研究领域：

旨在系统解析细胞命运谱系演变的动态调控机制，聚焦于肿瘤发生、神经发育与生殖细胞演化三大核心生物学过程。整合单细胞转录组与空间转录组技术，构建跨尺度细胞演化图谱，并以细胞极性建立与命运重编程为关键表型终点，阐明表观遗传网络、信号通路及环境因子对细胞身份决定的时空调控机制，最终目标在于构建一个连接分子元件、细胞行为与组织功能的系统性理论模型，为理解生命程序编码逻辑及疾病干预提供新范式。

科研项目：

（1）西安交通大学医学“基础-临床”融合创新项目，2022041，2022/09-2024/09，在研，主持。

（2）陕西省重点研发计划项目，2023-YBSF-447，2023/01- 2024/12，在研，主持。

（3）国家自然科学基金青年基金项目，81802788，2019/01-2021/12，已结题，主持。

（4）陕西省自然科学基金面上项目，2018JM7028，2018/01-2019/12，已结题，主持。

（5）中国博士后科学基金（特别资助），2019T120918，2017/09-2019/07，已结题，主持。

（6）中国博士后科学基金面上项目（一等），2017M620458，2017/09-2019/07，已结题，主持。

（7）陕西省博士后基金面上项目, 2018BSHEDZZ91, 2017/09-2019/07，已结题，主持。

（8）中国博士后科学基金面上项目，2014M552461，2013/10-2015/07，已结题，主持。

（9）陕西省博士后基金面上项目，2014/01-2015/12，已结题，主持。

（10）西安交通大学基本科研业务费前沿与交叉项目，xjj2017192，2017/01-2019/12，已结题，主持。

（11）西安交通大学基本科研业务费自由探索类项目，xjj2014065，2014/01-2016/12，已结题，主持。

指导大学生创新项目

(1) 2023级省级大学生创新训练项目， FOXI1-CSN6-PD-L1轴参与肺癌细胞增殖迁移的机制研究。

(2) 西安交通大学第三十六届“腾飞杯”创新创业大赛创新赛道二等奖，TRIM33通过泛素化降解FOXI1转录调控DEFA6表达在结肠癌中的潜在机制研究（24XJTUFCX0279）。

(3) 西安交通大学第三十六届“腾飞杯”创新创业大赛创新赛道优秀奖，TRIM71基因在多种癌症中的表达及其在癌症诊断和预后的临床价值研究（24XJTUFCX1120）。

发表文章

(1) Meili Pei#, Yanqi Yang#, Bing Su, Na Li, Minyi Zhao, Juan Zhao, Ting Yang, Li Wang, Shimin Quan, Ruifang Sun*, Xiaofeng Yang*. Lnc-THAP7-AS1 suppresses the ovarian cancer progression by targeting miR-92b-5p/fatty acid 2-hydroxylase signal axis. Transl Oncol. 2025 Nov:61:102514. doi: 10.1016/j.tranon.2025.102514. Epub 2025 Aug 27 (IF=4.1).

(2) Sun Ruifang#, Yang Yang#, Lü Weidong#, Yang Yanqi, Li Yulong, Liu Zhigang, Diao Dongmei, Wang Yang, Chang Su'e, Lu Mengnan, Jiang Qiuyu, Dai Bingling, Ma Xiaobin, Zhao Chang'an, Lü Moqi, Zhang Juan, Ding Caixia, Li Na, Zhang Jian, Xiao Zhengtao #, Zhou Dangxia#, Huang Chen#. Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression. Cell Biosci. 2023; 13: 62. (IF=9.597).

(3) Zhao Xinliang#, Lu Mengnan#, Liu Zhigang#, Zhang Mingming, Yuan Hongmei, Dan Zhaoqiang, Wang Daihua, Ma Bingbing, Yang Yanqi, Yang Funing, Sun Ruifang*, Li Lin*, Dang Chengxue*. Comprehensive analysis of alfa defensin expression and prognosis in human colorectal cancer, Front Oncol. 2023 Jan 10;12:974654. (IF=6.244).

