Basic Information



Zhihui Feng

Professor, Ph.D.


Center for Mitochondrial Biology and Medicine

Sochool of Life Science and Technology

Frontier Institute of Science and Technology

Xi'an Jiaotong University




Tel: 029-82665849


Address: Rm #304,

                School of Life Sci & Tech

                No. 28 West Xianning Rd, Xi'an

                710049, China.

Research Interests

  • Involvement of mitochondrial dysfunction in prenatal stress induced offspring cognitive decline and effects of nutritional intervention.


  • Mitochondrial dynamic regulation in obesity, diabetes, NALFD and other accociated metabolic syndromes.


  • Pathophysiological systemic regulation of organ homeostasis: the role of mitochondria.


  • Mitochondrial targeted therapeutic against metabolic and aging associated diseases.


2008-2012, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences,

                      Chinese Acadey of Sciences.

                      Ph.D. Majoring in Biochemistry and Molecular Biology

2006-2008, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences,

                      Chinese Acadey of Sciences.

                      Master Majoring in Biochemistry and Molecular Biology

2001-2005, Shandong University, Bachelor Majoring in Biology Science



2016-Present, School of Life Science and Technology / Frontier Institute of Science and Technology,

                          Xi'an Jiaotong University. Professor.

2012-2016,      Frontier Institute of Science and Technology,

                          Xi'an Jiaotong University. Associate Professor.

2015-2018,      UT Southwestern Medical Center, US. Posdoctoral Fellow.

Recent Articles

    Publications as Corresponding / First Author

    (# indicates corresponding authors / * indicates first authors)

    2010-2023 in reverse chronological order


  1. Xuan Zou, Mengqi Zeng, Yuan Zheng, Adi Zheng, Li Cui, Wenli Cao, Xueqiang Wang, Jiankang Liu, Jie Xu#, Zhihui Feng#. Comparative study of hydroxytyrosol acetate and hydroxytyrosol in activating Phase II enzymes. Antioxidants. 2023; 12(10): 1834. (IF: 7.0, #Corresponding Authors)
  2. Ke Cao, Jie Xu, Wenli Cao, Xueqiang Wang, Weiqiang Lv, Mengqi Zeng, Xuan Zou, Jiankang Liu#Zhihui Feng#. Assembly of mitochondrial succinate dehydrogenase in human health and disease. Free Radic Biol Med. 2023 Jul 23; 207: 247-259. (IF: 8.101, #Corresponding Authors)
  3. Xueqiang Wang, Xing Zhang, Ke Cao, Mengqi Zeng, Xuyang Fu, Adi Zheng, Feng Zhang, Feng Gao, Xuan Zou, Hao Li, Min Li, Weiqiang Lv, Jie Xu, Jiangang Long, Weijin Zang, Jinghai Chen, Feng Gao, Jian Ding#, Jiankang Liu#, Zhihui Feng#. Cardiac disruption of SDHAF4-mediated mitochondrial complex II assembly promotes dilated cardiomyopathy. Nature Communications. 2022 July 8; 13(1): 3947. (IF: 17.694, #Corresponding Authors)
  4. Xueqiang Wang, Weiqiang Lv, Jie Xu, Adi Zheng, Mengqi Zeng, Ke Cao, Xun Wang, Yuting Cui, Hao Li, Meng Yang, Yongping Shao, Fang Zhang, Xuan Zou, Jiangang Long, Zhihui Feng#, Jiankang Liu#. Hepatic Suppression of Mitochondrial Complex II Assembly Drives Systemic Metabolic Benefits. Advanced Science. 2022 Jan 17; 2105587. (IF: 17.521, #Corresponding Authors)
  5. Yuting Cui, Yue Xiong, Hua Li, Mengqi Zen, Yan Wang, Yuan Li, Xuan Zou, Weiqiang Lv, Jing Gao, Ruijun Cao, Lingjie Meng, Jiangang Long, Jiankang Liu#, Zhihui Feng#. Chalcone-Derived Nrf2 Activator Protects Cognitive Function via Maintaining Neuronal Redox Status. Antioxidants. 2021 Nov 15; 10(11): 1811. (IF: 7.675, #Corresponding Authors)
  6. Adi Zheng, Hao Li, Zhihui Feng#, Jiankang Liu#. Integrative Analyses Reveal Tstd1 as a Potential Modulator of HDL Cholesterol and Mitochondrial Function in Mice. Cells.2021 Nov 1; 10(11): 2976. (IF: 7.666, #Corresponding Authors)
  7. Cao, K.; Lv, W.; Wang, X.; Dong, S.; Liu, X.; Yang, T.; Xu, J.; Zeng, M.; Zou, X.; Zhao, D.; Ma, Q.; Ling, M.; Long, J.; Zang, W.; Gao, F.; Feng, Z.#; Liu, J.Hypermethylation of hepatic mitochondrial ND6 provokes systemic insulin resistance. Advanced Science. 2021 May 2; 8(11): 2004507. (IF: 17.521, #Corresponding Authors)
  8. Zeng, M.; Xu, J.; Zhang, Z.; Zou, X.; Wang, X.; Cao, K.; Lv, W.; Cui, Y.; Long, J.; Feng, Z.#; Liu, J.# Htd2 deficiency-associated suppression of α-lipoic acid production provokes mitochondrial dysfunction and insulin resistance in adipocytes. Redox Biology. 2021 May; 41: 101948. (IF: 10.787, #Corresponding Authors)

