• 校内登录

个人信息 更多+
  • 教师姓名: 杨磊
  • 性别: 男
  • 职称: 副教授
  • 硕士生导师: 是
  • 学位: 博士
  • 电子邮箱:
  • 办公地点: 陕西省西安市雁塔西路76号医学部
  • 联系方式:

科学研究

当前位置: 中文主页 - 科学研究
科研项目

主持科研项目(课题)情况

  1. 云南保山产业园区管理委员会,保山精品小粒咖啡药理成分与健康效应分析研究,2026.7-2027.12

  2. 国际癌症护士协会(西安交大城市学院),农村居民消化道癌症筛查培训方案的构建及验证研究,2026.6-2027.12

  3. 中央高校基本科研业务费,数智驱动下边疆多民族地区农村居民主动健康管理模式构建及应用研究,2026.1-2026.12

  4. 陕西省教育厅,员工健康管理AI模型,2024.01-2026.12

  5. 美国中华医学基金会,基于认知行为疗法的数字化围产期抑郁干预方案的效果评价:随机对照试验,2022.01-2024.12

  6. 陕西省社会发展项目,miRNA-140在大骨节病软骨损伤中的作用机制及以外泌体为载体的靶向干预,2022.01-2023.12

  7. 陕西卫生健康科研项目,基于接纳承诺疗法的护士心理压力干预方案的构建和评价,2022.4-2024.3

  8. 基本科研自由探索项目,围产期抑郁变化轨迹及基于接纳承诺疗法的干预模型构建及评价研究,2022.6.1-2024.12.31

  9. 雅安市女娲儿童友好公益服务中心,THPP+照护者心理管理模式改编项目,2022.6.1-2023.6.1

  10. 国家自然科学基金青年项目,PTHrP-HDAC4信号通路在大骨节病软骨细胞分化障碍中的作用及分子机制,2020.01-2022.12

  11. 陕西省自然科学基金青年项目,组蛋白H4K20甲基化修饰在T-2毒素诱导软骨细胞DNA损伤中的作用机制,2019.01-2020.12

  12. 中国博士后科学基金面上项目,2018M643679,T-2毒素诱导软骨细胞DNA损伤的组蛋白H4K20甲基化机制,2019.01-2020.12

  13. 陕西省博士后科学基金项目,大骨节病与原发性骨关节炎软骨下骨病理改变及差异 miRNA 的对比分析,2018.06-2019.12

  14. 中央高校基本科研业务费,基于WHO健康思维指南的围产期抑郁移动管理平台的开发和应用研究,2019.07~2022.06

  15. 中华医学会杂志社护理学科研究课题重点项目,基于手机应用的围产期抑郁症干预技术的开发与临床应用,2020.08~2021.08

参与科研项目(课题)情况

  1. 国家自然科学基金面上项目,肠道菌Prevotella通过SCFAs调控FRZB/Wnt信号通路致大骨节病软骨细胞损伤作用机制,82273752

  2. 国家自然科学基金面上项目,mTOR信号通路和线粒体-内质网自噬在大骨节病软骨细胞损伤中的分子机制,2019.01-2021.12

  3. 中国科学技术协会服务国家社会治理品牌建设项目,基于移动 App 的围产期抑郁患者健康思维干预方案的构建和效果评价,2018.01~2018.12.31

  4. 国家自然科学基金国际(地区)合作与交流项目,大骨节病iPSCs模型建立及其在病因研究和软骨损伤靶向干预中的应用,2017.01-2021.12

  5. 国家重点研发计划-政府间国际科技创新合作重点专项,大骨节病硒代谢系统与硒蛋白的分子功能研究,2017.01-2020.12


科研论文

期刊论文(第一及通讯作者)

(1)     Yang L, Wang C, Cui L, Zhu Y, Wang X. Coffee, the Gut Microbiome, and Host Metabolism: Gastrointestinal Fate, Microbial Transformation, Mechanistic Insights, and Prospects for Precision Nutrition. Metabolites. 2026 Sep 16;16(9):680. doi: 10.3390/metabo16090680. PMID: 42783805.(JCR Q2)

