Yujin Zong, Ph.D.

Professor, Department of Biomedical Engineering

Xian Jiaotong University, Beilin District, Xi’an, 710049, China

Office: Room 107s Jiao-Er Building

Tel: +86-29-82668668-805

Fax: +86-29-82668668-801





1.   Combined super-resolution ultrasound imaging based on localization of microbubbles and phase-change nanodroplets in and outside tumor microvasculature and its image guided nanodroplets induced drug delivery, 2021-2024, National Nature Science Foundation of China (No. 32071369)

2.   Synergistic manipulation of double-peaked distributed bimodal phase shifted nanodroplets using ultrasound/magnetic field and its application in tumor theranostics, 2018-2021,   National Nature Science Foundation of China (No. 31771075)

3.   3D microbubble and cavitation ultrasound imaging and theranostic system for transcranial blood brain barrier opening and thrombolysis, 2016-2018,  Ministry of Science and Technology (No. 2016YFC0100702 )   

4.   Atherosclerosis animal model based on controlled ultrasound cavitation endothelial injury and its in vivo evaluation, 2015-2018, National Nature Science Foundation of China (No. 31470909)

5.   Study on the methods of building local plaque animal modal based on ultrasound cavitation endothelium damage, 2013, National Nature Science Foundation of China (No. 31271003)

6.    Super-broadband ultrasound perfusion imaging of deep microvascular and single bubble within the vascular, 2008-2010, National Nature Science Foundation of China (No. 10704060).   



1.  Ultrasonic System for Cerebral Small Vessel Imaging    with Super-Resolution and Dynamic Multi Parameters, 2019-2023,  National Major Scientific Instruments and  Equipments Development Project of National Natural Science Foundation of China,  No. 81827801

2.  Noninvasive and high resolution ultrasound functional and molecular quantitative imaging of vulnerable plaque, National Basic Research Program 973 (No. 2010CB732603), Ministry of Science and Technology, 2010-2014

3.  Drug-carried microparticles or Microbubbles, Locallized Controlled Release by Low Intensity Focused Ultrasound (LIFU) and Real-time Monitoring Imaging, State Key Program of National Natural Science of China (No. 30630024).


2006        Ph.D. in Biomedical Engineering

                Dept. Biomedical Engineering, School of Life Science and Technology, Xian Jiaotong University, China

2000        M.S. in Material Engineering

                School of Materials Science & Engineering, Xian Jiaotong University, China

1995        B.S. in Chemical Engineering

                  Dept. Chemical Engineering, Qingdao University of Science and Technology 

Research Experience

2006-08   Research assistant, Dept. Biomedical Engineering, School of Life Science and Technology, Xian Jiaotong University

2008-14   Associate Professor,  Dept. Biomedical Engineering, School of Life Science and Technology, Xian Jiaotong University

2015-16   Visiting Scholar, Center of Medical and Industrial Ultrasound, Applied Physics Laboratory, University of Washinton, Seattle

2016-19   Associate Professor,  Dept. Biomedical Engineering, School of Life Science and Technology, Xian Jiaotong University

2020-       Professor,  Dept. Biomedical Engineering, School of Life Science and Technology, Xian Jiaotong University



1. 万明习,宗瑜瑾,王素品,生物医学超声学,北京:科学出版社,2010

2. 万明习,宗瑜瑾,王素品,陆明珠,生物医学超声实验,西安:西安交通大学出版社,2010

3. Yujin Zong, Shanshan Xu, Tom Matula, Mingxi Wan, Chapter 5. Cavitation-enhanced mechanical effects and applications, in book: Cavitation in Biomedicine, Principles and Techniques, Editor: M.Wan, Y. Feng, Gail ter Haar, Springer, 2015



  1. Meiling Liang, Jiacheng Liu, Chao Guo, Yujin Zong*, Mingxi Wan*, Velocity field estimation in transcranial small vessel using super-resolution ultrasound imaging velocimetry, Ultrasonics, 2023, 132: 107016

  2. Anqi Huang, Shizhe An, Yuebo Wang, Kangyi Feng, Haiyang Yu, Zhuonan Chen, Mingxi Wan* and Yujin Zong*, Acoustic super-resolved spatiotemporal monitoring of theranostic nanodroplets with tuned post-activation dynamics, Appl. Phys. Lett. 2023, 122: 124102