  9. Ke Cao, Weiqiang Lv, Shaoqin Hu, Jing Gao, Jiankang Liu,# and Zhihui Feng#. Punicalagin Activates AMPK/PGC-1α/Nrf2 Cascade in Mice: The Potential Protective Effect against Prenatal Stress. Mol Nutr Food Res. 2020 Jul; 64(14): e2000312. (IF: 6.575, #Corresponding Authors)

  10. Yuting Cui, Yuan Li, Na Huang, Yue Xiong, Ruijun Cao, Lingjie Meng, Jiankang Liu#Zhihui Feng#. Structure based modification of chalcone analogue activates Nrf2 in the T human retinal pigment epithelial cell line ARPE-19. Free Radic Biol Med. 2020 Feb 20; 148: 52-59. (IF: 8.101, #Corresponding Authors)

  11. Feng, Z.*; Zou, X.*; Chen, Y.; Wang, H.; Duan, Y.; Bruick, R. Modulation of HIF-2α PAS-B domain contributes to physiological responses. PNAS. 2018 Dec; 115(52): 13240-13245. (IF: 12.779, *First Authors)

  12. Li, Y.; Zou, X.; Gao, J.; Cao, K,; Feng, Z.#; Liu, J.# APR3 modulates oxidative stress and mitochondrial function in ARPE-19 cells. FASEB J. 2018 Nov; 32: 5851-5861. (IF: 5.834, #Corresponding Authors)

  13. Jie Xu, Ke Cao, Zhihui Feng#, Jiankang Liu#. Benefits of the soluble and insoluble fractions of bitter gourd in mice fed a high-fat diet. Journal of Functional Foods. 42 (2018) 216–223. (IF: 5.223, #Corresponding Authors)

  14. Hai‐Tao Yu, Xiao‐Yi Fu, Bing Liang, Shuang Wang, Jian‐Kang Liu, Shu‐Ran Wang#Zhi‐Hui Feng#. Oxidative damage of mitochondrial respiratory chain in different organs of a rat model of diet‐induced obesity. Eur J Nutr. 2018 Aug; 57(5): 1957-1967. (IF: 4.865, #Corresponding Authors)

  15. Jing Gao*, Zhihui Feng*, Xueqiang Wang, Mengqi Zeng, Jing Liu, Shujun Han, Jie Xu, Lei Chen, Ke Cao, Jiangang Long, Zongfang Li, Weili Shen and Jiankang Liu. SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress. Cell Death Differ. 2018 Feb; 25(2): 229-240. (IF: 12.067, *First Authors)

  16. Jie Xu, Xiaojie Wang, Ke Cao, Zhizhong Dong, Zhihui Feng# and Jiankang Liu#. Combination of β-glucan and Morus alba L. Leaf Extract Promotes Metabolic Benefits in Mice Fed a High-Fat Diet. Nutrients. 2017 Oct 12; 9(10): 1110. (IF: 6.706, #Corresponding Authors)

