科研项目

没有找到条目。
项目编号 项目名称 项目来源 起讫时间 承担角色 项目类别
82473882 基于原位激活时间分辨亲和色谱技术的FXI/FXIa凝血通路抑制剂的筛选研究 国家自然科学基金项目 2025-01~2028-12 负责人 纵向项目
2021JM-039 凝血酶高效亲和色谱柱的制备研究 陕西省自然科学基金 2021-01~2022-12 负责人 纵向项目
2018M643681 二维凝血酶亲和色谱串联质谱从中药中筛选凝血酶抑制剂 国家教育部项目 2018-09~2020-02 负责人 纵向项目
2017JQ8024 α1A 受体高表达细胞膜色谱法中特异性与非特异性吸附研究 陕西省自然科学基金 2017-1~ 负责人 纵向项目
xjj2013119 乳制品中蛋白质安全评价系统的构建 西安交通大学基本科研业务费学科综合交叉类项目（自然科学类） 2013-1~2015-12 负责人 纵向项目
81227802 天然药物中目标物快速“识别鉴定”二维色谱仪研制 国家自然科学基金项目 2013-1~ 骨干成员 纵向项目
81230079 细胞膜色谱技术用于中药安全性和有效性评价的基础研究 国家自然科学基金项目 2013-1~ 骨干成员 纵向项目
81102414 MCF-7/CMC和MDA-MB-231/CMC法筛选中药中与ER受体相互作用的抗肿瘤活性成分及差异蛋白研究 国家自然科学基金项目 2011-1~ 负责人 纵向项目
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奖项

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奖项名称 获奖年份 奖项类型 奖项等级 申报部门
细胞膜仿生涂层关键技术及其在中药筛选中的应用 2023 局厅级科技成果奖 一等奖 陕西省科技厅
二维联用色谱技术在药物筛选和乳制品分析中的应用 2017 省部级科技成果奖 二等奖 陕西省人民政府
二维联用色谱技术在药物筛选和乳制品分析中的应用 2016 局厅级科技成果奖 一等奖 陕西省科技厅

科研论文

 

