发布时间：2026-06-30

DOI码：10.1021/acs.biomac.4c00759

论文名称：Nonionic Water-Soluble Oligo(ethylene glycol)-Modified Polypeptides with a β-Sheet Conformation

发表刊物：Biomacromolecules

关键字：Ethylene glycol; Chemistry; Polymer chemistry; Beta sheet; Water soluble; Organic chemistry; Biochemistry

摘要：The secondary structures of polypeptides, such as an α-helix and a β-sheet, often impart specific properties and functions, making the regulation of their secondary structures of great significance. Particularly, water-soluble polypeptides bearing a β-sheet conformation are rare and challenging to achieve. Here, a series of oligo(ethylene glycol)-modified lysine N -carboxylic anhydrides ( EG m K-NCA, where m = 1–3) and the corresponding polymers EG m K n are synthesized, with urethane bonds as the linker between the side-chain EG and lysine. The secondary structure of EG m K n is delicately r…

合写作者：Zhu Z, Wang S, Xin J, Zhou H, Wang L, Tong H, Cui C, Zhang Y, Sun F, Yang L, Gao Y, Lu H

第一作者：Jing X

论文类型：期刊论文

通讯作者：Yang L, Gao Y, Lu H

论文编号：120

卷号：25

期号：8

页面范围：5343-5351

ISSN号：1525-7797;1526-4602

是否译文：否

发表时间：2024-07-13

收录刊物：SCI

发布期刊链接：https://doi.org/10.1021/acs.biomac.4c00759