Basic Information

Doctor of Medicine (M.D.)

Doctoral Supervisor

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类别/站点

Experience

1. 2018.01-Present  Xi'an Jiaotong University Health Science Center, Xi’an, China. Associate Professor    

2. 2012.01-2017.12  Xi'an Jiaotong University Health Science Center, Xi’an, China. Lecturer 

Education

1. 2007.09-2011.12  Human anatomy and histo-embryology, Xi’an Jiaotong University, Xi’an, China.  PhD.

2. 2004.09-2007.07  Cell Biology, Xi’an Jiaotong University, Xi’an, China.  M.S.

3. 1998.09-2002.07  Biology, Shaanxi University of Technology, China.  B.S.

Research Area(s)

1. Molecular mechanisms of oncogenesis and development

2. Cancer gene therapy

3. Neural stem cells and neural regeneration

Representative Publications

 

  1. Tong DD, Zhang J, Wang X, Li Q, Liu LY, Yang J, Guo B, Ni L, Zhao LY*, Huang C*. MeCP2 facilitates breast cancer growth via promoting ubiquitination-mediated P53 degradation by inhibiting RPL5/RPL11 transcription. Oncogenesis, 9:56, 2020
  2. Zhao LY, Xue M, Zhang L, Guo B, Qin Y, Jiang Q, Sun R, Yang J, Wang L, Liu L, Wang X, Huang C*, Tong D*. MicroRNA-4268 inhibits cell proliferation via AKT/JNK signalling pathways by targeting Rab6B in human gastric cancer. Cancer Gene Ther, 27:461-472, 2020
  3. Zhao LY, Liu YX, Tong D, Qin Y, Yang J, Xue M, Du N, Liu L, Guo B, Hou N, Han J, Liu S, Liu N, Zhao X, Wang L, Chen YK, Huang C*. MeCP2 promotes gastric cancer progression through regulating FOXF1/Wnt5a/β-Catenin and MYOD1/Caspase-3 signaling pathways. EBioMedicine, 16:87-100, 2017
  4. Zhao LY* (Corresponding author), Tong DD, Xue M, Ma HL, Liu SY, Yang J, Liu YX, Guo B, Ni L, Liu LY, Qin YN, Wang LM, Zhao XG, Huang C*. MeCP2, a target of miR-638, facilitates gastric cancer cell proliferation through activation of the MEK1/2-ERK1/2 signaling pathway by upregulating GIT1. Oncogenesis, 6:e368, 2017
  5. Zhao LY, Jiao Q, Yang PB, Chen XL, Zhang JF, Zhao BQ, Zheng P, Liu Y*. Metabotropic Glutamate receptor 5 promotes proliferation of human neural stem/progenitor cells with activation of mitogen-activated protein kinases signaling pathway in vitro. Neuroscience, 192:185-194, 2011
  6. Zhao LY, Jiao Q, Chen XL, Yang PB, Zhao BQ, Zheng P, Liu Y*. mGluR5 is involved in proliferation of rat neural progenitor cells exposed to hypoxia with activation of MAPK signaling pathway. J Neurosci Res, 90(2): 447-460, 2012
  7. Zhang JF, Shi LL, Zhang L, Zhao ZH, Liang F, Xu X*, Zhao LY* (Corresponding author), Yang PB, Zhang JS, Tian YF. MicroRNA-25 negatively regulates cerebral ischemia/reperfusion injury-induced cell apoptosis through Fas/FasL pathway. J Mol Neurosci, 58(4):507-516, 2016
  8. Zhao LY, Zhang J, Guo B, Yang J, Han J, Zhao XG, Wang XF, Liu LY, Li ZF, Song TS, Huang C*. MeCP2 promotes cell proliferation by activating ERK1/2 and inhibiting p38 activity in human hepatocellular carcinoma Hepg2 cells. Cell Mol Biol, Suppl 59: OL1876-1881, 2013
