（1）单个活细胞的光寻址电化学成像。对传统光寻址电位传感成像技术进行改进，基于半导体-电解液界面发展了新型光电化学成像系统，最终实现了单个活细胞光寻址电化学成像，可检测单细胞-基底接触面的电荷分布，适用于成骨细胞，小鼠神经细胞，人间充质干细胞等多种细胞类型。并用于药物诱导乳腺癌细胞凋亡过程的动态免标记成像监测。（Anal. Chem., 2019, 91, 5896-5903;  Anal. Chem. 2023, 95(23): 8898-8905）

（2）光寻址方波伏安法及其在生物传感与成像中的应用。提出了一种新型光寻址方波伏安法，采用恒定激光照射场效应结构半导体芯片，激发产生原位光生载流子，通过方波电压脉冲调制光生载流子的定向迁移和扩散过程，检测得到原位光电流，对其光电流的信号机制给出了完整的解释。将光寻址方波伏安法用于离子传感、酶促反应检测和电化学阻抗成像。（ ACS Sens. 2021, 6(4): 1636-1642）

2024

   (1) Qiaoyu Yang; Jiaming Liao; Luyao Feng; Sen Wang; Zhibin Zhao; Jian Wang*; Yazhong Bu*; Jian Zhuang; De-Wen Zhang*, One-step construction of multiplexed enzymatic biosensors using light-addressable electrochemistry on a single silicon photoelectrode. Biosensors and Bioelectronics 2024, 253, 116194. https://doi.org/10.1016/j.bios.2024.116194 (IF =12.6)

2023

   (1) Fangming Chen^#, Qian Guo^#, Qiaoyu Yang, Yao Meng, Mingrui Jiang, Jian Wang*, De-Wen Zhang*. Label-Free Imaging of Cell Apoptosis by a Light-Addressable Electrochemical Sensor. Analytical Chemistry 2023, 95(23): 8898-8905.  https://pubs.acs.org/doi/10.1021/acs.analchem.3c00566 (IF = 7.4)

   (2) Mingrui Jiang, Fangming Chen, Yao Meng, Qiaoyu Yang, Jian Wang, De-Wen Zhang*, Yaqiong Wang*. Carbonized polydopamine layer-protected silicon substrates for light-addressable electrochemical sensing and imaging. Talanta 2023, 254: 124124. https://doi.org/10.1016/j.talanta.2022.124124 (IF = 6.1)

   (3) Jian Wang, Fangming Chen, Qiaoyu Yang, Yao Meng, Mingrui Jiang, Yaqiong Wang, De-Wen Zhang*, Liping Du*. Light-addressable electrochemical immunoassay for multiplexed detection of antigen. Sensors and Actuators B: Chemical 2023, 374: 132821. https://doi.org/10.1016/j.snb.2022.132821（IF =8.4）

2022

   (1) Fangming Chen, Qiaoyu Yang, MingRui Jiang, Yao Meng, De-Wen Zhang*, Jian Wang*. Visualization of electrochemical reactions on microelectrodes using light-addressable potentiometric sensor imaging. Analytica Chimica Acta 2022, 1224: 340237. https://doi.org/10.1016/j.aca.2022.340237（IF = 6.2）

   (2) Yao Meng, Fangming Chen, Chunsheng Wu, Steffi Krause, Jian Wang*, De-Wen Zhang*. Light-Addressable Electrochemical Sensors toward Spatially Resolved Biosensing and Imaging Applications. ACS Sensors 2022, 7(7): 1791-1807.  https://doi.org/10.1021/acssensors.2c00940 (IF =8.9)

2021 

     (1) Yao Meng, Fangming Chen, Mingrui Jiang, Qin Guo, Yaqiong Wang, Jian Wang*, De-Wen Zhang*. A Homogeneous Label-Free Electrochemical microRNA Biosensor Coupling With G-Triplex/Methylene Blue Complex and λ-Exonuclease-Assisted Recycling Amplification. Frontiers in Chemistry 2021, 9(975). (IF =5.5)

