基本信息

       胡劲松,男,副教授。博士毕业于第四军医大学(2009年, 细胞生物学专业)、布鲁塞尔自由大学(2012年, 医学博士)。目前任职于西安交通大学医学部基础医学院细胞生物学与遗传学系。曾担任西安交通大学医学部基础医学院细胞生物学与遗传学系副系主任(主持工作,2015年4月-2019年4月)。现任基础医学实验教学中心副主任。

      主要从事多发性骨髓瘤的细胞与分子病理机制、NK细胞免疫治疗血液肿瘤方面的研究。以第一作者或通讯作者在专业领域权威期刊BloodLeukemiaMolecular Cancer TherapeuticsJournal of Biological ChemistryJournal of ImmunotherapyJournal of Immunology ResearchJournal of Leukocyte BiologyStem Cell Research & Therapy等发表研究论文30余篇,在NK免疫治疗领域获批PCT国际专利1项、中国专利1项。主持有国家自然科学基金面上项目2项,国际合作课题1项,省部级课题3项。参与编写中英文专著及教材13部。

       美国血液学会会员; 欧洲血液学会会员; 比利时血液学会会员; 中国细胞生物学会会员。 

       学术任职:

       中华医学会医学细胞生物学分会第六届委员会委员 2018年)

   中国抗癌协会肿瘤分子医学专业委员会第一届委员(2017年)

   中国肿瘤防治联盟陕西省淋巴瘤专业委员会委员(2017年)

   陕西省细胞生物学学会第四届理事会常务理事(2018年)

   中国肿瘤防治联盟陕西省淋巴瘤专业委员会第一届委员(2017年)

   中国多发性骨髓瘤研究联盟理事(2018年)

   中国抗癌协会第五届血液肿瘤专业委员会骨髓瘤与浆细胞疾病学组委员 2019年)

   中国医药教育协会-智能医学专业委员会常委(2019

   中国转化医学联盟细胞生物学分会第一届委员(2019​​​​​​​

 

      

       联系方式:  E-mail:jinsong.hu@xjtu.edu.cn

 

 

科学研究与研究生教育

 研究领域:血液肿瘤细胞分子生物学、肿瘤免疫

 研究方向:(1)多发性骨髓瘤、淋巴瘤的细胞与分子病理机制、耐药分子机制。

                   (2)干细胞及其成骨分化分化机制研究。

                   (3)基因工程改造NK细胞治疗恶性血液系肿瘤。

研究生招生: 欢迎医学(含动物医学)、生物学等专业学生报考。具体招生信息请参阅当年简章或邮件与导师联系。

        为研究生提供严谨、科学、自由、奋进的科学研究氛围;与美国哈佛大学医学院Dana-Farber Cancer Institute、比利时布鲁塞尔自由学、法国nantes大学、爱 尔兰国立大学医学院、德国国家癌症中心(NCI)、法国里尔大学附属医院等著名机构有深入合作关系,能为研究生提供一流的出国学习、合作研究机会。

科研项目:(1)国家自然科学基金项目2项。 (2)中-爱国际合作横向科研项目1项。(3)西安交大医学部-秦农银行COVID-19专项(重点)

Publications (# first author, * corresponding author)

Publications (# first author, * corresponding author)

  1. Wang J#, Xu Y, Zhang X, Wang S, Peng Z, Guo J, Jiang H, Liu J, Xie Y, Wang J, Li X, Liao J, Wan C, Yu L, Hu J*, Liu B*, Liu Z*. Leptin correlates with monocytes activation and severe condition in COVID-19 patients. J Leukoc Biol. 2021 Jan 6. doi: 10.1002/JLB.5HI1020-704R.   (Highlighted Article)
  2. Lei L#, Zhang Y#, Jian Q, Lei L, Lv N, Williamson RA, Chen P, Zhang D, Hu J*. Resistance of osteosarcoma cells to the proapoptotic effects of carfilzomib involves activation of mitogen activated protein kinase pathways. Exp Physiol. 2021 Feb;106(2):438-449. doi: 10.1113/EP088762. Epub 2020 Dec 17.​​​​​​​
  3. Zhang D#, Guo R#, Lei L#, Liu H#, Wang Y, Wang Y, Qian H, Dai T, Zhang T, Lai Y, Wang J, Liu Z, Chen T, He A*, O'Dwyer M*, Hu J*. COVID-19 infection induces readily detectable morphologic and inflammation-related phenotypic changes in peripheral blood monocytes. J Leukoc Biol. 2021 Jan;109(1):13-22. doi: 10.1002/JLB.4HI0720-470R. Epub 2020 Oct 11. (Highlighted Article)
  4. Zhang D#, De Veirman K#, Fan R#, Jian Q, Zhang Y, Lei L, Evans H, Wang Y, Lei L, Wang B, Williamson RA, Chantry A, He P, Li A, De Raeve H, Vanderkerken K, He A, Hu J*. ER stress arm XBP1s plays a pivotal role in proteasome inhibition-induced bone formation. Stem Cell Res Ther. 2020 Nov 30;11(1):516. doi: 10.1186/s13287-020-02037-3.
  5. Lei L#, Qian H#, Yang X, Zhang X, Zhang D, Dai T, Guo R, Shi L, Cheng Y, Zhang B, Zhou X*, Hu J*, Guo Y*. The phenotypic changes of γδ T cells in COVID-19 patients. J Cell Mol Med. 2020 Oct;24(19):11603-11606. doi: 10.1111/jcmm.15620. Epub 2020 Aug 30. IF=4.486
  6. Yang X#, Dai T#, Zhou X, Qian H, Guo R, Lei L, Zhang X, Zhang D, Shi L, Cheng Y, Hu J*, Guo Y*, Zhang B*. Naturally activated adaptive immunity in COVID-19 patients. J Cell Mol Med. 2020 Nov;24(21):12457-12463. doi: 10.1111/jcmm.15771. Epub 2020 Sep 25.
  7. Teng R#, Wang Y#, Nan Lv, Zhang D, Williamson RA, Lei L, Chen P, Lei L, Wang B, Fu J, Liu X, He A, O’Dwyer M*, Hu J*. Hypoxia Impairs NK Cell Cytotoxicity through SHP-1-Mediated Attenuation of STAT3 and ERK Signaling Pathways. Journal of Immunology ResearchPub Date: 2020-06-19, DOI10.1155/2020/4598476.
  8. Zhang D#, Teng R#, Lv N, Lei L, Wang Y, Williamson RA, Chen P, Gao P, O'Dwyer M, Li A*, Hu J*. A novel CD2 staining-based flow cytometric assay for assessment of natural killer cell cytotoxicity. J Clin Lab Anal. 2020 Aug 17:e23519. DOI: 10.1002/jcla.23519.
  9. Zhang D#, Fan R#, Lei L, Lei L, Wang Y, Lv N, Chen P, Williamson RA, Wang B, Hu J*. Cell cycle exit during bortezomib-induced osteogenic differentiation of mesenchymal stem cells was mediated by Xbp1s-upregulated p21Cip1 and p27Kip1. J Cell Mol Med. 2020 Jul 6;24(16):9428–38. DOI: 10.1111/jcmm.15605.
  10. Peng Y#, Li F, Zhang P, Wang X, Shen Y, Feng Y, Jia Y, Zhang R, Hu J*, He A*. IGF-1 promotes multiple myeloma progression through PI3K/Akt-mediated epithelial-mesenchymal transition. Life Sci. 2020 Mar 3;249:117503. DOI: 10.1016/j.lfs.2020.117503.
  11. Huang L#, Wang Y, Bai J, Yang Y, Wang F, Feng Y, Zhang R, Li F, Zhang P, Lv N, Lei L, Hu J*, He A*. Blockade of HSP70 by VER-155008 synergistically enhances bortezomib-induced cytotoxicity in multiple myeloma. Cell Stress Chaperones. 2020 Mar;25(2):357-367. DOI: 10.1007/s12192-020-01078-0
  12. Huang LJ#, Shen Y, Bai J, Wang FX, Feng YD, Chen HL, Peng Y, Zhang R, Li FM, Zhang PH, Lei XR, Xue F, Ma YP, Hu JS*, He AL*. High Expression Levels of Long Noncoding RNA Small Nucleolar RNA Host Gene 18 and Semaphorin 5A Indicate Poor Prognosis in Multiple Myeloma. Acta Haematol. 2019 Oct 9.1-10. DOI: 10.1159/000502404
  13. Jia X#, Zhao Q, Zhang Y, Dong Y, Lei L, Williamson RA, Lei Y, Tan X, Zhang D*, Hu J*. Identification of a Five-CpG Signature with Diagnostic Value in Thyroid Cancer. J Comput Biol. 2019;26(12):1409-1417. DOI: 10.1089/cmb.2019.0165
  14. Zhang D#, Cui G#, Sun C, Lei L, Lei L, Williamson RA, Wang Y, Zhang J, Chen P, Wang A, Fan R, Han S, Wang Y*, Hu J*. Hypoxia promotes osteosarcoma cell proliferation and migration through enhancing platelet-derived growth factor-BB/platelet-derived growth factor receptor-β axis. Biochem Biophys Res Commun. 2019;512(2):360-366. DOI: 10.1016/j.bbrc.2019.03.040
  15. Zhu M#Tian YZhang HMa XShang BZhang JJiao YZhang YHu J*Wang Y*. Methylphenidate ameliorates hypoxia-induced mitochondrial damage in human neuroblastoma SH-SY5Y cells through inhibition of oxidative stress. Life Sci. 2018 Mar 15;197:40-45. DOI: 10.1016/j.lfs.2018.01.027.
  16. Hu J#, Van Valckenborgh E, Dehui X, Menu E, De Raeve H, De Bruyne E, Xu S, Van Camp B, Handisides D, Hart CP, Vanderkerken K*. Synergistic induction of apoptosis in multiple myeloma cells by bortezomib and hypoxia-activated prodrug TH-302, in vivo and in vitro. Mol Cancer Ther. 2013;12(9):1763-1773.   
  17. Hu J#, Van Valckenborgh E, Menu E, De Bruyne E, Vanderkerken K*. Understanding the hypoxic niche of multiple myeloma: therapeutic implications and contributions of mouse models. Dis Model Mech. 2012;5(6):763-71.            
  18. Hu J#, Dang N, Menu E, De Bryune E, Xu D, Van Camp B, Van Valckenborgh E, Vanderkerken K*. Activation of ATF4 mediates unwanted Mcl-1 accumulation by proteasome inhibition. Blood. 2012;119(3):826-37. IF>10   
  19. Hu J#*, Dang N, Song T, Vanderkerken K. Mcl-1 reduction due to caspase-dependent cleavage during endoplasmic reticulum stress-induced apoptosis. J Biol Chem. 2011;286(44):le24.  
  20. Hu J#, Handisides DR, Van Valckenborgh E, De Raeve H, Menu E, Vande Broek I, Liu Q, Sun JD, Van Camp B, Hart CP, Vanderkerken K*. Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug. Blood. 2010;116(9):1524-7.  IF>10   
  21. Hu J#, Dang N#, Yao H, Li Y, Zhang H, Yang X, Xu J, Bian H, Xing J, Zhu P, Chen Z*. Involvement of HAb18G/CD147 in T cell activation and immunological synapse formation. J Cell Mol Med. 2010;14(8):2132-43.  
  22. Dang N#, Hu J#, Liu X, Li X, Ji S, Zhang W, Su J, Lu F, Yang A, Han H, Han W, Jin B, Yao L*.        CD167 acts as a novel costimulatory receptor in T-cell activation. J Immunother.         2009;32(8):773-84. 

  1. Xu D#, Hu J, Xu S, De Bruyne E, Menu E, Van Camp B, Vanderkerken K, Van Valckenborgh E*. Dll1/Notch activation accelerates multiple myeloma disease development by promoting CD138+ MM-cell proliferation. Leukemia. 2012;26(6):1402-5.    (IF>10)    
  2. Azab AK#, Hu J, Quang P, Azab F, Pitsillides C, Awwad R, hompson B, Maiso P, Sun JD, Hart CP, Roccaro AM, acco A, Ngo HT, Lin CP, Kung AL, Carrasco DR, Vanderkerken K, Ghobrial IM*. Hypoxia promotes dissemination of multiple myeloma through acquisition of endothelial to mesenchymal transition-like features. Blood. 2012;119(24):5782-94.   (IF=>10)  
  3. Xu D#, Hu J, Bruyne ED, Menu E, Schots R, Vanderkerken K, Van Valckenborgh E*. Dll1/Notch activation contributes to bortezomib resistance by upregulating CYP1A1 in multiple myeloma. Biochem Biophys Res Commun. 2012;428(4):518-24.    
  4. Xu S#, Evans H, Buckle C, De Veirman K, Hu J, Xu D, Menu E, De Becker A, Vande Broek I, Leleu X, Camp BV, Croucher P, Vanderkerken K, Van Riet I*. Impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients is associated with a blockade in the deactivation of the Notch signaling pathway. Leukemia. 2012;26(12):2546-9.  (IF>10)
  5. Wang H#*, Lei L#, Hu J, Li Y. Oncostatin M upregulates Livin to promote keratinocyte proliferation and survival via ERK and STAT3 signalling pathways. Exp Physiol. 2020 Jul;105(7):1151-1158. DOI: 10.1113/EP088584.
  6. Sarkar S#, Chauhan SKS, Daly J, Natoni A, Fairfield H, Henderson R, Nolan E, Swan D, Hu J, Reagan MR, O'Dwyer M*. The CD38low natural killer cell line KHYG1 transiently expressing CD16F158V in combination with daratumumab targets multiple myeloma cells with minimal effector NK cell fratricide. Cancer Immunol Immunother.2020 Mar;69(3):421-434. DOI: 10.1007/s00262-019-02477-8.
  7. Shen Y#, Feng Y, Li F, Jia Y, Peng Y, Zhao W, Hu J, He A*. lncRNA ST3GAL6‑AS1 promotes invasion by inhibiting hnRNPA2B1‑mediated ST3GAL6 expression in multiple myeloma. Int J Oncol. 2021 Apr;58(4):5. doi: 10.3892/ijo.2021.5185. Epub 2021 Mar 2.

 

获批专利
  1. Michael O’Dwyer, Jinsong HuImproved NK-based Cell Therapy2018.6.14PCTWO 2018/104554 A1
  2. 胡劲松,张丹,雷莉,王爱英。一种基于流式细胞术检测NK细胞杀伤活性的方法。专利号:PCN19002920 201910420306.5)。
 

 

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