科研成果 - 李 小军
1. Xiao-Jun Li*, Charles Morgan, Phan Q. Duy, Lale Evsen, Hao T. Lee, Roxane Machavoine, Kahina Belhous, Sylvain Ernest, Françoise Denoyelle, Cyril Mignot, Frederic Brioude, Marine Parodi, Prathamesh T Nadar Ponniah, Waldemar Kolanus, Kristopher T. Kahle, Sandrine Marline**, Angelika Doetzlhofer***(2025).The RNA-binding protein TRIM71 times auditory sensory organ development and is essential for hearing in human and mice. PNAS (第一和共同通讯作者，Accepted).
2. Xiao-Jun Li*, Charles Morgan, Lin Li, Dr Elena Chrysostomou, Wan-Yu Zhang, Angelika Doetzlhofer*(2025).The Notch ligand Jagged1 plays a dual role in cochlear hair cell regeneration. Nature communication (第一和共同通讯作者，Accepted).
3. Xiaolong Fu‡, Si Wang‡, Yunhao Wu‡, Yu Sun‡, Wenwen Liu‡, Xin Xi,Geng-Lin Li*, Ke Liu*, Wei Yuan*, Fangyi Chen*, Hongyang Wang*, Tao Yang*, Yuhe Liu*, Jialin Zheng*, Haibo Shi*, Jing Qu* , Xiaowei Chen*, Limin Suo*, Yideng Huang*, Xinbo Xu*, Xuxia Tang*, Xiaojun Li*, Lei Xu*, Xia Gao*, Lisheng Yu*, Yilai Shu*, Weiqi Zhang*, Jinpeng Sun*, Huijun Yuan*, Shusheng Gong*, Wenyan Li*, Xiulan Ma*, Dingjun Zha*, Jiangang Gao*, Huawei Li*, Zuhong He*, Guang-Hui Liu* , Gang Pei*, Weijia Kong*, Haibo Wang*, Renjie Chai* (2025). A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement. Life Medicine. Volume 4, lnaf011 (共同通讯作者).
4. Xiao-Jun Li, Charles Morgan, Prathamesh Nadar Ponniah, Waldemar Kolanus, and Angelika Doetzlhofer (2023). TRIM71 reactivation enhances the mitotic and hair cell-forming capacity of cochlear-supporting cells. EMBO Reports. 24(9):e56562.
5. Xiao-Jun Li, Charles Morgan, Loyal A. Goff, Angelika Doetzlhofer (2022). Follistatin promotes LIN28B mediated supporting cell reprogramming and hair cell regeneration in the murine. Science Advances. 8(6):eabj7651.
6. Xiao-Jun Li, Doetzlhofer A (2020). LIN28B/let-7 control the ability of neonatal murine auditory supporting cells to generate hair cells through mTOR signaling. PNAS. 117(36):22225-22236.
7. Xiao-Jun Li, XJ Liu, B Yang, YR Fu, F. Zhao, ZZ Shen, LF Miao, S Rayner, SChavanas, H Zhu, WJ Britt, QY Tang, MA McVoy, and MH Luo (2015). Human Cytomegalovirus Infection Dysregulates the Localization and Stability of NICD1 and Jag1 in Neural Progenitor Cells. J Virol. 89(13):6792-6804.
8. Pan X*, Xiao-Jun Li*, (*共同第一作者) Liu XJ, Yuan H, Li JF, Duan YL, Ye HQ, Fu YR, Qiao GH, Wu CC, Yang B, Tian XH, Hu KH, Miao LF, Chen XL, Zheng J, Rayner S, Schwartz PH, Britt WJ, Xu J, Luo MH (2013). Later Passage Neural Progenitor Cells from Neonatal Brain Are More Permissive for Human Cytomegalovirus Infection. J Virol. 87(20):10968-10979.
