(5.)Scientific Research

Lei Zhang, Hao Wang, Jian Guo, Huijing Xu, Yihua Qian*, Meiyan Sun*. High level of ANO1 promotes pancreatic cancer growth in concert with oncogenic KRAS. Mol Biol Rep., 2023, 50(4): 3297-3307.*Corresponding author

Li Zilong, Ma Haotian, Wang Meng, Qian Yihua*. Research trend of microbiota-gut-brain axis in Alzheimer’s disease based on CiteSpace (2012–2021): A bibliometrics analysis of 608 articles. Front. Aging Neurosci. 2022 Nov 22;14:1036120. doi: 10.3389/fnagi.2022.1036120.*Corresponding author

Meng Wang, Li-Rong Feng, Zi-Long Li, Kai-Ge Ma, Ke-Wei Chang, Xin-Lin Chen, Peng-Bo Yang, Sheng-Feng Ji, Yan-Bing Ma, Hua Han, John Bosco Ruganzua, Wei-Na Yang, Yi-Hua Qian* .

          Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice. J Neuroinflammation. 2021, 18

         (1):146. doi: 10.1186/s12974-021-02166-3. *Corresponding author, IF=9.5

Lan Zhang, Fanglin Liu, Zhixing Meng, Qingyue Luo, Daojing Pan, Yihua Qian*. Inhibited HDAC3 promotes microRNA-376c-3p to suppress malignant phenotypes of gastric cancer cells by  reducing WNT2b, Genomics,

        2021

 

Liu ZQ, Ren JJ, Zhao JL, Zang J, Long QF, Du JJ, Jia XT, Gu NB, Di ZL, Qian YH*, Li SZ* MicroRNA-144 represses gliomas progression and elevates susceptibility to Temozolomide by targeting

      CAV2 and FGF7. Sci Rep. 2020,10(1):4155 (*Corresponding author).

 

Wang M, Zong HF, Chang KW, Han H, Yasir Rizvi M, Iffat Neha S, Li ZY, Yang WN, Qian YH*. 5-HT1AR alleviates Aβ-induced cognitive decline and neuroinflammation through crosstalk with NF-κB pathway in mice. Int Immunopharmacol. 2020, 82:106354(*Corresponding author).

Ke-Wei Chang, Hang-Fan Zong, Meng Wang, Mohammad Yasir Rizvi, Saema Iffat Neha, Wei-Na Yang, Sheng-Feng Ji , Yan-Bing Ma, Yi-Hua Qian*. PNU282987 alleviates Aβ-induced anxiety and depressive-like behaviors through upregulation of α7nAChR by ERK-serotonin receptors pathway. Neurosci Lett. 2020, 731:135118 (*Corresponding author).

Gui-hong Zhang, Krishna Dilip Murthy, Rahmawati Binti Pare, Yi-hua Qian*. Protective effect of Tβ4 on central nervous system tissues and its developmental prospects. European Journal of Inflammation. 2020, 18: 1-11.(*Corresponding author).

 

Gu N, Wang X, Di Z, Xiong J, Ma Y, Yan Y, Qian Y*, Zhang Q, Yu J. Silencing lncRNA FOXD2-AS1 inhibits proliferation, migration, invasion and drug 

      resistance of drug-resistant glioma cells and promotes their apoptosis via microRNA-98-5p/CPEB4 axis. Aging (US). 2019 Nov 26;11(22):10266-

      10283. (*Corresponding author, IF=5.515)

 

Qiankun Quan, Yihua Qian*, Xi Li, Ming Li. CDK5 Participates in Amyloid-β Production by Regulating PPARγ Phosphorylation in Primary Rat

      Hippocampal Neurons. J Alzheimers Dis. 2019 Aug 6. doi: 10.3233/JAD-190026. (*Corresponding author)

 

Qiankun Quan, Yihua Qian*, Xi Li, Ming Li. Pioglitazone Reduces β Amyloid Levels via Inhibition of PPARγ Phosphorylation in a Neuronal Model of

      Alzheimer's Disease.Front Aging Neurosci. 2019 Jul 17;11:178. doi: 10.3389/fnagi.2019.00178. eCollection 2019. (*Corresponding author)

 

 Gu N, Wang J, Di Z, Liu Z, Jia X, Yan Y, Chen X, Zhang Q, Qian Y*.The Effects of Intelectin-1 on Antioxidant and Angiogenesis in HUVECs Exposed to 

      Oxygen Glucose Deprivation.Front Neurol. 2019 Apr 16;10:383. doi: 10.3389/fneur.2019.00383. eCollection 2019. (*Corresponding author)

 

