憨勇  (教授)

博士生导师 硕士生导师

性别:男

学历:博士研究生毕业

学位:博士

所在单位:材料科学与工程学院

电子邮箱:

办公地点:仲英楼5楼

联系方式:

学科:材料科学与工程

   

近5年代表性论文

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(1)     X.Y Li, Y.F Zhang, Z.X Deng, X. Zhao*, S.Q Zhang, Y.H Shan, B.L Guo*, Y. Han*. Polymer-based stimuli-responsive biomaterials featuring self-generated electric fields for tissue repair. Progress in Materials Science (2026) 101660.

(2)     J. Ye, B. Li, M. Yu, Y.G Zhang, Y. Han*. Bone matrix-mimetic multi-ion doped hydroxyapatite nanorod arrays for enhanced immuno-osteogenesis and prevention of aseptic loosening. Bioactive Materials 55 (2026) 74-93.

(3)     Y. Xue, L. Zhang*, M.T Mao, S.D Wu, Y.G Zhang, Y. Han*. “Sandwich” structured nanorods for timely antibiosis, immunoregulation and neuroangiogenesis to accelerate osteogenesis of Zn-based implants in diabetics. Biomaterials324 (2026) 123540

(4)     H.H Xie, L.Zhang*, T.X Ding, D.H Wang, K. Liu, D.S Li, Y.X Shi, Y.T Lu, C.M Zhang, S.D Wu, S.L Wu, Y. Han*. A bimetallic catalyst core-shell nanoplatform enabling all-stage management of infected diabetic wound healing. Biomaterials (2025) 123771.

(5)     Y. Xue, J. Shi, L. Zhang*, X.J Zhang, Y.G Zhang, Y. Han*. One-step engineered multifunctional gauze: On-demand antibiosis, accelerated hemostasis and angiogenesis for tissue regeneration. International Journal of Biological Macromolecules (2025) 146866.

(6)     M.T Mao, L.Zhang*, S.D Wu, Y. Han*. A core–shell structured VEGF-SiO2@ ZnO nanorod array for enhancing osteogenesis performance of Zn-based implants. Journal of Materials Chemistry B 13.32 (2025) 9937-9953.

(7)     S.M Chen, X.Q Liu, W.H Zhang, B. Li*, F.W Liu, Y.G Zhang, Y. Han*. Nanozyme coating-mediated mitochondrial metabolic reprogramming of macrophages for immunomodulatory osseointegration in rheumatoid arthritis case. ACS Nano 19.28 (2025) 26127-26146.

(8)     J.L Luo, Z. Liang, X. Zhao*, S.F Huang, Y.N Gu, Z.X Deng, J. Ye, X.M Cai, Y. Han, B.L Guo*. Piezoelectric dual-network tough hydrogel with on-demand thermal contraction and sonopiezoelectric effect for promoting infected-joint-skin-wound healing via FAK and AKT signaling pathways. National Science Review 12.5 (2025) nwaf118.

(9)     J.J Xie, B. Li*, D.K Wang, X.Q Liu, L.L Zhang, Y. Han*. Construction of dual-ion co-doped LDH coatings on magnesium alloys for marine applications: Achieving self-healing and anti-biocorrosion properties. Corrosion Science 252 (2025) 112984.

(10)  T.X Ding, L. Zhang*, J. Chen, D.Y. Ma, J. Han, Y. Han*.“Thermal bubbles”: Photothermally triggered by a carbon monoxide nanocontainer for antibiosis and immune modulation therapy. Nano Today 63 (2025) 102758.

(11)  J. Zhang, Y. Xue, L. Zhang*, J. Chen, D.Y Ma, Y.G Zhang, Y. Han*. A targeted core–shell ZIF-8/Au@ Fe3O4 platform with multiple antibacterial pathways for infected skin wound regeneration. ACS Applied Materials & Interfaces 17.14 (2025) 20901-20918.

(12)  S.J Wang, Y.C Wang, X.M Cai, B.J Wang*, C. Zhao*, G.J Pan, C. Harder, Y. Bulut, B.C Zhang, S. Zhang, Y.X Kong, K.X Huang, B.M Xie, P. Müller-Buschbaum, S.V Roth, L. Yang, Y.X Li, Y. Han, G. Bao, W. Ma*. A high-frequency artificial nerve based on homogeneously integrated organic electrochemical transistors. Nature Electronics 8.3 (2025) 254-266.

(13)  J.L Luo, Z.Y Wu, X. Zhao*, L.P Qiao, Y. Huang, J.Y Chen, Y.L Shan, Z.X Deng, Z. Liang, Y. Han, B.L Guo*. Network‐remodeling, electroactive and antibacterial cryogel with tissue sealing and pro‐coagulant activity for hemostasis and skin wound healing. Advanced Functional Materials 35.22 (2025) 2419037.

