发表论文

(* 贡献相同，# 通讯作者)

 

代表性文章:

  1. Li H*, Perino A*, Huang Q, von Alvensleben G, Banaei-Esfahani A, Velazquez-Villegas L, Gariani K, Korbelius M, Bou Sleiman M, Imbach J, Sun Y, Li X, Bachmann A, Goeminne L, Gallart-Ayala H, Williams E, Ivanisevic J, Auwerx J#, Schoonjans K#. Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis. Cell Metab. 2022 Oct 4;34(10):1594-1610.e4. doi: 10.1016/j.cmet.2022.08.015.
  2. Li H, Rukina D, David F, Li TY, Oh C-M, Gao AW, Katsyuba E, Bou Sleiman M, Komljenovic A, Huang Q, Williams RW, Robinson-Rechavi M, Schoonjans K, Morgenthaler S, Auwerx J#. Identifying gene function and module connections by the integration of multi-species expression compendia. Genome Res. 2019 Dec; 29(12):2034-2045. doi: 10.1101/gr.251983.119.
  3. Li H*, Wang X*, Rukina D, Huang Q, Lin T, Sorrentino V, Zhang H, Bou Sleiman M, Arends D, McDaid A, Luan P, Ziari N, Velázquez-Villegas LA, Gariani K, Kutalik Z, Schoonjans K, Radcliffe RA, Prins P, Morgenthaler S, Williams RW, Auwerx J#. An integrated systems genetics and omics toolkit to probe gene function. Cell Syst. 2018 Jan 24;6(1):90-102.e4. doi: 10.1016/j.cels.2017.10.016.
  4. Li H, Auwerx J#. Mouse systems genetics as a prelude to precision medicine. Trends Genet. 2020 Apr; 36(4):259-272. doi: 10.1016/j.tig.2020.01.004.
  5. Zhao L*, Li H*, Wang Y, Zheng A, Cao L, and Liu J#. Autophagy deficiency leads to impaired antioxidant defense via p62-FOXO1/3 axis. Oxid Med Cell Longev. 2019 Dec; 2019:2526314. doi: 10.1155/2019/2526314.

其他文章:

  1. Lin M, Hartl K, Heuberger J, Beccaceci G, Berger H, Li H, Liu L, Müllerke S, Conrad T, Heymann F, Woehler A, Tacke F, Rajewsky N, Sigal M. Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche. Nat Commun. 2023 May 25;14(1):3025. doi: 10.1038/s41467-023-38780-3.
  2. Lima TI, Laurila PP, Wohlwend M, Morel JD, Goeminne LJE, Li H, Romani M, Li X, Oh CM, Park D, Rodríguez-López S, Ivanisevic J, Gallart-Ayala H, Crisol B, Delort F, Batonnet-Pichon S, Silveira LR, Sankabattula Pavani Veera Venkata L, Padala AK, Jain S, Auwerx J. Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging. Sci Transl Med. 2023 May 17;15(696):eade6509. doi: 10.1126/scitranslmed.ade6509.
  3. English J, Orofino J, Cederquist CT, Paul I, Li H, Auwerx J, Emili A, Belkina A, Cardamone D, Perissi V. GPS2-mediated regulation of the adipocyte secretome modulates adipose tissue remodeling at the onset of diet-induced obesity. Mol Metab. 2023 Mar;69:101682. doi: 10.1016/j.molmet.2023.101682.
  4. Li TY*, Gao AW*, Li X, Li H, Liu YJ, Lalou A, Neelagandan N, Naef F, Schoonjans K, Auwerx J#. V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans. J Cell Biol. 2023 Jan 2;222(1):e202205045. doi: 10.1083/jcb.202205045.
  5. Bou Sleiman M*, Roy S*, Gao AW, Sadler MC, von Alvensleben GVG, Li H, Sen S, Harrison DE, Nelson JF, Strong R, Miller RA, Kutalik Z, Williams RW, Auwerx J. Sex- and age-dependent genetics of longevity in a heterogeneous mouse population. Science. 2022 Sep 30;377(6614):eabo3191. doi: 10.1126/science.abo3191.
  6. Wang X*, Zhang X*, Cao K*, Zeng M*, Fu X*, Zheng A, Zhang F, Gao F, Zou X, Li H, Li M, Lv W, Xu J, Long J, Zang W, Chen J, Ding J#, Liu J#, Feng Z#. Cardiac disruption of SDHAF4-mediated mitochondrial complex II assembly promotes dilated cardiomyopathy. Nat Commun. 2022 Jul 8;13(1):3947. doi: 10.1038/s41467-022-31548-1.
  7. Bresciani N*, Demagny H*, Lemos V, Pontanari F, Li X, Sun Y, Li H, Perino A, Auwerx J, Schoonjans K#. The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis. J Hepatol. 2022 Oct;77(4):1071-1082. doi: 10.1016/j.jhep.2022.05.040.
  8. Wang X*, Lv W*, Xu J*, Zheng A, Zeng M, Cao K, Wang X, Cui Y, Li H, Yang M, Shao Y, Zhang F, Zou X, Long J, Feng Z#, Liu J#. Hepatic Suppression of Mitochondrial Complex II Assembly Drives Systemic Metabolic Benefits. Adv Sci. 2022 Jan 17:e2105587. doi: 10.1002/advs.202105587.
  9. Zheng A, Li H, Feng Z#, Liu J#. Integrative Analyses Reveal Tstd1 as a Potential Modulator of HDL Cholesterol and Mitochondrial Function in Mice. Cells. 2021 Nov 1;10(11):2976. doi: 10.3390/cells10112976.
  10. Luan P*, D’Amico D*, Andreux PA, Laurila PP, Wohlwend M, Li H, de Lima TI, Place N, Rinsch C, Zanou N, Auwerx J#. Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy. Sci Transl Med. 2021 Apr 7;13(588):eabb0319. doi: 10.1126/scitranslmed.abb0319.
  11. Li TY, Bou Sleiman M, Li H, Gao AW, Mottis A, Bachmann A, Schoonjans K, Auwerx J#. The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress. Nat Aging (2021). Feb;1(2):165-178. doi: 10.1038/s43587-020-00025-z.
  12. Romani M*, Sorrentino V*, Oh C-M*, Li H, de Lima TI, Zhang H, Shong M, Auwerx J#. NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle. Cell Rep. 2021 Jan 19;34(3):108660. doi: 10.1016/j.celrep.2020.108660.
  13. Yoon H, Spinelli JB, Zaganjor E, Wong SJ, German NJ, Randall EC, Dean A, Clermont A, Paulo JA, Garcia D, Li H, Agar NY, Goodyear LJ, Shaw RJ, Gygi SP, Auwerx J, Haigis MC#. PHD3 loss promotes exercise capacity and fat oxidation in skeletal muscle. Cell Metab. 2020 Aug 4;32(2):215-228.e7. doi: 10.1016/j.cmet.2020.06.017.