  17. Xun Wang*, Zhihui Feng*, Xueqiang Wang, Liang Yang, Shujun Han, Ke Cao, Jie Xu, Lin Zhao, Yong Zhang, Jiankang Liu. O-GlcNAcase deficiency suppresses skeletal myogenesis and insulin sensitivity in mice through the modulation of mitochondrial homeostasis. Diabetologia. 2016 Jun; 59(6): 1287-96. (IF: 10.460, *First Authors) 

  18. Chunhong Yan, Wenyan Sun, Xun Wang, Jiangang Long, Xuebo Liu, Zhihui Feng# and Jiankang Liu#. Punicalagin attenuates palmitate-induced lipotoxicity in HepG2 cells by activating the Keap1-Nrf2 antioxidant defense system. Mol Nutr Food Res. 2016 May; 60(5): 1139-49. (IF: 6.575, #Corresponding Authors)

  19. Gao, J.; Zou, X.; Yang, L.; Feng, Z.#; Liu, J.# Hydroxytyrosol protects against acrolein induced preosteoblast cell toxicity: Involvement of Nrf2/Keap1 pathway. J Funct Foods. 2015 Dec; 19: 28-38. (IF: 5.223, #Corresponding Authors)

  20. Ke Cao, Jie Xu, Wenjun Pu, Zhizhong Dong, Lei Sun, Weijin Zang, Feng Gao, Yong Zhang, Zhihui Feng# & Jiankang Liu#. Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation. Sci Rep. 2015 Sep 15; 5: 14014. (IF: 4.996, #Corresponding Authors)

  21. Adi Zheng, Hao Li, Jie Xu, Ke Cao, Hua Li, Wenjun Pu, Ziqi Yang, Yunhua Peng, Jiangang Long, Jiankang Liu# and Zhihui Feng#. Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation. Br J Nutr. 2015 Jun 14; 113(11): 1667-76. (IF: 4.125, #Corresponding Authors)

  22. Zheng, A.; Li, H.; Cao, K.; Xu, J.; Zou, X.; Li, Y.; Chen, C.; Liu, J.; Feng, Z.# Maternal hydroxytyrosol administration improves neurogenesis and cognitive function in prenatally stressed offspring. J Nutr Biochem. 2015 Feb; 26(2): 190-9. (IF: 6.117, #Corresponding Authors)

  23. Wang, X.; Li, H.; Zheng, A.; Yang, L.; Liu, J.; Chen, C.; Tang, Y.; Zou, X.; Li, Y.; Long, J.; Liu, J.; Zhang, Y.#Feng, Z.# Mitochondrial dysfunction-associated OPA1 cleavage contributes to muscle degeneration: preventative effect of hydroxytyrosol acetate. Cell Death Dis. 2014 Nov 13; 5: e1521. (IF: 9.685, #Corresponding Authors)

  24. Zou, X.; Yan, C.; Shi, Y.; Cao, K.; Xu, J.; Wang, X.; Chen, C.; Luo, C.; Li, Y.; Gao, J.; Pang, W.; Zhao, J.; Zhao, F.; Li, H.; Zheng, A.; Sun, W.; Long, J.; Szeto, IM.; Zhao, Y.; Dong, Z.; Zhang, P.; Wang, J.; Lu, W.; Zhang, Y.; Liu, J.#Feng, Z.# Mitochondrial dysfunction in obesity associated non-alcoholic fatty liver disease: The protective effects of pomegranate with its active component punicalagin. Antioxid Redox Signal. 2014 Oct 10; 21(11): 1557-70. (IF: 7.468, #Corresponding Authors) 

  25. Cao, K.; Zhang, A.; Xu, J.; Li, H.; Liu, J.; Peng, Y.; Long, J.; Zou, X.; Li, Y.; Chen, C.; Liu, J.; Feng, Z.# AMPK activation prevents prenatal stress-induced cognitive impairment: modulation of mitochondrial content and oxidative stress. Free Radic Biol Med. 2014 Oct; 75: 156-66. (IF: 8.101, #Corresponding Authors) 

  26. Zhao L, Zou X, Feng Z#, Luo C, Liu J, Li H, Chang L, Wang H, Li Y, Long J, Gao F#, Liu J. Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats. Exp Gerontol. 2014 Aug; 56: 3-12. (IF: 4.253, #Corresponding Authors) 

