科研项目

          项目来源                                                          项目名称                                                                  项目编号                        执行时间                      角色

国家自然科学基金项目西安交通压电诱导骨再生的功能化骨植入物力/电耦合设计方法研究                       12202347                      2023.01-2025.12            负责人

陕西省基金一般项目西安交通大压电诱导再生的大段骨仿生制造                                                              2022JQ-378                  2022.01-2023.12            负责人

中国博士后科学基金西安交通大多孔植入物与骨组织在生物体内的力学/生物学耦合作用机理研究             2020M683458               2020.09-2023.08            负责人

西安交大基本科研业务费西安交压电诱导再生的大段骨仿生制造                                                              XZY012021007              2021.08-2023.08            负责人

国家重点研发计划项目西安交通国产高强度高韧性半个性化假体的强韧性能调控技术研发和检验               2021YFC2401302          2021.12-2024.11            子课题负责人

国家自然科学基金重点项目西交软组织-PEEK-骨共生的植入物设计制造及其功能研究                               51835010                      2019.01-2023.12             骨干

国家重点研发计划项目西安交大材料结构一体化3D打印技术与医学应用                                                   2018YFE0207900          2019.12-2022.11             骨干

国家重点研发计划项目西安交大假肢矫形器的个性化设计与增材制造关键技术                                          2018YFB1107003          2018.05-2021.04             骨干

广东省重点领域研发项目西交大定制化功能仿生PEEK骨植入物增材制造技术及医疗应用                           2018B090906001          2019.01-2022.12             骨干

陕西省科技统筹创新工程西交大面向定制化医学假体制造的激光选区金属熔化成形技术                            2014KTZB01-02-02       2014.01-2015.12             参与

论文

[1] Changning Sun#, Enchun Dong#, Yucong Tian, Jianfeng Kang, Jibao Zheng, Qing Zhang, Lei Wang, Chaozong Liu, Ling Wang, Dichen Li. Functional Biomimetic Design of 3D Printed Polyether-ether-ketone Flexible Chest Wall Reconstruction Implants for Restoration of the Respiration[J]. Materials and Design, 2024, 237: 112574

[2] Changning Sun#, Huiyu Zhao#, Lei Wang, Jinghua Zhang, Jibao Zheng, Zijian Yang, Lijun Huang, Ling Wang*, Chaozong Liu, Dichen Li*, Qingchu Li*. Additive Manufactured Polyether-ether-ketone Composite Scaffolds with Hydroxyapatite Filler and Porous Structure Promoted the Integration with Soft Tissue[J]. Biomaterials Advance, 2022, 141: 213119

[3] Changning Sun, Enchun Dong, Jiayu Chen, Jibao Zheng, Jianfeng Kang, Zhongmin Jin, Chaozong Liu, Ling Wang*, Dichen Li*. The Promotion of Mechanical Properties by Bone Ingrowth in Additive Manufactured Titanium Scaffolds[J]. Journal of Functional Biomaterials, 2022, 13(3):127

[4] Changning Sun, Jianfeng Kang, Ling Wang*, Zhongmin Jin, Chaozong Liu, Dichen Li*. Stress-dependent Design and Optimization Methodology of Gradient Porous Implant and Application in Femoral Stem[J]. Computer Methods in Biomechanics and Biomedical Engineering, 2022

[5] Changning Sun, Jianfeng Kang, Chuncheng Yang, Jibao Zheng, Yanwen Su, Enchun Dong, Yingjie Liu, Siqi Yao, Changquan Shi, Huanhao Pang, Jiankang He, Ling Wang*, Chaozong Liu, Jianhua Peng, Liang Liu, Yong Jiang, Dichen Li*. Additive Manufactured Polyether-ether-ketone implants for Orthopaedic Applications: A Narrative Review [J]. Biomaterials Translational, 2022, 3(2):  116-133

[6] Changning Sun, Ling Wang, Jianfeng Kang, Dichen Li*, Zhongmin Jin. Biomechanical Optimization of Elastic Modulus Distribution in Porous Femoral Stem for Artificial Hip Joints[J]. Journal of Bionic Engineering, 2018, 15(4) :693-702
[7] Changning Sun, Xiaoyong Tian*, Ling Wang, Yaxiong Liu, Cynthina M. Wirth, Jens Günster, Dichen Li, Zhongmin Jin. Effect of particle size gradation on the performance of glass-ceramic 3D printing process[J]. Ceramics International, 2017 43(1):578-584.
[8] Changning Sun, Ling Wang*, Zhen Wang, Lei Geng, Dichen Li, Miao Sui, Zhongmin Jin. Finite Element Analysis of a Retrieved Custom-Made Knee Prosthesis [J]. Journal of Mechanics in Medicine & Biology, 2015, 15(3). 

