董珊珊 教授，博士生导师
学院：生命科学与技术学院
系所/中心：生物医学信息与基因组学中心
办公地点：创新港18号巨构（泓生楼）
联系方式：dongss@xjtu.edu.cn
针对影响人类健康的复杂疾病（如肥胖及相关代谢疾病等），开展人工智能、功能基因组学与分子生物学的深度交叉研究。通过整合大规模队列的多组学数据及医学影像等临床表型信息，开发高效的计算方法与分析框架，解析疾病发生的分子机制，并构建风险预测模型，为疾病早期干预和新型治疗策略的探索提供理论支撑。相关代表性成果以第一或者通讯作者（含共同）发表在Nature Neuroscience、Nature Human Behaviour、Nature Communications和American Journal of Human Genetics等期刊。主持国家自然科学基金三项。
1. Zhu RJ#, Guo Y#, Wang JH, Yu K, Shi W, Pan W, Yu XL, Chen W, Dong SS*, Yang TL*. Revealing the genetic architectures underlying organ-specific aging based on proteomic data. Nature Communications. 2026, 17:528.
2. Shi W#, Dong SS#, Zhu RJ, Tang SH, Wang JH, Jiang F, Wu H, Duan YY, Guo J, Liu K, Li ZQ, Li M, Wang J*, Guo Y*, Yang TL*. Genetic Insights into Head-to-Body Ratios Via Deep Learning-Based Image Segmentation and Implications for Common Diseases. Nature Communications.2026, 17:864.
3. Dong SS#, Duan YY#, Zhu RJ, Jia YY, Chen JX, Huang XT, Tang SH, Yu K, Shi W, Chen XF, Jiang F, Hao RH, Liu Y, Liu Z, Guo Y*, Yang TL*. Systematic functional characterization of non-coding regulatory SNPs associated with central obesity. American Journal of Human Genetics. 2025 Jan 2;112(1):116-134.
4. Guo J#, Yu K#, Dong SS#, Yao S, Rong Y, Wu H, Zhang K, Jiang F, Chen YX, Guo Y*, Yang TL*. Mendelian randomization analyses support causal relationships between brain imaging-derived phenotypes and risk of psychiatric disorders. Nature Neuroscience. 2022,25(11):1519-1527.
5. Yao S#, Zhang M#, Dong SS#, Wang JH, Zhang K, Guo J, Guo Y*, Yang TL*. Bidirectional two-sample Mendelian Randomization analysis identifies causal associations between relative carbohydrate intake and depression. Nature Human Behaviour. 2022; 6(11):1569-1576. ESI热点与高被引
6. Hu WX#, Rong Y#, Guo Y, Jiang F, Tian W, Chen H, Dong SS*, Yang TL*. ExsgRNA: reduce off-target efficiency by on-target mismatched sgRNA. Briefings in Bioinformatics, 2022;23(5):bbac183.
7. Dong SS#, Zhang K#, Guo Y, Ding JM, Rong Y, Feng JC, Yao S, Hao RH, Jiang F, Chen JB, Wu H, Chen XF, Yang TL*. Phenome-wide investigation of the causal associations between childhood BMI and adult trait outcomes: A two-sample Mendelian randomization study. Genome Medicine. 2021, 13(1):48.
8. Dong SS#, He WM#, Ji JJ, Zhang C, Guo Y*, Yang TL*. LDBlockShow: a fast and convenient tool for visualizing linkage disequilibrium and haplotype blocks based on variant call format files. Briefings in Bioinformatics, 2021, 22(4):bbaa227.ESI高被引
9. Dong SS#,Zhu DL#,Zhou XR, Rong Y, Zeng M, Chen JB, Jiang F, Tuo XM, Feng Z, Yang TL, Guo Y*. An intronic risk SNP rs12454712 for central obesity acts as an allele-specific enhancer to regulate BCL2 expression. Diabetes. 2021, 70(8):1679-1688.
10. Dong SS#,Guo Y#, Yao S, Chen YX, He MN, Zhang YJ, Chen XF, Chen JB, Yang TL*. Integrating regulatory features data for prediction of functional disease-associated SNPs. Briefings in Bioinformatics. 2019, 20(1):26-32.
11. Zhang C#,Dong SS #,Xu JY, He WM*, Yang TL*. PopLDdecay: a fast and effective tool for linkage disequilibrium decay analysis based on variant call format files. Bioinformatics. 2019, 35(10):1786-1788. ESI热点与高被引
12. Dong SS, Zhang YJ, Chen YX, Yao S, Hao RH, Rong Y, Niu HM, Chen JB, Guo Y*, Yang TL*. Comprehensive review and annotation of susceptibility SNPs associated with obesity related traits. Obesity Reviews. 2018, 19(7):917-930.
13. Zhao S#, Zheng P#, Dong S#, Zhan X#, Wu Q#, Guo X, Hu Y, He W, Zhang S, Fan W, Zhu L, Li D, Zhang X, Chen Q, Zhang H, Zhang Z, Jin X, Zhang J, Yang H, Wang J, Wang J*, Wei F*. Whole-genome sequencing of giant pandas provides insights into demographic history and local adaptation. Nature Genetics. 2013, 45(1):67-71.
