专著

1.      《牙齿的热-力-电生理耦合行为》  卢天健 林敏 徐峰  著  科学出版社March 2015, ISBN：9787030433473.

专著章节

2.         M. Lin, S.B. Liu, F. Xu^#, T.J. Lu^#, B.F. Bai, G. Genin. Thermal pain in tooth: heat transfer, thermomechanics, and ion transport, Transport in Biological Media, Elsevier, Edited by Sid M. Becker, Andrey V. Kuznetsov, 2013, (ISBN: 978-0-12-415824-5)

3. S.B. Liu, H. Liu, M. Lin^#, F. Xu, T.J. Lu^#. Intracellular Microfluid Transportation in Fast Growing Pollen Tubes, Modelling of Microscale Transport in Biological Processes, Elsevier, Edited by Sid M. Becker, 2016, (ISBN: 978-0-12-804595-4)

 Selected Publications 

1.       Jinteng Feng*, Guoqing Zhao*, Lingzhu Zhao, Luying Geng, Shirong Zhang, Longwen Xu, Mengjie Liu, Guangjian Zhang, Feng Xu, M. Lin#, Hui Guo#,        Integrin-Mediated Mechanosensing of Modeled Lymph Node Microenvironment Promotes T cell Activation via Nuclear Deformation, Research, 2026

   

   
   

2.  L.Z. Zhao, Guoqing Zhao, J.X. Fu, Y. Liu, J.T. Feng, G.J. Zhang, F. Xu, H. Guo, M. Lin#, Programmed cell Death Protein 1 Engagement Impairs Cytoskeletal Forces and Nuclear Mechanotransduction in T Cells, ACS Nano, 2025, 19(46): 39667-39681.  

   

   
   

3. Huan Gao*, Bo Cheng*, Guorui Jin*, Yulong Han, Qi Tian, Yan Zhou, Xiwen Zhao, Yan Liu, Chunyu Cao, Lizhe Zhu, Juan Zhang, Lin Wang, Binghe Xu#,     Hui Guo#, Min Lin#, Jin Yang#, Feng Xu#, Multicellular force coordination constructs microchannel networks for barrier-free metastasis across extracellular matrix,  Science Advances, 2025, 11(51)

   

   
   

4. H.Y.Zhu. X.X. Liu, J. Wang, Y.Y. Mia, Y. Liu, H. Guo, J. Yang, Z. Wang, T.J. Lu, F. Xu, M. Lin#,Traction-Regulated Persistence Governs Durotaxis across Cell Types, European Journal of Cell Biology, 2025.

   

   
   

5.  B. Cheng, M.X. Li, M. Lin#, Hui Guo#, Feng Xu# , Mechanobiology across Timescales, Nature Reviews Physics, 2025.

6.  S.M. Zhang*, H.Y. Zhu*, Z.E. Zhu, S. Wu, Y.Q. Song, J. Wang, X.L. Chen, W.K. Qian, J.P. Li, Y.Y. Yue, Q.H. Xu, Z.P. Ruan, Q. Li, Y.M. Zhu, T.J. Lu, G. Genin,  F. Xu, Z. Wang#, M. Lin#, MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis, Advanced Science, 2025

   

7. Z. Zhang, X.X. Liu, S.B., Y. Zhang, L.Z. Zhao, G.Q. Zhao, J.T. Feng, Y. Zhang, J. Yang, Z. Wang, F. Xu, T.J. Lu, M.Lin #. Tunable Integrin-Ligand Coupling  Strength Modulates Cellular Adaptive Mechanosensing. Nano Letters, 2025, 25(11):4170-4179.

   

   
   

8. H.Y. Zhu*, J. Wang*, Y. Liu, X.H Wang, T.J. Lue, F. Xu, M. Lin#. Estrogen Attenuates Stiffness-Driven Fibrotic Signaling via Transcriptional Regulation. Biophysical Journal, 2025.

   

   
   

9.  H.Y. Zhu, X.X Liu, J.Y. Zhang, G.Q. Zhao, J. Wang, H. Zhang, Y. Liu, H. Guo, J. Yang, Z. Wang, Ti.J. Lu, F. Xu, M. Lin#. Cadherin Dynamics and Cortical Tension  in Remodeling Cell-Cell Adhesion During EMT. Biophysical Journal. DOI: 10.1016/j.bpj.2025.05.001.

   

   
   

10. H.Y. Zhu, R. Miao, J. Wang, M. Lin#. Advances in modeling cellular mechanical perceptions and responses via the membrane-cytoskeleton-nucleus machinery.  Mechanobiology in Medicine, 2024, 2(1), 100040.

    

    
    

11.  Zhang Z, Zhu H Y, Zhao G Q, Miao Y Y, Zhao L Z, Feng J T, Zhang H, Miao R, Sun L, Gao B, Zhang W C, Wang Z, Zhang J F, Zhang Y, Guo H, Xu F, Lu T J, Genin G M, Lin M#. Programmable and reversible integrin‐mediated cell adhesion reveals hysteresis in actin kinetics that alters subsequent mechanotransduction[J]. Advanced Science, 2023, 10(35): 230241.  DOI: 10.1002/advs.202302421.
    

