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Zephycandidine A, the First Naturally Occurring Imidazo[1,2-f] phenanthridine Alkaloid from Zephyranthes candida, Exhibits Significant Anti-tumor and Antiacetylcholinesterase Activities
发布时间：2025-04-30
- 论文名称：
- Zephycandidine A, the First Naturally Occurring Imidazo[1,2-f] phenanthridine Alkaloid from Zephyranthes candida, Exhibits Significant Anti-tumor and Antiacetylcholinesterase Activities
- 发表刊物：
- Scientific Reports
- 摘要：
- Abstract:
Zephycandidine A (1), the first naturally occurring imidazo[1,2-f]phenanthridine alkaloid, was isolated from Zephyranthes candida (Amaryllidaceae). The structure of 1 was elucidated by spectroscopic analyses and NMR calculation, and a plausible biogenetic pathway for zephycandidine A (1) was proposed. Zephycandidine A (1) exhibited significant cytotoxicity against five cancer cell lines with
IC50 values ranging from 1.98 to 7.03 μM with selectivity indices as high as 10 when compared to the normal Beas-2B cell. Further studies suggested that zephycandidine A (1) induces apoptosis in leukemia cells by the activation of caspase-3, upregulation of Bax, downregulation of Bcl-2, and degradation of PARP expression. In addition, zephycandidine A (1) showed acetylcholinesterase (AChE) inhibitory activity, and the docking studies of zephycandidine A (1) and galanthamine (2) with AChE revealed that interactions with W286 and Y337 are necessary.
- 合写作者：
- Guanqun Zhan, Xiaolan Qu, Guangmin Yao, et al.
- 卷号：
- 6
- 页面范围：
- 33990
- 是否译文：
- 否
- 发表时间：
- 2016-09-23
