基本信息

           

                           庞正达 副教授 

大阪大学 医学博士。2015年加入西安交通大学医学部，生理学与病理生理学系。2017年获得国家博士后国际交流引进计划项目。主持国家自然科学基金青年项目、中国博士后科学基金项目、陕西省自然科学基金项目等多项基金。近年来以第一作者在PNAS，FASEB J等国际期刊杂志发表论文。

联系方式

E-mail: pangzd@mail.xjtu.edu.cn

陕西省西安市西咸新区西交大创新港21号4136

站点计数器

研究领域

研究方向为心血管病理生理学, 主要研究方向为钙激活钾通道在糖尿病和血管内皮功能调节中的作用及机制。

教育及工作经历

2015年至今 西安交通大学医学部基础医学院生理学与病理生理学系，讲师 / 副教授

2015年毕业于大阪大学内科学， 获得医学博士学位  

2008年毕业于兰州大学临床医学专业，获得医学学士学位 

 

代表性论文

  1. Pang ZD, Sun X, Bai RY, Han MZ, Zhang YJ, Wu W, Zhang Y, Lai BC, Zhang Y, Wang Y, Du XJ, Deng XL. YAP-galectin-3 signaling mediates endothelial dysfunction in angiotensin II-induced hypertension in mice. Cell Mol Life Sci. 2023 Jan 11;80(2):38.
  2. ​​​​​​​Wu W, Ziemann M, Huynh K, She G, Pang ZD, Zhang Y, Duong T, Kiriazis H, Pu TT, Bai RY, Li JJ, Zhang Y, Chen MX, Sadoshima J, Deng XL, Meikle PJ, Du XJ. Activation of Hippo signaling pathway mediates mitochondria dysfunction and dilated cardiomyopathy in mice. Theranostics. 2021 Aug 21;11(18):8993-9008.
  3. Pang ZD, Wang Y, Song Z, She G, Ma XZ, Sun X, Wu W, Lai BC, Zhang J, Zhang Y, Du XJ, Shyy JYJ, Deng XL. AMPK upregulates KCa2.3 channels and ameliorates endothelial dysfunction in diet-induced obese mice. Biochem Pharmacol. 2021 Jan;183:114337.  
  4. Zhang Y, Hou MC, Li JJ, Qi Y, Zhang Y, She G, Ren YJ, Wu W, Pang ZD, Xie W, Deng XL, Du XJ. Cardiac β-adrenergic receptor activation mediates distinct and cell type-dependent changes in the expression and distribution of connexin 43. J Cell Mol Med. 2020 Aug;24(15):8505-8517.
  5. Pang ZD, Wang Y, Wang XJ, She G, Ma XZ, Song Z, Zhao LM, Wang HF, Lai BC, Gou W, Du XJ, Deng XL. KCa3.1 channel mediates inflammatory signaling of pancreatic β cells and progression of type 2 diabetes mellitus. FASEB J. 2019 Dec;33(12):14760-14771.
  6. Wang Y, Wang XJ, Zhao LM, Pang ZD, She G, Song Z, Cheng X, Du XJ, Deng XL. Oxidative stress induced by palmitic acid modulates KCa2.3 channels in vascular endothelium. Exp Cell Res. 2019 Oct 15;383(2):111552.
  7. Ma XZ, Pang ZD, Wang JH, Song Z, Zhao LM, Du XJ, Deng XL. The role and mechanism of KCa3.1 channels in human monocyte migration induced by palmitic acid. Exp Cell Res. 2018 Aug 15;369(2):208-217.
  8. Pang Z, Kushiyama A, Sun J, Kikuchi T, Yamazaki H, Iwamoto Y, Koriyama H, Yoshida S, Shimamura M, Higuchi M, Kawano T, Takami Y, Rakugi H, Morishita R, Nakagami H. Glial fibrillary acidic protein (GFAP) is a novel biomarker for the prediction of autoimmune diabetes. FASEB J. 2017 Sep;31(9):4053-4063.
  9. Pang Z, Higuchi M, Koriyama H, Yoshida S, Kurinami H, Shimamura M, Takami Y, Rakugi H, Morishita R, Nakagami H. Evaluating the potential of the GFAP-KLH immune-tolerizing vaccine for type 1 diabetes in mice. FEBS Lett. 2017 Jan;591(1):129-136.
  10. Nakagami H, Pang Z, Shimosato T, Moritani T, Kurinami H, Koriyama H, Tenma A, Shimamura M, Morishita R. The dipeptidyl peptidase-4 inhibitor teneligliptin improved endothelial dysfunction and insulin resistance in the SHR/NDmcr-cp rat model of metabolic syndrome. Hypertens Res. 2014 Jul;37(7):629-35.
  11. Shimamura M, Nakagami H, Osako MK, Kurinami H, Koriyama H, Zhengda P, Tomioka H, Tenma A, Wakayama K, Morishita R. OPG/RANKL/RANK axis is a critical inflammatory signaling system in ischemic brain in mice. Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8191-6.
  12. Pang Z, Nakagami H, Osako MK, Koriyama H, Nakagami F, Tomioka H, Shimamura M, Kurinami H, Takami Y, Morishita R, Rakugi H. Therapeutic vaccine against DPP4 improves glucose metabolism in mice. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):E1256-63.
  13. Kyutoku M, Nakagami H, Koriyama H, Tomioka H, Nakagami F, Shimamura M, Kurinami H, Zhengda P, Jo DH, Kim JH, Takakura N, Morishita R. Development of novel DNA vaccine for VEGF in murine cancer model. Sci Rep. 2013 Nov 29;3:3380.