  3. Mingting Zhu#, Pengying Wu#, Yan Li, Lei Zhang, Yujin Zong* and Mingxi Wan*, Synergistic therapy for orthotopic gliomas via biomimetic nanosonosensitizer-mediated sonodynamic therapy and ferroptosis, Biomaterials Science, 2022, 10, 3911

  4. Pengying Wu, Zhen Ya, Yan Li, Mingting Zhu, Lei Zhang, Yujin Zong*, Shifang Guo*, and Mingxi Wan*, Focused Acoustic Vortex-Regulated Composite Nanodroplets Combined with Checkpoint Blockade for High-Performance Tumor Synergistic Therapy, ACS Appl. Mater. Interfaces 2022, 14, 30466−30479

  5. X. Qiao, Y. Wen, J. Yu, A. Bouakaz, Y. Zong* and M. Wan*, Noninvasive Pressure Estimation Based on the Subharmonic Response of SonoVueTM: Application to Intracranial Blood Pressure assessment, IEEE Trans. Ultrasonics, Ferroelectrics, and Frequency Control, 2022, 69(3): 957-966

  6. Pengying Wu, Mingting Zhu, Yan Li, Zhen Ya, Yabo Yang, Yuchen Yuan, Wei Dong,Shifang Guo, Shukuan Lu, Lei Zhang, Yujin Zong*, and Mingxi Wan*, Cascade-Amplifying Synergistic Therapy for Intracranial Glioma via Endogenous Reactive Oxygen Species-Triggered ”All-in-One” Nanoplatform, Adv. Funct. Mater., 2021, 31(46): 2105786

  7. Wei Dong, Anqi Huang, Jixiu Huang, Pengying Wu, Shifang Guo, Huasheng Liu, Mengfan Qin, Xinxing Yang, Bo Zhang, Mingxi Wan*, and Yujin Zong*, Plasmid loadable magnetic/ultrasound responsive nanodroplets with SPIO-NPs dispersed perfluoropentane core and lipid shell for tumor-targeted intracellular plasmid delivery, Biomater. Sci., 2020, 8: 5329-5345

  8. Wei Dong, Pengying Wu, Mengfan Qin, Shifang Guo, Huasheng Liu, Xinxing Yang, Wen He, Ayache Bouakaz, Mingxi Wan*, and Yujin Zong*, Multipotent miRNA Sponge-Loaded Magnetic Nanodroplets with Ultrasound/Magnet-Assisted Delivery for Hepatocellular Carcinoma Therapy, Mol. Pharmaceut. 2020, 17(8): 891–2910

  9. Wei Dong, Pengying Wu, Di Zhou, Jixiu Huang, Mengfan Qin, Xinxing Yang, Mingxi Wan, and Yujin Zong*, Ultrasound-Mediated Gene Therapy of Hepatocellular Carcinoma Using Pre-microRNA Plasmid-Loaded Nanodroplets, Ultrasound Med. Biol., 2020, 46(1): 90-107

  10. Yi Huang, Hua Wang, Wenqi Cui, Yujin Zong, Chuyun Zheng, Yue Liu, Weili Min, Sihan Wang, Mingjun Hu*, Yaohui Zhang*, Analysis of Ultrasonic Manifestations of Pulmonary Lesions in Patients with COVID-19, Advanced Ultrasound in Diagnosis and Therapy, 2020, 4 (2): 73-78.

  11. Pengying Wu, Wei Dong, Xuyan Guo, Xiaoyang Qiao, Shifang Guo, Lei Zhang,  Mingxi Wan*, and Yujin Zong*, ROS-Responsive Blended Nanoparticles: CascadeAmplifying Synergistic Effects of Sonochemotherapy with On-demand Boosted Drug Release During SDT Process, Adv. Healthcare Mater. 2019, 8, 1900720

  12. Shifang Guo, Xuyan Guo, Xin Wang, Di Zhou, Xuan Du, Meng Han, Yujin Zong*, Mingxi Wan*, Reduced clot debris size in sonothrombolysis assisted with phase-change nanodroplets, Ultrason. Sonochem., 2019, 54:183-191

  13. Shukuan Lu, Xianbo Yu, Renyan Li, Yujin Zong*, Mingxi Wan*, Passive cavitation mapping using dual apodization with cross-correlation in ultrasound therapy monitoring, Ultrason. Sonochem., 2019, 54: 18-31

