science Insights Medicine. 2016, 2016: e00019.

  45. Han Jing, Hou Zhenqing, Wang YG, Guo Xiong. Synthesis and evaluation of hydroxycamptothecin-encapsulated chitosan nanospheres for the treatment of liver cancer. Technology in Cancer Research & Treatment. 2015, 14(1):111-7.

  46. Han Jing, Wang Werizhuo, Qu Chenjuan, Liu Ruiyu, Li Wenrong, Gao Zongqiang, Guo Xiong. Role of inflammation in the process of clinical Kashin-Beck disease: latest findings and interpretations. Inflammation Research. 2015, 64(11): 853-860.

  47. Han Jing#, Yu Fangfang#, Chang Zaiping, Yang Bo, Qu Chenjuan, Zhou Tiantian, Liu Ruiyu, Guo Xiong. Changing grains for the prevention and treatment of Kashin-Beck disease in children: a meta-analysis. Biomedical and Environmental Science. 2015, 28(4): 308-311.

  48. Han Jing, Guo Xiong. Down-regulation of ATF2 in the inhibition of T-2-toxin-induced chondrocyte apoptosis by selenium chondroitin sulfate nanoparticles. Journal of Nanoparticle Research. 2013, 15(12): 1-8.

  49. Han Jing, Guo Xiong, Tan Wuhong, Zhang Feng, Liu Jiangtao, Wang Werizhuo, Xu Peng, Lammi Mikko J. The expression of p-ATF2 involved in the chondeocytes apoptosis of an endemic osteoarthritis, Kashin-Beck disease. BMC Musculoskeletal Disorders. 2013, 14: 209-218.

  50. Han Jing, Guo Xiong, Lei Yanxia, Dennis Bannel S., Wu Shixun, Wu Cuiyan. Synthesis and characterization of selenium-chondroitin sulfate nanoparticles. Carbohydrate Polymers. 2012, 90: 122-126.