彭韵桦  (副教授)

博士生导师 硕士生导师

电子邮箱：

所在单位：生命科学与技术学院

学科：生物学

   
  • 更多栏目
手机版 校内登录
当前位置: 中文主页 >> 主页

  • 研究领域：

    • 蛋白质质量控制：蛋白质翻译后修饰 + 靶向蛋白质降解药物开发

    • 代谢性疾病：能量代谢重编程 + 靶向能量代谢营养素开发

     

     

    Publications：

    *: These authors contribute equally to this work, #: co-correspondence

    1. Y. Peng*, T. Li*, D. Liu*, W. Li, Y. Zhang, Y. Zhao, X. Jiang, Y. Liang, P. Chen, B. Ma, J. Liu, H. Chen#. Development of cathepsin B-responsive GalNAc-PROTACs for hepatocyte-targeting protein degradation. Journal of Medicinal Chemistry, 69(1) (2026) 517–532. 
    2. Y. Peng*, J. Liu*, H. Inuzuka, J. Liu#, W. Wei#. Targeting the cell-cycle machinery for cancer therapy. Trends in Cell Biology (2025) S0962-8924(25)00203-X. 
    3. T. Zhang*,, S. Zhang*,, J. Ma, D. Atiakshin, S. Han, M. Noda, M. Hiramatsu, J. Liu, Y. Peng#, J. Long#. Luteolin in Safflower Leaves Suppresses Microglial Inflammation Through FOXO3-Mediated Trem2 Transcription. Antioxidants, 14(12) (2025) 1495. 
    4. Y. Song, B. Zhou, J. Long#, Y. Peng#. Targeted protein degradation in autoimmune diseases: from mechanisms to therapeutic breakthroughs. Journal of Autoimmunity 156 (2025) 103475. 
    5. Y. Wang, Y. Hu, P. Wang, R. Hu, Z. Chen, T. Zhang, J. Liu, M. Noda, J. Long#, Y. Peng#. Distinct hepatic metabolic reprogramming in acute and chronic sleep deprivation and the protective effects of the chalcone analogue TAK. International Journal of Molecular Sciences 26(8) (2025) 3485.
    6. Y. Peng*, D. Liu*, D. Huang, H. Inuzuka#, J. Liu#. PROTAC as a novel anti-cancer strategy by targeting aging-related signaling. Seminars in Cancer Biology 106-107 (2024) 143-155. 
    7. J. Ma*, L. Li*, B.Ma*, T. Liu, Z. Wang, Q. Ye, Y. Peng, B. Wang, Y. Chen, S. Xu, K. Wang, F. Dang, X. Wang, Z. Zeng, Y. Jian, Z. Ren, Y. Fan, X. Li, J. Liu, Y. Gao, W. Wei, L. Li#, MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation. Nature Communications 15(1) (2024) 1871. 
    8. Y. Hu, Y. Wang, Y. Wang, Y. Zhang, Z. Wang, X. Xu, T. Zhang, T. Zhang, S. Zhang, R. Hu, L. Shi, X. Wang, J. Li, H. Shen, J. Liu, M. Noda, Y. Peng#, J. Long#. Sleep Deprivation Triggers Mitochondrial DNA Release in Microglia to Induce Neural Inflammation: Preventative Effect of Hydroxytyrosol Butyrate. Antioxidants (Basel, Switzerland) 13(7) (2024) 833. 
    9. 王颖, 王一方, 罗朝桂, 刘健康, 龙建纲, 彭韵桦#. 脂肪肝中的线粒体氧化应激分子机制及营养素干预策略. 中国科学:生命科学(2024).
    10. Y. Peng*, J. Liu*, H. Inuzuka, W. Wei#, Targeted protein posttranslational modifications by chemically induced proximity for cancer therapy, Journal of Biological Chemistry 299(4) (2023) 104572. 
    11. X. Guo*, Y. Peng*, Q. Song*, J.Wei, X. Wang, Y. Ru, S. Xu, X Cheng, X. Li, D.Wu, L. Chen, B. Wei#, X. Lv#, Ji, G#, A liquid biopsy signature for the early-detection of patients with gastric cancer, Gastroenterology (2023) S0016-5085(23)00236-6.
    12. 彭韵桦, 刘莎, 崔莉, 刘健康, 龙建纲#, 靶向蛋白质泛素修饰及降解在前列腺癌治疗中的机遇与挑战.生物化学与生物物理进展 50(4) (2023) 782-794.
    13. Y. Peng*, J. Liu*, Z. Wang*, C. Cui*, T. Zhang, S. Zhang, P. Gao, Z. Hou, H. Liu, J. Guo, J. Zhang, Y. Wen, W. Wei, L. Zhang#, J. Liu#, J. Long#, Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc, Cell Death and Differentiation 29(9) (2022) 1730-1743.