  14. Komljenovic A, Li H, Sorrentino V, Kutalik Z, Auwerx J, Robinson-Rechavi M#. Cross-species functional modules link proteostasis to human normal aging. PLoS Comput Biol. 2019 Jul 3;15(7):e1007162. doi: 10.1371/journal.pcbi.1007162.
  15. D'Amico D, Mottis A, Potenza F, Sorrentino V, Li H, Romani M, Lemos V, Schoonjans K, Zamboni N, Knott G, Schneider BL, Auwerx J#. The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging. Mol Cell. 2019 Feb 21;73(4):775-787.e10. doi: 10.1016/j.molcel.2018.11.034.
  16. Besprozvannaya M, Dickson E, Li H, Ginburg KS, Bers DM, Auwerx J, Nunnari J#. GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells. Elife. 2018 Feb 22;7. pii: e31019. doi: 10.7554/eLife.31019.
  17. McDaid AF, Joshi PK, Porcu E, Komljenovic A, Li H, Sorrentino V, Litovchenko M, Bevers RPJ, Rüeger S, Reymond A, Bochud M, Deplancke B, Williams RW, Robinson-Rechavi M, Paccaud F, Rousson V, Auwerx J, Wilson JF, Kutalik Z#. Bayesian association scan reveals loci associated with human lifespan and linked biomarkers. Nat Commun. 2017 Jul 27;8:15842. doi: 10.1038/ncomms15842.
  18. Fan W, Waizenegger W, Lin CS, Sorrentino V, He MX, Wall CE, Li H, Liddle C, Yu RT, Atkins AR, Auwerx J, Downes M, Evans RM#. PPARδ Promotes Running Endurance by Preserving Glucose. Cell Metab. 2017 May 2;25(5):1186-1193.e4. doi: 10.1016/j.cmet.2017.04.006.
  19. Zheng A, Li H, Xu J, Cao K, Li H, Pu W, Yang Z, Peng Y, Long J, Liu J#, Feng Z#. Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation. Br J Nutr. 2015 Jun 14;113(11):1667-76. doi: 10.1017/S0007114515000884.
  20. Zheng A, Li H, Cao K, Xu J, Zou X, Li Y, Chen C, Liu J, Feng Z#. Maternal hydroxytyrosol administration improves neurogenesis and cognitive function in prenatally stressed offspring. J Nutr Biochem. 2015 Feb;26(2):190-9. doi: 10.1016/j.jnutbio.2014.10.006.
  21. Wang X, Li H, Zheng A, Yang L, Liu J, Chen C, Tang Y, Zou X, Li Y, Long J, Liu J, Zhang Y#, Feng Z#. Mitochondrial dysfunction-associated OPA1 cleavage contributes to muscle degeneration: preventative effect of hydroxytyrosol acetate. Cell Death Dis. 2014 Nov 13;5:e1521. doi: 10.1038/cddis.2014.473.
  22. Cao K, Zheng A, Xu J, Li H, Liu J, Peng Y, Long J, Zou X, Li Y, Chen C, Liu J, Feng Z#. AMPK activation prevents prenatal stress-induced cognitive impairment: Modulation of mitochondrial content and oxidative stress. Free Radic Biol Med. 2014 Oct;75:156-66. doi: 10.1016/j.freeradbiomed.2014.07.029.
  23. Zou X, Yan C, Shi Y, Cao K, Xu J, Wang X, Chen C, Luo C, Li Y, Gao J, Pang W, Zhao J, Zhao F, Li H, Zheng A, Sun W, Long J, Szeto IM, Zhao Y, Dong Z, Zhang P, Wang J, Lu W, Zhang Y, Liu J#, Feng Z#. Mitochondrial dysfunction in obesity-associated nonalcoholic fatty liver disease: the protective effects of pomegranate with its active component punicalagin. Antioxid Redox Signal. 2014 Oct 10;21(11):1557-70. doi: 10.1089/ars.2013.5538.
  24. Zhao L*, Zou X*, Feng Z, Luo C, Liu J, Li H, Chang L, Wang H, Li Y, Long J, Gao F#, Liu J#. Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats. Exp Gerontol. 2014 Aug;56:3-12. doi: 10.1016/j.exger.2014.02.001.
  25. Cao K*, Xu J*, Zou X, Li Y, Chen C, Zheng A, Li H, Li H, Szeto IM, Shi Y, Long J, Liu J#, Feng Z#. Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice. Free Radic Biol Med. 2014 Feb;67:396-407. doi: 10.1016/j.freeradbiomed.2013.11.029.
  26. Zheng A, Li H, Wang X, Feng Z, Xu J, Cao K, Zhou B, Wu J#, Liu J#. Anticancer effect of a curcumin derivative B63: ROS production and mitochondrial dysfunction. Curr Cancer Drug Targets. 2014;14(2):156-66.