    

12. Zhang Z, Sha B Y, Zhao L Z, Zhang H, Feng J T, Zhang C, Sun L, Luo M Q, Gao B, Guo H, Wang Z, Xu F, Lu T J, Genin G M, Lin M#. Programmable integrin and N-cadherin adhesive interactions modulate mechanosensing of mesenchymal stem cells by cofilin phosphorylation[J]. Nature Communications, 2022, 13(1): 6854. DOI: 10.1038/s41467-022-34424-0.

    

    
    

13. A. Isomursu*, K.Y. Park*, J. Hou*, B. Cheng*, M. Mathieu, G. Shamsan, B.J Fuller, J. Kasim, M. M. Mahmoodi, T.J.Lu, G.M. Genin, F. Xu, M. Lin#, M. Distefano#, J. Ivaska#, D.J. Odde#. Directed cell migration toward softer environments. Nature Materials, 2022, 21: 1081-1090. DOI: 10.1038/s41563-022-01294-2.

    

14. H. Zhang, H.Y. Zhu, J.T. Feng, Z. Zhang, S.M. Zhang, Z. Wang, L. Sun, W.C. Zhang, B. Gao, Y. Zhang, M. Lin#. Reprogramming of activated pancreatic stellate cells via mechanical modulation of transmembrane force-sensitive N-cadherin Receptor. Journal of Molecular Biology, 2022, DOI: 10.1016/j.jmb.2022.167819.

    

15.  M. Lin#. Cellular mechanosensing of texture features. Biophysical Journal, 2022.https://doi.org/10.1016/j.bpj.2022.10.028  (Invited Commentary)

16. 张欢, 赵国清, 冯锦腾, 林敏#. 力敏感受体介导细胞功能调控的力学生物学研究. 力学进展, 2022. DOI: 10.6052/1000-0992-22-029（长篇综述：106页）

    

    
    

17. C. Zhang*, H.Y Zhu*, X.R. Ren, B. Gao, B. Cheng, S.B. Liu, B.Y. Sha, Z.Q. Li, Z. Zhang, Y. Lv, H.H. Wang, H. Guo, T.J. Lu, F. Xu, G.M. Genin, M. Lin#. Mechanics-driven nuclear localization of YAP can be reversed by N-cadherin ligation in mesenchymal stem cells. Nature Communications, 2021, 12(1):6229. https://doi.org/10.1038/s41467-021-26454-x

    

    
    

18. B. Cheng*, W. Wan*, G. Huang, Y. Li, G.M. Genin, M.R.K. Mofrad, T.J. Lu, F. Xu, M. Lin#. Nanoscale integrin cluster dynamics controls cellular mechanosensing via FAKY397 phosphorylation. Science Advances, 2020, 6(10): eaax1909.(Journal Cover)  https://www.science.org/doi/10.1126/sciadv.aax1909

    

19. H.Y. Zhu, H.Q. Yang, Y.F. Ma, T.J. Lu, F. Xu, G.M. Genin^#, M. Lin^#. Spatiotemporally controlled photoresponsive hydrogels: design and predictive modeling from processing through application. Advanced Functional Materials, 2020, 30(32), 2000639.

    

20. W.T. Wan*, B. Cheng*, C. Zhang, Y.F. Ma, A. Li, F. Xu, M. Lin^#. Synergistic effect of matrix stiffness and inflammatory factors on osteogenic differentiation of MSC. Biophysical Journal, 2019, 117(1):129-142. (Journal Cover) DOI: 10.1016/j.bpj.2019.05.019.

    

以下为课题组数据处理所用到的程序，点击即可下载：

1、YAP核质比计算

2、黏着斑面积计算

3、细胞收缩力计算

Dr. Min Lin is a full professor in the School of Life Science and Technology at Xi’an Jiaotong University. Dr. Lin achieved B.S. degree (2005) in Material Science and Engineering from Hefei University of Technology and M.S. degree (2008) in Material Science and Engineering from Xi’an Jiaotong University. Dr. Lin completed his Ph.D. degree in Mechanics at Xi’an Jiaotong University in 2011. He joined the faculty of Xi’an Jiaotong University in 2011. During 2014-2015, Dr. Lin worked as a research fellow at Harvard Medical School and Massachusetts General Hospital. Dr. Lin’s current research interest lies in the mechanobiology of cells, with a focus on force-sensitive receptor-ligand interactions, and the subsequent development of mechanical forces in cells, and theoretical models for cell mechanosensing.

Living cells often respond to mechanical cues from their surrounding extracellular matrix or adjacent cells thus dictate their fates, a process called cellular mechanotransduction. These mechanosensing arises from integrated information from the membrane-localized receptors that bind ligands present on another cell or the extracellular matrix. This introduces a number of physical effects including spatial organization of receptor-ligand complexes and development of mechanical forces in cells. The transmission of force over space and time and their conversion into biochemical signals that initiate cellular pathology and physiology. Dr. Lin’s current research interest lies in the mechanobiology of cells, with a focus on force-sensitive receptor-ligand interactions, and the subsequent development of mechanical forces in cells, and theoretical models for cell mechanosensing.

Personal key words:  Cellular Mechanotransduction，Cellular microenvironment, Receptor-ligand interaction，Computational model.