(2)     Zhou J, Gao S, Jiang Q, Qian Y, Zhao W, Ding W, Yang L. Psychological Flexibility as a Mediator Between Parenting Stress and Depression Among Chinese Primary Caregivers of Infants: A Cross-Sectional Study. Nurs Rep. 2026 Aug 8;16(8):278. doi: 10.3390/nursrep16080278.(通讯作者)(JCR Q2)

(3)     Sun J, Gao Y, Nan Y, Jiang Y, Wang D, Rahman A, Li X, Yang L. The prenatal anxiety trajectory and its correlation with stress and psychological flexibility: a longitudinal study. BMC Psychol. 2025 Oct 15;13(1):1152. (通讯作者)(JCR Q1)

(4)     Yang L, Nan Y, Zhou J, Sun J, Huo L, Liu F, Wang D, Rahman A, Li X. The effectiveness of a nurse-assisted digital thinking healthy program for postpartum depression: A randomized controlled trial. Psychiatry Res. 2025 Sep;351:116639.(JCR Q1)

(5)     Yang L, Wang C, Zhou J, Chen F, Liu L, Bai L, Wang X, Guo X, Yi S. Investigating the Role and Regulatory Mechanisms of the Histone Deacetylase 4 Gene in Chondrocyte Differentiation Impairments Associated With Kashin-Beck Disease. J Biochem Mol Toxicol. 2025 Apr;39(4):e70231. doi: 10.1002/jbt.70231. (JCR Q2)

(6)     Jiang Y, Tian T, Li F, Sun J, Guo Q, Wang D, Li X, Yang L. Chinese translation and validation of the Personalized Psychological Flexibility Index (PPFI) for medical college students. BMC Psychol. 2024 Nov 6;12(1):630. doi: 10.1186/s40359-024-02121-w.(通讯作者)(JCR Q1)

(7)     Chang L, Wang Y, Zhang J, Zhao W, Li X, Yang L. Effect of music therapy combined with aerobic exercise on sleep quality among breast cancer patients undergoing chemotherapy after a radical mastectomy: a randomized controlled trial. BMC Womens Health. 2024 Jul 18;24(1):408.(通讯作者)

(8)     Tian T, Sun J, Jiang Y, Guo Q, Huang Z, Wang D, Rahman A, Li Xi, Yang L.Translation, adaptation, and initial evaluation of a guided self-help intervention to reduce psychological distress among nurses during COVID-19 in China. Front. Psychiatry. 2023, 14: 1168117. doi:10.3389/fpsyt.2023.1168117.(通讯作者)

(9)     Yang L, Sun J, Nan Y, Waqas A, Nisar A, Wang D, Rahman A, Li X. Prevalence of perinatal anxiety and its determinants in mainland China: A systematic review and meta-analysis. J Affect Disord. 2023, 323:193-203. doi: 10.1016/j.jad.2022.11.075.(JCR Q1)

(10)  Yang L, Sun J, Zhang Y, Guo X and Zhao G. Comprehensive comparative analysis of histopathology and gene expression in subchondral bone between kashin-beck disease and primary osteoarthritis. Front. Genet. 2022, 13:942326. doi: 10.3389/fgene.2022.942326(JCR Q2)

(11)  Yang Lei, Sun Jingwen, Wang Duolao, Rahman Atif, Shi Zumin, Wang Youfa, Li Xiaomei. Emotional Distress and Associated Factors among the General Population during the COVID-19 Pandemic in China: A Nationwide Cross-Sectional Survey. COVID. 2022; 2 (3):261-272. (JCR Q4)

(12)  Yang L, Yin J, Wang D, Rahman A, Li X. Urgent Need to Develop Evidence-Based Self-Help Interventions for Mental Health of Healthcare Workers in COVID-19 Pandemic. Psychol Med. 2020, 28;1-2. 

(13)  Yang L, Wang D, Li X, Yuan H, Fang H, Guo X. Comparison of the responsiveness of the WOMAC and the 12-item WHODAS 2.0 in patients with Kashin-Beck disease. BMC Musculoskelet Disord. 2020, 25;21(1):188. 