9. Phan Q. Duy, Stefan C. Weise, Claudia Marini, Xiao-Jun Li, Dan Liang, Peter J. Dahl, Shaojie Ma 1, Ana Spajic, Weilai Dong, Jane Juusola, Emre Kiziltug, Adam J. Kundishora, Sunil Kounda, Maysam Z. Pedram, Lucia A. Torres-Fernández, Kristian Händler, Elena De Domenico, Matthias Becker, Thomas Ulas, Stefan A. Juranek, Elisa Cuevas, Le Thi Hao, Bettina Jux, André M. M. Sousa, Fuchen Liu, Suel-Kee Kim, Mingfeng Li, Yiying Yang, Yutaka Takeo, Alvaro Duque, Carol Nelson-Williams, Yonghyun Ha, Kartiga Selvaganesan, Stephanie M. Robert, Amrita K. Singh, Garrett Allington, Charuta G. Furey, Andrew T. Timberlake, Benjamin C. Reeves, Hannah Smith, Ashley Dunbar, Tyrone DeSpenza Jr., June Goto, Arnaud Marlier, Andres Moreno-De-Luca, Xin Yu, William E. Butler, Bob S. Carter, Evelyn M. R. Lake, R. Todd Constable, Pasko Rakic, Haifan Lin, Engin Deniz, Helene Benveniste, Nikhil S. Malvankar, Juvianee I. Estrada-Veras, Christopher A. Walsh, Seth L. Alper, Joachim L. Schultze, Katrin Paeschke, Angelika Doetzlhofer, F. Gregory Wulczyn, Sheng Chih Jin, Richard P. Lifton, Nenad Sestan, Waldemar Kolanus and Kristopher T. Kahle (2022). Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus. Nature Neuroscience. 10.1038/s41593-022-01043-3.
10. Yue-Peng Zhou, Xian-Zhang Wang, Sheng-Nan Huang, Lin Chen, Ming Zhang, Xin-Yan Li, Hai-Bin Qin, Xiao Dong, Shuang Cheng, Le Wen, Bo Yang, Xue-Fang An, Ao-Di He, Bing Zhang, Wen-Bo Zeng, Xiao-Jun Li, Youming Lu,Hong-Chuang Li, Haidong Li, Wei-Guo Zou,Alec J Redwood,Simon Rayner, Han Cheng, Michael A Mc Voy, Qiyi Tang, William J Britt, Xin Zhou, Xuan Jiang,Min-Hua Luo. (2022). A congenital CMV infection model for follow-up studies of neurodevelopmental disorders, neuroimaging abnormalities, and treatment. JCI insight. 2022;7(1):e152551.
11. Evsen L, Xiao-Jun Li, Zhang S, Razin S, Doetzlhofer A (2020). Let-7 miRNAs inhibit CHD7 expression and control auditory-sensory progenitor cell behavior in the developing inner ear. Development. 147(15):dev183384.
12. Wu CC, Jiang X, Wang XZ, Liu XJ, Xiao-Jun Li, Yang B, Ye HQ, Harwardt T, Jiang M, Xia HM, Wang W, Britt WJ, Paulus C, Nevels M, Luo MH (2018). Human Cytomegalovirus Immediate Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the Nucleus. J Virol. 92(17):e00340-18.
13. Liu XJ, Yang B, Huang SN, Wu CC, Xiao-Jun Li, Cheng S, Jiang X, Hu F, Ming YZ, Nevels M, Britt WJ, Rayner S, Tang Q, Zeng WB, Zhao F, Luo MH (2017). Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligase. PloS Pathogens. 13(7):e1006542.
14. Rolland M, Xiao-Jun Li, Sellier Y, Martin H, Perez-Berezo T, Rauwel B, Benchoua A, Bessières B, Aziza J, Cenac N, Luo M, Casper C, Peschanski M, Gonzalez-Dunia D, Leruez-Ville M, Davrinche C, Chavanas S (2016). PPARγ Is Activated during Congenital Cytomegalovirus Infection and Inhibits Neuronogenesis from Human Neural Stem Cells. PloS Pathogens. 12(4):e1005547. (The week's Featured Research Article).
