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陈瑶

性别:男

职称:副教授

博士生导师:是

硕士生导师:是

学历:博士研究生毕业

学位:博士

所在单位:仪器科学与技术学院

学科: 仪器科学与技术

招生学科 仪器科学与技术

应用于医疗的量子传感芯片

(一)片上超低场核磁共振谱仪

本课题组聚焦片上超低场核磁共振(NMR)技术,致力于其微型化、便携化与低成本化。传统核磁共振系统体积庞大、成本高昂,严重限制了其广泛应用。我们通过利用量子测量的超高灵敏特性,探索在接近零磁场下微弱核自旋信号的高灵敏探测与噪声抑制,旨在突破现有技术瓶颈,实现手性分子的精密识别与检测。

我们的研究内容涵盖:

  • 晶圆级NMR敏感芯片的异质集成:结合MEMS工艺,实现高性能传感器的片上集成。
  • 基于原子吸收与磁场调制的单光束信号探测方法:利用全光学测量方法,提升检测灵敏度与稳定性。
  • 有机分子超低场高效检测关键技术:开发适用于实际应用的高效检测方案。

通过深入研究MEMS技术、电路设计以及量子精密测量等交叉领域,我们旨在推动新一代超低场NMR谱仪在前沿应用与规模化推广,为生命科学、材料科学等领域提供革新性工具。

期待致力于突破前沿物理与工程界限的硕士生和博士生加入,共同将实验室成果推向实际应用!

 

 

On-chip Ultra-Low-Field Nuclear Magnetic Resonance Spectrometer

Our group focuses on on-chip ultra-low-field nuclear magnetic resonance (NMR) technology, aiming for its miniaturization, portability, and cost-effectiveness. Traditional NMR systems are bulky and expensive, significantly limiting their widespread application. By leveraging the ultra-high sensitivity of quantum measurement, we investigate highly sensitive detection of weak nuclear spin signals and noise suppression near zero magnetic fields. Our goal is to overcome existing technical bottlenecks and achieve precise identification and detection of chiral molecules.

Our research areas include:

  • Wafer-level heterogeneous integration of NMR-sensitive chips: Utilizing MEMS processes for on-chip integration of high-performance sensors.
  • Single-beam signal detection based on atomic absorption and magnetic field modulation: Employing all-optical measurement methods to enhance detection sensitivity and stability.
  • Key techniques for high-efficiency detection of organic molecules under ultra-low fields: Developing efficient detection solutions suitable for practical applications.

Through in-depth research at the intersection of MEMS technology, circuit design, and quantum precision measurement, we aim to advance the frontier applications and large-scale deployment of next-generation ultra-low-field NMR spectrometers, providing revolutionary tools for life sciences, materials science, and other fields.

We welcome master's and Ph.D. students who are passionate about pushing the boundaries of physics and engineering to join our team and translate laboratory breakthroughs into real-world applications!

 

 

基于核自旋补偿的运动脑磁测量

(二)应用于医疗的量子传感芯片:脑磁探测

本课题组致力于开发应用于医疗领域的量子传感芯片,尤其在脑磁探测方向深耕细作。量子传感器凭借原子、分子、电子、光子等微观粒子的超高灵敏特性,能够对磁场等物理量进行极其精密的测量。为了突破传统量子传感器体积庞大的限制,我们专注于将微光机电系统(MEMS)技术与量子传感技术深度融合,旨在研制高性能、小型化的量子传感芯片,从而极大拓展其在医疗健康领域的应用。

芯片原子磁强计与核心敏感元件制备

我们以芯片原子磁强计为核心,利用原子自旋对磁场的敏感特性,实现fT(飞特斯拉)量级的超高灵敏磁场测量。这使得我们能够对人脑产生的微弱磁场进行精准成像,为阿尔茨海默症的早期诊断、抑郁症及癫痫术前病灶定位、以及未来脑机接口等前沿应用提供强有力的新型工具。通过芯片化技术,我们有望显著缩小现有传感器的体积,提升脑磁等极弱磁信号的空间分辨率,并大幅降低传感器的成本。

本研究的核心优势在于对核心敏感元件的自主制备与集成。我们重点攻克包括:

  • MEMS气室:设计与制备高性能微型原子气室,这是实现芯片级原子磁强计的关键所在,确保原子密度和光学传输效率。
  • 无磁加热技术:开发创新的无磁加热方案,在维持原子气室工作温度的同时,避免引入额外磁噪声,从而保证测量精度。
  • 双平面线圈集成:设计并集成微型双平面线圈,用于产生和控制原子磁强计所需的环境磁场与射频场,实现对原子自旋的精准操控。

