课题组基本信息

PI简介:

    吴昊,西安交通大学基础医学院医学工程研究所特聘研究员,西安交通大学青拔人才。博士毕业于中科院大连化物所,师从马小军研究员、谭明乾教授,专业为生物化工,期间获得国家研究生奖学金宝洁企业奖学金2016年至2020年,于美国加州大学戴维斯分校医学中心从事博士后研究及新药研发工作,其中一项纳米药物开发于2022年经FDA批准进入临床阶段,另有两项纳米剂型接受NICHD的SBIR资助处于临床前开发阶段。20208月全职回国,入选西安交通大学“青年拔尖人才B类”;主持多项国家自然、省自然科学基金项目和多项横向开发项目;任陕西省省康复医学会委员,Food Biotechnology International杂志客座编辑;主要米药物递送系统及递送过程动力学过程研究,致力于开发医工结合纳米探针、药剂及便携检测设备开发,应用出口包括多种癌症、眼视光及体外检测等多个方向。主要研究成果有: 1)提出一种针对脑部药物递送的创新性程序化响应跨多屏障策略,成功实现对恶性度极高、无临床用药的小儿弥漫性脑干胶质瘤的有效药物治疗(NICHD的SBIR项目资助(Phase I))2)提出一种比率探针构建的新策略,首次实现对纳米结构的活细胞及在体组织中聚散行为的实时监控与定量分析,为生理环境下纳米结构的动力学过程的研究提供高效工具。研究成果发表在Adv. Mater.Nat. Commun.、Funct. Mater.、Theranostics等杂志上,总引用1138余次,H-因子18, i10-index因子 25

(Prof. Hao Wu,  School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University Health Science Center. The youth talent support program of Xian Jiaotong University; National Scholarship for Graduate Students; P&G - Chinese Academy of Sciences Outstanding Student Scholarship.

Funding: 

NSFC52203186, multi-barrier-cross delivery system of monoclonal antibody for the NSCLC brain metastasis immunotherapy, 2023-01 to 2025-12, 300,000 RMB, Hosting;

Natural Science Foundation of Shaanxi Provincial Department of Education, 2022JM-101Responsive nano-delivery system to improve the oral bioavailability of astaxanthin2022-01 to 2023-1250,000 RMB, Hosting;

Young Talent Support Plan of Xi'an Jiaotong University, YX6J014, Development of A-beta protein aggregation behavior tracing probe for Alzheimer's early diagnosis, 2020-08 to 2026-07, 1,000,000 RMB, Hosting;

Shaanxi Nedke Medical Technology Co., Ltd, Development of responsive drug controlled-release silicon hydrogel technology, 20210485, 2021.5 to 2024.5, 3,000,000 RMB, Hosting;

Shaanxi Nedke Medical Technology Co., Ltd, Development of contact mirror surface treatment technology, 2021.11 to 2022.11, 100,000 RMB, Hosting;)

 

课题组教师简介(一):

      雷文茜,西安交通大学基础医学院医学工程研究所助理研究员,青秀人才A类。博士毕业于德国卡尔斯鲁厄理工学院。主要从事微阵列检测技术开发,

基于聚多巴胺的仿生光热杀菌涂层、基于聚乙烯亚胺/聚丙烯酸聚电解质多孔膜负载抗菌肽的动态杀菌涂层、基于微液滴阵列的高通量筛选抗菌药物系统等,揭示了涂层光热杀菌等新机制、负载抗菌肽等新药物的涂层和微液滴阵列新平台在抵抗耐药菌的重要作用。重要成果体现在:以第一作者在 Advanced Science、Small 等国际期刊发表论文 6 篇,专利申请进行中一项表论文 16 篇,总被引用次数 988 次。

联系方式

Mail: Lfshwu@xjtu.edu.cn

 

站点计数器

研究领域

1、跨多屏障递送系统(Drug delivery system for tackling multi-barriers);(Adv. Mater. 2020, 32, 1903759; Biomaterials 2022, 290, 121852Theranostics 2017,7,16)

2、递送动力学比率探针开发(ratio probe on the dynamic process);(Adv. Funct. Mater. 2020, 30, 1910348; Chem. Commun., 2016, 52)

