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Rhodomollanol A, a Highly Oxygenated Diterpenoid with a 5/7/5/5 Tetracyclic Carbon Skeleton from the Leaves of Rhododendron molle
发布时间：2025-04-30
- 论文名称：
- Rhodomollanol A, a Highly Oxygenated Diterpenoid with a 5/7/5/5 Tetracyclic Carbon Skeleton from the Leaves of Rhododendron molle
- 发表刊物：
- Organic Letters (2017), 19, (14), 3935-3938.
- 摘要：
- Abstract:
A novel diterpenoid with an unprecedented carbon skeleton, rhodomollanol A (I), and a new grayanane diterpenoid, rhodomollein XXXI (II), were isolated from the leaves of Rhododendron molle. Their structures were elucidated using comprehensive spectroscopic methods and single-crystal X-ray diffraction. Compd. I possesses a unique cis/trans/trans/cis/cis-fused 3/5/7/5/5/5 hexacyclic ring system featuring a rare 7-oxabicyclo[4.2.1]nonane core decorated with three cyclopentane units. The plausible biosynthetic pathway for I was proposed. Compd. I exhibited moderate PTP1B inhibitory activity.
- 合写作者：
- Junfei Zhou, Guanqun Zhan, Guangmin Yao, et al.
- 卷号：
- 19
- 页面范围：
- 3935
- 是否译文：
- 否
- 发表时间：
- 2017-07-13
