基本信息

 李宏宝，博士，副教授，博士研究生导师

联系方式

 

联系地址：陕西省西安市雁塔西路76号西安交通大学医学部基础医学院

                  陕西省西安市中国西部科技创新港泓仁楼4-109

 

联系电话：15829688942

 

电子邮箱：hongbaoli1985@163.com; lhb15891752503@mail.xjtu.edu.cn

站点计数器

个人简介

   李宏宝，生理学博士，副教授，博士生导师。中国生理学会会员。美国生理学会会员。2012年获兰州大学生理学硕士学位。2015年毕业于西安交通大学医学院留校工作至今，一直从事宿主肠道微生物与心血管疾病、慢性肾脏病相关机制的研究。2017-2018年在美国佛罗里达大学公派访学。

 

   目前主持国家自然科学基金2项、中国博士后面上项目2项、陕西省重点研发项目1项、陕西省博士后基金1项、陕西省自然科学基金青年项目1项，教育部春晖计划项目1项，另参与国家自然科学基金重大研究计划项目、面上项目等多个科研项目。

 

            累计发表SCI论文42篇，其中以第一作者/通讯作者在Hypertension, Gut Microbes, Molecular Nutrition & Food Research等国际学术期刊上发表SCI收录论文12篇。其中影响因子大于10的高水平SCI论文2篇。任SCI杂志Frontiers in Nutrition (IF=6.57；副主编)，Frontiers in Cellular and Infection Microbiology (IF=5.29；副主编)， Cardiovascular Toxicology (IF=3.23)编委，中华高血压杂志青年编委等。同时长期担任Toxicology and Applied Pharmacology, Frontiers in Cellular and Infection Microbiology, Journal of functional foods, Cardiovascular Toxicology等SCI杂志审稿人。

 

主持项目

  1.  国家自然科学基金面上项目（82170443）：肠道菌F.prausnitzii通过室旁核SLC25A51基因改善高血压的机制研究，2022-01至2025-12月，55万元，在研，主持
  2. ​​​​​​陕西省重点研发计划一般项目（2021SF-153）：基于肠-脑轴研究肠道菌F. prausnitzii改善高血压的中枢机制，2021-01至2022-12月，7万元，在研，主持
  3. 西安交通大学基本科研业务费（xzy012020087）：基于丁酸-GPR43/GPR109A受体信号研究肠道菌F. prausnitzii改善肾脏炎性损伤的作用机制，2020-01至2022-12月，6万元，在研，主持
  4.  国家自然科学基金青年项目（81700373）：下丘脑室旁核活性肽salusinβ通过TLR4/MAPK/NF-κB信号通路调控高血压的研究，2018-01至2020-12, 20万元，已结题，主持
  5. 中国博士后面上项目一等资助（2019M660259）：肠道微生物-肠-脑轴介导运动训练改善高血压的研究，2020-01至2021-12, 12万元，已结题，主持
  6. 教育部“春晖计划”合作科研项目：基于脑-肠轴肠道微生物持续参与母体高血压控制产生的跨代交流，2020-01至2021-12, 3万元，在研，主持
  7. 陕西省自然科学基金青年项目(2017JQ8011)：TLR4/NF-κB信号通路介导salusinβ在高血压中的作用，2017-01至2018-12， 5万元，已结题，主持
  8. 中国博士后面上项目二等资助（2016M592802）：Salusin β调控TLR4/NF-κB信号通路在高血压中的作用，2017-01至2018-12， 5万元，已结题，主持
  9. 陕西省博士后基金项目(2016BSHEDZZ88)：基于TLR4/NF-κB 信号通路室旁核活性肽salusin β 调控高血压的机制研究，2016-01至2017-12月，2万元，已结题，主持
  10. 西安交通大学新讲师科研支持计划项目：活性肽salusin β在高血压中的作用和分布，2016-01至2018-12月，10万元，已结题，主持

代表论文

部分第一/通讯作者文章：本人通讯作者以*标出

 