3、微阵列芯片开发(microarray);(Small, 2020, 16(52); Adv.Sci., 2019, 6(13))

4、高特异性MRI造影剂(MRI contrast agent);(Nat. Commun. 2018, 9,3653; Biomaterials 2015, 70, 11)

5、眼部药物递送系统开发(Drug delivery system for eye disease);

  1. Hao Wu, Hongwei Lu, Wenwu Xiao, Jinfan Yang, Hongxu Du, Yingbin Shen, Haijing Qu, Bei Jia, Suman K Manna, Mythili Ramachandran, Xiangdong Xue, Zhao Ma, Xiaobao Xu, Zhongling Wang, Yixuan He, Kit S. Lam, Robert J. Zawadzki, Yuanpei Li* and Tzu-Yin Lin*. Sequential Targeting in Crosslinking Nanotheranostics for Tackling the Multibarriers of Brain Tumors . Adv.Mater. (IF: 32.086). 2020, 1903759. https://onlinelibrary.wiley.com/doi/10.1002/adma.201903759
  2. Hao Wu§, Lu Zhang§, Jinfan Yang, Ruonan Bo, Lin Kai, Dalin Zhang, Hongxu Du, Mythili Ramachandran, Yingbin Shen, Yangxi Xu, Xiangdong Xue, Zhao Ma, Tzu-Yin Lin and Yuanpei Li*. Rotatable Aggregation-Induced-Emission / Aggregation-Caused-Quenching Ratio Strategy for Real-Time Tracking Nanoparticle Delivery Dynamics, Adv. Funct. Mater. (IF: 19.924). 2020, 1910348. https://onlinelibrary.wiley.com/doi/10.1002/adfm.201910348
  3. Hongwei Lu§, Ji Xu§, Jinfan Yang§, Zhongling Wang, Peng Xu, Qian Hao, Wen Luo, Shuaijun Li, Zhengqing Li, Xiangdong Xue, Hongbo Zheng, Zhangjian Zhou, Hao Wu*, Xiaobin Ma* and Yuanpei Li*. On-demand Targeting Nanotheranostics with Stimuli-responsive Releasing Property to Improve Delivery Efficiency to Cancer, Biomaterials (IF: 15.304). 2022, (290) 121852. https://www.sciencedirect.com/science/article/pii/S0142961222004926; https://authors.elsevier.com/c/1fxY3WWN0sh2~
  4.  Hao Wu§, Huihui Wang§, Han Liao, Yan Lv, Xiaojie Song, Xiaojun Ma and Mingqian Tan*. Multifunctional Nanostructures for Tumor Targeted Molecular Imaging and Photodynamic Therapy. Adv.Healthc.Mater. (IF: 11.092), 2016, 5, 311–318. https://onlinelibrary.wiley.com/doi/10.1002/adhm.201500668
  5.  Jinfan Yang*, Zhifeng Ao, Hao Wu*, Sufeng Zhang, Concong Chi, Chen Hou, Liwei Qian. Waste paper-derived magnetic carbon composite: A novel eco-friendly solid acid for the synthesis of n-butyl levulinate from furfuryl alcohol. Renew. Energ. (IF: 8.634), 2020, 146, 477-483. https://doi.org/10.1016/j.renene.2019.06.167
  6. Jinfan Yang*, Zhengqing Li, Xiaoru Niu, Ji Xu, Wenxi Lei, Hao Wu*. Hierarchical porous N-doped carbon encapsulated CoFe2O4-CoO nanoparticles derived from layered double hydroxide/chitosan biocomposite for the enhanced degradation of tetracycline. Sep. Purif. Technol. (IF: 9.136), 2022, 295, 121291. https://doi.org/10.1016/j.seppur.2022.121291
  7. Jinfan Yang*, Zhifeng Ao, Hao Wu*, Sufeng Zhang. Immobilization of chitosan-templated MnO2 nanoparticles onto filter paper by redox method as a retrievable Fenton-like dip catalyst. Chemosphere. (IF: 8.943) 4.2021, 268, 12883. https://doi.org/10.1016/j.chemosphere.2020.128835
  8. Hanxiao Cui§, Luyao Dai§, Yuanhang Bao, Liqun Hu, Zhangjian Zhou, Meng Wang, Shuai Lin, Xiaobin Ma*, Hao Wu*, Huafeng Kang*. Nomogram Predicts the Role of Primary Tumor Surgery on de novo stage-IV Breast Cancer. Front. Oncol. (IF: 5.738), 2022, 819531. https://doi.org/10.3389/fonc.2022.819531
  9. Luyao Dai§, Hanxiao Cui§, Yuanhang Bao, Liqun Hu, Zhangjian Zhou, Meng Wang, Shuai Lin, Hao Wu*, Xiaobin Ma*, Huafeng Kang*. The relationship between immediate postmastectomy reconstruction modalities and survival benefits in patients with triple negative breast cancer. Cancer Medicine (IF: 4.711), 2022, accepted.
