Introduction

Yanke Chen, Ph.D, Prof., Department of Cell Biology and Genetics, School of Basic Medical Sciences, Xi’an Jiaotong University.

Research Interest：The mechanism of DNA damage repair and cancer biology

     Work  Experience

  1. 2016-present, Associate professor and Professor, Department of Cell Biology and Genetics, Health Science Center, Xi’an Jiaotong University;
  2. 2014-2015, Visiting scholar, Medicine School of Yale University, USA;
  3. 2009-2014, lecturer, Department of Cell Biology and Genetics, Health Science Center, Xi’an Jiaotong University;
  4. 2007-2009,Postdoctor, Cell Engineering Research Center & Department of Cell Biology, State Key Laboratory of Cancer Biology，The Forth Military Medical University

contact information

Telephone: 18710438459

Email: paincyk@xjtu.edu.cn

Address: Health Science Center, Xi'an Jiaotong University, 76 West Yanta Road, Xi 'an, Shaanxi, 710061, China

Grants and Publications

Grants

  1. ZBTB7B regulates the cGAS-STING-IFN pathway inhibits tumor progression by remodeling the tumor microenvironment after radiotherapy (Project Approval No. : 82173181), Project supported by the Natural Science Foundation of China, in research.
  2. Shaanxi Province Science and Technology Resources Open Sharing Platform -- Construction of Xi 'an Jiaotong University Biomedical Sharing Platform (Project Approval No. : 2018PT-09), Science and Technology Innovation Base project of Shaanxi Science and Technology Department, completed.
  3. Study on radiosensitization of ABTT-NPS nanoparticles coated miRNA4796 for brain metastasis of breast cancer (Project Approval No. 2017KW-059), International Science and Technology Cooperation General Project of Science and Technology Department of Shaanxi Province, completed.
  4. Simultaneous Reduction in Cancer Pain and Bone Destruction by Selective Inhibition of CD147 (81101744)，Project supported by the Natural Science Foundation of China, completed.

Publications

  1. Chen Yanke#, Jiang Ting#, Zhang Hongyi#, Gou Xingchun#, Han Cong, Wang Jianhui, Chen Ann T., Ma Jun, Liu Jun, Chen Zeming, Jing Xintao, Lei Hong, Wang Zhenzhen, Bao Youmei, Baqri Mehdi, Zhu Yong, Bindra Ranjit S., Hansen James E, Dou Jun, Huang Chen*, Zhou Jiangbing*. LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy, Nature Cell Biology, 2020, 22(10): 1276-1306.
  2. Wang Zhenzhen#, Tong Dongdong#, Han Cong, Zhao Zhenhao,Wang Xiaofei, jiang Ting; Li Qian; Liu Siyuan; Chen Lin; Chen Yanke*; Li Aang*; Huang Chen*;Blockade of miR-3614 Maturation by IGF2BP3 Increases TRIM25 Expression and Promotes Breast Cancer Cell Proliferation., EBioMedicine, 2019, 41: 357-368.
  3. Chen Yanke#*; Luan Jing#, Jiang Ting, Cai Donghui, Sun Chao, Wang Xiaofei, Zhao Xiaoge, Gou Xingchun*. Knockdown of EMMPRIN (OX47) in MRMT-1 Carcinoma Cells Inhibits Tumor Growth and Decreases Cancer-induced Bone Destruction and Pain, Cancer Research and Treatment, 2021, 53(2): 357-368.