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论文期刊

论文标题    Alterations of Nedd4-2-binding capacity in PY-motif of NaV 1.5 channel underlie long QT syndrome and Brugada syndrome.
作者    Wang Y, Du Y, Luo L, Hu P, Yang G, Li T, Han X, Ma A, Wang T*.
发表/完成日期    2020-06-01
期刊名称    Acta Physiol (Oxf).
期卷    229(2):e13438.
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论文简介    Our data suggest that the PY-motif plays an essential role in modifying the expression/function of NaV 1.5 channels through Nedd4-2-mediated ubiquitination. Alterations of NaV 1.5-Nedd4-2 interaction represent a novel pathological mechanism for NaV 1.5 channel diseases caused by SCN5A variants.
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