主要研究成果有： 1）提出一种针对脑部药物递送的创新性程序化响应跨多屏障策略，成功实现对恶性度极高、无临床用药的小儿弥漫性脑干胶质瘤的有效药物治疗(NICHD的SBIR项目资助(Phase I))；2）提出一种比率探针构建的新策略，首次实现对纳米结构的活细胞及在体组织中聚散行为的实时监控与定量分析，为生理环境下纳米结构的动力学过程的研究提供高效工具。研究成果发表在Adv. Mater.、Nat. Commun.、Funct. Mater.、Theranostics等杂志上，总引用1138余次，H-因子18， i10-index因子 25。

2024year

43.Li, S., Meng, C., Hao, Q., Zhou, R., Dai, L., Guo, Y., Zhao, S., Zhou, X., Lou, C., Xu, J., Xu, P., Yang, J., Ding, Y., Lv, Y., Han, S., Li, S., Li, J., Kang, H., Xiao, Z., Tan, M., … Wu, H*. (2024). "On/off"-switchable crosslinked PTX-nanoformulation with improved precise delivery for NSCLC brain metastases and restrained adverse reaction over nab-PTX. Biomaterials, 307,(IF=14.0) 122537. https://doi.org/10.1016/j.biomaterials.2024.122537

42. Maoxin Lv, Shihao Shang, Kepu Liu, Yuliang Wang, Peng Xu, Hao Song, Jie Zhang, Zelong Sun, Yuhao Yan, Zheng Zhu, Hao Wu*, and Hao Li*. Revitalizing Bacillus Calmette–Guérin Immunotherapy for Bladder Cancer: Nanotechnology and Bioengineering Approaches. Pharmaceutics. 2024; 16(8):1067. https://doi.org/10.3390/pharmaceutics16081067

41. Dandan Liu, Lidan Chang, Xuyan Zhao, Luyao Dai, Hanxiao Cui, Peinan Liu, Zhen Zhai, Hao Wu*, Xiaobin Ma*, Huafeng Kang*. Effect of T Stages on the Choice of Axillary Evaluation Modality in Breast Cancer Patients With 1-2 Sentinel Lymph Node Metastases. Clinical breast cancer, 24(4), e232–e243.e1. https://doi.org/10.1016/j.clbc.2024.01.012

40. Luyao Dai, Wenyu Yan, Xueting Ren, Dandan Liu, Lidan Chang, Shuai Lin, Hao Wu*, Huafeng Kang*, Xiaobin Ma*. Construction and Validation of a Nomogram Predicting the Overall Survival Benefit of Unilateral Breast Cancer Patients Undergoing Contralateral Prophylactic Mastectomy. Clinical breast cancer, 24(4), 351–362. https://doi.org/10.1016/j.clbc.2024.02.001

39. Dandan Liu, Lidan Chang, Qian Hao, Xueting Ren, Peinan Liu, Xingyu Liu, Yumeng Wei, Meng Wang, Hao Wu*, Huafeng Kang*, Shuai Lin*. Is neoadjuvant chemotherapy necessary for T2N0-1M0 hormone receptor-positive/HER2-negative breast cancer patients undergoing breast-conserving surgery?. Journal of cancer research and clinical oncology, 150(5), 285. https://doi.org/10.1007/s00432-024-05810-6

38. Qian Hao, Luyao Dai, Lidan Chang, Dingli Song, Dandan Liu, Xiaobin Ma*, Hao Wu*, Huafeng Kang*. Evaluation of neoadjuvant chemotherapy for clinical T1 triple-negative breast cancer. Scientific reports, 14(1), 18055. https://doi.org/10.1038/s41598-024-68719-7

37.Peng Xu, Wen Luo, Jingjing Hu, Xiaobin Ma, Qian Hao, Wentao Hui, Zhangjian Zhou, Shuai Lin, Meng Wang, Hao Wu*, Zhijun Dai*, Huafeng Kang*. Favorable outcome of neoadjuvant endocrine treatment than surgery-first in female HR-positive/HER2-negative breast cancer patients—A NCDB analysis (2010–2016). Cancer Med. 2024; 13:e7244. http://doi.org/10.1002/cam4.7244

2023year

36. S.Li, C. Meng, Q. Hao, L. Dai, J. Shi, J. Xu, X. Zhou, S. Zhao, J. Yang, H. Kang, Y. Hou, M. Zhang, X. Ma, M. Tan,

H. Wu, A Multistage-Responsive Antibody-Delivery Strategy to Improve Immunotherapy for NSCLC Brain Metastasis by Ultrasensitive Releasing and Tumor-Anchoring. Adv. Funct. Mater. 2024, 2312595. (IF=19.0) https://doi.org/10.1002/adfm.202312595