[9] Mo Zhou, Changning Sun, Seyed Ataollah Naghavi, Ling Wang, Maryam Tamaddon, Jinwu Wang, Chaozong Liu*. The design and manufacturing of a Patient-Specific wrist splint for rehabilitation of rheumatoid arthritis[J]. Materials & Design, 2024, 238: 112704

[10] Lei Wang#, Chuncheng Yang#, Changning Sun#, Xiaolong Yan, Jiankang He, Changquan Shi, Chaozong Liu, Dichen Li*, Tao Jiang*, Lijun Huang*. Fused Deposition Modeling PEEK Implants for Personalized Chest Wall Reconstruction: from Clinical Need to Biofabrication [J]. International Journal of Bioprinting, 2022, 8(3): 0048

[11] Seyed Ataollah Naghavi#, Churun Lin#, Changning Sun#, Maryam Tamaddon, Mariam Basiouny, Pilar Garcia–Souto, Stephen Taylor, Jia Hua, Dichen Li, Ling Wang, Chaozong Liu. Stress Shielding and Bone Resorption of Press-Fit Polyether–Ether–Ketone (PEEK) Hip Prosthesis: a SAWBONE Model Study[J]. Polymers, 2022

[12] Seyed Ataollah Naghavi#, Changning Sun#, Mahbubeh Hejazi, Maryam Tamaddon, Jibao Zheng, Leilei Wang, Chenrui Zhang, Swastina Nath Varma, Dichen Li, Mehran Moazen, Ling Wang, Chaozong Liu. On the mechanical aspect of additive manufactured polyether-ether-ketone scaffold for repair of large bone defects[J]. Biomaterials Translational, 2022, 3(2):  142-151

[13] Yikai Wang, Xiao Qin, Naixin Lv, Lin Gao *, Changning Sun *, Zhiqiang Tong, Dichen Li. Microstructure Optimization Design of Porous Tantalum Scaffolds Based on Mechanical Properties and Permeability[J]. Materials, 2023

[14] Siwei Lu, Beining Zhang, Jingyi Niu, Chuncheng Yang, Changning Sun, Ling Wang, Dichen Li, Effect of fiber content on mechanical properties of carbon fiber-reinforced polyether-ether-ketone composites prepared using screw extrusion-based online mixing 3D printing[J], Additive Manufacturing, 2024.

[15] Ling Wang, Ziyu Wang, Jiayin Liu, Yijun Hui, Yanwen Su, Chenrui Zhang, Changning Sun, Kaishu Li, Dichen Li, Yawei Liu. The effects of structural & materials design on the Mechanisms of tissue integration with the 3D printed Polyether-ether-ketone cranial implants in vivo[J]. Chinese Journal of Mechanical Engineering: Additive Manufacturing Frontiers, 2023

[16] Yang Li, Jibao Zheng, Changning Sun, Dichen Li*. Transfer film effects induced by 3D-printed polyether-ether-ketone with excellent tribological properties for joint prosthesis[J]. Bio-Design and Manufacturing, 2023

[17] Yajie Lu, Xiantao Chen, Xiao Lu, Changning Sun, Minghui Li, Guojing Chen, Zuoyao Long, Yuan Gao, Haoqiang Zhang, Mengquan Huang, Chuanlei Ji, Hongbin Fan, Dong Liu, Yuewen Hao, Hong Wang, Leilei Zhang, Hongmei Zhang, Jianxi Lu, Jing Li, Zhen Wang. Bio-Adaptive Reconstruction of Avascular Necrotic Femoral Head Through a Bioceramic System: From Design to Application[J]. Bioactive Materials, 2023

[18] Lin Gao*, Yikai Wang, Xiao Qin, Naixin Lv, Zhiqiang Tong, Changning Sun, Dichen Li. Optimization of laser powder bed fusion process for forming porous Ta scaffold[J] Metals, 2023

