研究领域：

（1）消化道肿瘤分子病理

（2）环境污染物与消化道病理

（3）精神压力与消化道疾病

科研项目：

（1）西安交通大学医学“基础-临床”融合创新项目，2022041，2022/09-2024/09，在研，主持。

（2）陕西省重点研发计划项目，2023-YBSF-447，2023/01- 2024/12，在研，主持。

（3）国家自然科学基金青年基金项目，81802788，2019/01-2021/12，已结题，主持。

（4）陕西省自然科学基金面上项目，2018JM7028，2018/01-2019/12，已结题，主持。

（5）中国博士后科学基金（特别资助），2019T120918，2017/09-2019/07，已结题，主持。

（6）中国博士后科学基金面上项目（一等），2017M620458，2017/09-2019/07，已结题，主持。

（7）陕西省博士后基金面上项目, 2018BSHEDZZ91, 2017/09-2019/07，已结题，主持。

（8）中国博士后科学基金面上项目，2014M552461，2013/10-2015/07，已结题，主持。

（9）陕西省博士后基金面上项目，2014/01-2015/12，已结题，主持。

（10）西安交通大学基本科研业务费前沿与交叉项目，xjj2017192，2017/01-2019/12，已结题，主持。

（11）西安交通大学基本科研业务费自由探索类项目，xjj2014065，2014/01-2016/12，已结题，主持。

发表文章：

(1) Sun Ruifang#, Yang Yang#, Lü Weidong#, Yang Yanqi, Li Yulong, Liu Zhigang, Diao Dongmei, Wang Yang, Chang Su'e, Lu Mengnan, Jiang Qiuyu, Dai Bingling, Ma Xiaobin, Zhao Chang'an, Lü Moqi, Zhang Juan, Ding Caixia, Li Na, Zhang Jian, Xiao Zhengtao #, Zhou Dangxia#, Huang Chen#. Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression. Cell Biosci. 2023; 13: 62. (IF=9.597).

(2) Zhao Xinliang#, Lu Mengnan#, Liu Zhigang#, Zhang Mingming, Yuan Hongmei, Dan Zhaoqiang, Wang Daihua, Ma Bingbing, Yang Yanqi, Yang Funing, Sun Ruifang*, Li Lin*, Dang Chengxue*. Comprehensive analysis of alfa defensin expression and prognosis in human colorectal cancer, Front Oncol. 2023 Jan 10;12:974654. (IF=6.244).

(3) Yang Yan-Qi, Ge Pan, Lv Mo-Qi, Yu Peng-Fei, Liu Zhi-Gang, Zhang Jian, Zhao Wen-Bao, Han Shui-Ping, Sun Rui-Fang*, Zhou Dang-Xia*. Rno_circRNA_008646 regulates formaldehyde induced lung injury through Rno-miR-224 mediated FOXI1/CFTR axis. Ecotoxicol Environ Saf, 2022 Aug 20;243:113999. doi: 10.1016/j.ecoenv.2022.113999. (IF=7.129).

(4) Sun Ruifang#, Liu Zhigang#, Lv Yun#, Yang Yanqi, Yang Yang, Xiang Yu, Jiang Qiuyu, Zhao Chang'an, Lv Moqi, Zhang Jian, Zhang Juan, Ding Caixia, Zhou Dangxia*. FOCAD/miR-491-5p, downregulated by EGR1, function as tumor suppressor by inhibiting the proliferation and migration of gastric cancer cells. Prog Biophys Mol Biol, 2022 Jul 3;S0079-6107(22)00064-5. doi: 10.1016/j.pbiomolbio.2022.06.003. (IF=4.799).

      (5) Changan Zhao#, Jiyu Miao#, Ruifang Sun#, Rui Liang, Wenhu Chen, Yi Gao, Xiaofei Wang, Shuiping Han, Wenbao Zhao, Ting Lei, Chen Huang. MBD1/HDAC3-miR-5701-FGFR2 axis promotes the development of gastric cancer, Aging (Albany NY). 2022 Jul 22;14(14):5878-5894. (IF=5.955).

       (6) Wu Shaobo, Liang Yuxia, Zang Qijuan, Xing Zixuan, Yin Pan, Sun Ruifang*, Dai Bingling*. FLG Is a Potential Biomarker of Prognosis and Immunotherapy in Skin Cutaneous Melanoma. Applied Bionics and Biomechanics, 2022 May 14;2022:5160748. doi: 10.1155/2022/5160748. eCollection 2022.

