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微流控芯片检测技术及仪器开发
细胞力学信息检测技术及装置开发
● Siyu Li, Zhaonan Liu, Chuyao Zhang, Zhennan Hou, Mengqi Kong, Zonghao Li, Jie Hu, Zedong Li*, Birui Jin*. Piezoelectric Printing-Based Droplet Digital PCR for Noninvasive and Sensitive Detection of Helicobacter Pylori in Stool Samples. Talanta, 2026.
● Shichun Wang#, Ting Pan#, Qi Liu#, Zedong Li#, Ting Wen*, Bo Cheng*, Feng Xu*, Chunyan Yao*. Blood Mechanical Intelligence: From Force Sensing to Precision Mechanomedicine. Research, 2026.
● Long Li, Jing Ji, He Ren, Lilan Gao, Xiaona Li, Ning Li, Songbai Zhang, Kai Tang, Zedong Li, Weiyan Ren, Qing-ping Yao, Kai Huang, He Gong, Yingfeng Shao, Xianglong Lin, Xin Wang, Xiuqing Qian, Jie Song, Yiran Jiang, Hui Chen, Bo Che, Dongyuan Lü, Yu Du, Fan Feng, Yanli Liu, Yan Li, Meiying Luo, Ruotian Du, Cunyu Zhang, Guanshuo Hu, Yufei Ma, Shutong Wang, Rui Yang, Fang Pu, Bingjie Xiang, Ming Zhang, Xinghua Shi, Lizhen Wang, Bo Li, Damir Kračun, Qian Chen, Ahmed Elsheikh, Zi-Jun Liu, Baoyu Liu, Chuanrong Zhao, Yonggang Lü, Zhu Zeng, Zhiyong Li, Yiyao Liu, Guixue Wang, Wenchang Tan, Chunqiu Zhang*, Min Zhang*, Jizhong Lou*, Youhua Tan*, Linhong Deng*, Mian Long*, Ying-Xin Qi*, Weiyi Chen*, Feng Xu*, Yubo Fan*, Fan Song*. Transformative biomechanics and mechanobiology breakthroughs shaping the future of health and medicine. The Innovation, 2026.
● Haoqing Zhang, Lei Cao, Jan Brodsky, Imrich Gablech, Feng Xu, Zedong Li*, Marie Korabecna*, Pavel Neuzil*. Quantitative or digital PCR? A comparative analysis for choosing the optimal one for biosensing applications. TrAC Trends in Analytical Chemistry, 2024.
● Birui Jin, Chuan Ma, Chuyao Zhang, Huiling Yin, Guoxu Zhao, Jie Hu*, Zedong Li*. Point-of-care detection of Monkeypox virus clades using high-performance upconversion nanoparticle-based lateral flow assay. Microchimica Acta, 2024.
● Birui Jin, Chuyao Zhang, Chuan Ma, Huiling Yin, Siyu Li, Zhiguo Du, Guoxu Zhao, Huimei Huang*, Zedong Li*. Innovative strategies and approaches for enhancing performance in optical probe-based biosensors for point-of-care testing. TrAC Trends in Analytical Chemistry, 2024.
● Birui Jin, Siyu Li, Chuyao Zhang, Chuan Ma, Jie Hu*, Jun Wang*, Zedong Li. Systematic optimization of UCNPs-LFA for Helicobacter pylori nucleic acid detection at point-of-care. Microchimica Acta, 2024.
● Ning Xie#, Jin Tian#, Zedong Li#, Nianyuan Shi, Bin Li, Bo Cheng, Ye Li*, Moxiao Li*, Feng Xu*. Invited review for 20th anniversary special issue of PLRev “AI for mechanomedicine”. Physics of Life Reviews, 2024.
● Jie Liu, Shuang Wu, Chao Zhang, Minli You, Haoqing Zhang, Feng Xu, Won Gu Lee*, Hui Guo*, Zedong Li*. Integrated dual-biomarker detection: Transforming proteins and nucleic acids into ssDNA for enhanced disease diagnosis. Chemical Engineering Journal, 2024.
● Birui Jin, Zhiguo Du, Jingcheng Ji, Yuemeng Bai, Deding Tang, Lihua Qiao, Jiatao Lou, Jie Hu*, Zedong Li*. Regulation of probe density on upconversion nanoparticles enabling high-performance lateral flow assays. Talanta, 2023.
● Chao Zhang, Hao Liu, Xiujun Li, Feng Xu*, Zedong Li*. Modularized synthetic biology enabled intelligent biosensors. Trends in Biotechnology, 2023.
● Yulin Ren, Jingcheng Ji, Haoqing Zhang, Lei Cao, Jie Hu, Feng Xu, Zedong Li*. A three-in-one microfluidic droplet digital PCR platform for absolute quantitative analysis of DNA. Lab on a Chip, 2023.
● Pengpeng Jia#, Zedong Li#, Xuefeng Wang, Feng Xu, Minli You*, Shangsheng Feng*. Performance improvement of lateral flow assay using heterogeneous nitrocellulose membrane with nonuniform pore size. International Communications in Heat and Mass Transfer, 2023.
