基本信息（Basic Information）

杨维娜 

西安交通大学医学部基础医学院人体解剖与组织胚胎学系副教授，博士研究生导师，国家自然科学基金函审专家，陕西省解剖学会理事。

Weina Yang, Ph.D., Associate professor in the Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center.

 

研究领域（Research Area）

Neurobiology of Alzheimer’s disease

1. 神经系统退行性疾病的发病机制及防治

2. 神经胶质细胞与阿尔茨海默病

 

教育背景（Education Background）

 

09/2008---06/2014:  Ph.D., Department of Human Anatomy, Histology and Embryology, Xi’an Jiaotong University, Xi’an, P.R. China.

09/2004---06/2007:  M.S., Department of Pathology and Pathophysiology, Xi’an Jiaotong University, Xi’an, P.R. China.

09/1995---07/2000:  Bachelor of Medicine, Xi’an

Jiaotong University, Xi’an, P.R. China.

 

工作经历（Work Experience）

01/2016--- Present:  Associate professor in Xi’an Jiaotong University.

02/2016---07/2017:  As a Visiting Scholar in Harvard Medical School.

07/2005---12/2015:  Lecturer in Xi’an Jiaotong University.

07/2000---07/2005:  Assistant in Xi’an Jiaotong University.

联系方式（Contact information）

电子邮箱：wn_yang@mail.xjtu.edu.cn

个人主页：http://gr.xjtu.edu.cn/web/wn_yang

我的新闻

科研项目

  1. 国家自然科学基金项目（项目号：81500928）
  2. 陕西省自然科学基础研究计划项目（项目号：2018JM7056）
  3. 中国博士后科学基金第10批特别资助项目（项目号：2017T100758）
  4. 中国博士后科学基金第59批面上项目一等资助（项目号：2016M590955）
  5. 陕西省博士后科研项目第4批面上项目一等资助（项目号：2016BSHYDZZ04）
  6. 中央高校基本科研业务费项目（项目号：xjj2015054）