15. Fu YR, Liu XJ, Xiao-Jun Li, Shen ZZ, Yang B, Wu CC, Li JF, Miao LF, Ye HQ, Qiao GH, Rayner S, Chavanas S, Davrinche C, Britt WJ, Tang Q, McVoy M, Mocarski E, Luo MH (2014). MicroRNA miR-21 Attenuates Human Cytomegalovirus Replication in Neural Cells by Targeting Cdc25a. J Virol. 89(2):1070-1082.
2. Xiao-Jun Li*, Charles Morgan, Lin Li, Dr Elena Chrysostomou, Wan-Yu Zhang, Angelika Doetzlhofer*(2025).The Notch ligand Jagged1 plays a dual role in cochlear hair cell regeneration. Nature communication (第一和共同通讯作者，Accepted).
3. Xiaolong Fu‡, Si Wang‡, Yunhao Wu‡, Yu Sun‡, Wenwen Liu‡, Xin Xi,Geng-Lin Li*, Ke Liu*, Wei Yuan*, Fangyi Chen*, Hongyang Wang*, Tao Yang*, Yuhe Liu*, Jialin Zheng*, Haibo Shi*, Jing Qu* , Xiaowei Chen*, Limin Suo*, Yideng Huang*, Xinbo Xu*, Xuxia Tang*, Xiaojun Li*, Lei Xu*, Xia Gao*, Lisheng Yu*, Yilai Shu*, Weiqi Zhang*, Jinpeng Sun*, Huijun Yuan*, Shusheng Gong*, Wenyan Li*, Xiulan Ma*, Dingjun Zha*, Jiangang Gao*, Huawei Li*, Zuhong He*, Guang-Hui Liu* , Gang Pei*, Weijia Kong*, Haibo Wang*, Renjie Chai* (2025). A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement. Life Medicine. Volume 4, lnaf011 (共同通讯作者).
4. Xiao-Jun Li, Charles Morgan, Prathamesh Nadar Ponniah, Waldemar Kolanus, and Angelika Doetzlhofer (2023). TRIM71 reactivation enhances the mitotic and hair cell-forming capacity of cochlear-supporting cells. EMBO Reports. 24(9):e56562.
5. Xiao-Jun Li, Charles Morgan, Loyal A. Goff, Angelika Doetzlhofer (2022). Follistatin promotes LIN28B mediated supporting cell reprogramming and hair cell regeneration in the murine. Science Advances. 8(6):eabj7651.
6. Xiao-Jun Li, Doetzlhofer A (2020). LIN28B/let-7 control the ability of neonatal murine auditory supporting cells to generate hair cells through mTOR signaling. PNAS. 117(36):22225-22236.
7. Xiao-Jun Li, XJ Liu, B Yang, YR Fu, F. Zhao, ZZ Shen, LF Miao, S Rayner, SChavanas, H Zhu, WJ Britt, QY Tang, MA McVoy, and MH Luo (2015). Human Cytomegalovirus Infection Dysregulates the Localization and Stability of NICD1 and Jag1 in Neural Progenitor Cells. J Virol. 89(13):6792-6804.
8. Pan X*, Xiao-Jun Li*, (*共同第一作者) Liu XJ, Yuan H, Li JF, Duan YL, Ye HQ, Fu YR, Qiao GH, Wu CC, Yang B, Tian XH, Hu KH, Miao LF, Chen XL, Zheng J, Rayner S, Schwartz PH, Britt WJ, Xu J, Luo MH (2013). Later Passage Neural Progenitor Cells from Neonatal Brain Are More Permissive for Human Cytomegalovirus Infection. J Virol. 87(20):10968-10979.
