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Email: Yurong.Wen@xjtu.edu.cn
工作经历：
2019- 至今 西安交通大学医学部 教授、 研究员/博士生导师
2018-2019 加拿大阿尔伯塔大学 访问学者/博士后
2017-2019 西安交通大学生命学院 副教授/硕士生导师
2017 清华大学生命学院 访问学者
2014-2017 西安交通大学生命学院 讲师
学习经历：
2010-2014 比利时根特大学 生物化学与生物技术博士
2008-2010 西安交通大学医学部 生物化学与分子生物学硕士
2004-2008 西安交通大学生命学院 生物工程学士
(27) Yucheng Guo#, Zhenlin Ouyang#, Wenbo He, Qian Qin, Jiaxin Zhang, Ting Yu, Min Jiao, Peter M. Hwang, Fang Zheng*, Serge Muyldermans,*, Yurong Wen*. (2026) Mechanistic diversity of Bacteroides fragilis toxins and neutralization with single domain antibody. Cell Chemical Biology. 33(1), 102–116. (Cell子刊，IF: 9.0, 通讯作者)
(26) Wenbo He#, Zhenlin Ouyang#, Jiaxin Zhang, Xiaolong Guo, Min Jiao, Qian Qin, Xiaoyu He, Li Kang, Peter M. Hwang, Fang Zheng, Guangjian Zhang*, Yurong Wen*. (2025) Structural and mechanistic insights into the transcriptional regulation of chromosomal T6SS by large conjugative plasmid-encoded TetRs in Acinetobacter baumannii. Nucleic Acids Research. 53(14). gkaf755 （IF:16.8，通讯作者）
(25) Min Jiao, Wenbo He, Zhenlin Ouyang, Qinyue Yu, Jiaxin Zhang, Qian Qin, Ruochen Wang, Xiaolong Guo, Ruihan Liu, Xiaoyu He, Peter M. Hwang, Fang Zheng, Yurong Wen*. (2025) Molybdate uptake interplay with ROS tolerance modulates bacterial pathogenesis. Science Advances. 11(3):eadq9686 (Science 子刊，IF: 12.5，通讯作者)
(24) Zhenlin Ouyang #, Wenbo He #, Di Wu, Hao An, Lei Duan, Min Jiao, Xiaoyu He, Qinyue Yu, Jiaxin Zhang, Qian Qin, Ruochen Wang, Fang Zheng, Peter M Hwang, Xiaoting Hua, Li Zhu*, Yurong Wen*. (2025) Cryo-EM structure and complementary drug efflux activity othe Acinetobacter baumannii multidrug efflux pump AdeG. Structure. 2025, 33: 539-551. (Cell 子刊，通讯作者)
(23) Shiqi Jiang#, Xinru Lv#, Zhenlin Ouyang#, Hongli Chi, Yuchen Zeng, Yani Wang, Jiaxuan He, Jinling Chen, Jingyi Chen, Keli An, Ming Cheng, Yurong Wen*, Juan Li*, Penghui Zhang*. (2024) Programmable Circular Multivalent Nanobody-Targeting Chimeras (mNbTACs) for Multireceptor Mediated Protein Degradation and Targeted Drug Delivery. Angew. Chem. Int. Ed. 2024, 63. e202407986. (IF: 16.6, 通讯作者)
(22) Ting Yu#, Fang Zheng#, Wenbo He, Serge Muyldermans, Yurong Wen*. (2024) Single Domain Antibody: Development and Application in Biotechnology and Biopharma. Immunological Reviews. 328: 98-112. (IF: 10.7, 通讯作者)
(21) Dazhou Cheng, Zhenlin Ouyang, Xiaoyu He, Yusuke Nasu, Yurong Wen, Takuya Terai*, and Robert E. Campbell*. (2024) High-Performance Chemigenetic Potassium Ion Indicator. Journal of the American Chemical Society.146. 35117-35128. (IF: 15.4)
(20) Wenbo He #, Ke Wu #, Zhenlin Ouyang, Yixin Bai, Wen Luo, Di Wu, Hao An, Yucheng Guo, Min Jiao, Qian Qin, Jiaxin Zhang, Yi Wu, Junjun She, Peter M. Hwang, Fang Zheng, Li Zhu*, Yurong Wen*. (2023) Structure and Assembly of Type VI secretion system cargo delivery vehicle. Cell Reports. 42. 112781. (Cell 子刊,IF: 9.995, 通讯作者)
(19) Min Jiao, Wenbo He, Zhenlin Ouyang, Qian Qin, Yucheng Guo, Jiaxin Zhang, Yixin Bai, Xiaolong Guo, Qinyue Yu, Junjun She, Peter M. Hwang, Fang Zheng, Yurong Wen*. (2023) Mechanistic and Structural insights into the bifunctional enzyme PaaY from Acinetobacter baumannii. Structure. 31. 935-947. (Cell 子刊，通讯作者)
(18) Yi Shen*, Yurong Wen, Silvia Sposini, Anjali Amrapali Vishwanath, Ahmed S. Abdelfattah, Eric R. Schreiter, M. Joanne Lemieux, Jaime de Juan-Sanz, David Perrais, Robert E. Campbell*. (2023). Rational Engineering of an Improved Genetically Encoded pH Sensor Based on Superecliptic pHluorin. ACS Sensors. 8. 3014-3022. (IF: 8.9)
(17) Yucheng Guo†, Zhenlin Ouyang†, Wenbo He, Jiaxin Zhang, Qian Qin, Min Jiao, Serge Muyldermans, Fang Zheng*, Yurong Wen*. (2023) Screening and Epitope Characterization of Diagnostic Nanobody against Total and Activated Bacteroides fragilis Toxin. Frontiers in Immunology. 14: 1065274. (IF: 8.786, 通讯作者)
(16) Sheng-Yi Wu, Yurong Wen, Nelson B. C. Serre, Cathrine Charlotte Heiede Laursen, Andrea Grostøl Dietz, Brian R. Taylor, Mikhail Drobizhev, Rosana S. Molina, Abhi Aggarwal, Vladimir Rancic, Michael Becker, Klaus Ballanyi, Kaspar Podgorski, Hajime Hirase, Maiken Nedergaard, Matya´sˇ Fendrych, M. Joanne Lemieux, Daniel F. Eberl1, Alan R. Kay, Robert E. Campbell*, Yi Shen*. (2022) A sensitive and specific genetically encoded potassium ion biosensor for in vivo applications across the tree of life. Plos Biology. 20(9):e3001772. (IF: 9.65)
(15) Qian Qin, Hao Liu, Wenbo He, Yucheng Guo, Jiaxin Zhang, Junjun She, Fang Zheng, Sicai Zhang, Serge Muyldermans, Yurong Wen*. (2022) Single Domain Antibody application in Bacterial Infection Diagnosis and Neutralization. Front. Immunol. 13:1014377. (IF: 8.786, 通讯作者)
(14) Yunhua Peng, Jing Liu, Zhen Wang, Chunping Cui, Tiantian Zhang, Shuangxi Zhang, Peipei Gao, Zhanwu Hou, Huadong Liu, Jianping Gao, Jinfang Zhang, Yurong Wen, Wenyi Wei, Lingqiang Zhang, Jiankang Liu, Jiangang Long. (2022) Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc. Cell Death & Differentiation.29:1730-1743. (IF: 15.8)
(13) Yusuke Nasu, Ciaran Murphy-Royal, Yurong Wen, Jordan Haidey, Anne Schohl, Marion R. Van Horn, M. Rosana S. Molina, Abhi Aggarwal, Shuce Zhang, Yuki Kamijo, Kaspar Podgorski, Mikhail Drobizhev, Edward S. Ruthazer, Jaideep S. Bains, M. Joanne Lemieux, Grant R. Gordon, Robert E. Campbell*. (2021) A genetically encoded fluorescent biosensor for extracellular L-lactate. Nature Communications. 12: 7058. (IF: 14.9, Nature 子刊)
(12) Zhe Zhi, Zhenlin Ouyang, Yibo Ren, Ying Cheng, Peijun Liu , Yurong Wen and Yongping Shao. (2022) Non-canonical phosphorylation of Bmf by p38 MAPK promotes its apoptotic activity in anoikis. Cell Death & Differentiation. 29: 323-336. (IF: 15.8)
(11) Xiaocen Lu, Yurong Wen#, Shuce Zhang#, Wei Zhang, Yilun Chen, Yi Shen, M. Joanne Lemieux, Robert E. Campbell. (2021) Photocleavable Proteins that Undergo Fast and Efficient Dissociation. Chemical Science.12: 9658-9672. (IF: 9.8, # Contributed Equally, Chemical Science HOT article)
(10) Zhenlin Ouyang#, Fang Zheng#, Li Zhu#, Jan Felix, Di Wu, Ke Wu, Irina Gutsche, Yi Wu, Peter M Hwang, Junjun She*, Yurong Wen*.（2021）Proteolysis and multimerization regulate signaling along the two-component regulatory system AdeRS. iScience. 24(5): 102476. (Cell子刊, 通讯作者)
(9) Yufeng Zhao, Yi Shen, Yurong Wen*, and R.E. Campbell*. (2020) High performance intensiometric direct- and inverse-response genetically encoded biosensors for citrate. ACS Central Science. 6. 1441-1450. (IF: 18.7, 通讯作者)
(8) Yibo Ren, Zhenlin Ouyang, Zhanwu Hou, Yuwei Yan, Zhe Zhi, Mengjin Shi, Mengtao Du, Huadong Liu, Yurong Wen*, Yongping Shao*. (2020) CIC is a mediator of the ERK1/2-DUSP6 negative feedback loop. iScience. 23(11): 101635. (Cell 子刊, 通讯作者)
(7) Zhenlin Ouyang#, Fang Zheng#, Yingmei Pei, Jinhong Zhou, Keqing Wen, Miao Han, Peter M. Hwang, M. Joanne Lemieux, Yurong Wen*. (2019) Deciphering the activation and recognition mechanisms of Staphylococcus aureus response regulator ArlR. Nucleic Acids Research. 47(21):11418-11429.（IF: 16.96, 通讯作者）
(6) Zhenlin Ouyang, Jan Felix, Jinhong Zhou, Yingmei Pei, Peter M Hwang, M Joanne Lemieux, Irina Gutsche, Fang Zheng, Yurong Wen*. (2020) Trimeric structure of Kupffer cell C-type lectin receptor Clec4f. FEBS Letters. 594 (1):189-198（通讯作者）
(5) Yurong Wen#,*, Zhenlin Ouyang#, Yue Yu, Xiaorong Zhou, Yingmei Pei, Bart Devreese, Paul G Higgins, Fang Zheng* (2017). Mechanistic insight into how multidrug resistance Acinetobacter baumannii response regulator AdeR recognize its promoter DNA. Nucleic Acids Research.45(16): 9773-9787. (IF: 16.96, 第一兼通讯作者)
(4) Yurong Wen, Ester Behiels, Jan Felix, Jonathan Elegheert, Bjorn Vergauwen, Bart Devreese*, Savvas Savvides*. (2014). The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence. Nucleic Acids Research. 42(15): 10134-47.(IF: 16.96,第一作者)
(3) Yurong Wen#,*, Zhenlin Ouyang#, Bart Devreese, Wangxiao He, Yongping Shao, Wuyuan Lu, Fang Zheng* (2017). Crystal structure of master biofilm regulator CsgD regulatory domain reveals an atypical receiver domain. Protein Science. 26: 2073-2082. (第一兼通讯作者)
(2) Johan Desmet#, Kenneth Verstraete#, Yehudi Bloch, Eric Lorent, Yurong Wen, Bart Devreese, Karen Vandenbroucke, Stefan Loverix, Thore Hettmann, Sabrina Deroo, Klaartje Somers, Paula Henderikx, Ignace Lasters*, Savvas Savvides*. (2014) Structural basis of IL-23 antagonism by an AlphabodyTMprotein scaffold. Nature Communications. 5: 5237. (IF: 12.4)
(1) Jan Felix, Jonathan Elegheert, Irina Gutsche, Alexander V Shkumatov, Yurong Wen, Nathalie Bracke, Erwin Pannecoucke, Isabel Vandenberghe, Bart Devreese, Dmitri I Svergun, Ewald Pauwels, Bjorn Vergauwen, Savvas N Savvides. (2013). Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor. Structure, 21, 528–539.