(14)  Y.Y Zhao, R.Y Hang, H.F Li, Y.H Sun, R.H Yao, X.B Huang, X.Y Zhang, X.H Yao*, H.Y Wang, Y. Xiao, D. Huang, Y. Han*, X. Wang*, R.Q Hang*. Biomaterial surface‐mediated macrophages exert immunomodulatory roles by exosomal CCL2‐induced membrane integrin β1 trafficking in recipient cells. Advanced Science 12.10 (2025) 2409809.

(15)  R.Y Hang, Y.Y Zhao, H.M Chen, X.M Li, R.H Yao, Y.H Sun, X.H Yao*, L. Bai*, H.Y Wang, Y. Han*, R.Q Hang*. Construction and high-throughput screening of gradient nanowire coatings on titanium surface towards ameliorated osseointegration. Materials Today Bio 30 (2025) 101392.

(16)  Y. Xue, L. Zhang*, J. Chen, D.Y Ma, Y.G Zhang, Y. Han*. An “all-in-one” therapeutic platform for programmed antibiosis, immunoregulation and neuroangiogenesis to accelerate diabetic wound healing. Biomaterials (2025) 123293.

(17)  Y.L Shan, F. Cao, X. Zhao*, J. Luo, H. Mei, L. Zhang, Y. Huang, Y. Yang, L. Yan, Y. Huang, L.R.J Yan, Y.Y Huang, Y. Han*, B.L Guo*. Procoagulant, antibacterial and antioxidant high-strength porous hydrogel adhesives in situ formed via self-gelling hemostatic microsheets for emergency hemostasis and wound repair. Biomaterials 315 (2025) 122936.

(18)  H.H Xie, L. Zhang*, J. Chen, C. Wang, Y.X Yan, S.L Deng, K. Liu, D.S Li, M. Yang, J.C Ren, S.L Wu, Y. Han*. A Dual-catalysis mode for ROS regulation to accelerate biointegration of implants in infected diabetic wound. Advanced Functional Materials (2025) 2423015.

(19)  M. Yu#, Y. Guo#, S.W Zhou#, Y.H Li, Z.X Deng*, X. Zhao*, Y. Han*. Spreadable thermosensitive nanocomposite hydrogel dressing with ultrasound-responsive bactericidal/repair-promoting regulation and cascade antioxidantion for infected burn wound repair. Journal of Materials Science & Technology 219 (2025) 189-204.

(20)  H.W Yang, Y. Han*. Enhanced corrosion fatigue strength of additively manufactured graded porous scaffold-coated Ti-6Al-7Nb alloy. Journal of Materials Science & Technology 212 (2025) 192-206.

(21)  X.M Cai#, B. Li#*, Y.G Zhang, J.H Han, Y. Han*. Piezopotential and vacancies co-enhanced sonodynamic response of a ZnO-TiO2-x heterojunction array for osteointegration in MRSA-infected osteomyelitis. Chemical Engineering Journal 479 (2024) 47804.

(22)  X.M Cai#, M. Yu#, *, B. Li, Y.G Zhang, Y. Han*. Cobalt ions-derived nanoenzyme array for endosseous neural network reconstruction and osseointegration. Bioactive Materials 42 (2024) 1-17.

(23)  X.Q Liu, R.L Qian, B. Li*, Y. Zhang, Y. Han*. Sono-catalytic tooth whitening and oral health enhancement with oxygen vacancies-enriched mesoporous TiO2 nanospheres: A nondestructive approach for daily tooth care. ACS Biomaterials Science & Engineering 10 (2024) 6634-6647.

(24)  H.W Yang#, Z.C Zhang#, J. Shu, Y. Han*. Gradient nanostructure, enhanced surface integrity and fatigue resistance of Ti-6Al-7Nb alloy processed by surface mechanical attrition treatment. Journal of Materials Science & Technology 188 (2024) 252-269.

(25)  M.T Mao, J. Chen, F.W Liu, L. Kong, Y. Han* and L. Zhang*. Reduced corrosion of Zn alloy by HA nanorods for enhancing early bone regeneration. Biomaterials Science 12 (2024) 1055-1068.

(26)  Y. Xue, L. Zhang*, J.H Zhou, J. Chen, Y.W Ma and Y. Han*. Low-dose Cu ions assisted by mild thermal stimulus inducing bacterial cuproptosis-like death for antibiosis and biointegration. Advanced Functional Materials 34 (2024) 2308197.

(27)  X. Zhao, Y. Huang, Z.L Li, J.Y Chen, J.L Luo, L. Bai, H.Y Huang, E.T Cao, Z.H Yin, Y. Han and B.L Guo*. Injectable self-expanding/self-propelling hydrogel adhesive with procoagulant activity and rapid gelation for lethal massive hemorrhage management. Advanced Materials 36 (2024) 2308701.

