基本信息

王亚文

医学博士、教授、博士生导师

1994年毕业于华西医科大学,曾赴美国Johns Hopkins University研修

联系方式

西安交通大学第一附属医院检验科

西安交通大学第一附属医院生物样本信息资源中心

Email:wangyw1269@mail.xjtu.edu.cn

Office:西安交通大学第一附属医院检验科基因诊断室

             西安交通大学第一附属医院科教楼生物样本信息资源中心

Tel:029-85324634

个人网页:wangyw1269.gr.xjtu.edu.cn

主要任职

1. 中国医药生物技术协会组织生物样本库分会常务委员、数据规范和应用学组副组长
2. 中国研究型医院学会临床数据与样本资源库专业委员会副主任委员
3. 中国中西医结合学会检验医学专业委员会委员
4. 中国医疗保健国际交流促进会临床微生物与感染分会委员
5. 中国医学装备协会基因检测分会委员
6. 中国优生科学协会妇儿临床分会副主任委员
7. 陕西省医师协会检验医师分会常务委员
8. 陕西省中西医结合学会检验医学专业委员会常务委员
9.陕西省抗癌协会肿瘤精准诊疗专业委员会副主委员 

研究领域

       王亚文教授长期从事感染性疾病的分子诊疗工作,建立陕西省最早的基因诊断实验室,申请获得国家首批国家发改委批准的“基因检测技术应用示范中心建设单位”,和“陕西省基因检测技术应用示范中心”。获得国家首批高通量测序技术临床应用试点单位(陕西省唯一一家在无创产前筛查、肿瘤诊断与治疗、遗传性疾病诊断三个专业领域均获授权的医疗执业单位)。研究工作主要集中在对病原微生物,尤其是病毒、细菌等微生物入侵及耐药机制及治疗的相关研究。主持和参与国家自然科学基金5项,国家生物安全关键技术研发重点专项“中国人类遗传资源样本库建设”子课题1项,陕西省科技攻关项目1项;参与国家“重大新药创制”科技重大专项1项,国家“863”计划课题1项、陕西省科技统筹创新工程计划项目1项。申请获得国家发明专利3项、陕西省政府科技三等奖1项、西安市科技进步二等奖1项、陕西省教委科技进步三等奖1项。已发表研究论文60余篇,其中SCI收录28篇。指导研究生14人。

 

发表论文和著作

主要科研情况:

近五年发表的一作和通讯作者的文章

  1. Zhang K#, Li S#, Wang Y#, Wang Z, Mulvenna N, Yang H, Zhang P, Chen H, Li Y, Wang H, Gao Y, Wigneshweraraj S, Matthews S, Zhang K, Liu B. Bacteriophage protein peip is a potent bacillus subtilis enolase inhibitor. Cell Rep 2022;40:111026. (IF: 9.995)
  2. Li Y, Zhu F, Li Y, Pan S, Wang H, Yang Z, Wang Z, Hu Z, Yu J, Barritt JD, Li T, Liu X, Wang Y*, Ma X*, Liu B*. Bacteriophages allow selective depletion of gut bacteria to produce a targeted-bacterium-depleted mouse model. Cell Reports Methods 2022:100324.
  3. Guo R, Gao J, Hui L, Li Y, Liu J, Fu Y, Shi L, Wang Y*, Liu B*. An improved method for quick quantification of unsaturated transferrin. Biosensors (Basel) 2022;12. (IF: 5.743)
  4. Shi X, Hu Z, Gan B, He Y, Zhang L, Chen M, Wang Y*, Li X*. Multivariate evaluation of DNA quality differences in different preanalytical procedures in mouse livers. Biopreserv Biobank 2022. (IF2.256)
  5. Peipei Zhang#, Xiaohui Zhao#Yawen Wang#Ke DuZhihao WangJianfeng YuGang ChangSteve Matthews , Hongliang Wang* , Bing Liu*.(2022). Bacteriophage protein Gp46 is a cross-species inhibitor of nucleoid-associated HU proteins. Proc Natl Acad Sci U S A. 119(9):e2116278119.
  6. Bing Liu #*,, Shanshan Li #Yang Liu #Huan ChenZhenyue Hu,  Zhihao Wang,  Yimin ZhaoLei ZhangBiyun MaHongliang Wang,  Steve MatthewsYawen Wang*,, Kaiming Zhang*,. Bacteriophage Twort protein Gp168 is a β-clamp inhibitor by occupying the DNA sliding channel. Nucleic Acids Research, 2021 Oct 6;gkab875. 
  7. Li J. #, Gao J.,# Li N., Wang,Y.* (2021). Distribution of human papillomavirus genotypes in western China and their association with cervical cancer and precancerous lesions. Archives of Virology, 166:853–862.
  8. Wang, F., Wang, X., Li, N., Liu, J., Zhang, L., Hui, L., Feng, A., Wang, Z., & Wang, Y.* (2021). Prolonged unfolded protein reaction is involved in the induction of chronic myeloid leukemia cell death upon oprozomib treatment. Cancer science112(1), 133–143. 
  9. Zhang, K., Wang, Z., Chang, G., Wang, H., Wang, Y.*, & Liu, B*. (2020). Resonance assignments of bacteriophage T4 Y04L protein. Biomolecular NMR assignments14(1), 51–54. IF0.765
  10. Hu, Y., Chen, T., Liu, M., Zhang, L., Wang, F., Zhao, S., Liu, H., Xia, H., Wang, Y.*, & Li, L*. (2020). Positive detection of SARS-CoV-2 combined HSV1 and HHV6B virus nucleic acid in tear and conjunctival secretions of a non-conjunctivitis COVID-19 patient with obstruction of common lacrimal duct. Acta ophthalmologica98(8), 859–863.
  11. Zhao, S., Zhang, K., Jiang, S., Liu,Zhi., Wang Zhi., Wang, Y.*, & Liu, B*. (2019). Resonance assignments of sigma factor S binding protein Crl from Escherichia coli.. Biomolecular NMR assignments13(1), 223-226.
  12. Li, Y., Liu, Z., Hui, L., Liu, X., Feng, A., Wang, W., Zhang, L., Li, N., Zhou, G., Wang, Q., Han, Q., Lv, Y., Wang, Q., Yang, G., & Wang, Y. * (2017). Transbody against virus core protein potently inhibits hepadnavirus replication in vivo: evidence from a duck model of hepatitis B virus. British journal of pharmacology174(14), 2261–2272.

近五年参与发表的文章:

  1. Kaining Zhang, Shanshan Li, Yawen Wang, Zhihao Wang, Nancy Mulvenna, Hang Yang, Peipei Zhang, Huan Chen, Yan Li, Hongliang Wang , Yongxiang Gao, Sivaramesh Wigneshweraraj, Steve Matthews, Kaiming Zhang, Bing Liu. (2022).Bacteriophage protein PEIP is a potent Bacillus subtilis enolase inhibitor. Cell Rep. 5;40(1):111026.
  2. Wang, Z., Zhao, S., Li, Y., Zhang, K., Mo, F., Zhang, J., Hou, Y., He, L., