许林峰 

博士  教授  博士生导师

西安交通大学 电信学部

国家医学攻关产教融合创新平台

西安交通大学 青年拔尖学者A类

海外引才、三秦英才青年、西安市高层次人才

Prof. Linfeng Xu, Ph.D.

Faculty of Electronic and Information Engineering

Xi'an Jiaotong University

邮箱：

xu.linfeng@xjtu.edu.cn

xu.linfeng at outlook.com

许林峰，教授，博导，主持并承担国家重点研发计划“基础科研条件与重大科学仪器设备研发”重点专项、国自然面上项目、中央引导地方专项等多个国家、省级项目，入选国家海外引才、陕西省三秦引才、西安市高层次人才、校青拔A类等人才项目，总经费超千万。获得多个美国专利，并转化初创公司（完成C轮融资），相关成果发表在Nature Communications、Advanced Materials、Nature Methods、Lab Chip等(Google Scholar)。实验室针对生化、医学等领域的实际问题，开展学科交叉，从事“硬件研发”（微流控、质谱、光学等仪器的研发、构建与自动化控制）与“软件开发“（大数据算法、多组学数据分析），课题组经费充足，科研及转化经验丰富，尊重并支持个人兴趣与未来发展，期待电子、自动化、计算机等工程学科和生化、医学等多学科学生、博后、实验人员、教师等优秀人才联系加入！

We are looking to recruit creative, idea-generating, and self-driven researchers. Our laboratory offers exceptional training across multiple disciplines, which is ideal for individuals who aspire to establish independent, research-focused careers in academia or industry. We adhere to a philosophy that advocates conducting top-notch scientific research by developing tools and methodologies to address critical biological inquiries that have significant real-world applications, using data produced within our lab. If you are enthusiastic about acquiring the mindset of a principal investigator, taking intellectual risks, and exploring uncharted territories in order to make significant advancements in knowledge and technology, we warmly encourage you to apply.

Research Interest

• Novel engineering tools based on MICROFLUIDICS for biochemistry applications.

• Handling a small volume of liquids at high precision and throughput is fundamental to large-scale biochemistry screening experiments. Our lab is skilled in micropump design & integration for POC, micro-droplet manipulation either passively by structure or actively by electrical force, handling of various syringe pumps, thermal control for PCR, blood separation & micro-magnetic particle-based immunoassay and cell culture through microfluidic devices.

• Exploring metabolism at the single-cell level

• We initiated and developed the workflow and new analysis method for single-cell metabolites study employing droplet printing and MALDI-MS imaging to solve directed evolution issues in synthetic biology and multimodal omics study at the single-cell level.

• Spatial Multimodal Omics

• Continuing our interest in mass spectrometry and droplet microfluidics, we further developed my method for brain tissues at spatial and multimodal omics level to study how the plaque caused by Alzheimer’s disease interfere with neighboring cells.

Lab: Chuangxingang Campus

School of Automation Science and Engineering

Xi'an Jiaotong University

Email: xu.linfeng@xjtu.edu.cn

          xu.linfeng at outlook.com

自主研发融合前沿生物技术、光学、电场控制、激光质谱及液滴微流控等的自动化装置，结合数据挖掘与分析算法实现了合成生物学蛋白酶的高通量定向进化

工业及学术科研经历

APPOINTMENTS

响应国家“健康中国、精准医疗”等国家战略，针对医疗千亿级市场研发具有自主知识产权的新型仪器系统与方法，促进国内产业升级发展，支撑创新驱动发展战略实施：

• 基于微流控微液滴技术的新型超高通量生化医学基础工具

• 基于微流控芯片常用硅胶材料自身的储气及透气特性，研发了流速可控且稳定的被动式微流泵，揭示了材料自身透气性质对微量样本流速的控制机制。

• 建立了基于表面张力的微液滴操控方法，实现了微液滴被动式精准操控与高效无错融合。

• 通过对微液滴的光学检测，实现了借助介电电泳的微液滴主动式融合与组装。

• 单细胞水平代谢研究及多维组学分析

• 提出了一种可增强微量样本质谱信号灵敏度及强度的新型表面结构及基于此的新型微流控芯片。此表面结构便于大规模制造，仅通过温度就可精确控制表面结构的弧度，并在此基础上实现了微量样本的质谱信号增强，可实现精准高效检测多分子的微流控芯片。

• 开发并发展了针对单细胞代谢物研究的工作流程和新的分析方法；构建了基于质谱信号的高通量分选平台，并利用此平台对单细胞展开包含代谢组在内的多维组学研究。提出并构建了多维度耦合检测的微流控芯片，可不借助荧光标记多维度分析细胞群的代谢产物谱。此外，开发出模式识别计算方法，对细胞代谢产物进行快速分析，筛选出目标分子高产的生物酶，为后续生物酶及合成生物学提供了关键技术支撑。

• 生物组织空间多维组学研究

• 在单细胞分析的基础上，研发适用于大脑组织切片的空间多维组学方法，首次结合空间代谢组与转录组，从多维组学的角度系统分析了由阿尔茨海默病引起的斑块是如何干扰邻近细胞的基因表达及表观特征。

Research Interest

• Novel engineering tools based on MICROFLUIDICS for biochemistry applications.

• Handling a small volume of liquids at high precision and throughput is fundamental to large-scale biochemistry screening experiments. Our lab is skilled in micropump design & integration for POC, micro-droplet manipulation either passively by structure or actively by electrical force, handling of various syringe pumps, thermal control for PCR, blood separation & micro-magnetic particle-based immunoassay and cell culture through microfluidic devices.

• Exploring metabolism at the single-cell level

• We initiated and developed the workflow and new analysis method for single-cell metabolites study employing droplet printing and MALDI-MS imaging to solve directed evolution issues in synthetic biology and multimodal omics study at the single-cell level.

• Spatial Multimodal Omics

• Continuing our interest in mass spectrometry and droplet microfluidics, we further developed my method for brain tissues at spatial and multimodal omics level to study how the plaque caused by Alzheimer’s disease interfere with neighboring cells.