  1. Xu D, Guo D, Zhang J, Tan X, Deng Z, Hou X*, et al. Innovative tumor interstitial fluid-triggered carbon dot-docetaxel nanoassemblies for targeted drug delivery and imaging of HER2-positive breast cancer. International Journal of Pharmaceutics. 2024;657.
  2. Jing Zhang, Dan Xu, Zijie Deng, Xueping Tan, Dongnan Guo, Yanru Qiao, You Li, Xiaofang Hou*, Sicen Wang*, and Junbo Zhang*, Using tungsten oxide quantum-dot enhanced electrochemiluminescence to measure thrombin activity and screen its inhibitors. Talanta, 2024. 267.125267
  3. Zijie Deng, Xueping Tan, Dongnan Guo, Jing Zhang, Dan Xu, Xiaofang Hou*, Sicen Wang, Junbo Zhang, Fen Wei, and Dongdong Zhang, MXene-sensitized electrochemiluminescence sensor for thrombin activity detection and inhibitor screening. Microchimica Acta, 2023. 190(8).328
  4. Yanru Qiao, Yingdi Shi, Chen Wu, Xiaofang Hou*, Xiaoyan Pan, Zijie Deng, sicen Wang*. Rapid screening and identification of anticoagulation component from carthami flos by two-dimensional thrombin affinity chromatography combined with HPLC-MS/MS. Journal of Separation Science. 2021;44(16):3061-3069.
  5. Xiaofang Hou, Meng Sun, Tao Bao, Xiaoyu Xie, Fen Wei, Sicen Wang*. Recent advances in screening active components from natural products based on bioaffinity techniques. Acta Pharmaceutica Sinica B. 2020.10(10): 1800-1813.
  6. Yingdi Shi, Wei Sun, Xiaoyan Pan, Xiaofang Hou *, Sicen Wang*, Junbo Zhang. Establishment of thrombin affinity column (TAC)-HPLC-MS/MS method for screening direct thrombin inhibitors from Radix Salviae Miltiorrhiae. Journal of Chromatography B. 2020,1139:121894.
  7. Ping Zhang, Yingdi Shi, Xiaoshuang He, Wei Sun, Yanni Lv, Xiaofang Hou *. Study on screening potential allergenic proteins from infant milk powders based on human mast cell membrane chromatography and histamine release assays. Journal of Pharmaceutical Analysis. 2019,9(1):55-61.
  8. Dan Xu, Sicen Wang, Xiaofang Hou*, Changshan Sun*. Preliminary Studies on Liquiritin, Deoxyschizandrin, and Tanshinone II A as Potential Anti-Neurodegenerative Disease Agent: Determination by Reverse-Phase Liquid Chromatography in Tianwang Buxin Pills. Journal of Analytical Methods in Chemistry. 2019,2019:1-8.
  9. Xiaoshuang He, Ping Zhang, Muhammad Saqib, Xiaofang Hou*, Sicen Wang. Screening active anti-breast cancer compounds from cortex magnolia officinalis by MCF-7 cell membrane chromatography coupled with UHPLC-ESI-MS/MS. Anal. Methods, 2017, 9(33): 4828-4836.
  10. Hou, X.; Hu, Y.; Wang, P.; Yang, L.; Al Awak, M. M.; Tang, Y.; Twara, F. K.; Qian, H.; Sun, Y.-P., Modified facile synthesis for quantitatively fluorescent carbon dots. Carbon 2017, 122, 389-394.
  11. Hu, Y.; Al Awak, M. M.; Yang, F.; Yan, S.; Xiong, Q.; Wang, P.; Tang, Y.; Yang, L.; LeCroy, G. E.; Hou, X.; Bunker, C. E.; Xu, L.; Tomlinson, N.; Sun, Y. P., Photoexcited State Properties of Carbon Dots from Thermally Induced Functionalization of Carbon Nanoparticles. Journal of materials chemistry. C, Materials for optical and electronic devices 2016, 4 (44), 10554-10561.
  12. Wang, P.; Liu, J.-H.; Gao, H.; Hu, Y.; Hou, X.; LeCroy, G. E.; Bunker, C. E.; Liu, Y.; Sun, Y.-P., Host–guest carbon dots as high-performance fluorescence probes. J. Mater. Chem. C 2017, 5 (25), 6328-6335.
  13. Meng Sun1, Xiaofang Hou1, Yuanyuan Lin, Jie Zhang and Sicen Wang. An improved cell membrane chromatography method for the simultaneous screening of two epidermal growth factor receptor antagonists from radix scutellariae. Journal of Separation Science. 2015, 38(22):3832-9314  
  14.  Xiaofang Hou, MengSun，Xiaoshuang He, Liang Chen, Ping Zhang, Langchong He. Simultaneous quantification of five proteins and seven additives in dairy products with the heart-cutting two-dimensional liquid chromatography method. Journal of Separation Science. 2015, 38(22): 3832-3838.
  15.  Xiaofang Hou, Jing Ma, Xiaoshuang He, Liang Chen, Sicen Wang, Langchong He. A stop-flow two-dimensional liquid chromatography method for determination of food additives in yogurt. Analytical Methods. 2015, 7, 2141-2148.
  16. Peng Zhang, Xiaofang Hou, Nan Lv, Liuxin Feng, Sicen Wang. Cell Membrane Chromatography with Zonal Elution for Characterization of Seven Alkaloids Binding to α1AAdrenoreceptor. Journal of Liquid Chromatography & Related Technologies 2015, 38, 986-992.
  17.  Xiaofang Hou, Sicen Wang, Tao Zhang, Jing Ma, Jie Zhang, Yanmin Zhang, Wen Lu, Huaizhen He, Langchong He*. Recent advances in cell membrane chromatography for traditional Chinese medicines analysis. Journal of Pharmaceutical and Biomedical Analysis. 2014,101: 141-150 
  18.  Jing Ma, Bing Zhang, Yunan Wang, Xiaofang Hou*. Comparison of Six Sample Preparation Methods for Analysis of Food Additives in Milk Powder. Food Analytical Methods. 2014,7(6):1345-1352  
  19. Jing Ma, Bing Zhang, Yunan Wang, Xiaofang Hou*, Langchong He. Determination of flavor enhancers in milk powder by one-step sample preparation and two-dimensional liquid chromatography. Journal of Separation Science. 2014;37(8):920-926.  
  20.  Jing Ma, Xiaofang Hou, Bing Zhang, Yunan Wang, Langchong He. The analysis of carbohydrates in milk powder by a new “heart-cutting” two-dimensional liquid chromatography method. Journal of Pharmaceutical and Biomedical Analysis. 2014 25;91:24-31.
  21.  Xiaofang Hou, Xilong Yuan, Bing Zhang, Sicen Wang. Screening active anti‐breast cancer compounds from Cortex Magnolia Officinalisby two dimensional liquid chromatography‐mass spectroscopy. Journal of Separation Science. 2013, 36, 706–712 
  22.  Xilong Yuan, Bing Zhang, Yunan Wang, Jing Ma, Xiaofang Hou*. An online coupled breast cancer cell membrane chromatography with HPLC/MS for screening active compounds from Fructus evodiae. Analytical Methods, 2013,5, 5767-5774.   
  23. Xiaofang Hou, Sicen Wang, Jingjing Hou, Langchong He. Establishment of A431 Cell Membrane Chromatography-RPLC Method for Screening Target Components from Radix Caulophylli. Journal of Separation Science. 2011, 34, 508–513 
  24. Miao Li, Xiaofang Hou, Sicen Wang, Qiang Fu, Langchong He. Applications of HPLC/MS in the analysis of traditional Chinese medicines. Journal of Pharmaceutical Analysis, 2011. 1(2): 81-91.
  25.  Xiaofang Hou, Jing Ren, Sicen Wang, Langchong He. Establishment of a High Expression of a1A Adrenergic Receptor Cell Membrane Chromatography-RPLC Method for Screening Target Components from Radix Caulophylli. Chromatographia. 2010, 72: 635-640 
  26.  Xiaofang hou, Mingzhe Zhou, Qiao Jiang, Sicen Wang, Langchong He. A Vascular Smooth Muscle Cell Membrane Chromatography-Offline-GC/MS Method for Recognition, Separation and Identification of Active Components from Chinese Traditional Medicines. Journal of Chromatography A. 2009,1216: 7081-7087 
  27.  XiaoFang Hou, ZhuJun Zhang, Yan Zhao, Jie Ma. Microdialysis sampling and chemi -luminescence detection for in vivo and real-time study of the lead metabolism in rabbit blood. Microchimica acta. 2007, 159: 223–228 
  28. Langchong He, Sicen Wang, Guangde Yang, Yanmin Zhang, Changhe Wang, Bingxiang Yuan, Xiaofang Hou. Progress in cell membrane chromatography. Drug discoveries & therapeutics 2007, 1, 104.
  29.  侯晓芳, 王嗣岑, 张涛, 贺浪冲.细胞膜色谱法应用于中药质量控制的思考. 世界科学技术-中医药现代化. 2014,16(3): 526-528.
  30. 侯晓芳, 杜晖, 贺晓双, 张平, 王嗣岑. 细胞膜色谱法用于药物与受体相互作用研究进展. 药学进展. 2015, 39(12):882-888.
  31. 侯晓芳，章竹君，赵琰，马杰. 流动注射化学发光法测定面粉中的增白剂-过氧化苯甲酰. 陕西师范大学学报（自然科学版）.2006,34(1): 67-70

专利

没有找到条目。
专利名称 申请号 专利类型 申请日期
RI-2D二维色谱智能分析（数据处理）系统V1.0 2015SR169873 发明 2015.01.01
一种FGFR4高表达的重组HEK293细胞及其应用 201110269675.2 发明 2011.10.26
一种合成塔斯品碱的方法 200810232351.X 发明 2008.10.23
配体-受体相互作用分析系统V1.0 2015SR206223 发明 1970.01.01

学术交流

2005.7.15~19日在山西太原参加“第八届全国发光分析和动力学分析学术研讨会”

2010.11.21日在西安参加“2010陕西省药学会学术年会”

2012.10.26~29日在青岛参加“中国化学会第十一届全国分析化学年会”

2015.4.19-4.21日在西安参加“第二十届全国色谱学术报告会及仪器展览会”

2015.9.24~25日在沈阳参加“《中国药学杂志》岛津杯第十二届全国药物分析优秀论文评选交流会暨第二届药物分析国际论坛”

2015.11.4~6日在南京参加“第五届全国药物分析大会”

2017.12.1~3日在西安参加“2017发光分析前沿论坛”

2017.11.25~27日在西安举办“国家自然科学基金重大研究计划2017年度学术交流会” 

2018.6.14-17日在西安参加“中国化学会第十三届全国分析化学年会”