(28)  S.W Zhuo#, Z. Deng#, Z.Y Wu, Y. Guo, Y.B Wu, X. Zhao*, Y. Han* and B.L Guo*. Janus gels for biomedical applications: progress and future prospective. Progress in Polymer Science (2024) 101856.

(29)  X. Zhao#, M.T Shi#, S.W Zhuo, R.N Dong, L. Bai, M.G Xu, N.Y Wen, Z.H Yin, Y. Han and B.L Guo*. Biodegradable conductive IPN in situ cryogels with anisotropic microchannels and sequential delivery of dual-growth factors for skeletal muscle regeneration. Nano Today 58 (2024) 102407.

(30)  S.W Zhuo, Y.P Liang, Z.Y Wu, X. Zhao*, Y. Han* and B.L Guo*. Supramolecular hydrogels for wound repair and hemostasis. Materials Horizons 11 (2024) 37-101.

(31)  S.M Chen, F.W Liu, H. Xin, D. Wen, Y.G Zhang, B. Li* and Y. Han*. Boosting MRSA infectious osteoporosis treatment: Mg-doped nanofilm on vacancy-enriched TiO2 coating for providing in situ sonodynamic bacteria-killing and osteogenic alkaline microenvironment. Advanced Functional Materials 34 (2024) 2311965.

(32)  T.X Ding, Y. Li, F.W Liu, J. Chen, Y.C Chen, L. Kong, Y. Han* and L. Zhang*. Electron spin polarization engineering in ferromagnetic bioheterojunction for sonotherapy of osteomyelitis. Advanced Functional Materials 34 (2024) 2401795.

(33)  T.X Ding, L. Zhang*, J. Han, J.H Zhou and Y. Han*. Photo-Responded antibacterial therapy of reinfection in percutaneous implants by nanostructured bio-heterojunction. Small 19 (2023) 2206265.

(34)  J.L Luo, X. Zhao*, B.L Guo* and Y. Han*. Preparation, thermal response mechanisms and biomedical applications of thermosensitive hydrogels for drug delivery. Expert Opinion on Drug Delivery 20 (2023) 641-672.

(35)  Y. Xue, L. Zhang*, F.W Liu, F. Dai, L. Kong, D.Y Ma and Y. Han*. Alkaline “nanoswords”   coordinate ferroptosis-like bacterial death for antibiosis and osseointegration. ACS Nano 17 (2023) 2711-2724.

(36)  Y. Xue, L. Zhang*, F.W Liu, L. Kong, D.Y Ma and Y. Han*. Fluoride releasing photothermal responsive TiO2 matrices for antibiosis, biosealing and bone regeneration. Journal of Controlled Release 363 (2023) 657-669.

(37)  M. Yu#, H.W Yang#, B. Li, R. Wang and Y. Han*. Molecular mechanisms of interrod spacing-mediated osseointegration via modulating inflammatory response and osteogenic differentiation. Chemical Engineering Journal 454 (2023) 140141.

(38)  X. Zhao, J.L Luo, Y. Huang, L. Mu, J.Y Chen, Z. Liang, Z.H Yin, D.K Chu, Y. Han* and B.L Guo*. Injectable antiswelling and high-strength bioactive hydrogels with a wet adhesion and rapid gelling process to promote sutureless wound closure and scar-free repair of infectious wounds.  ACS Nano 17 (2023) 22015-22034.

(39)  Y. Huang, L. Mu, X. Zhao, Y. Han and B.L Guo*. Bacterial growth-induced tobramycin smart release self-healing hydrogel for Pseudomonas aeruginosa-infected burn wound healing. ACS Nano 16 (2022) 13022-13036.

(40)  Y. Huang, X. Zhao, C.B Wang, J.Y Chen, Y.Q Liang, Z.L Li, Y. Han and B.L Guo*. High-strength anti-bacterial composite cryogel for lethal noncompressible hemorrhage hemostasis: synergistic physical hemostasis and chemical hemostasis. Chemical Engineering Journal 427 (2022) 131977.

(41)  B. Li, F.L Liu, J. Ye, X.M Cai, R.L Qian, K.W Zhang, Y.F Zheng, S.L Wu and Y. Han*. Regulation of macrophage polarization through periodic photo‐thermal treatment to facilitate osteogenesis. Small 18 (2022) 2202691.

(42)  M.T Mao, S. Zhu, L. Zhang*, F. Liu, L. Kong, Y. Xue, V. M. Rotello* and Y. Han*. An extracellular matrix-like surface for Zn alloy to enhance bone regeneration. ACS Applied Materials & Interfaces 14 (2022) 43955-43964.