  27. Chen, C.; Han, X.; Zou, X.; Li, Y.; Yang, L.; Cao, K.; Xu, J.; Long, J.; Liu, J.; Feng, Z.# 4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid (C75), an inhibitor of fatty-acid synthase, suppresses the mitochondrial fatty acid synthesis pathway and impairs mitochondrial function. J Biol Chem. 2014 Jun 13; 289(24): 17184-94. (IF: 5.486, #Corresponding Authors) 

  28. Zou, X.; Gao, J.; Zheng, Y.; Wang, X.; Chen, C.; Cao, K.; Xu, J.; Li, Y.; Lu, W.; Liu, J.; Feng, Z.# Zeaxanthin induces Nrf2-mediated phase II enzymes in protection of cell death. Cell Death Dis. 2014 May 8; 5: e1218. (IF: 9.685, #Corresponding Authors) 

  29. Xu, J.; Cao, K.; Li, Y.; Zou, X.; Chen, C.; Szeto IM.; Dong, Z.; Zhao, Y.; Shi, Y.; Wang, J.; Liu, J.#Feng, Z.# Bitter gourd inhibits the development of obesity-associated fatty liver in C57BL/6mice fed a high-fat diet. Journal of Nutrition. 2014 Apr; 144(4): 475-83. (IF: 4.687, #Corresponding Authors) 

  30. Cao, K.; Xu, J.; Zou, X.; Li, Y.; Chen, C.; Zheng, A.; Li, H.; Li, H.; Man-Yau Szeto I.; Shi, Y.; Long, J.; Liu, J.#Feng, Z.# Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice. Free Radic Biol Med. 2014 Feb; 67: 396-407. (IF: 8.101, #Corresponding Authors) 

  31. Zhao, L.; Feng, Z.#; Zou, X.; Cao, K.; Xu, J.; Liu, J.# Aging leads to elevation of O-GlcNAcylation and disruption of mitochondrial homeostasis in retina. Oxid Med Cell Longev. 2014; 2014: 425705. (IF: 7.310, #Corresponding Authors) 

  32. Li, Y.; Zou, X.; Cao, K.; Xu, J.; Yue, T.; Dai, F.; Zhou, B.; Lu, W.; Feng, Z.#; Liu, J.# Curcumin analog 1, 5-bis (2-trifluoromethylphenyl)-1, 4-pentadien-3-one exhibits enhanced ability on Nrf2 activation and protection against acrolein-induced ARPE-19 cell toxicity. Toxicol Appl Pharmacol. 2013 Nov 1; 272(3): 726-35. (IF: 4.460, #Corresponding Authors) 

  33. Jiong Yan*, Zhihui Feng*, Jia Liua, Weili Shenc, Ying Wangd, Karin Wertzd, Peter Weberd, Jiangang Longa, Jiankang Liu. Enhanced autophagy plays a cardinal role in mitochondrial dysfunction in type 2 diabetic Goto–Kakizaki (GK) rats: ameliorating effects of (−)-epigallocatechin-3-gallate. J Nutr Biochem. 2012 Jul; 23(7): 716-24. (IF: 6.117, *First Authors)

  34. Feng, Z.*; Zou, X.*; Jia, H.; Li, X.; Zhu, Z.; Liu, X.; Bucheli, P.; Ballevre, O.; Hou, Y.; Zhang, W.; Wang, J.; Chen, Y.; Liu, J. Maternal docosahexaenoic acid feeding protects against impairment of learning and memory and oxidative stress in prenatally stressed rats: possible role of neuronal mitochondria metabolism. Antioxid Redox Signal. 2012 Feb 1; 16(3): 275-89. (IF: 7.468, *First Authors)

  35. Zhihui Feng*, Liyuan Bai*, Jiong Yan, Yuan Li, Weili Shen, Ying Wang, Karin Wertz, Peter Weber, Yong Zhang, Yan Chen, Jiankang Liu. Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and mitochondrial dysfunction: Regulatory effects of hydroxytyrosol. Free Radic Biol Med. 2011 May 15; 50(10): 1437-46. (IF: 8.101, *First Authors)

  36. Zhihui Feng*, Zhongbo Liu, Xuesen Li, Haiqun Jia, Lijuan Sun, Chuan Tian, Lihong Jia, Jiankang Liu. α-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells. J Nutr Biochem. 2010 Dec; 21(12): 1222-31. (IF: 6.117, *First Authors)

