研究领域

（1）细胞命运决定的氧化还原机制

（2）代谢与衰老退行性病变的氧化还原病理生理机制

聚焦生命体氧化还原生物过程，以谷胱甘肽过氧化物还原酶（glutathione peroxidase reductase, GPx）与硒蛋白O（Selenoprotein O, SelenoO）为研究对象，观察软骨发育与稳态维持、以及肝脏代谢过程中氧化还原信号的时空动态与响应网络，阐述机体如何感受和利用氧，期望能够更好地理解氧化还原过程在机体生理和病理生理状态下的作用，特别是在软骨退性病变与肝脂质代谢紊乱方面，探索并发展有效的疾病诊断、治疗和预防措施。

研究项目

（1）国家自然科学基金面上项目“GPx1介导的氧化还原信号调控软骨形成与稳态维持的分子机制”

（2）西安交通大学基本科研业务费“谷胱甘肽巯基过氧化物酶信号”

（3）国家自然科学基金青年项目“硒敏感硒蛋白在氧自由基调控软骨细胞分化过程中的作用与机制”

（4）中国博士后科学基金项目“硒、氧自由基在软骨细胞分化过程中的作用与分子机制研究”

讲授课程

（1）组织学与胚胎学

发表文章

（1）M Sun, S Hussain, Y Hu, J Yan, Z Min, X Lan, Y Guo, Y Zhao, H Huang, M Feng, Y Han, F Zhang, W Zhu, L Meng, D Li, J Sun, S Lu. Maintenance of SOX9 stability and ECM homeostasis by selenium-sensitive PRMT5 in cartilage. Osteoarthritis Cartilage. 2019 Jun;27(6):932-944.

（2）Si Wang, Wenhua Zhu, Jing Xu, Yuanxu Guo, Jidong Yan, Liesu Meng, Congshan Jiang*(corresponding) and Shemin Lu*(corresponding). Interpreting the MicroRNA-15/107 Family: Interaction Identification by Combining Network Based and Experiment Supported Approach. 2019. BMC Medical Genetics 2019 May 31;20(1):96.

（3）Zhang R, Cong F, Li Q, Min Z, Yan J, Zhang Q, Ma J, Lu S, Ma J. miR-497 Is Implicated in the Process of Chondrogenesis and Inhibits IHH Gene Expression in Human Chondrocytes. Cartilage. 2018 Aug 29:1947603518796126.

（4）Guo Y, Min Z, Jiang C, Wang W, Yan J, Xu P, Xu K, Xu J, Sun M, Zhao Y, Hussain S, Zhang R, Wang Q, Han Y, Zhang F, Zhu W, Li D, Meng L, Sun J, Lu S. Downregulation of HS6ST2 by miR-23b-3p enhances matrix degradation through p38 MAPK pathway in osteoarthritis. Cell Death Dis. 2018 Jun 13;9(6):699.

（5）Yan J, Guo Y, Fei Y, Zhang R, Han Y, Lu S. GPx1 knockdown suppresses chondrogenic differentiation of ATDC5 cells through induction of reductive stress. Acta Biochim Biophys Sin (Shanghai). 2017 Feb;49 (2): 110-118.

（6）Yan J, Fei Y, Han Y, Lu S. Selenoprotein O deficiencies suppress chondrogenic differentiation of ATDC5 cells. Cell Biol Int. 2016 Oct;40(10):1033-40.

（7）Yan J, Xu J, Fei Y, Jiang C, Zhu W, Han Y, Lu S. TrxR2 deficiencies promote chondrogenic differentiation and induce apoptosis of chondrocytes through mitochondrial reactive oxygen species. Exp Cell Res. 2016 May 15;344(1):67-75.

（8）Lan X, Yan J, Ren J, Zhong B, Li J, Li Y, Liu L, Yi J, Sun Q, Yang X, Sun J, Meng L, Zhu W, Holmdahl R, Li D, Lu S. A novel long noncoding RNA Lnc-HC binds hnRNPA2B1 to regulate expressions of Cyp7a1 and Abca1 in hepatocytic cholesterol metabolism. Hepatology. 2016 Jul;64(1):58-72.

（9）Wang X, Wang M, Li H, Lan X, Liu L, Li J, Li Y, Li J, Yi J, Du X, Yan J, Han Y, Zhang F, Liu M, Lu S, Li D. Upregulation of miR-497 induces hepatic insulin resistance in E3 rats with HFD-MetS by targeting insulin receptor. Mol Cell Endocrinol. 2015 Nov 15; 416:57-69.

（10）Xu J, Jiang C, Zhu W, Wang B, Yan J, Min Z, Geng M, Han Y, Ning Q, Zhang F, Sun J, Meng L, Lu S. NOD2 pathway via RIPK2 and TBK1 is involved in the aberrant catabolism induced by T-2 toxin in chondrocytes. Osteoarthritis Cartilage. 2015 Sep;23(9):1575-85.