  1. Wen-Jie Xia, Meng-Lu Xu, Xiao-Jing Yu, Meng-Meng Du, Xu-Hui Li, Tao Yang, Lu Li, Qing Su, Jia-Xi Xu, Xiao-Lian Shi, Hong-Bao Li*(通讯作者), Yu-Ming Kang, Antihypertensive effects of exercise involve reshaping of gut microbiota and improvement of gut-brain axis in spontaneously hypertensive rat, Gut Microbes, 2021, 13(1):1-24. IF: 10.245.
  2. Ying Li, Rawya Mohamed Salih Ibrahim, Hong-Li Chi, Tong Xiao, Wen-Jie Xia, Hong-Bao Li*(通讯作者), Yu-Ming Kang*, Altered gut microbiota is involved in the anti-hypertensive effects of Vitamin C in spontaneously hypertensive rat, Molecular Nutrition and Food Research, 2021, 65(7):e2000885. IF: 5.914 (封面论文)
  3. Ying Li*, Salman Zafar, Rawya Mohamed Salih Ibrahim, Hong-Li Chi, Tong Xiao, Wen-Jie Xia, Hong-Bao Li*(通讯作者), Yu-Ming Kang*, Exercise and food supplement of vitamin C ameliorate hypertension through improvement of gut microflora in the spontaneously hypertensive rats, Life Sciences, 2021, 269:119097. IF: 5.037.
  4. Hong-Bao Li, Tao Yang，Elaine M. Richards, Carl J. Pepine, Mohan K. Raizada, Maternal treatment with captopril persistently alters gut-brain communication and attenuates hypertension of male Offspring，Hypertension, 2020, 75:1315-1324. IF: 10.19.
  5. Hong-Bao Li, Xiao-Jing Yu, Juan Bai, Qing Su, Mo-Lin Wang, Chan-Juan Huo, Wen-Jie Xia, Qiu-Yue Yi, Kai-Li Liu, Li-Yan Fu, Guo-Qing Zhu, Jie Qi, Yu-Ming Kang, Silencing salusin β ameliorates heart failure in aged spontaneously hypertensive rats by ROS-relative MAPK/NF-κB pathways in the paraventricular nucleus, International Journal of Cardiology, 2019, 280:142-151. IF: 3.229.
  6. Hui Zhang, Hong-Bao Li (共同一作), Jian-Rui Lyu, Xiao-Ming Lei, Wei Li, Gang Wu, Jun Lyu, Zhi-Ming Dai, Specific ACE2 expression in small intestinal enterocytes may cause gastrointestinal symptoms and injury after 2019-nCoV infection, International Journal of Infectious Diseases, 2020, 96:19-24. IF: 3.623.
  7. Meng-Lu Xu, Xiao-Jing Yu, Jian-Qiang Zhao, Yan Du, Wen-Jie Xia, Qing Su, Meng-Meng Du, Qing Yang, Jie Qi, Ying Li, Shao-Wen Zhou, Guo-Qing Zhu, Hong-Bao Li*(通讯作者), Yu-Ming Kang. Calcitriol ameliorated autonomic dysfunction and hypertension by down-regulating inflammation and oxidative stress in the paraventricular nucleus of SHR. Toxicology and Applied Pharmacology, 2020, 394:114950. IF: 3.585.
  8. Tao Yang, Hong-Bao Li, Aline C Oliveira, Ruby Goel，Elaine M. Richards, Carl J. Pepine, Mohan K. Raizada, Transcriptomic signature of gut microbiome-contacting cells in colon of spontaneously hypertensive rats，Physiological Genomics，2020, 2(3):121-132. IF: 3.107.
  9. Tao Yang, Victor Aquino, Gilberto O. Lobaton, Hong-Bao Li, Luis Colon-Perez, Ruby Goel, Yan-Fei Qi,  Jasenka Zubcevic, Marcelo Febo, Elaine M. Richards, Carl J. Pepine, Mohan K. Raizada, Sustained captopril-Induced reduction in blood pressure is associated with alterations in gut-brain axis in the spontaneously hypertensive rat, Journal of the American Heart Association, 2019, 8(4):e010721. IF: 4.605.