  37. Zhihui Feng*, Haiqun Jia, Xuesen Li, Zhuanli Bai, Zhongbo Liu, Lijuan Sun, Zhongliang Zhu, Peter Bucheli, Olivier Ballèvre, Junkuan Wang, Jiankang Liu. A milk-based wolfberry preparation prevents prenatal stress-induced cognitive impairment of offspring rats, and inhibits oxidative damage and mitochondrial dysfunction in vitro. Neurochem Res. 2010 May; 35(5): 702-11. (IF: 4.414, *First Authors)



    Other Publications as Co-Author

    2008-2023 in reverse chronological order


  1. Yue Xiong, Jie Xu, Wenli Cao, Jiawei Zhang, Zhihui Feng, Ke Cao*, Jiankang Liu*. Hydroxytyrosol improves strenuous exercise-associated cardiac pathological changes viamodulation of mitochondrial homeostasis. Food & Function. 2022 Jul 29. Online ahead of print. (IF: 6.317) 
  2. Jie Xu, Ke Cao, Xuyun Liu, Lin Zhao, Zhihui Feng, Jiankang Liu*. Punicalagin Regulates Signaling Pathways in Inflammation-Associated Chronic Diseases. Antioxidants. 2021 Dec 24;11(1):29. (IF: 7.675) 
  3. Cao K, Feng Z, Gao F, Zang W, Liu J*. Mitoepigenetics: An intriguing regulatory layer in aging and metabolic-related diseases. Free Radic Biol Med. 2021 Dec;177: 337-346. (IF: 8.101)
  4. Dong SS, Zhu DL, Zhou XR, Rong Y, Zeng M, Chen JB, Jiang F, Tuo XM, Feng Z, Yang TL, Guo Y*. An Intronic Risk SNP rs12454712 for Central Obesity Acts As an Allele-Specific Enhancer To Regulate BCL2 Expression. Diabetes. 2021 Aug; 70(8): 1679-1688. (IF: 9.337)
  5. Fan Y, Wang J, Feng Z, Cao K, Xu H, Liu J. Pinitol attenuates LPS-induced pneumonia in experimental animals: Possible role via inhibition of the TLR-4 and NF-κB/IκBα signaling cascade pathway. J Biochem Mol Toxicol. 2021 Jan; 35(1): e22622. (IF: 3.568)
  6. Wang YJ, Liu MG, Wang JH, Cao W, Wu C, Wang ZY, Liu L, Yang F, Feng ZH, Sun L, Zhang F, Shen Y, Zhou YD, Zhuo M, Luo JH, Xu TL, Li XY. Restoration of Cingulate Long-Term Depression by Enhancing Non-apoptotic Caspase 3 Alleviates Peripheral Pain Hypersensitivity. Cell Rep. 2020 Nov 10; 33(6): 108369. (IF: 9.995)
  7. Liu R, Chen L, Wang Y, Zhang G, Cheng Y, Feng Z, Bai X, Liu J*. High ratio of ω-3/ω-6 polyunsaturated fatty acids targets mTORC1 to prevent high-fat diet-induced metabolic syndrome and mitochondrial dysfunction in mice. J Nutr Biochem. 2020 May; 79: 108330. (IF: 6.117)
  8. Cao K, Lv W, Liu X, Fan Y, Wang K, Feng Z, Liu J, Zang W, Xing L, Liu J*. Herba Houttuyniae Extract Benefits Hyperlipidemic Mice via Activation of the AMPK/PGC-1α/Nrf2 Cascade. Nutrients. 2020 Jan 7; 12(1): 164. (IF: 6.706)
  9. Liu X, Cao K, Lv W, Feng Z, Liu J, Gao J, Li H, Zang W, Liu J*. Punicalagin attenuates endothelial dysfunction by activating FoxO1, a pivotal regulating switch of mitochondrial biogenesis. Free Radic Biol Med. 2019 May 1; 135: 251-260. (IF: 8.101)
  10. Wang YJ, Zuo ZX, Wu C, Liu L, Feng ZH, Li XY. Cingulate Alpha-2A Adrenoceptors Mediate the Effects of Clonidine on Spontaneous Pain Induced by Peripheral Nerve Injury. Front Mol Neurosci. 2017 Sep 12; 10: 289. (IF: 6.261)
  11. Wang YJ, Zuo ZX, Zhang M, Feng ZH, Yan M, Li XY. The Analgesic Effects of (5R,6R)6-(3-Propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo [3.2.1] Octane on a Mouse Model of Neuropathic Pain. Anesth Analg. 2017 Apr; 124(4): 1330-1338. (IF: 6.627)
