Bacic Information

 

 

 

   Dr. Baojun Zhang is the professor in immunology, the dean of Basic Medicine School, Xi’an Jiaotong University, the dean of Institute of Translational Medicine, Western China Science and Technology Innovation Harbor, the member of the Transplantation Immunology Branch of the Chinese Society for Immunology, the director of Xi’an Key Laboratory of Basic and Translational Research on Immune-related Diseases, and the leader of Youth Innovation team in Shaanxi Universities. Prof. Zhang has been recognized by National Thousand Youth Talents Program, Thousand Talent Program and San Qin Scholar of Shaanxi Province, and Distinguished Young Talents Program of Xi’an Jiaotong University. Prof. Zhang found TCB research group in Sep, 2017. The TCB group focus on investigating the regulatory mechanisms of immune cell development and differentiation, and their roles in anti-tumor response, anti-viral infection and autoimmune diseases. So far, more than 60 original papers were published in high-impact journals such as Immunity, J Clin Invest, PNAS, J Immunother Cancer, Sci Adv, Nat Immunol, PLoS Genet, J Immunol, Cell Rep, etc., and have been cited over 1,000 times. Prof. Zhang is serving as a Senior Editorial Board Member of BMC Immunol. Prof. Zhang has participated in the compilation of teaching materials for the 13th Five-year Plan of National Organ-system Integration. The research projects are supported by International (Regional) Cooperation and Exchange NSFC Program, NSFC General Program and several talent programs.

Team Name

Email: bj.zhang@mail.xjtu.edu.cn

Academic Exchange

 

1.     Wang, X.; Sun, L.; Yang, B.; Li, W.; Zhang, C.; Yang, X.; Sun, Y.; Shen, X.; Gao, Y.; Ju, B.; Gao, Y.; Liu, D.; Song, J.; Su, Y.; Jiao, A.; Liu, H.; Zhang, L.; He, L.; Lei, L.; Chen, W.; Zhang, B., Zfp335 establishes eTreg lineage and neonatal immune tolerance by targeting Hadha-mediated fatty acid oxidation. J Clin Invest  2023 Oct 16;133(20):e166628. doi: 10.1172/JCI166628.

2.    Jiao, A.; Sun, C.; Wang, X.; Lei, L.; Liu, H.; Li, W.; Yang, X.; Zheng, H.; Ding, R.; Zhu, K.; Su, Y.; Zhang, C.; Zhang, L.; Zhang, B., DExD/H-box helicase 9 intrinsically controls CD8(+) T cell-mediated antiviral response through noncanonical mechanisms. Sci Adv  2022, 8 (6), eabk2691.

3.    Zhang, C.; Lei, L.; Yang, X.; Ma, K.; Zheng, H.; Su, Y.; Jiao, A.; Wang, X.; Liu, H.; Zou, Y.; Shi, L.; Zhou, X.; Sun, C.; Hou, Y.; Xiao, Z.; Zhang, L.; Zhang, B., Single-cell sequencing reveals antitumor characteristics of intratumoral immune cells in old mice. J Immunother Cancer  2021, 9 (10).

4.     Jiao, A.; Zhang, C.; Wang, X.; Sun, L.; Liu, H.; Su, Y.; Lei, L.; Li, W.; Ding, R.; Ding, C.; Dou, M.; Tian, P.; Sun, C.; Yang, X.; Zhang, L.; Zhang, B., Single-cell sequencing reveals the evolution of immune molecules across multiple vertebrate species. J Adv Res  2023.

5.     Sun, L.; Su, Y.; Jiao, A.; Wang, X.; Zhang, B., T cells in health and disease. Signal Transduct Target Ther  2023, 8 (1), 235.

6.     Wang, X.; Jiao, A.; Sun, L.; Li, W.; Yang, B.; Su, Y.; Ding, R.; Zhang, C.; Liu, H.; Yang, X.; Sun, C.; Zhang, B., Zinc finger protein Zfp335 controls early T-cell development and survival through β-selection-dependent and -independent mechanisms. Elife  2022, 11.

7.     Liu, H.; Wang, X.; Ding, R.; Jiao, A.; Zheng, H.; Zhang, C.; Feng, Z.; Su, Y.; Yang, X.; Lei, L.; Sun, L.; Zhang, L.; Sun, C.; Zhang, B., The Transcription Factor Zfp335 Promotes Differentiation and Persistence of Memory CD8(+) T Cells by Regulating TCF-1. J Immunol  2022, 209 (5), 886-895.

8.     Jiao, A.; Liu, H.; Ding, R.; Zheng, H.; Zhang, C.; Feng, Z.; Lei, L.; Wang, X.; Su, Y.; Yang, X.; Sun, C.; Zhang, L.; Bai, L.; Sun, L.; Zhang, B., Med1 Controls Effector CD8(+) T Cell Differentiation and Survival through C/EBPβ-Mediated Transcriptional Control of T-bet. J Immunol  2022, 209 (5), 855-863.

9.     Zhang, B.; Liu, S. Q.; Li, C.; Lykken, E.; Jiang, S.; Wong, E.; Gong, Z.; Tao, Z.; Zhu, B.; Wan, Y.; Li, Q. J., MicroRNA-23a Curbs Necrosis during Early T Cell Activation by Enforcing Intracellular Reactive Oxygen Species Equilibrium. Immunity  2016, 44 (3), 568-581.

10.   Zhang, B.; Jia, Q.; Bock, C.; Chen, G.; Yu, H.; Ni, Q.; Wan, Y.; Li, Q.; Zhuang, Y., Glimpse of natural selection of long-lived T-cell clones in healthy life. Proc Natl Acad Sci U S A  2016, 113 (35), 9858-63.

11.   Zhang, B.; Jiao, A.; Dai, M.; Wiest, D. L.; Zhuang, Y., Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity. J Immunol  2018, 201 (5), 1452-1459.

12.  Zhang, B.; Wu, J.; Jiao, Y.; Bock, C.; Dai, M.; Chen, B.; Chao, N.; Zhang, W.; Zhuang, Y., Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells. J Immunol  2015, 195 (9), 4282-91.

13.   Zhang, B.; Lin, Y. Y.; Dai, M.; Zhuang, Y., Id3 and Id2 act as a dual safety mechanism in regulating the development and population size of innate-like γδ T cells. J Immunol  2014, 192 (3), 1055-1063.

14.   Liu, J.; Zhang, H.; Su, Y.; Zhang, B., Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases. Cell Biosci  2022, 12 (1), 68.

15.   Yang, X.; Wang, X.; Lei, L.; Su, Y.; Zou, Y.; Liu, H.; Jiao, A.; Zhang, C.; Liu, J.; Li, W.; Ding, R.; Zhou, X.; Shi, L.; Zhang, D.; Sun, C.; Zhang, B., Arid1a promotes thymocyte development through β-selection-dependent and β-selection-independent mechanisms. Immunology  2022, 165 (4), 402-413.