  10. Xiao-Jing Yu, Yu-Wang Miao, Hong-Bao Li (共同一作), Qing Su, Kai-Li Liu, Li-Yan Fu, Yi-Kang Hou, Xiao-Lian Shi, Ying Li, Jian-Jun Mu, Wen-Sheng Chen, Wei Cui, Guo-Qing Zhu, Philip J Ebenezer, Joseph Francis, Yu-Ming Kang, Blockade of Endogenous Angiotensin-(1-7) in Hypothalamic Paraventricular Nucleus Attenuates High Salt-Induced Sympathoexcitation and Hypertension, Neuroscience Bulletin, 2019, 35(1):47-56. IF: 4.326.
  11. Hong-Bao Li, Chan-Juan Huo, Qing Su, Xiang Li, Juan Bai, Guo-Qing Zhu, Yu-Ming Kang, Exercise training attenuates proinflammatory cytokines, oxidative stress and modulates neurotransmitters in the rostral ventrolateral medulla of salt-induced hypertensive rats, Cellular Physiology and Biochemistry, 2018;48(3):1369-1381. IF: 5.5.
  12. Hong-Bao Li, Xiang Li, Chan-Juan Huo, Qing Su, Jing Guo, Zu-Yi Yuan, Guo-Qing Zhu, Xiao-Lian Shi, Jin-Jun Liu, Yu-Ming Kang, TLR4/MyD88/NF-κB signaling and PPAR-γ within the paraventricular nucleus are involved in the effects of telmisartan in hypertension, Toxicology and Applied Pharmacology, 2016, 305:93-102. IF: 3.791.
  13. Qiu-Yue Yi, Hong-Bao Li (共同一作), Jie Qi, Xiao-Jing Yu, Chan-Juan Huo, Xiang Li, Juan Bai, Hong-Li Gao, Bo Kou, Kai-Li Liu, Dong-Dong Zhang, Wen-Sheng Chen, Wei Cui, Guo-Qing Zhu, Xiao-Lian Shi, Yu-Ming Kang, Toxicology letters, 2016, 262:105-113. IF: 3.858.
  14. Hong-Bao Li, Da-Nian Qin, Kang Cheng, Qing Su, Yu-Wang Miao, Jing Guo, Meng Zhang, Guo-Qing Zhu, Yu-Ming Kang, Central blockade of salusin β attenuates hypertension and hypothalamic inflammation in spontaneously hypertensive rats, Scientific Reports, 2015, 5:11162. IF: 5.228.
  15. Hong-Bao Li, Da-Nian Qin, Yu-Ping Suo, Jing Guo, Qing Su, Yu-Wang Miao, Wen-Yan Sun, Qiu-Yue Yi, Wei Cui, Kang Cheng, Guo-Qing Zhu, Yu-Ming Kang, Blockade of salusin β in hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy in salt-induced hypertensive rats, Journal of cardiovascular pharmacology, 2015, 66(4):323-331. IF: 2.538.
  16. Hong-Bao Li, Yan Lu, Jin-Jun Liu, Yu-Wang Miao, Tian-Zhen Zheng, Qing Su, Jie Qi, Hong Tan, Zu-Yi Yuan, Guo-Qing Zhu, Yu-Ming Kang, Salusin β within the nucleus tractus solitarii suppresses blood pressure via inhibiting the activities of presympathetic neurons in the rostral ventrolateral medulla in spontaneously hypertensive rats, Cardiovascular Toxicology, 2016, 16(3):223-234. IF: 2.712.
  17. Hong-Bao Li, Da-Nian Qin, Le Ma, Yu-Wang Miao, Dong-Mei Zhang, Yan Lu, Xin-Ai Song, Guo-Qing Zhu, Yu-Ming Kang, Chronic infusion of lisinopril into hypothalamic paraventricular nucleus modulates cytokines and attenuates oxidative stress in rostral ventrolateral medulla in hypertension, Toxicology and Applied Pharmacology, 2014, 279(2):141-149. IF: 3.973.