  12. Zhao L, Feng Z, Yang X, Liu J. The regulatory roles of O-GlcNAcylation in mitochondrial homeostasis and metabolic syndrome. Free Radic Res2016 Oct; 50(10): 1080-1088. (IF: 4.354)
  13. Zhao F, Pang W, Zhang Z, Zhao J, Wang X, Liu Y, Wang X, Feng Z, Zhang Y, Sun W, Liu J. Pomegranate extract and exercise provide additive benefits on improvement of immune function by inhibiting inflammation and oxidative stress in high-fat-diet-induced obesity in rats. J Nutr Biochem2016 Jun; 32: 20-8. (IF: 6.117)
  14. Hou C, Wang Y, Zhu E, Yan C, Zhao L, Wang X, Qiu Y, Shen H, Sun X, Feng Z, Liu J, Long J. Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer. Biochem Pharmacol. 2016 Mar 1; 103: 85-97. (IF: 6.100)
  15. Zhao L, Liu Z, Jia H, Feng Z, Liu J, Li X. Lipoamide Acts as an Indirect Antioxidant by Simultaneously Stimulating Mitochondrial Biogenesis and Phase II Antioxidant Enzyme Systems in ARPE-19 Cells. PLoS One. 2015 Jun 1; 10(6): e0128502. (IF: 3.752)
  16. Zuo ZX, Wang YJ, Liu L, Wang Y, Mei SH, Feng ZH, Wang M, Li XY. Huperzine A Alleviates Mechanical Allodynia but Not Spontaneous Pain via Muscarinic Acetylcholine Receptors in Mice. Neural Plast. 2015; 2015: 453170. (IF: 3.144)
  17. Chen C, Hyun TK, Han X, Feng Z, Li Y, Liu X, Liu J*. Coexpression within Integrated Mitochondrial Pathways Reveals Different Networks in Normal and Chemically Treated Transcriptomes. Int J Genomics. 2014; 2014: 452891. (IF: 2.758)
  18. Liu J, Tang Y, Feng Z, Hou C, Wang H, Yan J, Liu J, Shen W, Zang W, Liu J, Long J. Acetylated FoxO1 mediates high-glucose induced autophagy in H9c2 cardiomyoblasts: Regulation by a polyphenol -(-)-epigallocatechin-3-gallate. Metabolism. 2014 Oct; 63(10): 1314-23. (IF: 13.934)
  19. Sun W, Zheng Y, Lu Z, Wang H, Feng Z, Wang J, Xiao S, Liu F, Liu J*. LL-37 attenuates inflammatory impairment via mTOR signaling-dependent mitochondrial protection. Int J Biochem Cell Biol2014 Sep; 54: 26-35. (IF: 5.652)
  20. Liu J, Peng Y, Feng Z, Shi W, Qu L, Li Y, Liu J, Long J*. Reloading functionally ameliorates disuse-induced muscle atrophy by reversing mitochondrial dysfunction, and similar benefits are gained by administering a combination of mitochondrial nutrients. Free Radic Biol Med2014 Apr; 69: 116-28. (IF: 8.101)
  21. Jiang HK, Wang YH, Sun L, He X, Zhao M, Feng ZH, Yu XJ, Zang WJ*. Aerobic interval training attenuates mitochondrial dysfunction in rats post-myocardial infarction: roles of mitochondrial network dynamics. Int J Mol Sci. 2014 Mar 26; 15(4): 5304-22. (IF: 6.208)
  22. Jiang HK, Miao Y, Wang YH, Zhao M, Feng ZH, Yu XJ, Liu JK, Zang WJ*. Aerobic interval training protects against myocardial infarction-induced oxidative injury by enhancing antioxidase system and mitochondrial biosynthesis. Clin Exp Pharmacol Physiol. 2014 Mar; 41(3): 192-201. (IF: 2.963)
  23. Zheng A, Li H, Wang X, Feng Z, Xu J, Cao K, Zhou B, Wu J, Liu J*. Anticancer Effect of a Curcumin Derivative B63: ROS Production and Mitochondrial Dysfunction. Curr Cancer Drug Targets2014; 14(2): 156-66. (IF: 2.907)