● Chao Zhang, Zedong Li*, Jie Liu, Chang Liu, Haoqing Zhang, Won Gu Lee, Chunyan Yao*, Hui Guo*, Feng Xu*. Synthetic gene circuit-based assay with multilevel switch enables background-free and absolute quantification of circulating tumor DNA. Research, 2023.
● Ruihua Tang, Ming Yue Xie, Min Li, Lei Cao, Shangsheng Feng, Zedong Li*, Feng Xu*. Nitrocellulose membrane for paper-based biosensor. Applied Materials Today, 2022.
● Yuemeng Bai, Jingcheng Ji, Fengdan Ji, Shuang Wu, Yuan Tian, Birui Jin*, Zedong Li*. Recombinase polymerase amplification integrated with microfluidics for nucleic acid testing at point of care. Talanta, 2022.
● Birui Jin, Zedong Li*, Guoxu Zhao, Jingcheng Ji, Jie Chen, Yexin Yang, Rong Xu. Upconversion fluorescence-based paper disc for multiplex point-of-care testing in water quality monitoring. Analytica Chimica Acta, 2022.
● Zedong Li, Shuang Wu, Jingcheng Ji, Yuemeng Bai, Pengpeng Jia, Yan Gong, Shangsheng Feng, Fei Li*. Ball pen writing-without-ink: a truly simple and accessible method for sensitivity enhancement in lateral flow assays. RSC advances, 2022.
● Ruihua Tang, Min Li, Xueyan Yan, Mingyue Xie, Li Na Liu, Zedong Li*, Feng Xu*. Comparison of paper-based nucleic acid extraction materials for point-of-care testing applications. Cellulose, 2022.
● Ping Peng, Chang Liu, Zedong Li, Zhenrui Xue, Ping Mao, Jie Hu, Feng Xu, Chunyan Yao*, Minli You*. Emerging ELISA derived technologies for in vitro diagnostics. TrAC Trends in Analytical Chemistry, 2022.
● Jie Liu, Chao Zhang, Lei Cao, Minli You, Zedong Li, Hui Guo, Chunyan Yao, Jiatao Lou, Penghui Zhang*, Feng Xu*. Ultrasensitive multiplexed detection of small molecules and enzymes using stimuli-responsive nucleic acids. Chemical Engineering Journal, 2022.
● Chao Zhang, Penghui Zhang, Hui Ren, Pengpeng Jia, Jingcheng Ji, Lei Cao, Peiwei Yang, Yuxin Li, Jie Liu, Zedong Li, Minli You, Xiaoman Duan, Jie Hu, Feng Xu*. Synthetic biology-powered biosensors based on CRISPR/Cas mediated cascade signal amplification for precise RNA detection. Chemical Engineering Journal, 2022.
● Yulin Ren, Lei Cao, Minli You, Jingcheng Ji, Yan Gong, Hui Ren, Feng Xu, Hui Guo*, Jie Hu*, Zedong Li*. “SMART” digital nucleic acid amplification technologies for lung cancer monitoring from early to advanced stages. TrAC Trends in Analytical Chemistry, 2022.
● Birui Jin, Zhiguo Du, Chuyao Zhang, Zhao Yu, Xuemin Wang, Jie Hu*, Zedong Li*. Eu-chelate polystyrene microsphere-based lateral flow immunoassay platform for hs-CRP detection. Biosensors, 2022.
● Zedong Li, Yuemeng Bai, Minli You, Jie Hu, Chunyan Yao*, Lei Cao*, Feng Xu*. Fully integrated microfluidic devices for qualitative, quantitative and digital nucleic acids testing at point of care. Biosensors and Bioelectronics, 2021.
● Wanghong He, Minli You, Zedong Li, Lei Cao, Feng Xu, Fei Li*, Ang Li*. Upconversion nanoparticles-based lateral flow immunoassay for point-of-care diagnosis of periodontitis. Sensors and Actuators B: Chemical, 2021.
● Minli You, Pengpeng Jia, Xiaocong He, Zheyu Wang, Shangsheng Feng, Yulin Ren, Zedong Li, Lei Cao, Bin Gao, Chunyan Yao, Srikanth Singamaneni* and Feng Xu*. Quantifying and adjusting plasmon‐driven nano‐localized temperature field around gold nanorods for nucleic acids amplification. Small Methods, 2021.
● Lei Cao, Xiaojin Guo, Ping Mao, Yulin Ren, Zedong Li, Minli You, Jie Hu, Miao Tian, Chunyan Yao, Fei Li, Feng Xu*. A portable digital loop-mediated isothermal amplification platform based on microgel array and hand-held reader. ACS Sensors, 2021.
● Zedong Li, Minli You, Yuemeng Bai, Yan Gong, Feng Xu*. Equipment‐free quantitative readout in paper‐based point‐of‐care testing. Small Methods, 2020.