35.Dai L, Li R, Hao Q, Bao Y, Hu L, Zhang Y, Kang H, Wu H, Ma X, Song Y. Breast cancer is associated with coronary heart disease: a cross-sectional survey of NHANES 1999-2018. Front Cardiovasc Med. 2023 Dec 6;10:1274976. doi: 10.3389/fcvm.2023.1274976

34. Qu, H., Yang, J., Li, S., Xu, J., Zhou, X., Xue, X., Zhang, D., Du, H., Shen, Y., Ramachandran, M., Zheng, H., Wu, Y., Ding, Y., Wu, H., Ma, X., Lin, T. Y., & Li, Y. (2023). Programmed-response cross-linked nanocarrier for multidrug-resistant ovarian cancer treatment. Journal of controlled release : official journal of the Controlled Release Society, S0168-3659(23)00198-0. Advance online publication. （IF=11.467）https://doi.org/10.1016/j.jconrel.2023.03.031

2022year

33. Hongwei Lu§, Ji Xu§, Jinfan Yang§, Zhongling Wang, Peng Xu, Qian Hao, Wen Luo, Shuaijun Li, Zhengqing Li, Xiangdong Xue, Hongbo Zheng, Zhangjian Zhou, Hao Wu*, Xiaobin Ma* and Yuanpei Li*. On-demand Targeting Nanotheranostics with Stimuli-responsive Releasing Property to Improve Delivery Efficiency to Cancer, Biomaterials (IF: 15.304). 2022, (290) 121852.https://authors.elsevier.com/c/1fxY3WWN0sh2~

32. Shanshan Tie, Wentao Su, Yannan Chen, Shida Wu, Hao Wu, Yukun Song, Siyuan Fei, Mingqian Tan. Dual targeting procyanidin nanoparticles with glutathione response for colitis treatment. Chemical Engineering Journal (IF: 13.273), 2022, 441, 136095.

31. Jinfan Yang*, Zhengqing Li, Xiaoru Niu, Ji Xu, Wenxi Lei, Hao Wu*. Hierarchical porous N-doped carbon encapsulated CoFe2O4-CoO nanoparticles derived from layered double hydroxide/chitosan biocomposite for the enhanced degradation of tetracycline. Sep. Purif. Technol. (IF: 9.136), 2022, 295, 121291. https://doi.org/10.1016/j.seppur.2022.121291

30. Hanxiao Cui§, Luyao Dai§, Yuanhang Bao, Liqun Hu, Zhangjian Zhou, Meng Wang, Shuai Lin, Xiaobin Ma*, Hao Wu*, Huafeng Kang*. Nomogram Predicts the Role of Primary Tumor Surgery on de novo stage-IV Breast Cancer. Front. Oncol. (IF: 5.738), 2022, 819531. https://doi.org/10.3389/fonc.2022.819531

29. Luyao Dai§, Hanxiao Cui§, Yuanhang Bao, Liqun Hu, Zhangjian Zhou, Meng Wang, Shuai Lin, Hao Wu*, Xiaobin Ma*, Huafeng Kang*. The relationship between immediate postmastectomy reconstruction modalities and survival benefits in patients with triple negative breast cancer. Cancer Medicine (IF: 4.711), 2022, accepted.

2021 year

28. Jinfan Yang*, Zhifeng Ao, Hao Wu*, Sufeng Zhang. Immobilization of chitosan-templated MnO2 nanoparticles onto filter paper by redox method as a retrievable Fenton-like dip catalyst. Chemosphere. (IF: 8.943) 4.2021, 268, 12883. https://doi.org/10.1016/j.chemosphere.2020.128835

2020 year

27. Wu, H., Lu, H., Xiao, W., Yang, J., Du, H., Shen, Y., Qu, H., Jia, B., Manna, S. K., Ramachandran, M., Xue, X., Ma, Z., Xu, X., Wang, Z., He, Y., Lam, K. S., Zawadzki, R. J., Li, Y., Lin, T.-Y., Sequential Targeting in Crosslinking Nanotheranostics for Tackling the Multibarriers of Brain Tumors. Adv. Mater. 2020, 32, 1903759.(IF: 32.086). 2020, 1903759. https://onlinelibrary.wiley.com/doi/10.1002/adma.201903759

26. Hao Wu§, Lu Zhang§, Jinfan Yang, Ruonan Bo, Lin Kai, Dalin Zhang, Hongxu Du, Mythili Ramachandran, Yingbin Shen, Yangxi Xu, Xiangdong Xue, Zhao Ma, Tzu-Yin Lin and Yuanpei Li*. Rotatable Aggregation-Induced-Emission / Aggregation-Caused-Quenching Ratio Strategy for Real-Time Tracking Nanoparticle Delivery Dynamics, Adv. Funct. Mater. (IF: 19.924). 2020, 1910348. https://onlinelibrary.wiley.com/doi/10.1002/adfm.201910348