  24. Li H, Kong Y*, Chang L, Feng Z, Chang N, Liu J, Long J*. Determination of Lipoic Acid in Biological Samples with Acetonitrile–Salt Stacking Method in CE. Chromatographia. 2014 Jan; 77, 145–150. (IF: 2.213)
  25. Luo C, Li Y, Wang H, Cui Y, Feng Z, Li H, Li Y, Wang Y, Wurtz K, Weber P, Long J*, Liu J*. Hydroxytyrosol Promotes Superoxide Production and Defects in Autophagy Leading to Anti-proliferation and Apoptosis on Human Prostate Cancer Cells. Curr Cancer Drug Targets2013 Jul; 13(6): 625-39. (IF: 2.907)
  26. Luo C, Li Y, Zhou B, Yang L, Li H, Feng Z, Li Y, Long J*, Liu J*. A monocarbonyl analogue of curcumin, 1,5-bis(3-hydroxyphenyl)-1,4-pentadiene-3-one (Ca 37), exhibits potent growth suppressive activity and enhances the inhibitory effect of curcumin on human prostate cancer cells. Apoptosis. 2014 Mar; 19(3): 542-53. (IF: 5.561)
  27. Luo C, Li Y, Yang L, Feng Z, Li Y, Long J*, Liu J*. A cigarette component acrolein induces accelerated senescence in human diploid fibroblast IMR-90 cells. Biogerontology. 2013 Oct; 14(5): 503-11. (IF: 4.284)
  28. Luo C, Li Y, Wang H, Feng Z, Li Y, Long J, Liu J*. Mitochondrial accumulation under oxidative stress is due to defects in autophagy. J Cell Biol. 2013 Jan; 114(1): 212-9. (IF: 4.480)
  29. Chen YM, Liu ZQ, Feng ZH, Xu F, Liu JK. Adhesive protein-free synthetic hydrogels for retinal pigment epithelium cell culture with low ROS level. J Biomed Mater Res A. 2014 Jul; 102(7): 2258-67. (IF: 4.854)
  30. Qu X, Shen L, Zheng Y, Cui Y, Feng Z, Liu F*, Liu J*. A Signal Transduction Pathway from TGF-beta1 to SKP2 via Akt1 and c-Myc and its Correlation with Progression in Human Melanoma. J Invest Dermatol. 2014 Jan; 134(1): 159-167. (IF: 7.590)
  31. Zou X, Feng Z, Li Y, Wang Y, Wertz K, Weber P, Fu Y, Liu J*. Prevention of oxidative stress-induced cell apoptosis by hydroxytyrosol in human retinal pigment epithelial cells: Activation of Nrf2, JNK and p62/SQSTM1 pathways. J Nutr Biochem. 2012; 23: 994-1006. (IF: 6.117)
  32. Shen W, Hao J, Feng Z, Tian C, Chen W, Packer L, Shi X, Zang W, Liu J. Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway. Br J Pharmacol. 2011 Mar; 162(5): 1213-24. (IF: 9.473)
  33. Zhu L, Liu Z, Feng Z, Hao J, Shen W, Li X, Sun L, Sharman E, Wang Y, Wertz K, Weber P, Shi X, Liu J*.Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells. J Nutr Biochem. 2010 Nov; 21(11): 1089-98. (IF: 6.117)
  34. Hao J, Shen W, Yu G, Jia H, Li X, Feng Z, Wang Y, Weber P, Wertz K, Sharman E, Liu J*. Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes. J Nutr Biochem. 2010 Jul ;21(7): 634-44(IF: 6.117)
  35. Jia H, Liu Z, Li X, Feng Z, Hao J, Li X, Shen W, Zhang H, Liu J*. Synergistic anti-Parkinsonism activity of high doses of B vitamins in a chronic cellular model. Neurobiol Aging. 2010 Apr; 31(4): 636-46. (IF: 5.133)
  36. Cai X, Jia H, Liu Z, Hou B, Luo C, Feng Z, Li W, Liu J*. Polyhydroxylated fullerene derivative C(60)(OH)(24) prevents mitochondrial dysfunction and oxidative damage in an MPP(+) -induced cellular model of Parkinson's disease. J Neurosci Res2008 Dec; 86(16): 3622-34. (IF: 4.433)
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