     (2) Jian Wang, Fangming Chen, Qin Guo, Yao Meng, Mingrui Jiang, Chunsheng Wu, Jian Zhuang, De-Wen Zhang*. Light-Addressable Square Wave Voltammetry (LASWV) Based on a Field-Effect Structure for Electrochemical Sensing and Imaging. ACS Sensors 2021, 6(4): 1636-1642.  (IF =8.9)

    (3) Fangming Chen, Xingchuang Fu, Yao Meng, Mingrui Jiang, Jian Wang*, Ying-Lin Zhou*, De-Wen Zhang*. A novel miniaturized homogeneous label-free electrochemical biosensing platform combining integrated microelectrode and functional nucleic acids. Analytica Chimica Acta 2021, 1158: 338415.  (IF = 6.2)

     (4) Bo Zhou, Anirban Das*, Muchun Zhong, Qian Guo, De-Wen Zhang, Karin A. Hing, Ana Jorge Sobrido, Maria-Magdalena Titirici, Steffi Krause*. Photoelectrochemical imaging system with high spatiotemporal resolution for visualizing dynamic cellular responses. Biosensors and Bioelectronics 2021, 180: 113121-113121.  (IF = 12.6)

    (5) Yun-Chong Li, Bo Jiao*, Yi-Jun Zhang, Jian Wang*, Wei Ren, De-Wen Zhang, Xun Hou, Zhao-Xin Wu*. Bipolar Light-Addressable Potentiometric Sensor Based on Fullerene Photosensitive Layer. Advanced Materials Technologies 2021, 6(8): 2001221. (IF =6.8)

2020 

    (1) Jian Wang^#, Yulan Tian^#, Fangming Chen, Wei Chen, Liping Du, Zhiyuan He, Chunsheng Wu*, De-Wen Zhang*. Scanning Electrochemical Photometric Sensors for Label-Free Single-Cell Imaging and Quantitative Absorption Analysis. Analytical Chemistry 2020, 92(14): 9739-9744. (IF = 7.4)

    (2) Ying Tu, Candice Kyle, Hui Luo, De-Wen Zhang, Anirban Das, Joe Briscoe, Steve Dunn, Maria-Magdalena Titirici, Steffi Krause*. Ammonia Gas Sensor Response of a Vertical Zinc Oxide Nanorod-Gold Junction Diode at Room Temperature. ACS Sensors 2020, 5(11): 3568-3575. (IF =8.9)

2019 

    (1) Jian Wang, Zhao Yang, Wei Chen, Liping Du, Bo Jiao, Steffi Krause, Ping Wang, Qiuping Wei, De-Wen Zhang^*, Chunsheng Wu^*. Modulated light-activated electrochemistry at silicon functionalized with metal-organic frameworks towards addressable DNA chips. Biosensors and Bioelectronics 2019, 146: 111750.  (IF = 12.6)

    (2) Jian Wang, Shu Kong, Fangming Chen, Wei Chen, Liping Du, Wen Cai, Liquan Huang, Chunsheng Wu^*, De-Wen Zhang^*. A bioelectronic taste sensor based on bioengineered Escherichia coli cells combined with ITO-constructed electrochemical sensors. Analytica Chimica Acta 2019, 1079: 73-78.  (IF = 6.2)

    (3) Fan Wu, Bo Zhou, Jian Wang, Muchun Zhong, Anirban Das, Michael Watkinson, Karin Hing, De-Wen Zhang^*, Steffi Krause^*. Photoelectrochemical Imaging System for the Mapping of Cell Surface Charges. Analytical Chemistry 2019, 91(9): 5896-5903. (IF = 7.4)