(4) Yang Yan-Qi, Ge Pan, Lv Mo-Qi, Yu Peng-Fei, Liu Zhi-Gang, Zhang Jian, Zhao Wen-Bao, Han Shui-Ping, Sun Rui-Fang*, Zhou Dang-Xia*. Rno_circRNA_008646 regulates formaldehyde induced lung injury through Rno-miR-224 mediated FOXI1/CFTR axis. Ecotoxicol Environ Saf, 2022 Aug 20;243:113999. doi: 10.1016/j.ecoenv.2022.113999. (IF=7.129).

(5) Sun Ruifang#, Liu Zhigang#, Lv Yun#, Yang Yanqi, Yang Yang, Xiang Yu, Jiang Qiuyu, Zhao Chang'an, Lv Moqi, Zhang Jian, Zhang Juan, Ding Caixia, Zhou Dangxia*. FOCAD/miR-491-5p, downregulated by EGR1, function as tumor suppressor by inhibiting the proliferation and migration of gastric cancer cells. Prog Biophys Mol Biol, 2022:176:25-37. (IF=4.799).

(6) Changan Zhao#, Jiyu Miao#, Ruifang Sun#, Rui Liang, Wenhu Chen, Yi Gao, Xiaofei Wang, Shuiping Han, Wenbao Zhao, Ting Lei, Chen Huang. MBD1/HDAC3-miR-5701-FGFR2 axis promotes the development of gastric cancer, Aging (Albany NY). 2022 Jul 22;14(14):5878-5894. (IF=5.955).

(7) Lü Wei-Dong#*, Liu Yi-Zhi, Yang Yan-Qi, Liu Zhi-Gang, Zhao Kun, Lu Jian-Rong, Lei Guang-Yan, Wang Yi-Yu, Cai Lin, Sun Rui-Fang*. Effect of naturally derived surgical hemostatic materials on the proliferation of A549 human lung adenocarcinoma cells. Materials Today Bio, 2022, 4;14:100233. (Q1, IF=10.761).

(8) Sun Ruifang#, Lü Weidong #, Liu Zhigang #, Yang Yang, Wang Xiaofei, Zhao Xinliang, Fu Shufeng, Dai Wei, Huang Chen *, Diao Dongmei *. FOXI1 inhibits gastric cancer cell proliferation by activating miR-590/ATF3 axis via integrating ChIP-seq and RNA-seq data. Progress in Biophysics and Molecular Biology, 2021, 163: 34-45. (IF=4.799).

(9) Liu zhigang#, Yun Lü#, Qiuyu Jiang, Yang Yang, Chengxue Dang*, Ruifang Sun*. miR-491 inhibits BGC-823 cell migration via targeting HMGA2. The International Journal of Biological Markers, 2019, 34(4): 364-372. (IF=3.248).

(10) Sun Ruifang*#, Liu Zhigang*, Han Lin, Yang Yang, Wu Fei, Jiang Qiuyu, Zhang Huahua, Ma Ruili, Miao Jiyu, He Kang, Wang Xiaofei, Zhou Dangxia#, Huang Chen#. miR-22 and miR-214 targeting BCL9L, inhibit proliferation, metastasis and epithelial-mesenchymal transition, by downregulating Wnt signaling in colon cancer, The FASEB Journal. 2019, 33(4):5411-5424. (Q1, IF=5.834)

(11) Lü Weidong#*, Sun Ruifang#, Hu Yerong*, Lu Janrong, Gu Lu, Liu Zhigang, Lei Guangyan, Qiang Zhun, Cai Lin. Photooxidatively crosslinked acellular tumor extracellular matrices as potential tumor engineering scaffold, Acta Biomaterialia, 2018,71:460-473. (Q1, IF= 10.633)

(12) Sun Ruifang#, Liu Zhigang#, Tong Dongdong, Yang Yang, Guo Bo, Wang Xiaofei, Zhao Lingyu, Huang Chen*. miR-491-5p, mediated by Foxi1, functions as a tumor suppressor by targeting Wnt3a/β-catenin signaling in the development of gastric cancer, Cell Death & Disease, 2017,8(3):e2714.(Q1, IF=9.685)

(13) Liu Zhigang#, Sun Ruifang#*, Zhang Juan, Ding Caixia, Ma Gang, Zhao Xinliang, LüWeidong, Wang Xiang, Dang Chengxue*. Prognostic value of MRP, LRP and P-gp in patients with non-small cell lung cancer, International Journal of Clinical and Experimental Pathology, 2017,10(6):6799-6808.