    14. J. Liu*, Y. Peng*, H. Inuzuka, W. Wei#, Targeting micro-environmental pathways by PROTACs as a therapeutic strategy, Seminars in Cancer Biology 86(Pt 2) (2022) 269-279.
    15. P. Gao*, Z. Wang*, M. Lei, J. Che, S. Zhang, T. Zhang, Y. Hu, L. Shi, L. Cui, J. Liu, M. Noda, Y. Peng#, J. Long#, Daphnetin ameliorates Aβ pathogenesis via STAT3/GFAP signaling in an APP/PS1 double-transgenic mouse model of Alzheimer's disease, Pharmacological Research 180 (2022) 106227.
    16. Y. Peng, H. Liu#, J. Liu, J. Long#, Post-translational modifications on mitochondrial metabolic enzymes in cancer, Free Radical Biology & Medicine 179 (2022) 11-23.
    17. J. Liu*, Y. Peng*, W. Wei#, Cell cycle on the crossroad of tumorigenesis and cancer therapy, Trends in Cell Biology 32(1) (2022) 30-44.[ESI高被引论文]
    18. T. Zhang*, S. Zhang*, Y. Peng#, Y. Wang, P. Gao, Y. Hu, Z. Wang, M. Noda, M. Hiramatsu, J. Liu, J. Long#, Safflower leaf ameliorates cognitive impairment through moderating excessive astrocyte activation in APP/PS1 mice, Food & Function 12(22) (2021) 11704-11716.
    19. J. Liu*, Y. Peng*, W. Wei#, Light-controllable PROTACs for temporospatial control of protein degradation, Frontiers in Cell and Developmental Biology 9 (2021) 678077.
    20. J. Liu*, Y. Peng*, L. Shi*, L. Wan, H. Inuzuka, J. Long, J. Guo, J. Zhang, M. Yuan, S. Zhang, X. Wang, J. Gao, X. Dai, S. Furumoto, L. Jia, P.P. Pandolfi, J.M. Asara, W.G. Kaelin, Jr., J. Liu#, W. Wei#, Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle, Cell Research 31(1) (2021) 80-93.
    21. Y. Peng, P. Gao, L. Shi, L. Chen, J. Liu#, J. Long#, Central and peripheral metabolic defects contribute to the pathogenesis of Alzheimer's disease: targeting mitochondria for diagnosis and prevention, Antioxidants & Redox Signaling 32(16) (2020) 1188-1236.
    22. Y. Peng*, C. Hou*, Z. Yang, C. Li, L. Jia, J. Liu, Y. Tang, L. Shi, Y. Li, J. Long#, J. Liu#, Hydroxytyrosol mildly improve cognitive function independent of APP processing in APP/PS1 mice, Molecular Nutrition & Food Research 60(11) (2016) 2331-2342.
    23. Y. Peng, J. Liu, L. Shi, Y. Tang, D. Gao, J. Long#, J. Liu#, Mitochondrial dysfunction precedes depression of AMPK/AKT signaling in insulin resistance induced by high glucose in primary cortical neurons, Journal of Neurochemistry 137(5) (2016) 701-13.
    24. J. Liu*, Y. Peng*, X. Wang, Y. Fan, C. Qin, L. Shi, Y. Tang, K. Cao, H. Li, J. Long#, J. Liu#, Mitochondrial dysfunction launches dexamethasone-induced skeletal muscle atrophy via AMPK/FOXO3 signaling, Molecular Pharmaceutics 13(1) (2016) 73-84.
    25. Y. Peng, J. Liu, Y. Tang, J. Liu, T. Han, S. Han, H. Li, C. Hou, J. Liu#, J. Long#, High-fat-diet-induced weight gain ameliorates bone loss without exacerbating AβPP processing and cognition in female APP/PS1 mice, Frontiers in Cellular Neuroscience 8 (2014) 225.

     



  • 2025~至今，副教授，博导，西安交通大学，生命科学与技术学院

    2021~至今，副教授，硕导，西安交通大学，生命科学与技术学院

    2018~2019，访问学者，哈佛大学，BIDMC

    2018~2020，助理教授，西安交通大学，前沿科学技术研究院

    2015~2017，联合培养博士，哈佛大学，BIDMC

    2011~2017，博士，西安交通大学，前沿科学技术研究院

    2007~2011，学士，西安交通大学，生物工程