校内登录
Acetylcholinesterase Inhibitory Alkaloids from the Whole Plants of Zephyranthes carinata
发布时间：2025-04-30
- 论文名称：
- Acetylcholinesterase Inhibitory Alkaloids from the Whole Plants of Zephyranthes carinata
- 发表刊物：
- Journal of Natrual Products
- 摘要：
- Abstract:
Eleven new alkaloids (1−11), classified as the 12-acetylplicamine (1), N-deformyl-seco-plicamine (2), plicamine (3−6), 4a-epi-plicamine (7), seco-plicamine (8), and lycorine (9−11) framework types, along with 15 known alkaloids (12−26) were isolated from the whole plants of Zephyranthes carinata. The structures of the new alkaloids 1−11 were established by extensive spectroscopic data interpretation. The absolute configurations of 9 and 10 were defined by single-crystal X-ray diffraction analysis. Zephycarinatines A (1), B (2), and G (7) represent the first examples of 12-acetylplicamine, N-deformyl-seco-plicamine, and 4a-epi-plicamine alkaloids, respectively. Alkaloids 6, 11, 17, and 20−23 exhibited AChE inhibitory activities with IC50 values ranging from 1.21 to 184.05 μM, and a preliminary structure−activity relationship is discussed.
- 合写作者：
- Guanqun Zhan, Junfei Zhou, Guangmin Yao, et al.
- 卷号：
- 80
- 页面范围：
- 2462
- 是否译文：
- 否
- 发表时间：
- 2017-09-12