[19] Seyed Ataollah Naghavi, Maryam Tamaddon, Araslan Marghoub, Katherine Wang, Behzad Bahrami Babamiri, Kavan Hazeli, Wei Xu, Xin Lu, Changning Sun, Liqing Wang, Mehran Moazen, Ling Wang, Dichen Li, Chaozong Liu*. Mechanical Characterization and Numerical Modeling of TPMS-Based Gyroid and Diamond Ti6Al4V Scaffolds for Bone Implants: An Integrated Approach for Translational Consideration[J]. Bioengineering, 2022, 9(10): 504

[20] Jibao Zheng, Huiyu Zhao, Zhicong Ouyang, Xinying Zhou, Jianfeng Kang, Chuncheng Yang, Changning Sun, Minjian Xiong, Maoqing Fu, Dadi Jin, Ling Wang*, Dichen Li*, Qingchu Li*. Additively-manufactured PEEK/HA porous scaffolds with excellent osteogenesis for bone tissue repairing[J]. Composites Part B: Engineering, 2022, 232, 109508.

[21] Shoujin Zeng, Guang Liu, Weihui He, Jing Wang, Jianhua Ye, Changning Sun. Design and Performance Prediction of Selective Laser Melted Porous Structure fro Femoral Stem[J]. Materials Today Communication, 2022
[22] Jibao Zheng, Jianfeng Kang, Changning Sun, Chuncheng Yang, Ling Wang*, Dichen Li*. Effects of printing path and material components on mechanical properties of 3D-printed polyether-ether-ketone/hydroxyapatite composites[J]. Journal of the Mechanical Behavior of Biomedical Materials, 2021, 118: 104475.
[23] Jibao Zheng, Huiyu Zhao, Enchun Dong, Jianfeng Kang, Chaozong Liu, Changning Sun, Dichen Li*, Ling Wang*. Additively-manufactured PEEK/HA porous scaffolds with highly-controllable mechanical properties and excellent biocompatibility[J]. Materials Science and Engineering: C, 2021, 128: 112333.

[24] Jibao Zheng, Enchun Dong, Jianfeng Kang, Changning Sun, Chaozong Liu, Ling Wang*, Dichen Li*. Effects of Raster Angle and Material Components on Mechanical Properties of Polyether-Ether-Ketone/Calcium Silicate Scaffolds[J]. Polymers, 2021, 13(15): 2547.
[25] Ling Wang, Xifeng Peng, Changning Sun, Huayi Wang, Dichen Li, Jinyu Zhu, Zhongming Jin*, Senay Mihcin, Chaozong Liu. The Determination of the Volumetric Wear for Surgically Retrieved Hip Implants Based on CMM [J]. Journal of Mechanics in Medicine and Biology, 2016, 16(4)
[26] Ling Wang*, Jianfeng Kang, Changning Sun, Dichen Li, Yi Cao, Zhongmin Jin. Mapping porous microstructures to yield desired mechanical properties for application in 3D printed bone scaffolds and orthopaedic implants[J]. Material and Design 2017, 133, 62-68.

[27] Zheng Ma, Jiacheng Lin, Xiaoyue Xu, Ziwei Ma, Lei Tang, Changning Sun, Dichen Li, Chaozong Liu, Yongming Zhong, Ling Wang*. Design and 3D Printing of Adjustable Modulus Porous Structures for Customized Diabetic Foot Insoles[J]. International Journal of Lightweight Materials and Manufacture, 2019, 2(1): 57-63.
[28] Rong Ren, Zhen Wang, Guanghui Fu, Changning Sun, Lijun Yuan, Tiesheng Cao*. General Pascal's Law: A Possible Basic Hydrostatic Law[J]. CT Theory and Applications, 2018, 27(02): 137-143.

[29] 孙畅宁#,孟子捷#,王玲,贺健康,连芩,高琳,李骁,毛茅,朱卉,李涤尘*. 增材制造个性化植入物技术发展与挑战[J]. 中国医疗器械杂志,2024.

[30] 姚思琦,孙畅宁*,王玲,石长全,李涤尘.  聚醚醚酮3D打印各向异性对股骨替代物力学性能的影响[J]. 医用生物力学,2022.