(7) Lü Wei-Dong#*, Liu Yi-Zhi, Yang Yan-Qi, Liu Zhi-Gang, Zhao Kun, Lu Jian-Rong, Lei Guang-Yan, Wang Yi-Yu, Cai Lin, Sun Rui-Fang*. Effect of naturally derived surgical hemostatic materials on the proliferation of A549 human lung adenocarcinoma cells. Materials Today Bio, 2022, 4;14:100233. (Q1, IF=10.761).

  (8) Sun Ruifang#, Lü Weidong #, Liu Zhigang #, Yang Yang, Wang Xiaofei, Zhao Xinliang, Fu Shufeng, Dai Wei, Huang Chen *, Diao Dongmei *. FOXI1 inhibits gastric cancer cell proliferation by activating miR-590/ATF3 axis via integrating ChIP-seq and RNA-seq data. Progress in Biophysics and Molecular Biology, 2021, 163: 34-45. (IF=4.799).

  (9) Liu zhigang#, Yun Lü#, Qiuyu Jiang, Yang Yang, Chengxue Dang*, Ruifang Sun*. miR-491 inhibits BGC-823 cell migration via targeting HMGA2. The International Journal of Biological Markers, 2019, 34(4): 364-372. (IF=3.248).

 (10) Sun Ruifang*#, Liu Zhigang*, Han Lin, Yang Yang, Wu Fei, Jiang Qiuyu, Zhang Huahua, Ma Ruili, Miao Jiyu, He Kang, Wang Xiaofei, Zhou Dangxia#, Huang Chen#. miR-22 and miR-214 targeting BCL9L, inhibit proliferation, metastasis and epithelial-mesenchymal transition, by downregulating Wnt signaling in colon cancer, The FASEB Journal. 2019, 33(4):5411-5424. (Q1, IF=5.834).

  (11) Lü Weidong#*, Sun Ruifang#, Hu Yerong*, Lu Janrong, Gu Lu, Liu Zhigang, Lei Guangyan, Qiang Zhun, Cai Lin. Photooxidatively crosslinked acellular tumor extracellular matrices as potential tumor engineering scaffold, Acta Biomaterialia, 2018,71:460-473. (Q1, IF= 10.633).

 (12) Sun Ruifang#, Liu Zhigang#, Tong Dongdong, Yang Yang, Guo Bo, Wang Xiaofei, Zhao Lingyu, Huang Chen*. miR-491-5p, mediated by Foxi1, functions as a tumor suppressor by targeting Wnt3a/β-catenin signaling in the development of gastric cancer, Cell Death & Disease, 2017,8(3):e2714.(Q1, IF=9.685).

 (13) Liu Zhigang#, Sun Ruifang#, Lv Weidong, Dang Chengxue, Song Yangrong, Wang Cheng, Zhang Xi, Han Le, Cheng Hao, Gao Wei, Liu Jia, Lei Guangyan*. The -938A/A genotype of BCL2 gene is associated with esophageal cancer, Medical Oncology, 2012,29(4):2677-2683.

 (14) Sun Ruifang#, Zhu Yongsheng, Zhu Feng, Kuang Wenjian, Feng Jiali, Tian Zhao, Chai Zhaoqin, Liu Yao, Li Shengbin*. Genetic polymorphisms of 10 X-STR among four ethnic populations in northwest of China, Molecular Biology Reports, 2012,39(4):4077-408.

 (15) Sun Ruifang#, Zhu Yongsheng, Kuang Wenjian, Liu Yao*, Li Shengbin*. The G-712A polymorphism of brain-derived neurotrophic factor is associated with major depression but not schizophrenia, Neuroscience Letters, 2011,489(1):34-3.

 (16) Ogino Shuji#, Nishihara Reiko#, Lochhead Paul#, Imamura Yu, Kuchiba Aya, Morikawa Teppei, Yamauchi Mai, Liao Xiaoyun, Qian Zhi Rong, Sun Ruifang, Sato Kaori, Kirkner Gregory J, Wang Molin, Spiegelman Donna, Meyerhardt Jeffrey A, Schernhammer Eva S, Chan Andrew T*, Giovannucci Edward*, Fuchs Charles S*. Prospective study of family history and colorectal cancer risk by tumor LINE-1 methylation level, J Natl Cancer Inst, 2013,105(2):130-140. (IF=12.589).

(17) Liao Xiaoyun#, Lochhead Paul#, Morikawa Teppei, Kuchiba Aya, Yamauchi Mai, Imamura Yu, Qian Zhi Rong, Baba Yoshifumi, Shima Kaori, Sun Ruifang, Nosho Katsuhiko, Meyerhardt Jeffrey A, Giovannucci Edward, Fuchs Charles S*, Chan Andrew T*, Ogino Shuji*. Aspirin Use, Tumor PIK3CA Mutation, and Colorectal-Cancer Survival, New Engl J Med, 2012,367(17):1596-1606. (IF=72.406).