  10.  Hao Wu§, Haidong Zhao§, Xiaojie Song, Shen Li, Xiaojun Ma* and Mingqian Tan*. Self-assembly- induced near-infrared fluorescent nanoprobes for effective tumor molecular imaging, J. Mater. Chem. B. (IF: 7.571), 2014, 2, 5302–5308. https://pubs.rsc.org/en/content/articlelanding/2014/TB/C4TB00761A
  11. Jinfan Yang*, Xiaoru Niu, Hao Wu*, Hongyu Zhang, Zhifeng Ao, Sufeng Zhang. Valorization of humin as a glucose derivative to fabricate a porous carbon catalyst for esterification and hydroxyalkylation/alkylation. Waste. Manage. (IF: 8.816), 2020, 103, 407-415. https://doi.org/10.1016/j.wasman.2020.01.004
  12. Hao Wu, Ying Ma, Shuang Shan, Mingqian Tan* and Xiaojun Ma*. Separable cells co-culture method by microcapsules loading cells. Chinese Journal of Cell Biology, 2013, 35(5):697-702.
  13. Yan Luo§, Hao Wu§, Caihong Feng, Kai Xiao, Xixiao Yang, Qiangqiang Liu, Tzu-yin Lin, Hongyong Zhang, Jeffrey H. Walton, Yousif Ajena, Yide Hu, Kit S. Lam* and Yuanpei Li*.One-potfabrication of highly versatile and biocompatible poly (vinyl alcohol)-porphyrin-based nanotheranostics. Theranostics. (IF: 11.556), 2017, 7 (16) 3901-3914.
  14. Xue-Xiang Zhang§, Hao Wu§, Peng Li, Zong-Jin Qu, Ming-Qian Tan and Ke-Li Han*. A versatile two-photon fluorescent probe for ratiometric imaging E. coli β-galactosidase in live cells and in vivo, Chem. Commun. (IF: 6.222), 2016, 52, 8283-8286.
  15. Huihui Wang§, Hao Wu§, Hujun Shen, Shaote Geng, Beibei Wang, Yanfang Wang, Xiaojun Ma, Guohui Li and Mingqian Tan*. A bimodal MRI and NIR liposome nanoprobe for tumor targeted molecular imaging. J. Mater. Chem. B. (IF: 6.331), 2015, 3, 8832-8841.
  16. Zheyu Shen, Hao Wu, Sugeun Yang, Xuehua Ma, Zihou Li, Mingqian Tan* and Aiguo Wu*. A novel Trojan-horse targeting strategy to reduce the non-specific uptake of nanocarriers by non-cancerous cells, Biomaterials (IF: 12.479), 2015,70, 1-11.
  17. Xiaojie Song, Hao Wu, Shen Li,Yanfang Wang, Xiaojun Ma* and Mingqian Tan*. Ultrasmall Chitosan-genipin Nanocarriers Fabricated from Reverse Microemulsion Process for Tumor Photothermal Therapy in Mice. Biomacromolecules (IF: 6.988), 2015, 16, 2080−2090.
  18. Chengkun Jiang, Hao Wu, Xiaojie Song, Xiaojun Ma, Jihui Wang and Mingqian Tan*. Presence of photoluminescent carbondots in Nescafe original instant coffee: Applications to bioimaging. Talanta (IF: 6.057), 2014,127, 68–74.
  19. Shanshan Tie, Wentao Su, Yannan Chen, Shida Wu, Hao Wu, Yukun Song, Siyuan Fei, Mingqian Tan. Dual targeting procyanidin nanoparticles with glutathione response for colitis treatment. Chemical Engineering Journal (IF: 13.273), 2022, 441, 136095.
  20.  Xiangdong Xue, Yee Huang, Ruonan Bo, Bei Jia, Hao Wu, Ye Yuan, Zhongling Wang, Zhao Ma, Di Jing, Xiaobao Xu, Weimin Yu, Tzu-yin Lin & Yuanpei Li*. Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment, Nat. Commun. (IF: 14.919), 2018, 9, 3653.
  21. Zhongling Wang, Xiangdong Xue, Yixuan He, Ziwei Lu, Bei Jia, Hao Wu, Ye Yuan, Yee Huang, Han Wang, Hongwei Lu, Kit S Lam, TzuYin Lin, Yuanpei Li*. Novel RedoxResponsive Polymeric Magnetosomes with Tunable Magnetic Resonance Property for In Vivo Drug Release Visualization and DualModal Cancer Therapy, Adv. Funct. Mater. (IF: 18.808), 2018, 28, 1802159.