[31] 董恩纯,康建峰,孙畅宁,李涤尘,王玲*,栗向东*. 3D打印金属椎体替代物力学性能研究[J]. 医用生物力学,2023

[32] 汤磊,刘腾达,单存清,孙畅宁,王玲*,田小永,李涤尘. 3D打印大腿假肢接受腔形性协同制造策略[J]. 机械工程学报, 2022,58(01):172-178.

[33] 刘腾达,汤磊,孙畅宁,单存清,李涤尘,田小永,刘朝宗,王玲. 3D打印连续纤维复合假肢接受腔Z向强化制造策略[J]. 机械工程学报, 2022,58(07):267-275.

[34] 朱思尧, 李涤尘, 汤磊, 孙畅宁, 康建峰, 赵宏谋, 张言, 王玲*. 具有梯度模量的3D打印糖尿病鞋垫设计[J]. 医用生物力学, 2021, 36, 102-109.

[35] 康建峰,王玲*,孙畅宁,李涤尘,靳忠民. 面向3D打印可变模量金属假体的微结构设计[J]. 机械工程学报, 2017, 53(05): 175-180.
[36] 张博,曹毅,王玲,李涤尘*,康建峰,孙畅宁,杨东. 选区激光熔化体心立方多孔结构的各向异性[J]. 中国激光, 2017, 44 (8): 115-123

[37] 裴延军, 付军, 李靖, 陈国景, 吴智钢, 孙畅宁, 郭征*. 3D打印个性化钛合金下肢骨肿瘤假体的设计制作与临床应用[J]. 中华骨科杂志, 2020, 40 (12): 760-768.

[38] 耿磊,王臻*,郭征,范宏斌,栗向东,李靖,陈国景,付军,石磊,孙畅宁,王玲. 膝关节肿瘤型假体力线分析[J]. 中国骨与关节杂志, 2015, 4(10):790-794.

知识产权

[1] 孙畅宁,彭思琦,张益涵,王玲,李涤尘. 自适应调控骨长入的压电复合材料梯度骨植入物及其方法 中国[P]. CN 202311605443.9(已公开)

[2] 孙畅宁, 张益涵, 王玲, 李涤尘. 一种压电陶瓷/聚合物复合材料在线极化3D打印头: 中国[P]. CN 202210222701.4. (已公开)

[3] 王玲, 孙畅宁, 岳银恒, 王珂珈, 朱思尧, 李涤尘. 一种个性化占位鞋垫及其制备方法: 中国[P]. 申请号CN 20191092834232, 2019-09-28. (已公开)
[4] 孙畅宁, 王玲, 李涤尘. 一种个性化下肢长骨节段替代物及其制备方法: 中国[P]. ZL 201911082780.8, 2020-12-17. (已授权)
[5] 王玲, 孙畅宁, 李涤尘. 一种定向增强3D打印聚合物股骨近端替代物及其设计方法: 中国[P]. ZL 202010102033.2, 2021-01-11(已授权)

[6] 王玲, 孙畅宁, 康建峰, 李涤尘, 靳忠民. 一种基于宿主骨应力环境的定制化假体优化设计方法: 中国[P]. ZL 201610052671.1, 2018-08-07. (已授权)
[7] 王玲, 孙畅宁, 靳忠民, 李涤尘, 康建峰. 一种自适应后期稳定型股骨柄假体: 中国[P]. ZL 201611000103.3, 2018-03-22. (已授权)
[8] 王玲, 孙畅宁, 靳忠民, 李涤尘, 康建峰. 一种用于人工假体的中空缓冲结构: 中国[P]. ZL 201611224186.4, 2017-12-27. (已授权)
[9] 刘亚雄, 安超, 张博, 孙畅宁, 曹毅, 赵广宾, 王亚宁, 李涤尘, 贺健康, 连芩, 王玲. 一种面向粉末材料的SLM/SLS铺粉工艺: 中国[P]. ZL 201610561340.0, 2016-12-07. (已授权)
[10] 王玲, 张晨光, 李涤尘, 田小永, 孙畅宁, 汤磊. 一种具有自适应性的3D打印柔性接受腔: 中国[P]. 申请号CN 201810115628.4, 2018-02-02. (已授权)
[11] 王玲, 刘虎, 汤磊, 孙畅宁, 李涤尘. 一种柔性自适应假肢接受腔: 中国[P]. 申请号CN 201810295845.6, 2018-04-03. (已授权)
[12] 王玲, 惠亿军, 孙畅宁, 董恩纯, 李涤尘. 一种纤维增强3D打印聚合物盆骨替代物: 中国[P]. 申请号CN 202010103674.X, 2020-02-20(已公开)
[13] 西安交通大学, 陕西恒通智能机器有限公司. 定制化假体优化设计与多孔微结构构建软件OrthoDesign V1.0[CP]. 著作权登记号: 2017SR383580. (已登记)
[14] 西安交通大学. 定制糖尿病足鞋垫构建软件InsolEditor V1.0[CP]. 著作权登记号: 2019SR0602089. (已登记) 