通过这些关键元器件的精细加工与高度集成,我们能够构建出小型化、便携式的脑磁影像设备。相较于脑电信号,脑磁信号能够无畸变地穿透颅骨,从而探测到脑深部的精微活动,这对于癫痫病灶的准确识别具有里程碑式的意义。本研究将聚焦于从传感器核心敏感元件制备到整个脑磁系统搭建的全链条研发,研制具有广阔市场前景的新一代脑磁影像设备。该研究得到了西安交通大学医工交叉产教融合平台的有力支持,为项目的深入开展提供了坚实保障。

欢迎仪器、电子、微纳加工、光学工程、生物医学工程等相关专业的优秀硕士生、博士生加入我们的团队,共同攻克脑磁探测领域的国际前沿难题,为人类健康事业贡献力量!


On-chip Quantum Sensors for Medical Applications: Magnetoencephalography (MEG)

Our research group is dedicated to developing quantum sensing chips for medical applications, with a particular focus on Magnetoencephalography (MEG). Quantum sensors leverage the ultra-high sensitivity of microscopic entities such as atoms, molecules, electrons, and photons to precisely measure physical quantities like magnetic fields. To overcome the size limitations of conventional quantum sensors, we concentrate on integrating Micro-Electro-Mechanical Systems (MEMS) technology with quantum sensing, aiming to develop high-performance, miniaturized quantum sensing chips that significantly expand their applications in healthcare.

Chip-scale Atomic Magnetometers and Core Sensing Element Fabrication

At the core of our work is the chip-scale atomic magnetometer, which utilizes the magnetic field sensitivity of atomic spins to achieve ultra-high precision measurements in the femtotesla (fT) range. This enables us to accurately image the faint magnetic fields generated by the human brain, offering a powerful new tool for early diagnosis of Alzheimer's disease, preoperative localization for depression and epilepsy, and future brain-computer interfaces. Through chip-level integration, we expect to substantially reduce the size of existing sensors, enhance the spatial resolution of extremely weak magnetic fields like brain magnetism, and significantly lower sensor costs.

Our research's key strength lies in the independent fabrication and integration of core sensitive components. We are addressing critical challenges, including:

  • MEMS Vapor Cells: Designing and fabricating high-performance miniature atomic vapor cells, which are crucial for realizing chip-scale atomic magnetometers by ensuring optimal atomic density and optical transmission efficiency.
  • Magnetically Shielded Heating Technology: Developing innovative, magnetically inert heating solutions to maintain the required operating temperature of the vapor cell without introducing additional magnetic noise, thereby preserving measurement accuracy.
  • Dual-planar Coil Integration: Designing and integrating miniature dual-planar coils to generate and control the magnetic fields and radiofrequency fields necessary for atomic magnetometers, enabling precise manipulation of atomic spins.

Through the meticulous fabrication and high-level integration of these key components, we aim to construct miniaturized and portable MEG devices. Unlike electroencephalography (EEG) signals, MEG signals can penetrate the skull without distortion, allowing for the detection of subtle activities deep within the brain. This holds monumental significance for accurately identifying epileptic foci. This research focuses on the full spectrum of R&D, from the preparation of core sensitive components to the construction of the entire MEG system, aiming to develop a new generation of MEG imaging equipment with broad market prospects. This study is robustly supported by Xi'an Jiaotong University's Medical-Engineering Cross-Disciplinary Industry-Education Integration Platform, providing a solid guarantee for the project's in-depth development.

We welcome outstanding Master's and Ph.D. students from instrument science, electronics, micro/nano fabrication, optical engineering, biomedical engineering, and related fields to join our team. Together, let's tackle international frontier challenges in brain magnetic detection and contribute to human health!

 

 

(三)基于核自旋补偿的运动脑磁测量:

在人体运动状态下进行脑磁测量,是脑科学和神经工程领域的一项重大挑战,也是我们课题组的特色研究方向。本研究获得了国家自然科学基金面向项目支持,旨在突破运动伪影对脑磁信号的干扰,实现更真实、更自然状态下的人脑功能探测。

传统的脑磁测量(MEG)系统通常要求受试者保持静止,以避免运动造成的强大背景干扰磁场。而脑磁信号本身仅有约100 fT的微弱强度。即使在磁屏蔽房内,经过补偿后的残余磁场可控制在1 nT以内,但人体运动引起的磁场变化仍然远超这一范围,严重掩盖了脑部自身的微弱神经磁信号。

针对这一核心难题,我们课题组创新性地提出并正在开发基于核自旋的干扰磁场主动补偿技术。我们利用超极化的核自旋对磁场的超高灵敏度和可操控性,构建一个能够实时感知并抵消运动造成背景磁场变化的补偿系统。这意味着,我们将能够:

  • 突破运动限制: 实现对清醒、自由活动个体(如儿童、帕金森患者、运动员等)的脑功能测量,为更广泛的临床诊断和脑科学研究提供可能。
  • 提升测量精度: 在复杂动态环境中,依然保持对微弱脑磁信号的高灵敏度探测能力。
  • 推动应用前沿: 为脑机接口、神经康复、运动认知等领域的深入研究奠定基础,并有望为阿尔茨海默病、癫痫等疾病的早期诊断和治疗评估提供全新的工具。

 

 Motion Brain Magnetometry Based on Nuclear Spin Compensation

Measuring brain magnetism during human motion presents significant challenges in the fields of brain science and neural engineering, and it is a distinctive research direction of our group. This research is supported by the National Natural Science Foundation of China (NSFC) for Key Programs, aiming to overcome motion artifact interference with brain magnetic signals and achieve brain functional detection in more realistic and natural states.

Conventional magnetoencephalography (MEG) systems typically require subjects to remain still to avoid strong background interference magnetic fields caused by movement. Brain magnetic signals themselves are extremely weak, approximately 100 fT. Even within a magnetically shielded room, residual magnetic fields can be compensated to within 1 nT; however, magnetic field changes induced by human motion still far exceed this range, severely masking the brain's own subtle neural magnetic signals.

To address this core challenge, our research group has innovatively proposed and is developing an active compensation technology for interference magnetic fields based on nuclear spin. By leveraging the ultra-high sensitivity and controllability of hyperpolarized nuclear spins to magnetic fields, we are constructing a compensation system capable of real-time sensing and canceling background magnetic field changes caused by motion. This initiative will enable us to:

  • Break Motion Limitations: Realize brain function measurements in awake, freely moving individuals (e.g., children, Parkinson's patients, athletes), opening possibilities for broader clinical diagnoses and brain science research.
  • Enhance Measurement Precision: Maintain high-sensitivity detection capabilities for weak brain magnetic signals even in complex dynamic environments.
  • Advance Frontier Applications: Lay the foundation for in-depth research in brain-computer interfaces, neural rehabilitation, and motor cognition, and potentially provide new tools for early diagnosis and treatment evaluation of diseases such as Alzheimer's and epilepsy.

 

利用此磁强计,实现了灵敏度为3.2fT/Hz^(1/2) 的灵敏度。3.2fT/Hz^(1/2) magnetic field sensitivity has been achieved.

电力市场用的芯片原子磁强计

 量子电流传感器及其在电网中的应用

本课题组与国家电网深度合作,专注于超特高压电网量子电流传感器的研发,以满足新能源产业发展背景下,电力系统对高精度、全光学电流传感的迫切需求。我们致力于开发服务于未来智能电网智能调度的量子电流传感器,实现对电网大电流的精准监测。

当前,我们利用去多普勒饱和吸收谱技术进行相关测量,这是一种创新的全光学测量方案。通过将原子吸收谱线频率转化为磁场测量,我们能够实现对电网电流的非接触、高精度测量。这种方法避免了传统互感器的弊端,具有高绝缘、抗干扰等显著优势,特别适用于复杂的超特高压电网环境。

研究内容涵盖:

  • 原子磁强计芯片集成与微型化:将量子传感器的核心部件进行芯片级集成,实现小型化和低成本。
  • 全光学测量系统设计与优化:开发基于去多普勒饱和吸收谱的测量系统,并优化其性能。
  • 复杂电磁环境下量子电流传感技术:解决电网现场的电磁干扰问题,确保测量准确性。
  • 与电网合作进行现场测试与应用:将实验室成果推广到实际电网运行中。

本项目在量子物理、原子光谱、光学工程、电路设计以及电力系统应用等多个学科领域交叉融合,具有显著的原始创新性。特别是将原子吸收谱线频率转化为磁场测量,进而实现全光学的电网电流测量,为电力行业提供了新的的解决方案。加入我们的团队,您将有机会:

  • 掌握量子传感、精密光学测量与先进电路设计技能。
  • 参与国家电网重大科研项目,将前沿物理技术应用于国家能源战略。
  • 积累丰富的工程实践经验,为未来在量子技术、能源电力等高科技领域就业打下坚实基础。

期待对量子技术、能源电力充满热情的硕士生和博士生加入,共同开创智能电网新时代!

