基本信息

 

 

 何旺骁，Ph.D

西安交通大学博士生导师，特聘研究员，

青年拔尖人才计划入选者

联系方式

 QQ：120489452

电话（微信）：15319910808

Email：hewangxiao5366@xjtu.edu.cn

或 hewangxiao5366@sina.com

 

个人简介

 何旺骁，男，1991年生，2019年入选西安交通大学“青年拔尖人才”支持计划，西安交通大学特聘研究员，博士生导师。2019年博士科毕业于西安交通大学生命科学与技术学院。以第一或通讯作者发表论文24篇，SCI/EI收录 22篇，JCR 1区刊物 18篇，其中近五年发表领域内顶级期刊（IF>8）16篇, 累积IF>240，ESI高被引论文1篇；累积主持国家自然科学基金、陕西省自然科学基金等多种项目。

研究领域

  • （1）靶向蛋白质相互作用的药物开发

  • （2）基于蛋白质全化学合成的蛋白质功能研究

  • （3）多肽药物的设计与成药策略

代表性论文

  1. Yan J#,*, Wang Y#, Li X#, Guo D, Zhou Z, Bai G, Li J, Huang N, Diao J, Li Y, He W*, Liu W*, Tao K*. A Bionic Nano-Band-Aid Constructed by the Three-Stage Self-Assembly of Peptides for Rapid Liver Hemostasis[J]. Nano Letters, 2021. [JCR 1区；IF=11.189]
  2. Yan S#, Yan J#,*, Liu D#, Li X#, Kang Q, You W, Zhang J, Wang L, Tian Z, Lu W*, Liu W*, He W*. A nano-predator of pathological MDMX construct by clearable supramolecular gold(I)-thiol-peptide complexes achieves safe and potent anti-tumor activity. Theranostics. 2021, 11(14): 6833-6846. [JCR 1区；IF=11.556]
  3. Zheng X#, Yan J#,*, You W, Li F, Diao J, He W*, Yao Y*. De novo nano-erythrocyte structurally braced by biomimetic Au(I)-peptide skeleton for MDM2/MDMX predation toward augmented pulmonary adenocarcinoma immunotherapy. Small. 2021, e2100394. [JCR 1区；IF=13.281]
  4. Yan J#,*, He W#,*, Li X#, You W, Liu X, Lin S, Chen J, Zhao Y, Zhang Y*, Ji F*. Carnosic acid-induced co-self-assembly of metal-peptide complexes into a nanocluster-based framework with tumor-specific accumulation for augmented immunotherapy. Chemical Engineering Journal. 2021, 416: 129141. [JCR 1区；IF=13.273]
  5. Yan J#,*, Yao Y#, Yan S, Gao R, Lu W*, He W*. Chiral protein supraparticles for tumor suppression and synergistic immunotherapy: an enabling strategy for bioactive supramolecular chirality construction. Nano Letters. 2020, 20(8): 5844-5852.  [JCR 1区；IF=11.189]
  6. She J#,*, Li Y#, Yan S, Yan Y, Liu D, Li S, Guo Y, Xue Y, Yao Y, Yan J*, He W*. De novo supraparticle construction by a self-assembled Janus cyclopeptide to tame hydrophilic microRNA and hydrophobic molecule for anti-tumor cocktail therapy and augmented immunity. Chemical Engineering Journal. 2020, 401: 126080. [JCR 1区；IF=13.273]
  7. He W, Yan J*, Li Y, Yan S, Wang S, Hou P*, Lu W*. Resurrecting a p53 peptide activator - An enabling nanoengineering strategy for peptide therapeutics. Journal of Controlled Release. 2020, 325: 293-303. [JCR 1区；IF=9.776]
  8. Yan J#, Ji F#, Yan S#, You W, Ma F, Li F, Huang Y*, Liu W*, He W*. A general-purpose Nanohybrid fabricated by Polymeric Au(I)-peptide precursor to wake the function of Peptide Therapeutics. Theranostics. 2020, 10(19): 8513-8527. [JCR 1区；IF=11.556]