● Rui Hua Tang, Min Li, Li Na Liu, Su Feng Zhang, Nur Alam, Minli You, Yong Hao Ni, Zedong Li*. Chitosan-modified nitrocellulose membrane for paper-based point-of-care testing. Cellulose, 2020.
● Minli You, Zedong Li*, Shangsheng Feng, Bin Gao, Chunyan Yao, Jie Hu, Feng Xu*. Ultrafast photonic PCR based on photothermal nanomaterials. Trends in biotechnology, 2020.
● Rongyan He, Yan Niu, Zedong Li, Ang Li, Huayuan Yang, Feng Xu, Fei Li*. A hydrogel microneedle patch for point‐of‐care testing based on skin interstitial fluid. Advanced Healthcare Materials, 2020.
● Yan Niu, Hao Liu, Rongyan He, Zedong Li, Hui Ren, Bin Gao, Hui Guo, Guy M Genin, Feng Xu*. The new generation of soft and wearable electronics for health monitoring in varying environment: From normal to extreme conditions. Materials Today, 2020.
● Yingchun Li, Zedong Li, Hao Liu, Siyue Chen, Xiaojin Guo, Min Lin, Fei Li*. A portable electrochemical platform integrated with a 3D AuNPs/CNTs sponge for point-of-care testing of neurotransmitters. Journal of the Electrochemical Society, 2019.
● Rui Hua Tang, Li Na Liu, Su Feng Zhang, Ang Li, Zedong Li*. Modification of a nitrocellulose membrane with cellulose nanofibers for enhanced sensitivity of lateral flow assays: application to the determination of Staphylococcus aureus. Microchimica Acta, 2019.
● Zedong Li, Hao Liu, Xiaocong He, Feng Xu, Fei Li*. Pen-on-paper strategies for point-of-care testing of human health. TrAC Trends in Analytical Chemistry, 2018.
● Kelvin Ng, Bin Gao*, Kar Wey Yong, Yuhui Li, Meng Shi, Xin Zhao, Zedong Li, Xiaohui Zhang, Belinda Pingguan-Murphy, Hui Yang, Feng Xu*. Paper based cell culture platform and its emerging biomedical applications. Materials Today, 2017.
● Hao Liu, Huaibin Qing, Zedong Li, Yu Long Han, Min Lin, Hui Yang, Ang Li, Tian Jian Lu, Fei Li*, Feng Xu*. Paper: A promising material for human-friendly functional wearable electronics. Materials Science and Engineering: R: Reports, 2017.
● Lei Cao, Xingye Cui, Jie Hu, Zedong Li, Jane Ru Choi, Qingzhen Yang, Min Lin, Li Ying Hui, Feng Xu*. Advances in digital polymerase chain reaction (dPCR) and its emerging biomedical applications. Biosensors and Bioelectronics, 2017.
● Zedong Li, Fei Li*, Yue Xing, Zhi Liu, Minli You, Yingchun Li, Ting Wen, Zhiguo Qu, Xiao Ling Li, Feng Xu. Pen-on-paper strategy for point-of-care testing: Rapid prototyping of fully written microfluidic biosensor. Biosensors and Bioelectronics, 2017.
● Zedong Li, Hao Liu, Cheng Ouyang, Wei Hong Wee, Xingye Cui, Tian Jian Lu, Belinda Pingguan‐Murphy, Fei Li*, Feng Xu*. Recent advances in pen‐based writing electronics and their emerging applications. Advanced Functional Materials, 2016.
● Zedong Li, Fei Li, Jie Hu, Wei Hong Wee, Yu Long Han, Belinda Pingguan-Murphy, Tian Jian Lu, Feng Xu*. Direct writing electrodes using a ball pen for paper-based point-of-care testing. Analyst, 2015.
● Wei Hong Wee, Zedong Li, Jie Hu, Nahrizul Adib Kadri, Feng Xu, Fei Li, Belinda Pingguan-Murphy. Fabrication of dielectrophoretic microfluidic chips using a facile screen-printing technique for microparticle trapping. Journal of Micromechanics and Microengineering, 2015.
● Lei Cao, Zedong Li, Minli You, Feng Xu. Chapter 9: Microfluidic protein analysis and applications. Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-chip, 2022.(Book Chapter) link
● Minli You, Zedong Li, Penghui Zhang, Dan Bai, Min Lin, Feng Xu. Chapter 11: Nanomaterial- and Micromaterial-Based Immunoassays. Handbook of Immunoassay Technologies, 2018. (Book Chapter) link
2026， 陕西省科学技术进步奖二等奖 （排名：2/9）
2025，陕西省第一届卓越工程师大赛总决赛行业赛一等奖（排名：1/4）
2025，陕西高等学校科学技术研究优秀成果特等奖（排名：2/10）
2024，陕西高等学校科学技术一等奖（排名：10/14）
2023，“秦创原·沣东”杯陕西省科技工作者创新创业大赛二等奖（排名：2/3）
2020，陕西高等学校科学技术一等奖 （排名：3/10）