(14) Sun Ruifang#*, Liu Zhigang#, Ma Gang, Ding Caixia, Lv Weidong, Zhang Juan, Wang Xiang, Zhou Dangxia. Prognostic value of neuroendocrine markers for predicting survival in patients with small cell lung cancer, International Journal of Clinical and Experimental Pathology, 2016,9(6):5970-5979.

(15) Sun Ruifang#*, Liu Zhigang#, Ma Gang, Lv Weidong, Zhao Xinliang, Lei Guangyan, Xu Changfu. Associations of deregulation of mir-365 and its target mRNA TTF-1 and survival in patients with NSCLC, International Journal of Clinical and Experimental Pathology, 2015,8(3):2392-2399.

(16) Sun Ruifang#*, Liu Zhigang#, Wang Lumin, Lv Weidong, Liu Jia, Ding Caixia, Yuan Yong, Lei Guangyan, Xu Changfu. Overexpression of stathmin is resistant to paclitaxel treatment in patients with non-small cell lung cancer, Tumor Biology, 2015,36(9):7195-7204.

(17) Liu Zhigang#, Sun Ruifang#, Lv Weidong, Dang Chengxue, Song Yangrong, Wang Cheng, Zhang Xi, Han Le, Cheng Hao, Gao Wei, Liu Jia, Lei Guangyan*. The -938A/A genotype of BCL2 gene is associated with esophageal cancer, Medical Oncology, 2012,29(4):2677-2683

(18) Sun Ruifang#, Zhu Yongsheng, Zhu Feng, Kuang Wenjian, Feng Jiali, Tian Zhao, Chai Zhaoqin, Liu Yao, Li Shengbin*. Genetic polymorphisms of 10 X-STR among four ethnic populations in northwest of China, Molecular Biology Reports, 2012,39(4):4077-4081

(19) Sun Ruifang#, Zhu Yongsheng, Kuang Wenjian, Liu Yao*, Li Shengbin*. The G-712A polymorphism of brain-derived neurotrophic factor is associated with major depression but not schizophrenia, Neuroscience Letters, 2011,489(1):34-37

(20) Sun Ruifang#, Zhu Yongsheng, Feng Jiali, Tian Zhao, Kuang Wenjian, Liu Yao, Zhang Hongbo*, Li Shengbin*. Polymorphisms of three new microsatellite sites of the dystrophin gene, Genetics and Molecular Research, 2011,10(2):744-751

 (21) Ogino Shuji#, Nishihara Reiko#, Lochhead Paul#, Imamura Yu, Kuchiba Aya, Morikawa Teppei, Yamauchi Mai, Liao Xiaoyun, Qian Zhi Rong, Sun Ruifang, Sato Kaori, Kirkner Gregory J, Wang Molin, Spiegelman Donna, Meyerhardt Jeffrey A, Schernhammer Eva S, Chan Andrew T*, Giovannucci Edward*, Fuchs Charles S*. Prospective study of family history and colorectal cancer risk by tumor LINE-1 methylation level, J Natl Cancer Inst, 2013,105(2):130-140. (IF=12.589).

(22) Liao Xiaoyun#, Lochhead Paul#, Morikawa Teppei, Kuchiba Aya, Yamauchi Mai, Imamura Yu, Qian Zhi Rong, Baba Yoshifumi, Shima Kaori, Sun Ruifang, Nosho Katsuhiko, Meyerhardt Jeffrey A, Giovannucci Edward, Fuchs Charles S*, Chan Andrew T*, Ogino Shuji*. Aspirin Use, Tumor PIK3CA Mutation, and Colorectal-Cancer Survival, New Engl J Med, 2012,367(17):1596-1606. (IF=72.406).