 

Quantum Current Sensor for Power Grid Applications

In close collaboration with the State Grid Corporation of China, our group is dedicated to the research and development of quantum current sensors for ultra-high voltage power grids. This initiative addresses the urgent need for high-precision, all-optical current sensing in power systems, driven by the rapid growth of the new energy industry. Our goal is to develop quantum current sensors that enable precise monitoring of large currents in power grids, supporting the intelligent dispatching requirements of future smart grids.

Currently, we employ Doppler-free saturated absorption spectroscopy for measurements, representing an innovative all-optical sensing approach. By converting atomic absorption line frequencies into magnetic field measurements, we achieve non-contact, high-precision measurement of grid currents. This method overcomes the limitations of traditional current transformers, offering significant advantages such as high insulation, strong anti-interference capabilities, and a wide dynamic range, making it particularly suitable for complex ultra-high voltage power grid environments.

Our research areas include:

  • Chip integration and miniaturization of atomic magnetometers: Integrating core components of quantum sensors at the chip level for miniaturization and cost reduction.
  • Design and optimization of all-optical measurement systems: Developing and optimizing measurement systems based on Doppler-free saturated absorption spectroscopy.
  • Quantum current sensing technology in complex electromagnetic environments: Addressing electromagnetic interference in power grid sites to ensure measurement accuracy.
  • On-site testing and application in collaboration with the State Grid: Translating laboratory achievements into practical power grid operations.

This project demonstrates significant original innovation through the interdisciplinary integration of quantum physics, atomic spectroscopy, optical engineering, circuit design, and power system applications. Specifically, converting atomic absorption line frequencies into magnetic field measurements to realize all-optical power grid current measurement provides an unprecedented solution for the power industry. Joining our team offers the opportunity to:

  • Master skills in quantum sensing, precision optical measurement and advanced circuit design.
  • Participate in major scientific research projects with the State Grid, applying cutting-edge physics to national energy strategies.
  • Gain rich engineering practice experience, laying a solid foundation for future employment in high-tech fields such as quantum technology and power energy.

We welcome master's and Ph.D. students passionate about quantum technology and power energy to join us in pioneering a new era of smart grids!

离子阱

芯片上的Penning离子阱:量子计算与精密测量

本课题组致力于芯片上的Penning离子阱技术研究,主要目标是为未来量子计算构建高性能的物理平台。我们已初步搭建了相关实验平台,并在此基础上,将Penning离子阱应用于量子精密测量。

Penning离子阱通过精密的电磁场将离子囚禁,使其在二维平面内形成离子晶体。这些离子晶体构成了独特的量子机械振子和转子系统,其能级是量子化的。利用这种二维量子谐振子,我们能够实现对极微弱力的测量,极限灵敏度有望达到 10E(−24)N。

加入我们,你将有机会:

  • 参与芯片级离子阱的设计、制备与操控,掌握量子芯片的核心技术。
  • 深入学习量子力学、电磁场理论以及低温物理等前沿知识。
  • 锻炼精密光学、射频/微波电路设计与搭建、高真空系统等实验技能。
  • 投身于量子计算、量子模拟以及量子精密测量等领域的开创性研究。

我们热忱欢迎对量子计算、芯片级量子器件、量子精密测量以及电磁场理论感兴趣的硕士生和博士生加入,共同探索量子世界的前沿!

On-chip Penning Ion Traps: Quantum Computing and Precision Measurement

Our group is dedicated to research on on-chip Penning ion trap technology, with the primary goal of building high-performance physical platforms for future quantum computing. We have already established the relevant experimental platform, and on this basis, we apply Penning ion traps to quantum precision measurement.

Penning ion traps confine ions through precise electromagnetic fields, causing them to form ion crystals in a two-dimensional plane. These ion crystals constitute unique quantum mechanical oscillator and rotor systems with quantized energy levels. Utilizing these two-dimensional quantum harmonic oscillators, we can achieve measurements of extremely weak forces, with a projected sensitivity limit of 10E(−24) N.

Join us, and you will have the opportunity to:

  • Participate in the design, fabrication, and control of chip-scale ion traps, mastering core quantum chip technologies.
  • Delve into cutting-edge knowledge in quantum mechanics, electromagnetic field theory, and low-temperature physics.
  • Develop experimental skills in precision optics, RF/microwave circuit design and construction, and high-vacuum systems.
  • Engage in groundbreaking research in quantum computing, quantum simulation, and quantum precision measurement.

We warmly welcome master's and doctoral students interested in quantum computing, chip-scale quantum devices, quantum precision measurement, and electromagnetic field theory to join us in exploring the frontiers of the quantum world!

        

参考文献:Chen Y, Zhao L, Jiang Z. Rotation sensing with a compact Penning trapped calcium ion crystal system[J]. Bulletin of the American Physical Society, 2022. 链接

       

实验平台图: