基本信息

                    

                   李会霞      副教授

任国家自然科学基金同行评议专家;主持国家自然科学基金2项,主持中国博士后科学基金1项,参与国家重点研发计划1项以及国家自然科学基金5项。主要从事糖脂代谢与骨稳态间交互作用及机制的研究,近年来在Autophagy(第一作者)、Nature(第二作者)、JBMREndocrinology等国际期刊杂志参与发表论文27篇,其中第一作者/共同第一作者论文10余篇。

联系方式

联系地址:陕西省西安市雁塔西路76号西安交通大学医学部基础医学院

邮箱:lihuixia@xjtu.edu.cn

站点计数器

教育与工作经历

  • 2020年至今 西安交通大学 副教授
  • 2018-2019年 美国加州大学旧金山分校 访问学者
  • 2016-2019年 西安交通大学  讲师
  • 2016年毕业于西安交通大学  生物化学与分子生物学  博士
  • 2011年毕业于西安交通大学  护理学  医学学士

代表论文

1. Feng dongxu, Li huixia, et al. Downregulation of extracellular matrix protein 1 effectively ameliorates osteoarthritis progression in vivo. International Immunopharmacology. 2023. 1567-5769

2. Wang Q, Li HX, Tajima K, et al. Post-translational control of beige fat biogenesis by  PRDM16 stabilization. Nature (2022), 609 (7925), 151-158.

3. Li HX, Meng H, Xu M, et al. BMAL1 regulates osteoblast differentiation through mTOR/GSK3β  pathway. Journal of Molecular Endocrinology. 2023. 0952-5041

4. Yoneshiro T, Wang Q, Tajima K, Matsushita M, Maki H, Igarashi K, Dai Z, White PJ, McGarrah RW, Ilkayeva OR, Deleye Y, Oguri Y, Kuroda M, Ikeda K, Li H, Ueno A, Ohishi M, Ishikawa T, Kim K, Chen Y, Sponton CH, Pradhan RN, Majd H, Greiner VJ, Yoneshiro M, Brown Z, Chondronikola M, Takahashi H, Goto T, Kawada T, Sidossis L, Szoka FC, McManus MT, Saito M, Soga T, Kajimura S. BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. Nature. 2019;572(7771):614-619.

5. Li, Huixia; Li, Danhui; Ma, Zhengmin; Qian, Zhuang; Kang, Xiaomin; Jin, Xinxin; Li, Fang;Wang, Xinluan; Chen, Qian; Sun, Hongzhi; Wu, Shufang ; Defective autophagy in osteoblasts inducesendoplasmic reticulum stress and causes remarkable bone loss, Autophagy, 2018, 14(10): 1726-1741

6. Li, Huixia; Zhang, Zhuanmin; Feng, Dongxu; Xu, Lin; Li, Fang; Liu, Jiali; Jin, Xinxin; Qian, Zhuang; Kang, Xiaomin; Sun, Hongzhi ; PGRN exerts inflammatory effects via SIRT1-NF-κB in adipose insulin resistance, Journal of Molecular Endocrinology, 2020, 64(3): 181-193

7. Li, Huixia; Zhou, Bo; Liu, Jiali; Li, Fang; Li, Yulong; Kang, Xiaomin; Sun, Hongzhi; Wu,Shufang ; Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2 alpha-dependent manner, Cell Cycle, 2015, 14(12): 1893-1907 
8. Li, Huixia; Zhou, Bo; Xu, Lin; Liu, Jiali; Zang, Weijin; Wu, Shufang; Sun, Hongzhi ; Circulating PGRN Is Significantly Associated With Systemic Insulin Sensitivity and Autophagic Activity in Metabolic Syndrome, Endocrinology, 2014, 155(9): 3493-3507 
9. Li, Huixia; Zhou, Bo; Xu, Lin; Liu, Jiali; Zang, Weijin; Wu, Shufang; Sun, Hongzhi ; The reciprocal interaction between autophagic dysfunction and ER stress in adipose insulin resistance, Cell Cycle, 2014, 13(4): 565-579 

10. Progranulin modulates cartilage-specific gene expression via sirtuin 1-mediated deacetylation of the transcription factors SOX9 and P65. Feng, Dongxu; Kang, Xiaomin; Wang, Ruiqi; Chen, He; Zhang, Kun; Feng, Weilou; Li, Huixia; Zhu, Yangjun*; Wu, Shufang*JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 295(39): 13640-13650

11. Postnatal Conditional Deletion of Bmal1 in Osteoblasts Enhances Trabecular Bone Formation Via Increased BMP2 SignalsQian, Zhuang; Zhang, Ying; Kang, Xiaomin; Li, Huixia; Zhang, Yan; Jin, Xinxin; Gao, Xin; Xu, Mao; Ma, Zhengmin; Zhao, Liting; Zhang, Zhuanmin; Sun, Hongzhi*; Wu, Shufang*.Journal of Bone and Mineral Research, 2020, 35(8): 1481-1493.

12. Neuropeptide Y Acts Directly on Cartilage Homeostasis and Exacerbates Progression of Osteoarthritis Through NPY2R.Kang, Xiaomin; Qian, Zhuang; Liu, Jiali; Feng, Dongxu; Li, Huixia; Zhang, Zhuanmin; Jin, Xinxin; Ma, Zhengmin; Xu, Mao; Li, Fang; Zhang, Ying; Gao, Xin; Sun, Hongzhi*; Wu, Shufang*.Journal of Bone and Mineral Research, 2020, 35(7): 1375-1384

13. Adipose-specific knockdown of Sirt1 results in obesity and insulin resistance by promoting exosomes release. Li, Fang; Li, Huixia; Jin, Xinxin; Zhang, Ying; Kang, Xiaomin; Zhang, Zhuanmin; Xu, Mao; Qian, Zhuang; Ma, Zhengmin; Gao, Xin; Zhao, Liting; Wu, Shufang*; Sun, Hongzhi*. Cell Cycle, 2019, 18(17): 2067-2082