研究方向

1、抗肿瘤免疫机制

2、淋巴系统肿瘤基因组不稳定性机制

3、调控淋巴细胞发育和抗原受体多样性形成机制

科研基金

1、国家自然科学基金面上项目，81670157, V(D)J重组脱靶效应促进Ph染色体阳性急性淋巴细胞白血病发生机制. 2017/01-2020/12， 直接费用60万元，在研、主持

2、陕西省自然科学基金重点项目，2016JZ030RAG促进Ph+慢性粒细胞白血病进展到急性淋巴细胞白血病机制 2016/01-2019/12， 10万元，在研、主持

3、国家自然科学基金面上项目，31370874、重组激活基因蛋白造成B细胞非抗原受体基因位点发生转位的机制研究、2014/01-2017/12、80万元、结题、主持。

4、国家自然科学基金面上项目, 31170821，重组激活基因蛋白和转录因子Pax5相互作用形成免疫球蛋白V(H)到DJ（H）重排的机制、2012/01-2015/12、60万元。结题、主持。

发表文章

1、Jiao J, Jin Y, Zheng M, Zhang H, Yuan M, Lv Z, Odhiambo W, Yu X, Zhang P, Li C, Ma Y, Ji Y. AID and TET2 co-operation modulates FANCA expression by active demethylation in diffuse large B cell lymphoma. Clin Exp Immunol. 2019;195(2):190-201.

2、Gao S, Zhou B, Li H, Huang X, Wu Y, Xing C, Yu X, Ji Y. Long noncoding RNA HOTAIR promotes the self-renewal of leukemia stem cells through epigenetic silencing of p15.Exp Hematol. 2018;67:32-40.

3、Wu C, Dong Y, Zhao X, Zhang P, Zheng M, Zhang H, Li S, Jin Y, Ma Y, Ren H, Ji Y. RAG2 involves the Igκ locus demethylation during B cell development Mol Immunol. 2017; 88:125-134.

 4、Dong Y, Wu C, Zhao X, Zhang P, Zhang H, Zheng M, Li S, Jiao J, Yu X, Lv Z, Ji Y. Epigenetic modifications of the V_H region after DJ_H recombination in Pro-B cells.Immunology. 2017;152(2):218-231.

 5、Ma YF, Ren Y, Wu CJ, Zhao XH, Xu H, Wu DZ, Xu J, Zhang XL, Ji Y. Interleukin (IL)-24 transforms the tumor microenvironment and induces anticancer immunity in a murine model of colon cancer. Mol Immunol. 2016;75:11-20

 6、Dong Y, Liu F, Wu C, Li S, Zhao X, Zhang P, Jiao J, Yu X, Ji Y,.Illegitimate RAG-mediated recombination events are involved in IKZF1 Δ3-6 deletion in BCR-ABL1 lymphoblastic leukaemia. Clin Exp Immunol. 2016;185(3):320-31.

7、Teng G, Maman Y, Resch W, Kim M, Yamane A, Qian J, Kieffer-Kwon KR, Mandal M, Ji Y, Meffre E, Clark MR, Cowell LG, Casellas R, Schatz DG RAG Represents a Widespread Threat to the Lymphocyte Genome.Cell. 2015 Aug 13;162(4):751-65

8、Schatz DG, Ji Y. Recombination Centers and the Orchestration of V(D)J Recombination The Orchestration of V(D)J Recombination Nat Rev Immunol 2011;11(4):251-63

9、Ji Y, Little AJ, Banerjee JK, Hao B, Oltz EM, Krangel MS, Schatz DG*.Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination.J Exp Med. 2010; 207(13):2809-16.