Ma KG, Qian YH*. Alpha 7 nicotinic acetylcholine receptor and its effects on Alzheimer's disease. Neuropeptides. 2019, 73: 96-

      106(*Corresponding author

 

Yang W, Zhang J, Shi L, Ji S, Yang X, Zhai W, Zong H, Qian Y*. Protective effects of tanshinone IIA on SH-SY5Y cells against oAβ1-42-induced apoptosis

       due to prevention of endoplasmic reticulum stress. Int J Biochem Cell Biol. 2019,107:82-91. (*Corresponding author

 

Chang KW, Zong HF, Ma KG, Zhai WY, Yang WN, Hu XD, Xu JH, Chen XL, Ji SF, Qian YH*. Activation of α7 nicotinic acetylcholine receptor alleviates Aβ1-42-induced neurotoxicity via downregulation of p38 and JNK MAPK signaling pathways.Neurochem Int. 2018 ;120:238-250.(*Corresponding author) 

 

Kai-Ge Ma, Jia Lv, Wei-Na Yang, Ke-Wei Chang, Xiao-Dan Hu, Li-Li Shi, Wan-Ying Zhai, Hang-Fan Zong, Yi-Hua Qian*. The p38 mitogen activated protein kinase regulates β-amyloid protein internalization through theα7 nicotinic acetylcholine receptor in mouse brain. Brain Research Bulletin, 2018,13741-52 (*Corresponding author)

 

Naibing Gu, Yaru Dong, Ye Tian, Zhengli Di, Zhiqin Liu, Mingze Chang, Xiaotao Jia, Yihua Qian*,Weiping Zhang. Anti-apoptotic and angiogenic effects of intelectin-1 in rat cerebral ischemia. Brain Research Bulletin, 2017, 130:27-35. (*Corresponding author)

 

Zhang L, Xiao X, An H, Wang J, Ma Y, Qian YH*. Inhibition of CCR7 promotes NF-κB-dependent apoptosis and suppresses epithelial-mesenchymal

     transition in non-small cell lung cancer. Oncol Rep. 2017, 37(5):2913-2919. (*Corresponding author)

 

Wu SD, Xia F, Lin XM, Duan KL, Wang F, Lu QL, Cao H, Qian YH*, Shi M*. Ginsenoside-Rd Promotes Neurite Outgrowth of PC12 Cells through

      MAPK/ERK- and PI3K/AKT-Dependent Pathways. Int J Mol Sci. 2016 Jan 29;17(2). pii: E177. (*Corresponding authors

 

Ma KG, Lv J, Hu XD, Shi LL, Chang KW, Chen XL, Qian YH*, Yang WN*, Qu QM*. The p38 mitogen-activated protein kinase signaling pathway is

     involved in regulating low-density lipoprotein receptor-related protein 1-mediated β-amyloid protein internalization in mouse brain. Int J Biochem Cell Biol.

     2016 ,76:75-86. (*Corresponding authors

 

Chang Liu, YouxuanWu, ShuaZha, Mengping Liua, Ying Wang, Guangde Yang, Kaige Ma, Yulang Fei, Yaojie Zhang, Xiaodan Hu, Weina Yang*, Yihua Qian*. Treatment effects of tanshinone IIA against intracerebroventricular streptozotocininduced memory deficits inmice. Brain Res. 2016,1631:137-146 (*Corresponding authors

 

Yang WN, Ma KG, *Qian YH, Zhang JS, Feng GF, Shi LL, Zhang ZC, Liu ZH. Mitogen-activated protein kinase signaling pathways promote low-density lipoprotein receptor-related protein 1-mediated internalization of beta-amyloid protein in primary cortical neurons. Int J Biochem Cell Biol. 2015, 64:252-264 (*Corresponding authors)
 
Li-Tao Yang, Ning Wang , Zeng-Xian Li , Cui Liu, Xin He, Jian-Fei Zhang , Hua Han, You-Feng Wen , *Yi-Hua Qian , *Huan-Jiu Xi. Study on adult physique with Heath-Carter anthropometric somatotype in Han of Xi’an, China . Anat Sci Int.,2016,  91(2):180-187 (*Corresponding authors)
  

Songdi Wu, Ningning Li, Feng Xia, Kastytis Sidlauskas, Xuemei Lin, Yihua Qian, Wei Gao and Qinlu Zhang. Neurotrophic keratopathy due to dorsolateral medullary infarction (Wallenberg Syndrome): case report and literature review.BMC Neurol. 2014, 14(1):231(Page1-4).