25. Jinfan Yang*, Xiaoru Niu, Hao Wu*, Hongyu Zhang, Zhifeng Ao, Sufeng Zhang. Valorization of humin as a glucose derivative to fabricate a porous carbon catalyst for esterification and hydroxyalkylation/alkylation. Waste. Manage. (IF: 8.816), 2020, 103, 407-415. https://doi.org/10.1016/j.wasman.2020.01.004

Before 2020 year

24. Jinfan Yang*, Zhifeng Ao, Hao Wu*, Sufeng Zhang, Concong Chi, Chen Hou, Liwei Qian. Waste paper-derived magnetic carbon composite: A novel eco-friendly solid acid for the synthesis of n-butyl levulinate from furfuryl alcohol. Renew. Energ. (IF: 8.634), 2020, 146, 477-483. https://doi.org/10.1016/j.renene.2019.06.167

23. Xiangdong Xue, Yee Huang, Ruonan Bo, Bei Jia, Hao Wu, Ye Yuan, Zhongling Wang, Zhao Ma, Di Jing, Xiaobao Xu, Weimin Yu, Tzu-yin Lin & Yuanpei Li*. Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment, Nat. Commun. (IF: 14.919), 2018, 9, 3653.

22. Zhongling Wang, Xiangdong Xue, Yixuan He, Ziwei Lu, Bei Jia, Hao Wu, Ye Yuan, Yee Huang, Han Wang, Hongwei Lu, Kit S Lam, Tzu‐Yin Lin, Yuanpei Li*. Novel Redox‐Responsive Polymeric Magnetosomes with Tunable Magnetic Resonance Property for In Vivo Drug Release Visualization and Dual‐Modal Cancer Therapy, Adv. Funct. Mater. (IF: 18.808), 2018, 28, 1802159.

21. Yan Luo§, Hao Wu§, Caihong Feng, Kai Xiao, Xixiao Yang, Qiangqiang Liu, Tzu-yin Lin, Hongyong Zhang, Jeffrey H. Walton, Yousif Ajena, Yide Hu, Kit S. Lam* and Yuanpei Li*.“One-pot” fabrication of highly versatile and biocompatible poly (vinyl alcohol)-porphyrin-based nanotheranostics. Theranostics. (IF: 11.556), 2017, 7 (16) 3901-3914.

20. Hao Wu§, Huihui Wang§, Han Liao, Yan Lv, Xiaojie Song, Xiaojun Ma and Mingqian Tan*. Multifunctional Nanostructures for Tumor Targeted Molecular Imaging and Photodynamic Therapy. Adv.Healthc.Mater. (IF: 11.092), 2016, 5, 311–318. https://onlinelibrary.wiley.com/doi/10.1002/adhm.201500668

19. Xue-Xiang Zhang§, Hao Wu§, Peng Li, Zong-Jin Qu, Ming-Qian Tan and Ke-Li Han*. A versatile two-photon fluorescent probe for ratiometric imaging E. coli β-galactosidase in live cells and in vivo, Chem. Commun. (IF: 6.222), 2016, 52, 8283-8286.

18. Yang Liu, ShujunWang, Dongsheng Sun, Yongdong Liu, Yang Liu, YangWang, Chang Liu, Hao Wu, Yan Lv, Ying Ren, XinGuo, Guangwei Sun* and Xiaojun Ma*. Development of a Biomimetic Chondroitin Sulfate-modified Hydrogel to Enhance the Metastasis of Tumor Cells. Sci. Rep. (IF: 4.379), 2016 Jul 19; 6:29858.

17. Zheyu Shen, Hao Wu, Sugeun Yang, Xuehua Ma, Zihou Li, Mingqian Tan* and Aiguo Wu*. A novel Trojan-horse targeting strategy to reduce the non-specific uptake of nanocarriers by non-cancerous cells, Biomaterials (IF: 12.479), 2015,70, 1-11.

16. Xiaojie Song, Hao Wu, Shen Li,Yanfang Wang, Xiaojun Ma* and Mingqian Tan*. Ultrasmall Chitosan-genipin Nanocarriers Fabricated from Reverse Microemulsion Process for Tumor Photothermal Therapy in Mice. Biomacromolecules (IF: 6.988), 2015, 16, 2080−2090.

15. Nirun Jatupaiboon, Yanfang Wang, Hao Wu, Xiaojie Song, Yizhe Song, Jianbin Zhang, Xiaojun Ma* and Mingqian Tan*. A facile microemulsion template route for producing hollow silica nanospheres as imaging agents and drug nanocarriers. J. Mater. Chem. B. (IF: 6.331), 2015,3, 3130-3133.