9. Phan Q. Duy, Stefan C. Weise, Claudia Marini, Xiao-Jun Li, Dan Liang, Peter J. Dahl, Shaojie Ma 1, Ana Spajic, Weilai Dong, Jane Juusola, Emre Kiziltug, Adam J. Kundishora, Sunil Kounda, Maysam Z. Pedram, Lucia A. Torres-Fernández, Kristian Händler, Elena De Domenico, Matthias Becker, Thomas Ulas, Stefan A. Juranek, Elisa Cuevas, Le Thi Hao, Bettina Jux, André M. M. Sousa, Fuchen Liu, Suel-Kee Kim, Mingfeng Li, Yiying Yang, Yutaka Takeo, Alvaro Duque, Carol Nelson-Williams, Yonghyun Ha, Kartiga Selvaganesan, Stephanie M. Robert, Amrita K. Singh, Garrett Allington, Charuta G. Furey, Andrew T. Timberlake, Benjamin C. Reeves, Hannah Smith, Ashley Dunbar, Tyrone DeSpenza Jr., June Goto, Arnaud Marlier, Andres Moreno-De-Luca, Xin Yu, William E. Butler, Bob S. Carter, Evelyn M. R. Lake, R. Todd Constable, Pasko Rakic, Haifan Lin, Engin Deniz, Helene Benveniste, Nikhil S. Malvankar, Juvianee I. Estrada-Veras, Christopher A. Walsh, Seth L. Alper, Joachim L. Schultze, Katrin Paeschke, Angelika Doetzlhofer, F. Gregory Wulczyn, Sheng Chih Jin, Richard P. Lifton, Nenad Sestan, Waldemar Kolanus and Kristopher T. Kahle (2022). Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus. Nature Neuroscience. 10.1038/s41593-022-01043-3.
10. Yue-Peng Zhou, Xian-Zhang Wang, Sheng-Nan Huang, Lin Chen, Ming Zhang, Xin-Yan Li, Hai-Bin Qin, Xiao Dong, Shuang Cheng, Le Wen, Bo Yang, Xue-Fang An, Ao-Di He, Bing Zhang, Wen-Bo Zeng, Xiao-Jun Li, Youming Lu,Hong-Chuang Li, Haidong Li, Wei-Guo Zou,Alec J Redwood,Simon Rayner, Han Cheng, Michael A Mc Voy, Qiyi Tang, William J Britt, Xin Zhou, Xuan Jiang,Min-Hua Luo. (2022). A congenital CMV infection model for follow-up studies of neurodevelopmental disorders, neuroimaging abnormalities, and treatment. JCI insight. 2022;7(1):e152551.
11. Evsen L, Xiao-Jun Li, Zhang S, Razin S, Doetzlhofer A (2020). Let-7 miRNAs inhibit CHD7 expression and control auditory-sensory progenitor cell behavior in the developing inner ear. Development. 147(15):dev183384.
12. Wu CC, Jiang X, Wang XZ, Liu XJ, Xiao-Jun Li, Yang B, Ye HQ, Harwardt T, Jiang M, Xia HM, Wang W, Britt WJ, Paulus C, Nevels M, Luo MH (2018). Human Cytomegalovirus Immediate Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the Nucleus. J Virol. 92(17):e00340-18.
13. Liu XJ, Yang B, Huang SN, Wu CC, Xiao-Jun Li, Cheng S, Jiang X, Hu F, Ming YZ, Nevels M, Britt WJ, Rayner S, Tang Q, Zeng WB, Zhao F, Luo MH (2017). Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligase. PloS Pathogens. 13(7):e1006542.
14. Rolland M, Xiao-Jun Li, Sellier Y, Martin H, Perez-Berezo T, Rauwel B, Benchoua A, Bessières B, Aziza J, Cenac N, Luo M, Casper C, Peschanski M, Gonzalez-Dunia D, Leruez-Ville M, Davrinche C, Chavanas S (2016). PPARγ Is Activated during Congenital Cytomegalovirus Infection and Inhibits Neuronogenesis from Human Neural Stem Cells. PloS Pathogens. 12(4):e1005547. (The week's Featured Research Article).
15. Fu YR, Liu XJ, Xiao-Jun Li, Shen ZZ, Yang B, Wu CC, Li JF, Miao LF, Ye HQ, Qiao GH, Rayner S, Chavanas S, Davrinche C, Britt WJ, Tang Q, McVoy M, Mocarski E, Luo MH (2014). MicroRNA miR-21 Attenuates Human Cytomegalovirus Replication in Neural Cells by Targeting Cdc25a. J Virol. 89(2):1070-1082.
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