 

Weina Yang, Lili Shi, Lianji Chen, Bingyi Zhang, Kaige Ma, Yong Liu, *Yihua Qian. Protective effects of perindopril on D-galactose and aluminum trichloride induced neurotoxicity via the apoptosis of mitochondria-mediated intrinsic pathway in the hippocampusof mice. Brain Research Bulletin, 2014, 109: 46-53 (*Corresponding authors 

 

Yang WN, Ma KG, Chen XL, Shi LL, Bu G, Hu XD, Han H, Liu Y, *Qian YH. Mitogen-activated protein kinase signaling pathways are involved in regulating α7 nicotinic acetylcholine receptor-mediated amyloid-β uptake in SH-SY5Y cells. Neuroscience. 2014, 278: 276-290. (*Corresponding authors)

 

Wei-Na Yang,Xiao-Dan Hu, Hua Han, Li-Li Shi, Gai-Feng Feng,Yong Liu, *Yi-Hua Qian. The effects of valsartan on cognitive deficits induced by aluminium trichloride and D-galactose in mice. Neurological Research, 2014,36(7):651-658(*Corresponding authors)

 

Wei-Na Yang, Hua Han, Xiao-Dan Hu Gai-Feng Feng,*Yi-Hua Qian. The effects of perindopril on cognitive impairment induced by D-galactose and aluminum trichloride via inhibition of acetylcholinesterase activity and oxidative stress. Pharmacology, Biochemistry and Behavior, 2013 , 114-115: 31-36*Corresponding authors

 

Qian YH, Xiao Q, Xu J.The protective effects of tanshinone IIA on β-amyloid protein (1-42)-induced cytotoxicity via activation of the Bcl-xL pathway in neuron.Brain Res Bull. 2012, 88(4): 354-358

 

Shi LL, Yang WN, Chen XL, Zhang JS, Yang PB, Hu XD, Han H, *Qian YH, *Liu Y.The protective effects of tanshinone IIA on neurotoxicity induced by β-amyloid protein through calpain and the p35/Cdk5 pathway in primary cortical neurons.Neurochem Int. 201261(2): 227-235 *Corresponding authors

 

He X, Zhang JF, Li ZX, Liu C, Yang LT, Wang N, Han H, *Qian YH, Wen YF, *Xi HJ The traits of five types of tongue movement in Han of Shaanxi, China. Anat Sci Int. 2012,87(4):81-86.*Corresponding authors)

 

Yi-Hua Qian, Qingli Xiao, Hong Chen, Jan Xu. Dexamethasone Inhibits Camptothecin-Induced Apoptosis in C6-Glioma via Activation of Stat5/Bcl-xL Pathway. BBA - Molecular Cell Research, 2009, 1793(5):764-71

 

Qian YH, Han H, Hu XD Shi LL. Protective effect of ginsenoside Rb1 on amyloid protein(1-42)-induced neurotoxicity in cortical neurons. Neurol Res, 2009, 31(7): 663-667.

 

Lu HX, Li MJ, Song TS, Qian YH, Xiao XL, Chen XL, Zhang PB, Feng XS, Terence P, Liu Y. Retrovirus delivered neurotrophin-3 promotes survival, proliferation and neuronal differentiation of human fetal neural stem cells in vitro. BRAIN RESEARCH BULLETIN, 2008,77(4): 158-164

 

Jie-Hua Xu, Hai-Tao Hu, Yong Liu, Yi-Hua Qian, Zhao-Hui Liu,Qing-Rong Tan, Zhang-Jin Zhang.Neuroprotective effects of ebselen are associated with the regulation of Bcl-2 and Bax proteins in cultured mouse cortical neurons. Neuroscience Letters, 2006, 399: 210–214

 

Zhang-Jin Zhang, Yi-Hua Qian, Hai-Tao Hu, Jie Yang, Guang-De Yang.The herbal medicine Dipsacus asper Wall extract reduces the cognitive deficits and overexpression of β-amyloid protein induced by aluminum exposure. Life Sciences ,2003,73(19): 2443-2454

 

Qian YH, Liu Y, Hu HT, Ren HM, Chen XL, Xu JH.The effects of the total saponin of Dipsacus asperoides on the damage of cultured neurons induced by b-amyloid protein 25-35.Anatomical Science International,2002,77(3):196-200

 

 
 Wu SD, Xia F, Lin XM, Duan KL, Wang F, Lu QL, Cao H, Qian YH*, Shi M*. Ginsenoside-Rd Promotes Neurite Outgrowth of PC12 Cells through MAPK/ERK- and PI3K/AKT-Dependent Pathways. Int J Mol Sci. 2016 Jan 29;17(2). pii: E177. (*Corresponding authors)