    (4)  Norlaily Ahmad, Burcu Colak, Martin John Gibbs, De-Wen Zhang, Julien E. Gautrot, Michael Watkinson, C. Remzi Becer, Steffi Krause*. Peptide Cross-Linked Poly(2-oxazoline) as a Sensor Material for the Detection of Proteases with a Quartz Crystal Microbalance. Biomacromolecules 2019, 20(7): 2506-2514. (IF = 6.2)

 2018

    (1) Ying Tu, Norlaily Ahmad, Joe Briscoe, De-Wen Zhang^*, Steffi Krause^*, Light-Addressable Potentiometric Sensors Using ZnO Nanorods as the Sensor Substrate for Bioanalytical Applications. Analytical Chemistry, 2018, 90, 8708-8715. (IF = 7.4)

    (2) De-Wen Zhang, Nikolaos Papaioannou, Naomi Michelle David, Hui Luo, Hui Gao, Liviu Cristian Tanase, Thibault Degousée, Paolo Samorì, Andrei Sapelkin, Oliver Fenwick, Maria-Magdalena Titirici^*, Steffi Krause^*, Photoelectrochemical Response of Carbon Dots (Cds) Derived from Chitosan and Their Use in Electrochemical Imaging. Materials Horizons 2018, 5, 423-428. (IF = 13.3)

 Before 2017

    (1) De-Wen Zhang, Fan Wu, Steffi Krause^*, LAPS and SPIM Imaging Using Ito-Coated Glass as the Substrate Material. Analytical Chemistry, 2017, 89, 8129-8133. 

    (2)  Fan Wu, Inmaculada Campos, De-Wen Zhang^*, Steffi Krause^*, Biological Imaging Using Light-Addressable Potentiometric Sensors and Scanning Photo-Induced Impedance Microscopy. Proceedings of the Royal Society. A, Mathematical, physical, and engineering sciences, 2017, 473, 20170130.

    (3) De-Wen Zhang, Fan Wu, Jian Wang, Michael Watkinson, Steffi Krause^*, Image Detection of Yeast Saccharomyces Cerevisiae by Light-Addressable Potentiometric Sensors (LAPS). Electrochemistry Communications, 2016, 72, 41-45. 

    (4) Ting Cao, Ji Nie, Liang-Yuan Cai, Xiao-Hui Zhang, De-Wen Zhang*, Ying-Lin Zhou*, Xin-Xiang Zhang*, A Cupric Ion Triggered DNA Diode Based on a Tandem Linkage-Cleavage Reaction. Chemical Communications, 2016, 52, 12490-12493. 

     (5) De-Wen Zhang, Ji Nie, Fang-Ting Zhang, Li Xu, Ying-Lin Zhou*, Xin-Xiang Zhang*, Novel Homogeneous Label-Free Electrochemical Aptasensor Based on Functional DNA Hairpin for Target Detection. Analytical Chemistry, 2013, 85, 9378-9382.

    (6) De-Wen Zhang, Jing-Xin Liu, Ji Nie, Ying-Lin Zhou*, Xin-Xiang Zhang*, Micropipet Tip-Based Miniaturized Electrochemical Device Combined with Ultramicroelectrode and Its Application in Immobilization-Free Enzyme Biosensor. Analytical Chemistry, 2013, 85, 2032-2036.

    (7) De-Wen Zhang, Cui-Jin Sun, Fang-Ting Zhang, Li Xu, Ying-Lin Zhou*, Xin-Xiang Zhang*, An Electrochemical Aptasensor Based on Enzyme Linked Aptamer Assay. Biosensors and Bioelectronics, 2012, 31, 363-368. 

    (8) De-Wen Zhang, Fang-Ting Zhang, Yi-Ran Cui, Qin-Pei Deng, Steffi Krause, Ying-Lin Zhou*, Xin-Xiang Zhang*, A Label-Free Aptasensor for the Sensitive and Specific Detection of Cocaine Using Supramolecular Aptamer Fragments/Target Complex by Electrochemical Impedance Spectroscopy. Talanta, 2012, 92, 65-71.