科研成果汇总

2024

  • Wang T, Fan G, Xia Y, Zou Y, Liu Y, Wang J, Hu Y, *Teng J, *Huang N, *Chen J.  (2024) Dual roles of CCDC102A in governing centrosome duplication and cohesion. Cell Rep. (Article)  (Lead contact correspondence)

2023

  • Li, Y.S., Jiang, T., Du, M.Y., He, S.X., Huang, N., Cheng, B., Yan, C.Y., Tang, W.X., Gao, W., Guo, H.Y., et al. (2023). Ketohexokinase-dependent metabolism of cerebral endogenous fructose in microglia drives diabetes-associated cognitive dysfunction. Exp Mol Med.
  • Li Y, Tian Y, Pei X, Zheng P, Miao L, Li L, Luo C, Zhang P, Jiang B, *Teng J, *Huang N, *Chen J (2023). SCG10 is required for peripheral axon maintenance and regeneration in mice. J Cell Sci. (Article) (* co-correspondence)

Research Highlight: SCG10 promotes dynamic microtubules in peripheral axons | Journal of Cell Science | The Company of Biologists

  • Jiang T, Li Y, He S, Huang N, Du M, Zhai Q, Pu K, Wu M, Yan C, Ma Z, Wang Q. (2023). Reprogramming astrocytic NDRG2/NF-κB/C3 signaling restores the diabetes-associated cognitive dysfunction. EBioMedicine. 
  • Ma, D., Wang, F., *Teng, J., *Huang, N. and *Chen, J. (2023). Structure and function of distal and subdistal appendages of the mother centriole. J Cell Sci 136. (Review) (* co-correspondence)

2022

  • Huang, N., Sheng, Z.-H. (2022). Microfluidic devices as model platforms of CNS injury-ischemia to study axonal regeneration by regulating mitochondrial transport and bioenergetic metabolism, Cell Regeneration, (Methodology Article).
  • Cheng, X.-T., Huang, N., and Sheng, Z.-H. (2022). Programming axonal mitochondrial maintenance and bioenergetics in neurodegeneration and regeneration. Neuron. Review
  • Huang, N., Sheng, Z.-H. (2022). Chapter 2.2: Remodeling Mitochondrial Transport and Cellular Energetics in Axonal Regeneration and Spinal Cord Injury, Neuroscience in Spinal cord injury, Academic Press (In print, Review).
  • Ma, D., Wang, F., Wang, R., Hu, Y., Chen, Z., Huang, N., Tian, Y., Xia, Y., Teng, J., and Chen, J. (2022). α-/γ-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization. Elife 11.

2021

  • Huang, N., Li, S., Xie, Y., Han, Q., Xu, X.-M., and Sheng, Z.-H. (2021). Reprogramming an energetic AKT-PAK5 axis boosts axon energy supply and facilitates neuron survival and regeneration after injury and ischemia. Current Biology 31, 3098-3114. e3097.

Current Biology preview by Twiss et al., “Neurobiology: Resetting the axon’s batteries”.

  • *Chamberlain, K.A., *Huang, N., Xie, Y., LiCausi, F., Li, S., Li, Y., and Sheng, Z.-H. (2021). Oligodendrocytes enhance axonal energy metabolism by deacetylation of mitochondrial proteins through transcellular delivery of SIRT2. Neuron 109, 3456-3472. e3458.(* co-first author)

Neuron preview by Eva-Maria Albers: Superfood for axons: Glial exosomes boost axonal energetics by delivery of SIRT2.

  • Roney, J.C., Li, S., Farfel-Becker, T., Huang, N., Sun, T., Xie, Y., Cheng, X.-T., Lin, M.-Y., Platt, F.M., and Sheng, Z.-H. (2021). Lipid-mediated impairment of axonal lysosome transport contributing to autophagic stress. Autophagy 17, 1796-1798.
  • Roney, J.C., Li, S., Farfel-Becker, T., Huang, N., Sun, T., Xie, Y., Cheng, X.-T., Lin, M.-Y., Platt, F.M., and Sheng, Z.-H. (2021). Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C. Developmental Cell 56, 1452-1468. e1458.
  • Xiong, G.-J., Cheng, X.-T., Sun, T., Xie, Y., Huang, N., Li, S., Lin, M.-Y., and Sheng, Z.-H. (2021). Defects in syntabulin-mediated synaptic cargo transport associate with autism-like synaptic dysfunction and social behavioral traits. Molecular psychiatry 26, 1472-1490.