（11）Min Z, Zhao W, Zhong N, Guo Y, Sun M, Wang Q, Zhang R, Yan J, Tian L, Zhang F, Han Y, Ning Q, Meng L, Sun J, Lu S. Abnormality of epiphyseal plate induced by selenium deficiency diet in two generation DA rats. APMIS. 2015 Aug;123(8):697-705.

（12）Jidong Yan, Yuewen Zheng, Zixin Min, Qilan Ning, Shemin Lu. Selenium effect on selenoprotein transcriptome in chondrocytes. Biometals. 2013, 26(2):285-296

（13）Jidong Yan, Juan Tian, Yuewen Zheng, Yan Han, Shemin Lu. Selenium promotes proliferation of chondrogenic cell ATDC5 by increment of intracellular ATP content under serum deprivation. Cell Biochem Funct. 2012, 30(8):657-663

（14）Tian J, Yan J, Wang W, Zhong N, Tian L, Sun J, Min Z, Ma J, Lu S. T-2 toxin enhances catabolic activity of hypertrophic chondrocytes through ROS-NF-kappa B-HIF-2 alpha pathway. Toxicol In Vitro. 2012, 26(7):1106-13

（15）Zhang R, Yan JD, Valenzuela RK, Lu SM, Du XY, Zhong B, Ren J, Zhao SH, Gao CG, Wang L, Guo TW, Ma J. Further evidence for the association of genetic variants of ZNF804A with schizophrenia and a meta-analysis for genome-wide significance variant rs1344706. Schizophr Res. 2012, 141(1):40-47.

（16）Mi D, Zhang M, Yan JD, Zhang J, Wang X, Wang Q, Yang S, Zhu TH. PTHrP inhibits BMP-6 expression through the PKA signaling pathway in breast cancer cells. J Cancer Res Clin Oncol. 2011, 137 (2): 295-303.

（17）Hu Fen, Wang Chuan, Du Jun, Sun Wei, Yan Jidong, Mi Dong, Zhang Jie, Qiao Yuhuan, Zhu Tianhui, and Yang Shuang. δEF1 promotes breast cancer cell proliferation through down-regulating p21 expression. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2010, 1802 (2): 301-312.

（18）Yan Jidong, Yang Shuang, Zhang Jie, Zhai Chunli, Zhu Tianhui. BMP-6 attenuates oxidant injury in HK-2 cells via Smad-dependent HO-1 induction. Free Radical Biology & Medicine, 2009, 46 (9): 1275-1282.

（19）Yan Jidong, Yang Shuang, Zhang Jie, Zhu Tianhui. BMP-6 reverses TGF-beta1-induced changes in HK-2 cells: implication for treatment of renal fibrosis. Acta pharmacologica sinica, 2009, 30 (7): 994-1000.

（20）Yang S, Du J, Wang Z, Yan JD, Yuan W, Zhang J, Zhu T. Dual mechanism of deltaEF1 expression regulated by BMP-6 in breast cancer. International Journal of Biochemistry & Cell Biology. 2009, 41(4): 853-861.

（21）Zhang M, Wang Q, Yuan W, Yang S, Wang X, Yan JD, Du J, Yin J, Gao SY, Sun BC, Zhu TH. Epigenetic regulation of BMP-6 gene expression in breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology, 2007, 105:91-97.

（22）Ji-Dong YAN, Shuang YANG, Shu-Jun LÜ, Rong-Yue LEI and Tian-Hui ZHU. Expression of recombinant human BMP-6 in CHO cell by fusion of a BMP-6 mature peptide to the signal peptide and propeptide of another homologue protein. Chinese journal of biotechnology, 2007, 23(3): 414−418.

（23）Zhang M, Yan JD, Zhang L, Wang Q, Lü SJ, Zhang J, Zhu TH. Activation of BMP-6 gene transcription in MCF-7 cells by estrogen. Chinese Medical Journal, 2005, 118:1629-1636.

（24）翟春莉，闫继东，杨爽，杜君，袁伟，王兆奇，朱天慧。 表达外源rhBMP2的CHO细胞株稳定性分析。生物工程学报，2008，24：862-866。

（25）雷荣悦，乔玉欢，闫继东，杨爽，朱天慧。重组人BMP6在大肠杆菌中可溶表达、纯化及活性分析。生物工程学报，2008，24：452-459。

（26）袁伟，孙伟，杨爽，闫继东，翟春利，杜君，王兆琦，朱天慧。不同蛋白标签对LMO2融合蛋白沉淀实验影响的研究。生物工程学报，2008，24：887-891。

（27）闫继东，杨爽，吕树军，雷荣悦，朱天慧。利用同源蛋白的信号肽和前肽序列在CHO细胞中表达重组人BMP6。生物工程学报，2007，23：413-417。

（28）张道永， 杨爽， 吕树军， 闫继东， 朱天慧。重组人骨形态发生蛋白2在CHO细胞中的表达、鉴定及活性分析。生物工程学报，2006，22：968-972。

（29）闫继东，高云芳。水蛭粉针剂抗凝血、抗血栓作用。西北大学报，2001，112-114。