  9. Zhao LY, Jiao Q, Huang C, Hou N, Chen XL, Zhang JS, Yang PB, Xu X, Song TS, Liu Y*. mGluR5 promotes the differentiation of rat neural progenitor cells into cholinergic neurons and activation of extracellular signal-related protein kinases. Neuroreport, 25(6):427-434, 2014
  10. Zhao LY, Jiao Q, Xu X, Yang PB, Song TS, Huang C, Zhang JF, Liu Y*. The decreasedself-renewal potential of NPCs during human embryonic brain development with reduced activity of MAPKs, Cell Mol Biol, 58 Suppl: OL1730-1736, 2012
  11. Han JM, Zhang L, Zhang J, Jiang QY, Tong DD, Wang XF, Gao XG, Zhao LY* (Corresponding author), Huang C*. CREBRF promotes the proliferation of human gastric cancer cells via the AKT signaling pathway. Cell Mol Biol, 64:40-45, 2018
  12. Zhang J, Tong DD, Xue M, Jiang QY, Wang XF, Yang PB, Ni L, Zhao LY* (Corresponding author), Huang C*. FAM196B acts as oncogene and promotes proliferation of gastric cancer cells through AKT signaling pathway. Cell Mol Biol, 63:18-23, 2017
  13. Qin Y, Zhao LY (Co-first author), Wang X, Tong D, Hoover C, Wu F, Liu Y, Wang L, Liu L, Ni L, Song T, Huang C.MeCP2 regulated glycogenes contribute to proliferation and apoptosis of gastric cancer cells. Glycobiology, 27(4):306-317, 2017
  14. Zhao LY, Yao Y, Han J, Yang J, Wang XF, Tong DD, Song TS, Huang C*, Shao Y*. miR-638 suppresses cell proliferation in gastric cancer by targeting Sp2. Dig Dis Sci, 59(8):1743-1753, 2014
  15. Zhao LY, Huang C*, Li ZF, Liu LY, Ni L, Song TS, STAT1/2 is involved in the inhibition of cell growth induced by U0126 in HeLa cells. Cell Mol Biol, 55 Suppl:OL1168-1174, 2009
  16. Qin Y, Chen Y, Yang J, Wu F, Zhao LY, Yang F, Xue P, Shi Z, Song T, Huang C. Serum glycopattern and Maackia amurensis lectin-II binding glycoproteins in autism spectrum disorder. Sci Rep, 7:46041, 2017
  17. Sun R, Liu Z, Tong D, Yang Y, Guo B, Wang X, Zhao LY, Huang C. miR-491-5p, mediated by Foxi1, functions as a tumor suppressor by targeting Wnt3a/β-catenin signaling in the development of gastric cancer. Cell Death Dis, 8(3):e2714, 2017
  18. Tong D, Zhao LY, He K, Sun H, Cai D, Ni L, Sun R, Chang S, Song T, Huang C. MECP2 promotes the growth of gastric cancer cells by suppressing miR-338-mediated antiproliferative effect. Oncotarget, 7(23):34845-34859, 2016
  19. Guo B, Wang W, Zhao Z, Li Q, Zhou K, Zhao LY, Wang L, Yang J, Huang C. Rab14 Act as Oncogene and Induce Proliferation of Gastric Cancer Cells via AKT Signaling Pathway. PLoS One, 12(1):e0170620, 2017
  20. Wang LM, Sun H, Wang X, Hou N, Zhao LY, Tong D, He K, Yang Y, Song T, Yang J, Huang C. EGR1 mediates miR-203a suppress the hepatocellular carcinoma cells progression by targeting HOXD3 through EGFR signaling pathway. Oncotarget, 7(29):45302-45316, 2016
  21. Liu LY, Wang W, Zhao LY, Guo B, Yang J, Zhao XG, Song TS, Huang C, Xu JR*. Silencing of polo-like kinase 2 increases cell proliferation and decreases apoptosis in SGC-7901 gastric cancer cells. Mol Med Rep,11(4):3033-3038, 2015