其他

科技奖励:

[1] 蔡虎,张勇杰,孙畅宁,许文峰,卢永波,刘立科,李闻涛,堵斌. 陕西省科技进步二等奖. 医疗增材制造及组织工程产品评价体系建立及应用,2022年.

标准:

[1] 孙畅宁,谢怀杰,马骋,刘益强,牟建新,于顺东,杨锐宾,曾达,吴卫东. 用于医学植入物的增材制造聚醚醚酮(PEEK)材料:T/CAMDI 015-2022[S]. 中国:医疗器械行业协会团体标准,2022

[2] 谷慧茹, 刘斌, 李曼, 张世庆, 孙嘉怿, 赵锋, 张菁, 陈成, 李剑, 闫和平, 郭欢, 樊渝江, 王玲, 樊瑜波, 张述, 安俊波, 孙畅宁. 基于增材制造的金属材料填充块样件压缩性能评价方法: T/CSBME 007-2019[S]. 中国: 生物医学工程学会团体标准, 2019
[3] 孙嘉怿, 刘斌, 张世庆, 徐丽明, 王健, 谷慧茹, 李曼, 赵锋, 陈成, 张菁, 安俊波,张述, 王玲, 孙畅宁, 樊渝江, 裴玄, 樊瑜波, 闫和平, 郭欢, 宋平, 张勃庆, 李天任. 基于金属粉末床熔融技术增材制造植入医疗器械残留不溶颗粒物评价方法: T/CSBME 008-2019[S]. 中国: 生物医学工程学会团体标准, 2019
[4] 赵丙辉, 李文姣, 张路, 陈长胜, 曹海鹏, 李仁耀, 赵文文, 樊匡平, 白艳丽, 王玲, 孙畅宁. 非组合式金属髋关节股骨柄有限元分析标准方法: YY/T 1714-2020[S]. 中国: 医药行业标准, 2020
[5] 王金武, 许苑晶, 刘非, 杨林, 黄亦武, 范之劲, 刘歆, 谢能, 王玲, 孙畅宁, 王黎明, 张晓玉, 裴国献, 蔺福辉, 黄文柱, 孙宏伟. 定制式增材制造膝关节矫形器临床评价技术规范: TCSBME 030-2020. 中国: 生物医学工程学会团体标准, 2020

[6] 定制式增材制造足底矫形器:T/CAMDI 089-2022. 中国:医疗器械行业协会团体标准,2022(指导专家组成员)

[7] 增材制造植入物设计输入要求:T/CAMDI 096-2022. 中国:医疗器械行业协会团体标准,2022(指导专家组成员)
[8] 孙畅宁等,医药行业标准,医用增材制造 定制式骨植入物的设计流程,已立项

专著:

[1] 郭征,石磊,王玲,刘斌,张涌泉,孙畅宁等,3D打印定制假体骨科应用81问[M],科学出版社.

[2] 中国机械工程技术路线图2021版[M], 机械工业出版社(编写委员会成员)

报纸:

[1] 李涤尘,孙畅宁. 建立并完善增材制造医疗器械监管科学体系[N]. 中国医药报,2021-07-13.

[2] 李涤尘,孙畅宁,贺健康,连芩. 技术产品创新迭代 法规标准加快推进——增材制造新材料医疗器械及相关监管科学研究进展概况[N]. 中国医药报. 2022-04-20.

[3] 李涤尘,孙畅宁. 抓住发展机遇 促进成果转化——加快增材制造医疗器械标准化进程[N]. 中国医药报. 2022-08-31. (医疗器械专刊头版)