张海峰,1984年03月。
医学博士,副教授,硕士生导师,就职西安交通大学医学部病理学系。2013年毕业于暨南大学,获医学博士学位,先后受聘西安交通大学医学部任讲师、美国罗格斯大学任博士后,2018年晋升副教授。主要从事肿瘤病理研究,对氯离子通道及其相关基因在肿瘤发生、发展的作用方面开展了系统深入研究,并探索其在肿瘤早期诊断和治疗中的应用。
招生:1)药学专硕;2)病理学硕;3)医学或生物学博后
张海峰,1984年03月。
医学博士,副教授,硕士生导师,就职西安交通大学医学部病理学系。2013年毕业于暨南大学,获医学博士学位,先后受聘西安交通大学医学部任讲师、美国罗格斯大学任博士后,2018年晋升副教授。主要从事肿瘤病理研究,对氯离子通道及其相关基因在肿瘤发生、发展的作用方面开展了系统深入研究,并探索其在肿瘤早期诊断和治疗中的应用。
招生:1)药学专硕;2)病理学硕;3)医学或生物学博后
* 通讯作者;#共同第一作者
[19] Duan S, Li B, Cui S, He Ying, Chen Y, Zhang H*, Fan L. Clcn3 deficiency ameliorates high-fat diet-induced obesity and improves metabolism in mice. Obesity (Under Review)
[18] Liu R, Zhao L, Cui S, Jing Z, Ren Y, Zhao W, Zhou D, Zhang H*. High expression of FLNA is associated with poor survival in colon cancer patients by promoting cell growth and migration. Oncology (Under Review)
[17] Zhang H, Liu R, Jing Z, Li C, Fan W, Li H, Li H, Ren J, Cui S, Zhao W, Yu L, Bai Y, Liu S, Fang C, Yang W, Wei Y, Li L, Peng S. LRRC8A as a central mediator promotes colon cancer metastasis by regulating PIP5K1B/PIP2 pathway. BBA Molecular Basis of Disease. 2024 Feb 11; DOI:10.1016/j.bbadis.2024.167066.
[16] Cheng Y, Yang Z, Gou X, Yang Q, Zhang Z, Cui S, Ren Y, Fan L, Zhang H*, Fang Z, Lu Y, Kai L, Hou X, Chen F. Heart valve-inspired self-lubricating anticoagulant surfaces. Chemical Engineering Journal. 2023 Oct 15; 474:145358.
[15] Zhang H, Jing Z, Liu R, Shada Y, Shria S, Cui S, Ren Y, Wei Y, Li L, Peng S. LRRC8A promotes the initial development of oxaliplatin resistance in colon cancer cells. Heliyon. 2023 Jun 1; 9(6): e16872.
[14] Jing Z, Zhang H*, Wen Y, Cui S, Ren Y, Liu R, Duan S, Zhao W, Fan L. Epigenetic and transcriptomic alterations in the ClC-3-deficient mice consuming a normal diet. Front Cell Dev Biol. 2023 May 23; 11:1196684.
[13] Zhang H, Cui S, Jing Z, Fu G, Liu R, Zhao W, Xu L, Yu L, Bai Y, Lv C, Wu M, Wei Y, Li L, Peng S. LRRC8A is responsible for exosome biogenesis and volume regulation in colon cancer cells. Biochem J. 2023 May 17;480(9):701-713.
[12] 崔诗雨,张海峰*. 外泌体在新型冠状病毒感染和传播中的作用[J]. 基础医学与临床,2023,43(04):680-684.
[11] 张海峰,李春英,陈丽新,王立伟. ClC-3氯离子通道对高分化鼻咽癌细胞突起形成的影响[J]. 中国病理生理杂志,2023,39(01):1-8.
[10] 樊珍,王丽芳,王立伟,陈丽新,张海峰*. 原子力显微镜观察细胞膜水通道AQP-3分布[J]. 空军军医大学学报,2022(06):720-724.
[9] 经争辉,李春英,刘蓉,任俞华,崔诗雨,赵文宝,张海峰*. Clcn3 敲除对幼龄小鼠实质器官的影响[J]. 中国实验动物学报,2022,30( 3):326-332.
[8] Zhang H, Deng Z, Zhang D, Li H, Zhang L, Niu J, Zuo W, Fu R, Fan L, Ye JH, She J. High expression of leucine-rich repeat-containing 8A is indicative of a worse outcome of colon cancer patients by enhancing cancer cell growth and metastasis. Oncol Rep. 2018 Sep;40(3):1275-1286.
[7] Zhang H, Deng Z, Yang L, Luo H, Liu S, Li Y, Wei Y, Peng S, Zhu L, Wang L, Chen L. The AQP-3 water channel is a pivotal modulator of glycerol-induced chloride channel activation in nasopharyngeal carcinoma cells. Int J Biochem Cell Biol. 2016 Mar; 72:89-99.
[6] Zhang H, Li H, Liu E, Guang Y, Yang L, Mao J, Zhu L, Chen L, Wang L. The AQP-3 water channel and the ClC-3 chloride channel coordinate the hypotonicity-induced swelling volume in nasopharyngeal carcinoma cells. Int J Biochem Cell Biol. 2014 Dec; 57:96-107.
[5] Zhang H, Li H, Yang L, Deng Z, Luo H, Ye D, Bai Z, Zhu L, Ye W, Wang L, Chen L. The ClC-3 chloride channel associated with microtubules is a target of paclitaxel in its induced-apoptosis. Sci Rep. 2013; 3:2615.
[4] Zhang H, Zhu L, Zuo W, Luo H, Mao J, Ye D, Li Y, Liu S, Wei Y, Ye W, Chen L, Wang L. The ClC-3 chloride channel protein is a downstream target of cyclin D1 in nasopharyngeal carcinoma cells. Int J Biochem Cell Biol. 2013 Mar;45(3):672-83.
[3] Bai Z, Zhang H#, Zhu L, Zuo W, Ye J, Feng J, Wang L, Chen L. Lithium inhibits cell volume regulation by acting on chloride channels and modifies ultrastructures of the cell membrane in nasopharyngeal carcinoma cells. Eur J Pharmacol. 2010 Sep 1;641(2-3):88-95.
[2] 张海峰,柏志全,陈丽新,王立伟. 电压门控氯通道ClC蛋白突变体及相关疾病研究进展[J]. 基础医学与临床, 2010, 30(09):999-1001.
[1] 柏志全,张海峰#,陈丽新,朱林燕,左婉红,和树同,王立伟. 细胞周期蛋白D1重组质粒的构建及其在鼻咽癌细胞中的表达[J]. 南方医科大学学报, 2010, 30(02):202-205.