  22. Yan Lv, Jianbin Zhang, Hao Wu, Shan Zhao, Yizhe Song, Shujun Wang, Bing Wang, Guojun Lv* and Xiaojun Ma*. A Protease Inhibition Strategy Based on Acceleration of Autolysis. Chem. Commun. (IF: 6.222), 2015 Apr 7;51(27):5959.
  23. Nirun Jatupaiboon, Yanfang Wang, Hao Wu, Xiaojie Song, Yizhe Song, Jianbin Zhang, Xiaojun Ma* and Mingqian Tan*. A facile microemulsion template route for producing hollow silica nanospheres as imaging agents and drug nanocarriers. J. Mater. Chem. B. (IF: 6.331), 2015,3, 3130-3133.
  24. Mingqian Tan*, Xintong Li, Hao Wu, Beibei Wang, Jing Wu. N-doped carbon dots derived from bovine serum albumin and formic acid with one- and two-photon fluorescence for live cell nuclear imaging. Colloids. Surface. B (IF: 5.268), 2015, 136, 141–149.
  25. Huizhen Zheng, Hongguo Xie, Hao Wu, Feng Wang, Xiudong Liu*, Weiting Yu* and Xiaojun Ma. Investigation of spherical hydrogel surface with optical interferometer. Colloid Surface A (IF: 4.538), 2015,484, 457-462.
  26. Zhiqiang Ye, Rong Tang, Hao Wu, Beibei Wang, Mingqian Tan* and Jingli Yuan. Preparation of europium complex-conjugated carbon dots for ratiometric fluorescence detection of copper(II) ions, New J. Chem. (IF: 3.591), 2014, 38 (12), 5721-5726.
  27. Beibei Wang, Yanfang Wang, Hao Wu, Xiaojie Song,Xin Guo, Demeng Zhang, Xiaojun Ma* and Mingqian Tan*. A mitochondria-targeted fluorescent probe based on TPP-conjugated carbon dots for both one- and two-photon fluorescence cell imaging. RSC Adv. (IF: 3.361), 2014,4, 49960-49963.
  28. Han Liao, Ziyi Wang, Song Chen, Hao Wu, Xiaojun Ma and Mingqian Tan*. One-pot synthesis of gadolinium (iii) doped carbon dots for fluorescence/magnetic resonance bimodal imaging. RSC Adv. (IF: 3.361), 2015,5(82), 66575-66581.
  29. Chang Liu, Yang Liu, Xiaoxi Xu, Hao Wu, Hongguo Xie, Li Chen, Ting Lu, Li Yang, Xin Guo, Guangwei Sun*. Potential effect of matrix stiffness on the enrichment of tumor initiating cells under three-dimensional culture conditions. Experimental cell research (IF: 3.905), 2015, 1, 123-134.
  30. Beibei Wang, Shujun Wang, Yanfang Wang, Yan Lv, Hao Wu, Xiaojun Ma* and Mingqian Tan*. Highly fluorescent carbon dots for visible sensing of doxorubicin release based on efficient nanosurface energy transfer. Biotechnology Letters (IF: 2.461), 2015.
  31. Yan Yang, Xiaojie Song, Yi Yao, Hao Wu, Jian Liu, Yaopeng Zhao, Mingqian Tan* and Qihua Yang*. Ultrasmall single micelle@ resin core–shell nanocarriers as efficient cargo loading vehicles for in vivo biomedical applications. J. Mater. Chem. B (IF: 6.331), 2015, 3, 4671-4678.
  32. Mingqian Tan, Lingxin Zhang, Rong Tang, Xiaojie Song, Yimin Li, Hao Wu, Yangfang Wang, Guojun Lv, Wangfa Liu and Xiaojun Ma*. Enhanced photoluminescence and characterization of multicolor carbon dots using plant soot as a carbon source. Talanta (IF: 6.057), 2013,115, 950-956.
  33. Yang Liu, ShujunWang, Dongsheng Sun, Yongdong Liu, Yang Liu, YangWang, Chang Liu, Hao Wu, Yan Lv, Ying Ren, XinGuo, Guangwei Sun* and Xiaojun Ma*. Development of a Biomimetic Chondroitin Sulfate-modified Hydrogel to Enhance the Metastasis of Tumor Cells. Sci. Rep. (IF: 4.379), 2016 Jul 19; 6:29858.