2020

  • Li, S., Xiong, G.-J., Huang, N., and Sheng, Z.-H. (2020). The cross-talk of energy sensing and mitochondrial anchoring sustains synaptic efficacy by maintaining presynaptic metabolism. Nature metabolism 2, 1077-1095.
  • Han, Q., Xie, Y., Ordaz, J.D., Huh, A.J., Huang, N., Wu, W., Liu, N., Chamberlain, K.A., Sheng, Z.-H., and Xu, X.-M. (2020). Restoring cellular energetics promotes axonal regeneration and functional recovery after spinal cord injury. Cell metabolism 31, 623-641. e628.
  • Puri, R., Cheng, X.-T., Lin, M.-Y., Huang, N., and Sheng, Z.-H. (2020). Defending stressed mitochondria: uncovering the role of MUL1 in suppressing neuronal mitophagy. Autophagy 16, 176-178.

2019

  • 张东慧, 黄宁, 陈建国, 滕俊琳 (2019). 初级纤毛的研究进展. 中国细胞生物学学报, 352-362.
  • Puri, R., Cheng, X.-T., Lin, M.-Y., Huang, N., and Sheng, Z.-H. (2019). Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts. Nature communications 10, 1-19.
  • Wang, T., Zou, Y., Huang, N., Teng, J., and Chen, J. (2019). CCDC84 acetylation oscillation regulates centrosome duplication by modulating HsSAS-6 degradation. Cell Reports 29, 2078-2091. e2075.

2018

  • *Huang, N., *Zhang, D., Li, F., Chai, P., Wang, S., Teng, J., and Chen, J. (2018). M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole. Nature communications 9, 1-15. (* co-first author)

Recommended by Faculty Opinions.

  • *Xia, Y., *Huang, N., Chen, Z., Li, F., Fan, G., Ma, D., Chen, J., and Teng, J. (2018). CCDC102B functions in centrosome linker assembly and centrosome cohesion. Journal of Cell Science 131, jcs222901. (* co-first author)
  • Cheng, X.-T., Xie, Y.-X., Zhou, B., Huang, N., Farfel-Becker, T., and Sheng, Z.-H. (2018). Characterization of LAMP1-labeled nondegradative lysosomal and endocytic compartments in neurons. Journal of Cell Biology 217, 3127-3139.
  • Cheng, X.-T., Xie, Y.-X., Zhou, B., Huang, N., Farfel-Becker, T., and Sheng, Z.-H. (2018). Revisiting LAMP1 as a marker for degradative autophagy-lysosomal organelles in the nervous system. Autophagy 14, 1472-1474.

2017及更早

  • *Huang, N., *Xia, Y., Zhang, D., Wang, S., Bao, Y., He, R., Teng, J., and Chen, J. (2017). Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68. Nature communications 8, 1-14.(* co-first author)
  • *He, R., *Huang, N., Bao, Y., Zhou, H., Teng, J., and Chen, J. (2013). LRRC45 is a centrosome linker component required for centrosome cohesion. Cell reports 4, 1100-1107. (* co-first author)
  • Li, Y., Xu, J., Liu, Y., Zhu, J., Liu, N., Zeng, W., Huang, N., Rasch, M.J., Jiang, H., and Gu, X. (2017). A distinct entorhinal cortex to hippocampal CA1 direct circuit for olfactory associative learning. Nature neuroscience 20, 559-570.
  • Zeng, Z., Chen, X., Wang, H., Huang, N., Shan, C., Zhang, H., Teng, J., and Xi, P. (2015). Fast super-resolution imaging with ultra-high labeling density achieved by joint tagging super-resolution optical fluctuation imaging. Scientific reports 5, 1-7.
  • He, R., Wu, Q., Zhou, H., Huang, N., Chen, J., and Teng, J. (2013). Cep57 protein is required for cytokinesis by facilitating central spindle microtubule organization. Journal of Biological Chemistry 288, 14384-14390.
  • Kuang, Y., Liu, Q., Shu, X., Zhang, C., Huang, N., Li, J., Jiang, M., and Li, H. (2012). Dicer1 and MiR‐9 are required for proper Notch1 signaling and the Bergmann glial phenotype in the developing mouse cerebellum. Glia 60, 1734-1746.