(14)  Yang L, Guo X. Response to comment on 'Comparison of the toxic mechanism of T-2 toxin and deoxynivalenol on human chondrocytes by microarray and bioinformatics analysis'. Toxicol Lett. 2020, 1;327:32.

(15)  Yang L, Wang S, Zhao G, Wang X, Guo X. Comparison of the toxic mechanism of T-2 toxin and deoxynivalenol on human chondrocytes by microarray and bioinformatics analysis. Toxicol Lett. 2020, 321:61-68. 

(16)  Yang L, Zhang J, Li X, Xu C, Wang X, Guo X. Expression Profiles of Selenium-Related Genes in Human Chondrocytes Exposed to T-2 Toxin and Deoxynivalenol. Biol Trace Elem Res. 2019, 190(2):295-302. 

(17)  Yang L, Zhao GH, Wang X, Wang YT, Lin XL, Yu FF, Goldring MB, Guo X, Lammi MJ. Cellular responses to T-2 toxin and/ or deoxynivalenol that induce cartilage damage are not specific to chondrocytes. Sci Rep, 2017, 7(1): 2231. 

(18)  Yang L, Zhang JP, Zhao GH, Wu CY, Ning YJ, Guo X, Wang X, Lammi MJ. Gene expression profiles and molecular mechanism of cultured human chondrocytes’ exposure to T-2 toxin and deoxynivalenol. Toxicon, 2017, 140:38-44. 

(19)  Yang L, Liu H, Guo X, Lammi MJ. The potential biochemical markers of Kashin-Beck disease: a meta-analysis. Biomarkers, 2016, 21(7): 633-638. 

(20)  Yang L, Zhao GH, Liu H, Wang X, Guo X, Lammi MJ. Field synopsis and meta-analyses of genetic epidemiological evidence for Kashin-Beck disease, an endemic osteoarthropathy in China. Mol Genet Genomics, 2016, 291(5): 1823-1833. 

(21)  Yang L, Zhao GH, Yu FF, Zhang RQ, Guo X. Selenium and iodine levels in subjects with Kashin-Beck disease: a meta-analysis. Biol Trace Elem Res, 2016, 170(1): 43-54. 

(22)  Zhao GH, Yang L, Lammi MJ, Guo X. A preliminary analysis of microRNA profiles in the subchondral bone between Kashin-Beck disease and primary knee osteoarthritis. Clin Rheumatol. 2019;38(9):2637-2645. (Co-first author)

(23)  杨磊,郭雄. T-2毒素、DON 诱导人软骨细胞差异表达基因与大骨节病的关系分析[J]. 中华地方病学杂志. 2022, 41(8):634-638.

(24)  赵光辉, 杨磊, 马建兵, 惠曙国. 大骨节病与骨性关节炎膝关节软骨下骨差异表达miRNA及其调控网络分析[J].西安交通大学学报(医学版),2021, 3(42): 414-418.(通讯作者)

(25)  杨磊, 鱼星锋, 李妍, 李小妹. 女性人格特征、情绪控制与乳腺癌发生危险的相关分析[J]. 中国健康心理学杂志, 2016, 24(02):202-206.

(26)  杨磊, 刘欢, 郭雄. 骨关节病生物标志物及其应用价值的研究进展[J]. 国外医学(医学地理分册), 2015, 36(4): 259-262.

(27)  杨磊,李小妹. 心理社会因素与乳腺癌相关性的研究进展. 护理学杂志, 2013, 28(22):92-94.


专利/软著

专利/软件著作权

1.西安交通大学. 阳光妈咪围产期抑郁干预APP软件v1.0. 2025SR0496829. (软件著作权)

2.西安交通大学. 阳光妈咪围产期抑郁干预管理平台.2025SR0496834.. (软件著作权)

3.西安交通大学.一种携瓶行走输液架:CN202122838581.4[P].2022-05-27.(发明人:孙敬文;姜悦;李翻玲;杨磊;李小妹)

4.西安交通大学.新生儿洗浴抚触床旁护理车:CN202223168706.8[P].2023-04-25.(发明人:姜悦;李翻玲;孙敬文;杨磊;郭茜;李小妹)