Patents

1.  Hao Wu, Tzu-Yin Lin, Yuanpei Li “Sequential Targeting in Crosslinking Nano-theranostics for Tackling the Multi-barriers of Brain Tumors” (USA) Filed 2019, NO.0577501-19-0074

2.  Hao Wu, Tzu-Yin Lin, Yuanpei Li “Rotatable Aggregation-Induced-Emission / Aggregation-Caused-Quenching Ratio Strategy for Real-Time Tracking Nanoparticle Delivery Dynamics” (USA) (submitted)

3.  Ma Xiaojun, Mingqian Tan and Hao Wu Preparation method and application for one kind of superparamagnetic and fluorescent microcapsule” (China) Filed 2012, NO.201210551859 .2

4.  Ma Xiaojun, Mingqian Tan and Hao Wu Preparation method and application for one kind of NIR fluorescent nanostructure (China) Issued 2014, NO.201210222884.6

5.  Mingqian Tan, Hao Wu and Ma Xiaojun Preparation method and application for one kind of MR&NIR fluorescent and targeted nanoprobes (China) Filed 2014, NO.201410778647.7

Conference and Book:

1. Hao Wu§, Lu Zhang§, Yuanpei Li* and Kit S. Lam*, Chapter12: Stimuli-Responsive Materials in Theranostics, “Stimuli-responsive Drug Delivery Systems”, Royal Society of Chemistry in 2018, ISBN 978-1-78801-113-6 (book)

2. Lu Zhang§, Hao Wu§, Yuanpei Li* and Kit S. Lam*, Chapter13: Reversible cross-linked polymeric for delivery purposes, “Nanoengineered Biomaterials for Advanced Drug Delivery”, Elsevier in 2019, ISBN 978-0-08102-985-5 (book)

3. Mingqian Tan, Hao Wu, Xiaojie Song, Yanfang Wang, Beibei Wang and Zhengrong Lu, “Tumor Targeted MRI Contrast Agents Based on Nanoglobules for Cancer Molecular Imaging”, Oral, The 2nd International Congress on Magnetic Resonance Imaging (ICMRI)& The 19th Annual Scientific Meeting of KSMRM, Seoul, Korea, Mar. 28-28,2014.

4. Yang Liu and Hao Wu, Chapter13: Protein-based Nanoparticles for Tumor Targeting Theranostics, “Nanomaterials for tumor-targeted theronostics”, World Scientific Published in 2014, ISBN 978-981-4635-41-7(book)