(43)  Y.Q Qiao, Y. D Xu, X.M Liu*, Y.F Zheng, B. Li, Y. Han, Z.Y Li, K. W. K. Yeung, Y.Q Liang and S.L Zhu, Z.D Cui, S.L Wu*. Microwave assisted antibacterial action of Garcinia nanoparticles on Gram-negative bacteria. Nature Communications 13 (2022) 2461.

(44)  Y. Xue, L. Zhang*, F.W Liu, Y.W Zhao, J.H Zhou, Y. Hou, H. Bao, L. Kong, F. Ma and Y. Han*. Surface bandgap engineering of nanostructured implants for rapid photothermal ion therapy of bone defects. Advanced Healthcare Materials 11 (2022) 2200998.

(45)  Z.Y Zhang#, X. Zhao#, C.B Wang, Y. Huang, Y. Han and B.L Guo*. Injectable conductive micro-cryogel as a muscle stem cell carrier improves myogenic proliferation, differentiation and in situ skeletal muscle regeneration. Acta Biomaterialia 151 (2022) 197-209.

(46)  X. Zhao#, Z.Y Zhang#, J.L Luo, Z.Y Wu, Z.F Yang, S.W Zhou, Y.P Tu, Y. Huang, Y. Han* and B.L Guo*. Biomimetic, highly elastic conductive and hemostatic gelatin/rGO-based nanocomposite cryogel to improve 3D myogenic differentiation and guide in vivo skeletal muscle regeneration. Applied Materials Today 26 (2022) 101365.

(47)  D.M. Yu#, S. Guo#, M. Yu#, W.W. Liu, X.K. Li, D.F. Chen, B. Li**, Z. Guo***, Y. Han*. Immunomodulation and osseointegration activities of Na2TiO3 nanorods-arrayed coatings doped with different Sr content. Bioactive Materials 10 (2022) 323-334.

(48)  J. Ye#, B. Li#**, M. Li, Y.F. Zheng, S.L. Wu, Y. Han*. Formation of a ZnO nanorods-patterned coating with strong bactericidal capability and quantitative evaluation of the contribution of nanorods-derived puncture and ROS-derived killing. Bioactive Materials 11 (2022) 181-191.

(49)  L. Zhang#, Y. Xue#, S. Gopalakrishnan, K. Li, Y. Han*, V.M. Rotello*. Antimicrobial peptide-loaded pectolite nanorods for enhancing  wound-healing and biocidal activity of titanium. ACS Applied Materials & Interfaces 13 (2021) 28764-28773.

(50)  Y. Xue, J. Chen, T.X. Ding, M.T. Mao, S.B. Zhu, J.H. Zhou, L. Zhang*, Y. Han**. Building biointegration of Fe2O3-FeOOH coated titanium implant by regulating NIR irradiation in an infected model. Bioactive Materials 8 (2022) 1-11.

(51)  J. Ye#, B. Li#, M. Li, Y.F. Zheng, S.L. Wu, D.F. Chen, Y. Han*. Eco-friendly bacteria-killing by nanorods through mechano-puncture with top selectivity. Bioactive Materials 15 (2022) 173-184.

(52)  D.M. Yu#, B. Li#, M. Yu#, S. Guo, Z. Guo**, Y. Han*. Cubic multi-ions-doped Na2TiO3 nanorod-like coatings: structure-stable, highly efficient platform for ions-exchanged release to immunomodulatory promotion on vascularized bone apposition. Bioactive Materials 18 (2022) 72-90.

(53)  R. Huang, L. Liu, B. Li, L. Qin, L. Huang, K.W.K. Yeung*, Y. Han*. Nanograins on Ti-25Nb-3Mo-2Sn-3Zr alloy facilitate fabricating biological surface through dual-ion implantation to concurrently modulate the osteogenic functions of mesenchymal stem cells and kill bacteria. Journal of Materials Science & Technology 73 (2021) 31-44. 

(54)  D.M. Yu#, S. Guo#, D. Yang#, B. Li*, Z. Guo*, Y. Han*. Interrod spacing dependent angiogenesis and osseointegration of Na2TiO3 nanorods-patterned arrays via immunoregulation. Chemical Engineering Journal 426 (2021) 131187.

(55)  K. Li, J. Chen, Y. Xue, T.X. Ding, S.B. Zhu, M.T. Mao, L. Zhang*, Y. Han*. Polymer brush grafted antimicrobial peptide on hydroxyapatite nanorods for highly effective antibacterial performance. Chemical Engineering Journal 423 (2021) 130133.

(56)  Y. Xue, J. Chen, L. Zhang*, Y. Han*. BSA-lysozyme coated NaCa2HSi3O9 nanorods on titanium for cytocompatibility and antibacterial activity. Journal of Materials Science & Technology 88 (2021) 240-249.