孔光耀,教授,博士生导师
西安交通大学青年拔尖人才
白血病致病机制研究
造血干细胞研究
白血病靶向治疗
小鼠动物模型构建
临床前动物模型构建
西安交通大学
中国西部科技创新港精准医疗研究院
生物诊断治疗国家地方联合工程研究中心
邮箱地址: konggy@xjtu.edu.cn
地址: 中国西部科技创新港21号楼5012室
教育及工作经历
2000-2007 陕西师范大学 本硕(生物学基地班、生态学)
2008-2011 南开大学 博士(生物化学与分子生物学)
2011-2016 美国威斯康星大学麦迪逊分校 博士后(Research Associate、Associate Researcher)
2017-至今 西安交通大学 教授
主要研究领域
代表性论文
1. Li J, Li R, Jiang W, Sun J, Li J, Guo Y, Zhu K, Zhang C, Kong G#, Li Z#. Splenic serum from portal hypertensive patients enhances liver stem cell proliferation and self-renewal via the IGF-II/ERK signaling pathway. Dig Liver Dis. 2020 (#corresponding author)
2. Zhang H, Zhang S, Zhang J, Zhou R, Nie Y, Ren S, Li J, Feng K, Ji F, Kong G#, Li Z#. Improvement of human platelet aggregation post-splenectomy with paraesophagogastric devascularization in chronic hepatitis B patients with cirrhotic hypersplenism. Platelets. 2019 (#corresponding author)
3. Zhu K, Li J, Li J, Sun J, Guo Y, Tian H, Li L, Zhang C, Shi M, Kong G#, Li Z#. Ring1 promotes the transformation of hepatic progenitor cells into cancer stem cells through the Wnt/β-catenin signaling pathway. J Cell Biochem. 2019 (#corresponding author)
4. Sun J, Guo Y, Bie B, Zhu M, Tian H, Tian J, Li J, Yang Y, Ji F, Kong G#, Li Z#. Silencing of long noncoding RNA HOXD-AS1 inhibits proliferation, cell cycle progression, migration and invasion of hepatocellular carcinoma cells through MEK/ERK pathway. J Cell Biochem. 2019 (#corresponding author)
5. You X, Wen Z, Chang YI, Ranheim EA, Zhou Y, Zhou L, Kong G#, Zhang J#. Systemic Notch downregulation promotes KrasG12D -induced myeloproliferative neoplasm. Br J Haematol. 2019 (#corresponding author)
6. Kong G*#, You X*, Wen Z, Chang YI, Qian S, Ranheim EA, Letson C, Zhang X, Zhou Y, Liu Y, Rajagopalan A, Zhang J, Stieglitz E, Loh M, Hofmann I, Yang D, Zhong X, Padron E, Zhou L, Pear WS, Zhang J.#. Downregulating Notch counteracts KrasG12D-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm. Leukemia. 2019 (#corresponding author)
7. Lu Z*, Hong CC*, Kong G*, Assumpção ALFV#, Ong IM, Bresnick EH, Zhang J, Pan X. Polycomb Group Protein YY1 Is an Essential Regulator of Hematopoietic Stem Cell Quiescence. Cell Rep. 22(6):1545-1559. 2018(*equal contribution)
8. Li Y, Jiang W, Li ZZ, Zhang C, Huang C, Yang J, Kong GY#, Li ZF#. Repetitive restraint stress changes spleen immune cell subsets through glucocorticoid receptor or β-adrenergic receptor in a stage dependent manner. Biochem Biophys Res Commun. 2018 (#corresponding author)
9. Wang P, Li Z, Ren S, Li J, Yang J, Kong G#, Jiang A#, Li Z#.Spleen Regulates Hematopoietic Stem/Progenitor Cell Functions Through Regulation of EGF in Cirrhotic Hypersplenism.Dig Dis Sci.2018 (#corresponding author)
10. Li L, Wei W, Li Z, Chen H, Li Y, Jiang W, Chen W, Kong G#, Yang J#, Li Z#. The Spleen Promotes the Secretion of CCL2 and Supports an M1 Dominant Phenotype in Hepatic Macrophages During Liver Fibrosis. Cell Physiol Biochem. 2018 (#corresponding author)
11. Jiang W, Li Y, Sun J, Li L, Li JW, Zhang C, Huang C, Yang J, Kong GY#, Li ZF#. Spleen contributes to restraint stress induced changes in blood leukocytes distribution. Sci Rep. 2017 (#corresponding author)
12. Zhang J*, Kong G*, Rajagopalan A, Lu L, Song J, Hussaini M, Zhang X, Ranheim EA, Liu Y, Wang J, Gao X, Chang YI, Johnson KD, Zhou Y, Yang D, Bhatnagar B, Lucas DM, Bresnick EH, Zhong X, Padron E, Zhang J. p53-/- synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia. Blood. 2017 (*equal contribution)
13. Kong G, Chang YI, You X, Ranheim EA, Zhou Y, Burd CE, Zhang J. The ability of endogenous Nras oncogenes to initiate leukemia is codon-dependent. Leukemia. 2016
14. Kong G*, Chang Y-I*, Damnernsawad A*, You X*, Du J, Ranheim E, Lee W, Ryu M, Zhou Y, Xing Y, Chang Q, Burd C, Zhang J. Loss of wild-type Kras promotes activation of all Ras isoforms in oncogenic Kras-induced leukemogenesis. Leukemia. 2016 (*equal contribution)
15. Johnson, K. D.*, Kong, G*, Gao, X., Chang, Y-I., Hewitt, K. J., Sanalkumar, R., Sanalkumar, P., Ranheim, R. A., Dewey, C. N., Zhang, J., and Bresnick, E. H. Cis-regulatory Mechanisms Governing Stem and Progenitor Cell Transitions. Science Advances. Science Advances 2015 (*equal contribution)
16. Kong G, Wunderlich M, Yang D, Ranheim EA, Young KH, Wang J, Chang YI, Du J, Liu Y, Tey SR, Zhang X, Juckett M, Mattison R, Damnernsawad A, Zhang J, Mulloy JC, Zhang J. Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm. The Journal of Clinical Investigation. 2014
17. Wang J*, Kong G*, Liu Y, Du J, Chang YI, Tey SR, Zhang X, Ranheim EA, Saba-El-Leil MK, Meloche S, Damnernsawad A, Zhang J, Zhang J. NrasG12D/+ promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions. Blood. 2013 (*equal contribution)
18. Kong G*, Du J*, Liu Y, Meline B, Chang YI, Ranheim EA, Wang J, Zhang J. Notch1 mutations target Kras G12D CD8+ cells and contribute to their leukemogenic transformation. J Biol Chem. 2013 (*equal contribution)
19. Zhang W*, Kong G*, Zhang J, Wang T, Ye L, Zhang X. MiR-520b inhibits growth of hepatoma cells by targeting cyclin D1 and MEKK2. PLoS ONE, 2012 (*equal contribution)
20. Kong G, Zhang J, Zhang S, Shan C, Ye L, Zhang X. Upregulated MicroRNA-29a by Hepatitis B Virus X Protein Enhances Hepatoma Cell Migration by Targeting PTEN in Cell Culture Model. PLoS ONE. 2011
21. Kong G, Zhang J, Zhang S, Shan C, Ye L, Zhang X. Hepatitis B Virus x protein promotes proliferation of hepatoma cells via upregulation of MEKK2. Acta Pharmacologica Sinica, 2011.
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