研究领域：

心血管等代谢性疾病的分子机制

主持科研项目：

国家自然科学基金面上项目1项

国家自然科学基金青年项目1项

中国博士后科学基金特别资助项目1项

中国博士后科学基金面上项目1项

陕西省博士后科学基金面上项目1项

发表论文：

1.  Yao, Q., Liu, J., Cui, Q., Jiang, T., Xie, X., Du, X., Zhao, Z., Lai, B., Xiao, L., and Wang, N. (2022) CCN1/Integrin α(5)β(1) Instigates Free Fatty Acid-Induced Hepatocyte Lipid Accumulation and Pyroptosis through NLRP3 Inflammasome Activation. Nutrients 14

2.  Yao, Q., Cui, Q., Liu, J., Xie, X., Jiang, T., Wang, H., Zhao, Z., Zhao, W., Du, X., Lai, B., Xiao, L., and Wang, N. (2022) Free fatty acids stabilize integrin β(1) via S-nitrosylation to promote monocyte-endothelial adhesion. J Biol Chem, 102765

3.  Yao, Q., Liu, J., Xiao, L., and Wang, N. (2019) Sonic hedgehog signaling instigates high-fat diet-induced insulin resistance by targeting PPARγ stability. J Biol Chem 294, 3284-3293

4.  Yao, Q., Liu, J., Zhang, Z., Li, F., Zhang, C., Lai, B., Xiao, L., and Wang, N. (2018) Peroxisome proliferator-activated receptor γ (PPARγ) induces the gene expression of integrin α(V)β(5) to promote macrophage M2 polarization. J Biol Chem 293, 16572-16582

5.  Yao, Q., Renault, M. A., Chapouly, C., Vandierdonck, S., Belloc, I., Jaspard-Vinassa, B., Daniel-Lamazière, J. M., Laffargue, M., Merched, A., Desgranges, C., and Gadeau, A. P. (2014) Sonic hedgehog mediates a novel pathway of PDGF-BB-dependent vessel maturation. Blood 123, 2429-2437

6.  Liu, J., Yao, Q., Xie, X., Cui, Q., Jiang, T., Zhao, Z., Du, X., Lai, B., Xiao, L., and Wang, N. (2022) Procyanidin B2 Attenuates Nicotine-Induced Hepatocyte Pyroptosis through a PPARγ-Dependent Mechanism. Nutrients 14

7.  Liu, J., Yao, Q., Xiao, L., Ma, W., Li, F., Lai, B., and Wang, N. (2020) PPARγ induces NEDD4 gene expression to promote autophagy and insulin action. Febs j 287, 529-545

8.  Liu, J., Yao, Q., Xiao, L., Li, F., Ma, W., Zhang, Z., Xie, X., Yang, C., Cui, Q., Tian, Y., Zhang, C., Lai, B., and Wang, N. (2020) APC/Cdh1 targets PECAM-1 for ubiquitination and degradation in endothelial cells. J Cell Physiol 235, 2521-2531

9.  Chapouly, C., Yao, Q., Vandierdonck, S., Larrieu-Lahargue, F., Mariani, J. N., Gadeau, A. P., and Renault, M. A. (2016) Impaired Hedgehog signalling-induced endothelial dysfunction is sufficient to induce neuropathy: implication in diabetes. Cardiovasc Res 109, 217-227

10. Zhang, Z., Xie, X., Yao, Q., Liu, J., Tian, Y., Yang, C., Xiao, L., and Wang, N. (2019) PPARδ agonist prevents endothelial dysfunction via induction of dihydrofolate reductase gene and activation of tetrahydrobiopterin salvage pathway. Br J Pharmacol 176, 2945-2961

11. Tian, Y., Yang, C., Yao, Q., Qian, L., Liu, J., Xie, X., Ma, W., Nie, X., Lai, B., Xiao, L., and Wang, N. (2019) Procyanidin B2 Activates PPARγ to Induce M2 Polarization in Mouse Macrophages. Front Immunol 10, 1895

12. Luo, X., Jia, R., Yao, Q., Xu, Y., Luo, Z., Luo, X., and Wang, N. (2016) Docosahexaenoic acid attenuates adipose tissue angiogenesis and insulin resistance in high fat diet-fed middle-aged mice via a sirt1-dependent mechanism. Mol Nutr Food Res 60, 871-885

13. Renault, M. A., Chapouly, C., Yao, Q., Larrieu-Lahargue, F., Vandierdonck, S., Reynaud, A., Petit, M., Jaspard-Vinassa, B., Belloc, I., Traiffort, E., Ruat, M., Duplàa, C., Couffinhal, T., Desgranges, C., and Gadeau, A. P. (2013) Desert hedgehog promotes ischemia-induced angiogenesis by ensuring peripheral nerve survival. Circ Res 112, 762-770

14. Zhang, M., Zhang, Z., Xie, X., Yao, Q., Liu, J., Lai, B., Xiao, L., and Wang, N. (2019) Xenobiotic pregnane X receptor promotes neointimal formation in balloon-injured rat carotid arteries. J Cell Physiol 234, 4342-4351

15. Renault, M. A., Robbesyn, F., Chapouly, C., Yao, Q., Vandierdonck, S., Reynaud, A., Belloc, I., Traiffort, E., Ruat, M., Desgranges, C., and Gadeau, A. P. (2013) Hedgehog-dependent regulation of angiogenesis and myogenesis is impaired in aged mice. Arterioscler Thromb Vasc Biol 33, 2858-2866

16. Zhang, C., Deng, J., Liu, D., Tuo, X., Xiao, L., Lai, B., Yao, Q., Liu, J., Yang, H., and Wang, N. (2018) Nuciferine ameliorates hepatic steatosis in high-fat diet/streptozocin-induced diabetic mice through a PPARα/PPARγ coactivator-1α pathway. Br J Pharmacol 175, 4218-4228

17. Luo, X., Luo, Z., Zhang, Z., Yang, H., Lai, B., Yao, Q., Xiao, L., and Wang, N. (2016) Homocysteine upregulates hepcidin expression through BMP6/SMAD signaling pathway in hepatocytes. Biochem Biophys Res Commun 471, 303-308

18. Xie, X., Yang, C., Cui, Q., Ma, W., Liu, J., Yao, Q., Zhang, Z., Xiao, L., and Wang, N. (2019) Stachydrine Mediates Rapid Vascular Relaxation: Activation of Endothelial Nitric Oxide Synthase Involving AMP-Activated Protein Kinase and Akt Phosphorylation in Vascular Endothelial Cells. J Agric Food Chem 67, 9805-9811

19. Renault, M. A., Vandierdonck, S., Chapouly, C., Yu, Y., Qin, G., Metras, A., Couffinhal, T., Losordo, D. W., Yao, Q., Reynaud, A., Jaspard-Vinassa, B., Belloc, I., Desgranges, C., and Gadeau, A. P. (2013) Gli3 regulation of myogenesis is necessary for ischemia-induced angiogenesis. Circ Res 113, 1148-1158