  9. Liu J#, Yan J#,*, Yan S#, Wang Y, Zhang R, Hou P, He W*, Ji M*. Biomimetic and self-assembled nanoclusters targeting β-catenin for potent anticancer therapy and enhanced immunotherapy. Nano Letters. 2019, 19(12): 8708-8715. [JCR 1区；IF=11.189]
  10. Yan J, Yan S, Hou P, Lu W, Ma PX, He W*, Lei B*. A hierarchical peptide–lanthanide framework to accurately redress intracellular carcinogenic protein–protein interaction. Nano Letters. 2019, 19(11): 7918-7926. [JCR 1区；IF=11.189]
  11. He W, Yan J, Wang L, Lei B, Hou P*, Lu W*, Ma PX*. A lanthanide-peptide-derived bacterium-like nanotheranostic with high tumor-targeting, -imaging and -killing properties. Biomaterials. 2019, 206: 13-24. [JCR 1区；IF=12.479]
  12. He W,Wang S, Yan J, Qu Y, Jin L, Sui F, Li Y, You W, Yang G, Yang Q, Ji M, Shao Y, Ma PX*, Lu W*, Hou P*. Self-assembly of therapeutic peptide into stimuli-responsive clustered nanohybrids for cancer-targeted therapy. Advanced Functional Materials. 2019, 29(10): 1807736. [JCR 1区；IF=18.808]
  13. He W*（第一兼通讯作者）, Yan J, Sui F, Wang S, Su X, Qu Y, Yang Q, Guo H, Ji M, Lu W, Shao Y*, Hou P*. Turning a luffa protein into a self-assembled biodegradable nanoplatform for multitargeted cancer therapy. ACS Nano. 2018, 12(11): 11664-11677. [JCR 1区；IF=15.881]
  14. He W, Yan J, Jiang W, Li S, Qu Y, Niu F, Yan Y, Sui F, Wang S, Zhou Y, Jin L, Li Y, Ji M, Ma PX, Liu M*, Lu W*, Hou P*. Peptide-induced self-assembly of therapeutics into a well-defined nanoshell with tumor-triggered shape and charge switch. Chemistry of Materials. 2018, 30(20): 7034-7046. [JCR 1区；IF=9.811]
  15. Niu F#, Yan J#, Ma B, Li S, Shao Y, He P, Zhang W, He W*, Ma PX*, Lu W*. Lanthanide-doped nanoparticles conjugated with an anti-CD33 antibody and a p53-activating peptide for acute myeloid leukemia therapy. Biomaterials. 2018, 167: 132-142. [JCR 1区；IF=12.479]
  16. Yan J#, He W#,*（共同第一兼通讯）, Yan S#, Niu F, Liu T, Ma B, Shao Y, Yan Y, Yang G, Lu W, Du Y, Lei B*, Ma PX. Self-assembled peptide-lanthanide nanoclusters for safe tumor therapy: overcoming and utilizing biological barriers to peptide drug delivery. ACS Nano. 2018, 12(2): 2017-2026. [JCR 1区；IF=15.881；ESI高被引（TOP 1%）]
  17. Bian Z#, Yan J#, Wang S#, Li Y, Guo Y, Ma B, Guo H, Lei Z, Yin C, Zhou Y, Liu M, Tao K*, Hou P*, He W*. Awakening p53 in vivo by D-peptides-functionalized ultra-small nanoparticles: Overcoming biological barriers to D-peptide drug delivery. Theranostics. 2018, 8(19): 5320-5335. [JCR 1区；IF=11.556]
  18. Yan J#, He W#（共同第一作者）, Li N, Yu M, Du Y, Lei B, Ma PX. Simultaneously targeted imaging cytoplasm and nucleus in living cell by biomolecules capped ultra-small GdOF nanocrystals. Biomaterials. 2015 Aug 1; 59:21-9.[JCR一区 ; IF =12.479]