  14. Shanshan Xu, Nan Chang, Rui Wang, Xiaodong Liu, Shifang Guo, Supin Wang, Yujin Zong*, Mingxi Wan*, Acoustic droplet vaporization and inertial cavitation thresholds and efficiencies of nanodroplets emulsions inside the focused region using a dual-frequency ring focused ultrasound, Ultrason. Sonochem., 2018, 48: 532–537

  15. Bai Chen, Mengling Ji, Ayache Bouakaz, Yujin Zong*, and Mingxi Wan*, Design and Characterization of an Acoustically and Structurally Matched 3-D-Printed Model for Transcranial Ultrasound Imaging, IEEE Trans. on UFFC, 2018, 65(5): 741-748

  16. Dui Qin, Lei Zhang, Nan Chang, Pengying Ni, Yujin Zong, Ayache Bouakaz, Mingxi Wan*, Yi Feng*, In situ observation of single cell response to acoustic droplet vaporization: Membrane deformation, permeabilization, and blebbing, Ultrason. Sonochem., 2018, 47: 141–150

  17. Diya Wang, Mengnan Xiao, Yu Zhang, Zhe Su, Yujin Zong, Supin Wang, Mingxi Wan, In-vitro evaluation of accuracy of dynamic contrast-enhanced ultrasound (DCEUS)-based parametric perfusion imaging with respiratory motion-compensation, Medical Physics, 2018, 45(5): 2119-2128

  18. Shukuan Lu, Hong Hu, Xianbo Yu, Jiangying Long, Bowen Jing, Yujin Zong*, Mingxi Wan*, Passive acoustic mapping of cavitation using eigenspace-based robust Capon beamformer in ultrasound therapy, Ultrason. Sonochem., 2018, 41: 670-679

  19. Diya Wang, Mengnan Xiao, Hong Hu, Yu Zhang, Zhe Su, Shanshan Xu, Yujin Zong, Mingxi Wan, DCEUS-based focal parametric perfusion imaging of microvessel with single-pixel resolution and high contrast, Ultrasonics, 2018, 84: 392-403

  20. Gao Xing, Nan Yang, Yuan Yuan, Gong Xue, Sun Yuanyuan, Zhou Huihui, Zong Yujin, Zhang Lijun, Yu Ming, Gas-filled ultrasound microbubbles enhance the immunoactivity of the HSP70-MAGEA1 fusion protein against MAGEA1-expressing tumours, Molecular Medicine Reports, 2018, 18(1):315-321

  21. Shifang Guo, Aiwei Shi, Shanshan Xu, Xuan Du, Xin Wang, Yujin Zong, Ayache Bouakaz, and Mingxi Wan, Lowering of acoustic droplet vaporization threshold via aggregation, Appl. Phys. Lett., 2017, 111: 254102

  22. Diya Wang, Yujin Zong, Xuan Yang, Hong Hu, Jinjin Wan, Lei Zhang, Ayache Bouakaz, Mingxi Wan, Ultrasound Contrast Plane Wave Imaging Based on Bubble Wavelet Transform: in vitro and in vivo Validations, Ultrasound Med. Biol., 2016,  42(7): 1584-1597

  23. J. Hu#Y. Zong#, J. Li, X. Zhou, J. Zhang, T. Zhu, M. Jiao, H. Su*, B. Bo*, InVitro and In Vivo Evaluation of Targeted Sunitinib-Loaded Polymer Microbubbles against Proliferation of Renal Cell Carcinoma, J. Ultras. Med., 2016, 35: 589-597.

  24.  A. Shi, P. Huang, S. Guo, L. Zhao, J. Jia, Y. Zong*, M. Wan*, Precise spatial control of cavitation erosion in a vessel phantom by using an ultrasonic standing wave, Ultrason. Sonochem., 2016, 31: 163-172.

  25. J. Tan, B. Pham, Y. Zong, C. Perez, D. Maris, A. Hemphill, C. Miao, T. Matula, P. Mourad, H. Wei, D. Sellers, P. Horner*, S. Pun*, Microbubbles and Ultrasound Increase Intraventricular Polyplex Gene Transfer to the Brain, J. Control. Release, 2016, 231:86-93