国家级领军人才、陕西省领军人才
西安交通大学基础医学院院长
中国西部科技创新港转化医学研究院院长
中国免疫学会副理事长
Life Sci/BMC Immunol/Int Immunopharmacol杂志副主编
陕西省免疫健康重点实验室主任
陕西省科技创新团队负责人
西安交通大学首届“青年优秀导师”(全校10人)
2.0拔尖班/强基计划/珠峰计划优秀指导教师
Welcome - 张 保军
研究方向：
研究免疫细胞谱系起源、发育分化及功能调控的分子机制，筛选并研发肿瘤、自身免疫病、免疫缺陷等疾病的免疫治疗靶点、药物和策略，具体包括：
1)免疫细胞发育及免疫重建的调控机制；
2)免疫细胞分化及抗肿瘤的分子机制；
3)自身免疫病的发生机制及治疗靶点；
4)多组学解析免疫力和疾病早期诊断与免疫治疗。
T细胞生物学（TCB）研究团队，包括教授1名、副教授6名、博士后6名、研究生10名。团队由国家领军人才领衔，团结协作，尊重个性，秉承个人成才与团队发展同频共振的理念，开展基础原创课题研究，解决生命医学科学难题和临床疾病问题。
欢迎副教授、博士后、研究生加入TCB研究团队！欢迎研究生报考TCB研究团队！
电子邮箱：bj.zhang@mail.xjtu.edu.cn
联系电话：82656681/18991906676
联系地址：雁塔西路76号交大医学部微免楼
2019年4月 － 至今：西安交通大学基础医学院院长
中国西部科技创新港转化医学研究院院长
2016年9月 － 至今：教授、博导，西安交通大学
2015年9月 － 2016年9月：Research Scientist，免疫学，美国杜克大学
2014年2月 － 2015年8月：Research Associate，免疫学，美国杜克大学
2009年2月 － 2014年1月：博士后，免疫学，美国杜克大学
2004年9月 － 2009年1月：博士，移植免疫学，中国科学院
主要业绩：
已在 Immunity、JCI、Sci Adv、PNAS、CMI、J Immunother Cancer、STTT、J Adv Res、Elife、Plos Genetics、J Immunol 等杂志发表SCI论文60余篇，共被引用1800余次；主编人卫、科学出版社等教材8部，主持国家级等6项教改项目，荣获省级教学成果奖1项，发表7篇教学论文。
主持科研项目：
主持国家重点研发计划课题、国家自然科学基金委国际(地区)合作与交流重点项目、面上项目、陕西省创新能力支撑计划、陕西省重点研发计划等项目。
| Paper Name | Author | Publication/Completion Time | Magazine Name |
|---|---|---|---|
| Targeting A Disintegrin and Metalloprotease (ADAM) 17-CD122 axis enhances CD8+ T cell effector differentiation and anti-tumor immunity (Accepted) | Lina Sun#, Anjun Jiao#, Haiyan Liu#, ..., Chenming, Sun*, Aijun Zhang*, Lianjun Zhang*, Baojun Zhang* | 2024-05-17 | Signal Transduct Target Ther |
| The Transcription Factor Zfp335 Promotes Differentiation and Survival of Effector Th1 Cells by Directly Regulating Lmna Expression | Haiyan Liu#, Zhao Feng#, Anjun Jiao#, Linbo Lan#, ..., Xiaofeng Yang*, Lianjun Zhang*, Lina Sun*, Baojun Zhang* | 2024-04-10 | J Immunol |
| Zfp335 establishes eTreg lineage and neonatal immune tolerance by targeting Hadha-mediated fatty acid oxidation | Xin Wang#, Lina Sun#, Biao Yang#, Wenhua Li#, Cangang Zhang#, ..., Lei Lei*, WanJun Chen*, Baojun Zhang* | 2023-08-15 | J Clin Invest |
| SEL1L preserves CD8(+) T-cell survival and homeostasis by fine-tuning PERK signaling and the IL-15 receptor-mediated mTORC1 axis | Yafeng Gao#, Wenhui Li#, Zhenghao Wang#, Cangang Zhang#, ..., Jinping Zhang*, Baojun Zhang*, Lianjun Zhang* | 2023-08-03 | Cell Mol Immunol |
| T cells in health and disease | Lina Sun#, Yanhong Su#, Anjun Jiao#, Xin Wang#, Baojun Zhang* | 2023-06-19 | Signal Transduct Target Ther |
| Single-cell sequencing reveals the evolution of immune molecules across multiple vertebrate species | Anjun Jiao#, Cangang Zhang#, Xin Wang#, Lina Sun#, Haiyan Liu, Yanhong Su, Lei Lei, Wenhua Li, Renyi Ding, Chenguang Ding, Meng Dou, Puxun Tian, Chenming Sun, Xiaofeng Yang*, Lianjun Zhang*, Baojun Zhang* | 2023-03-04 | J Adv Res |
| Med1 controls effector CD8+ T cell differentiation and survival through C/EBPβ-mediated transcriptional control of T-bet Running title: Med1 controls effector CD8+ T cell fate | Anjun Jiao#, Haiyan Liu#, Renyi Ding#, Huiqiang Zheng, Cangang Zhang, Zhao Feng, Lei Lei1, Xin Wang,Yanhong Su, Xiaofeng Yang,Chenming Sun, Lianjun Zhang, Liang Bai*, Lina Sun*, Baojun Zhang* | 2022-07-01 | J Immunol |
| The transcription factor Zfp335 promotes differentiation and persistence of memory CD8+ T cells by regulating TCF-1 Running title: Zfp335 regulates memory CD8+ T cells through TCF-1 | Haiyan Liu#, Xin Wang#, Renyi Ding#, Anjun Jiao#, Huiqiang Zheng, Cangang Zhang, Zhao Feng, Yanhong Su, Xiaofeng Yang, Lei Lei1, Lina Sun, Lianjun Zhang, Chenming Sun* , Baojun Zhang* | 2022-06-24 | J Immunol |
| Cytosolic Nuclear Sensor Dhx9 Controls Medullary Thymic Epithelial Cell Differentiation by p53-Mediated Pathways | Xue Dong*, Jiayu Zhang*, Qian Zhang*, Zhanfeng Liang*, Yanan Xu, Yong Zhao#, Baojun Zhang# | 2022-06-03 | Front Immunol |
| Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases. | Liu J＃, Zhang H＃, Su Y, Zhang B | 2022-05-26 | Cell Biosci |
| Functional assessment of the cell-autonomous role of NADase CD38 in regulating CD8+ T cell exhaustion | Kaili Ma#, Lina Sun#, Mingjing Shen#, ..., Feng Guo*, Baojun Zhang*, Lianjun Zhang* | 2022-05-04 | iScience |
| DExD/H-box helicase 9 intrinsically controls CD8+ T cell-mediated antiviral response through noncanonical mechanisms. | Jiao A＃, Sun C＃, Wang X＃, Lei L＃, Liu H＃, Li W, Yang X, Zheng H, Ding R, Zhu K, Su Y, Zhang C, Zhang L*, Zhang B* | 2022-02-11 | Sci Adv |
| Zinc finger protein Zfp335 controls early T-cell development and survival through β-selection-dependent and -independent mechanisms. | Wang X＃, Jiao A＃, Sun L＃, Li W＃, Yang B, Su Y, Ding R, Zhang C, Liu H, Yang X, Sun C, Zhang B* | 2022-02-03 | Elife |
| Arid1a promotes thymocyte development through β-selection-dependent and β-selection-independent mechanisms. | Yang X, Wang X, Lei L, Su Y, Zou Y, Liu H, Jiao A, Zhang C, Liu J, Li W, Ding R, Zhou X, Shi L, Zhang D, Sun C, Zhang B* | 2021-11-18 | Immunology |
| Single-cell sequencing reveals antitumor characteristics of intratumoral immune cells in old mice. | Zhang C＃, Lei L＃, Yang X＃, Ma K, Zheng H, Su Y, Jiao A, Wang X, Liu H, Zou Y, Shi L, Zhou X, Sun C, Hou Y, Xiao Z, Zhang L, Zhang B* | 2021-10-09 | J Immunother Cancer |
| Lineage Tracking the Generation of T Regulatory Cells From Microbial Activated T Effector Cells in Naïve Mice | Kun Zhu#, Chenfeng He#, ..., Baojun Zhang* | 2020-01-17 | Front Immunol |
| Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity. | Zhang B*, Jiao A, Dai M, Wiest DL, Zhuang Y | 2018-09-01 | J Immunol |
| Glimpse of natural selection of long-lived T-cell clones in healthy life. | Zhang B, Jia Q, Bock C, Chen G, Yu H, Ni Q, Wan Y*, Li Q*, Zhuang Y* | 2016-08-30 | Proc Natl Acad Sci U S A |
| MicroRNA-23a Curbs Necrosis during Early T Cell Activation by Enforcing Intracellular Reactive Oxygen Species Equilibrium. | Zhang B, Liu SQ, Li C, Lykken E, Jiang S, Wong E, Gong Z, Tao Z, Zhu B, Wan Y, Li QJ* | 2016-03-15 | Immunity |
| Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells | Zhang B, Wu J, Jiao Y, Bock C, Dai M, Chen B, Chao N, Zhang W, Zhuang Y* | 2015-11-01 | J Immunol |