代表性科研论文

  1. Xiaoqian Peng, Li Chen, Zijuan Wang, Yingying He, John Bosco Ruganzu, Hongsong Guo, Xiao Zhang, Shengfeng Ji, Liming Zheng, Weina Yang*. Tanshinone IIA    regulates glycogen synthase kinase-3β-related signaling pathway and ameliorates memory impairment in APP/PS1 transgenic mice. European Journal of Pharmacology, 2022,918:174772. (*通讯作者)
  2. John Bosco Ruganzu#, Xiaoqian Peng#, Xiangyuan Wu, Quzhao Zheng, Bo Ding, Chengheng Lin, Hongsong Guo, Zikang Yang, Xiao Zhang, Weina Yang*. Downregulation of TREM2 expression exacerbates neuroinflammatory responses through TLR4-mediated MAPK signaling pathway in a transgenic mouse model of Alzheimer’s disease. Molecular Immunology, 2022,142: 22-36. (*通讯作者)
  3. John Bosco Ruganzu, Quzhao Zheng, Xiangyuan Wu, Yingying He, Xiaoqian Peng, Hui Jin, Jinsong Zhou, Ruiyang Ma, Shengfeng Ji, Yanbing Ma, Yihua Qian, Yang Wang, Weina Yang*. TREM2 overexpression rescues cognitive deficits in APP/PS1 transgenic mice by reducing neuroinflammation via the JAK/STAT/SOCS signaling pathway. Experimental Neurology, 2021, 336: 113506.  (*通讯作者)
  4. Yingying He, John Bosco Ruganzu, Chengheng Lin, Bo Ding, Quzhao Zheng, Xiangyuan Wu, Ruiyang Ma, Qian Liu, Yang Wang, Hui Jin, Yihua Qian, Xiaoqian Peng, Shengfeng Ji, Liangliang Zhang, Weina Yang *, Xiaomei Lei*. Tanshinone IIA ameliorates cognitive deficits by inhibiting endoplasmic reticulum stress-induced     apoptosis in APP/PS1 transgenic mice. Neurochem. Int. 2020,133: 104610. (*通讯作者)
  5. Yingying He, John Bosco Ruganzu, Quzhao Zheng, Xiangyuan Wu, Hui Jin, Xiaoqian Peng, Bo Ding, Chengheng Lin, Shengfeng Ji, Yanbing Ma, Weina Yang *. Silencing of LRP1 exacerbates inflammatory response via TLR4/NF-κB/MAPKs signaling pathways in APP/PS1 transgenic mice. Mol. Neurobiol. 2020,57:3727-3743. (*通讯作者)
  6. Yingying He, John Bosco Ruganzu, Hui Jin, Xiaoqian Peng, Shengfeng Ji, Yanbing Ma, Liming Zheng, Weina Yang *. LRP1 knockdown aggravates Aβ1–42-stimulated microglial and astrocytic neuroinflammatory responses by modulating TLR4/NF-κB/MAPKs signaling pathways. Exp. Cell Res. 2020,394:112166. (*通讯作者)
  7. Hui Jin, Xiaoqian Peng, Yingying He, John Bosco Ruganzu, Weina Yang *. Tanshinone IIA suppresses lipopolysaccharide-induced neuroinflammatory responses through NF-κB/MAPKs signaling pathways in human U87 astrocytoma cells. Brain Res. Bull. 2020, 164: 136-145. (*通讯作者）
  8. Bo Ding, Chengheng Lin,Qian Liu, Yingying He, John Bosco Ruganzu, Hui Jin, Xiaoqian Peng, Shengfeng Ji, Yanbing Ma, Weina Yang *. Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE/NF-κB signaling pathway in vivo and in vitro. J. Neuroinflamm. 2020,17:302.
  9. Weina Yang, Jianshui Zhang, Lili Shi, Shengfeng Ji, Xiaohua Yang, Wanying Zhai, Hangfan Zong, Yihua Qian. Protective effects of tanshinone IIA on SH-SY5Y cells against oAβ1–42-induced apoptosis due to prevention of endoplasmic reticulum stress. Int J Biochem Cell Biol.
  10. Kaige Ma, Lv Jia, Xiaodan Hu, Lili Shi, Kewei Chang, Xinlin Chen, Yihua Qian*, Weina Yang*, Qiumin Qu*. The p38 mitogen- activated protein kinase signaling pathway is involved in regulating low-density lipoprotein receptor-related protein 1-mediated β-amyloid protein internalization in mouse brain. Int J Biochem Cell Biol. 2016,76:75-86. (*通讯作者)
  11. Chang Liu, Youxuan Wu, Shuai Zha, Mengping Liu, Ying Wang, Guangde Yang, Kaige Ma, Yulang Fei, Yaojie Zhang, Xiaodan Hu, Weina Yang*, Yihua Qian*.  Treatment effects of tanshinoneIIA against intracerebroventricular streptozotocin induced memory deficits in mice. Brain Res. 2016,1631:137-146. (*通讯作者)
  12. Weina Yang, Keige Ma, Yihua Qian, Jianshui Zhang, Gaifeng Feng, Lili Shi, Zhichao Zhang, Zhaohui Liu. Mitogen-activated protein kinase signaling pathways promote low density lipoprotein receptor-related protein 1-mediated beta-amyloid protein internalizetion in primary cortical neurons. Int J Biochem Cell Biol. 2015,64: 252-264.
  13. Weina Yang, Keige Ma, Xinlin Chen, Lili Shi, Guojun Bu, Xiaodan Hu, Hua Han,Yong Liu, Yihua Qian. Mitogen-activated protein kinase signaling pathways is involved in regulating α7 nicotinic cetylcholine receptor mediated amyloid- Aβ uptake in SH-SY5Y cells. Neuroscience. 2014,278:276-290.
  14. Weina Yang, Lili Shi, Lianji Chen, Bingyi Zhang, Kaige Ma, Yong Liu, Yihua Qian. Protective effects of perindopril on D-galactose and aluminum trichloride induced neurotoxicity via the apoptosis of mitochondria-mediated intrinsic pathway in the hippocampusof mice. Brain Res. Bull. 2014, 109:46-53.
  15. Weina Yang, Xiaodan Hu, Hua Han, Lili Shi, Gaifeng Feng,Yong Liu,Yihua Qian. The effects of valsartan on cognitive deficits induced by aluminium trichloride and D-galactose in mice. Neurol. Res. 2014,36:651-658.
  16. Weina Yang, Hua Han, Xiaodan Hu, Gaifeng Feng, Yihua Qian. The effects of perindopril on cognitive impairment induced by D-galactose and aluminum trichloride via inhibition of acetylcholinesterase activity and oxidative stress. Pharmacol. Biochem. Behav. 2013, 114-115;31-36.
  17. Weina Yang, Junjian Wang, Lili Shi, Linhua Yu, Yihua Qian, Yong Liu, Weixi Wang, Shaoli Cheng. Podocyte injury and overexpression of vascular endothelial growth factor and transforming growth factor-beta 1 in adriamycin-induced nephropathy in rats. Cytokine. 2012,59:370-376.

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