14. Yan Yang, Xiaojie Song, Yi Yao, Hao Wu, Jian Liu, Yaopeng Zhao, Mingqian Tan* and Qihua Yang*. Ultrasmall single micelle@ resin core–shell nanocarriers as efficient cargo loading vehicles for in vivo biomedical applications. J. Mater. Chem. B (IF: 6.331), 2015, 3, 4671-4678.

13. Huihui Wang§, Hao Wu§, Hujun Shen, Shaote Geng, Beibei Wang, Yanfang Wang, Xiaojun Ma, Guohui Li and Mingqian Tan*. A bimodal MRI and NIR liposome nanoprobe for tumor targeted molecular imaging. J. Mater. Chem. B. (IF: 6.331), 2015, 3, 8832-8841.

12.Yan Lv, Jianbin Zhang, Hao Wu, Shan Zhao, Yizhe Song, Shujun Wang, Bing Wang, Guojun Lv* and Xiaojun Ma*. A Protease Inhibition Strategy Based on Acceleration of Autolysis. Chem. Commun. (IF: 6.222), 2015 Apr 7;51(27):5959.

11. Mingqian Tan*, Xintong Li, Hao Wu, Beibei Wang, Jing Wu. N-doped carbon dots derived from bovine serum albumin and formic acid with one- and two-photon fluorescence for live cell nuclear imaging. Colloids. Surface. B (IF: 5.268), 2015, 136, 141–149.

10. Huizhen Zheng, Hongguo Xie, Hao Wu, Feng Wang, Xiudong Liu*, Weiting Yu* and Xiaojun Ma. Investigation of spherical hydrogel surface with optical interferometer. Colloid Surface A (IF: 4.538), 2015,484, 457-462.

9. Chang Liu, Yang Liu, Xiaoxi Xu, Hao Wu, Hongguo Xie, Li Chen, Ting Lu, Li Yang, Xin Guo, Guangwei Sun*. Potential effect of matrix stiffness on the enrichment of tumor initiating cells under three-dimensional culture conditions. Experimental cell research (IF: 3.905), 2015, 1, 123-134.

8. Han Liao, Ziyi Wang, Song Chen, Hao Wu, Xiaojun Ma and Mingqian Tan*. One-pot synthesis of gadolinium (iii) doped carbon dots for fluorescence/magnetic resonance bimodal imaging. RSC Adv. (IF: 3.361), 2015,5(82), 66575-66581.

7. Beibei Wang, Shujun Wang, Yanfang Wang, Yan Lv, Hao Wu, Xiaojun Ma* and Mingqian Tan*. Highly fluorescent carbon dots for visible sensing of doxorubicin release based on efficient nanosurface energy transfer. Biotechnology Letters (IF: 2.461), 2015.

6. Hao Wu§, Haidong Zhao§, Xiaojie Song, Shen Li, Xiaojun Ma* and Mingqian Tan*. Self-assembly- induced near-infrared fluorescent nanoprobes for effective tumor molecular imaging, J. Mater. Chem. B. (IF: 7.571), 2014, 2, 5302–5308. https://pubs.rsc.org/en/content/articlelanding/2014/TB/C4TB00761A

5. Chengkun Jiang, Hao Wu, Xiaojie Song, Xiaojun Ma, Jihui Wang and Mingqian Tan*. Presence of photoluminescent carbondots in Nescafe original instant coffee: Applications to bioimaging. Talanta (IF: 6.057), 2014,127, 68–74.

4.Zhiqiang Ye, Rong Tang, Hao Wu, Beibei Wang, Mingqian Tan* and Jingli Yuan. Preparation of europium complex-conjugated carbon dots for ratiometric fluorescence detection of copper(II) ions, New J. Chem. (IF: 3.591), 2014, 38 (12), 5721-5726.

3. Beibei Wang, Yanfang Wang, Hao Wu, Xiaojie Song,Xin Guo, Demeng Zhang, Xiaojun Ma* and Mingqian Tan*. A mitochondria-targeted fluorescent probe based on TPP-conjugated carbon dots for both one- and two-photon fluorescence cell imaging. RSC Adv. (IF: 3.361), 2014,4, 49960-49963.

2. Mingqian Tan, Lingxin Zhang, Rong Tang, Xiaojie Song, Yimin Li, Hao Wu, Yangfang Wang, Guojun Lv, Wangfa Liu and Xiaojun Ma*. Enhanced photoluminescence and characterization of multicolor carbon dots using plant soot as a carbon source. Talanta (IF: 6.057), 2013,115, 950-956.

1. Hao Wu, Ying Ma, Shuang Shan, Mingqian Tan* and Xiaojun Ma*. Separable cells co-culture method by microcapsules loading cells. Chinese Journal of Cell Biology, 2013, 35(5):697-702.