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Flavans with potential anti-inflammatory activities from Zephyranthes candida
发布时间：2025-04-30
- 论文名称：
- Flavans with potential anti-inflammatory activities from Zephyranthes candida
- 发表刊物：
- Bioorganic & Medicinal Chemistry Letters
- 摘要：
- Abstract:
Three new flavans, (2R,3R)-7-methoxy-flavan-3-ol (1), (2S)-7,30-dihydroxy-40-methoxyflavan 30-O-b-Dglucopyranoside (2), (2S)-7,30-dihydroxy-40-methoxyflavan 7-O-b-D-glucopyranoside (3), and one known flavan (4) were isolated from the whole plants of Zephyranthes candida (Amaryllidacea). The structures of the new flavans 1–3 were determined by extensive spectroscopic analyses including HRESIMS, NMR, and electronic circular dichroism (ECD), and the absolute configuration of 1 was confirmed by single-crystal X-ray diffraction analysis with Cu Ka irradiation. Flavans 1–3 displayed significant inhibitory effects on the LPS-induced NO production in RAW264.7 mouse macrophages with IC50 values of 17.34, 16.14, and 21.52 lM, respectively, suggesting their potentials for anti-inflammatory agents.
- 合写作者：
- Guanqun Zhan, Junfei Zhou, Guangmin Yao, et. al.
- 卷号：
- 26
- 页面范围：
- 5967
- 是否译文：
- 否
- 发表时间：
- 2016-10-13
- 上一条：Amaryllidaceae alkaloids with new framework types from Zephyranthes candida as potent acetylcholinesterase inhibitors
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