  22. Liu LY, Wang W, Zhao LY, Guo B, Yang J, Zhao XG, Hou N, Ni L, Wang AY, Song TS, Huang C*, Xu JR*. MiR-126 inhibits growth of SGC-7901 cells by synergistically targeting the oncogenes PI3KR2 and Crk, and the tumor suppressor PLK2. Int J Oncol, 45(3):1257-1265, 2014
  23. Hou N, Zhang X, Zhao LY, Zhao XG, Li ZF, Song TS, Huang C*. A novel chronic stress-induced shift in the Th1 to Th2 response promotes colon cancer growth. Biochem Biophys Res Commun, 439(4):471-476, 2013
  24. Yang J, Zhu J, He K, Zhao LY, Liu LY, Song TS, Huang C*. Proteomic profiling of invasive ductal carcinoma (IDC) using magnetic beads-based serum fractionation and MALDI-TOF MS. J Clin Lab Anal, 29(4):321-327, 2015
  25. Yang J, Yang J, Gao Y, Zhao LY, Liu L, Qin YN, Wang XF, Song T, Huang C*. Identification of potential serum proteomic biomarkers for clear cell renal cell carcinoma. PLoS One, 9(11):e111364, 2014
  26. Yang J, Xiong X, Liu S, Zhu J, Luo M, Liu LY, Zhao LY, Qin YN, Song T, Huang C*. Identification of novel serum peptides biomarkers for female breast cancer patients in Western China. Proteomics,  16(6):925-934, 2016
  27. Yang J, Hu LL, Wu Q, Liu LY, Zhao LY, Zhao XG, Song TS, Huang C*. A terrified-sound stress induced proteomic changes in adult malerat hippocampus. Physiol Behav, 128:32-38, 2014
  28. Yang J, Hu LL, Song TS, Liu Y, Wu Q, Zhao LY, Liu LY, Zhao XG, Zhang D, Huang C*. Proteomic Changes in Female Rat Hippocampus Following exposure to a Terrified Sound Stress. J Mol Neurosci, 53(2):158-165, 2014
  29. Zheng Q, Zhao LY, Kong Y, Nan KJ*, Yao Y, Liao ZJ. CDK-associated Cullin 1 can promote cell proliferation and inhibit cisplatin-induced apoptosis in the AGS gastric cancer cell line. World J Surg Oncol, 11:5, 2013
  30. Yang J, Hu LL, Liu LY, Zhao LY, Hou N, Ni L, Li ZF, Wang AY, Song TS, Huang C*. Proteomics Reveals Intersexual Differences in the Rat Brain Hippocampus. Anat Rec (Hoboken), 296(3):462–469,2013
  31. Guo B, Li J, Liu LY, Hou N, Chang DM, Zhao LY, Li ZF, Song TS, Huang C*. Dysregulation of miRNAs and their potential as biomarkers for the diagnosis of gastric cancer. Biomedical Reports, 1(6):907-912, 2013
  32. Yang PB, Zhang JF, Zhao LY, Jiao Q, Jin H, Xiao XL, Zhang HX, Hu M, Lu H, Liu Y*. Developmental distribution pattern of metabotropic glutamate receptor 5 in prenatal human hippocampus. Neurosci Bull, 28(6): 704-714, 2012
  33. Xu X, Zhang JF, Chen XL, Liu JX, Lu HX, Yang PB, Xiao XL, Zhao LY, Jiao Q, Zhao BQ, Zheng P, Liu Y*. The increased expression of metabotropic glutamate receptor 5 in subventricular zone neural progenitor cells and enhanced neurogenesis in a rat model of intracerebral hemorrhage. Neuroscience, 202:474-283, 2012
  34. Zhang JF, Shi QD, Chen XL, Yang PB, Qi CF, Zhang JS, Lu HX, Liu JX, Jiao Q, Zhao LY, Zhao BQ, Zheng P, Liu Y*. Hypoxia-regulated neurotrophin-3 expression by multicopy hypoxia response elements reduces apoptosis in PC12 cells. Int J Mol Med, 30(5):1173-1179, 2012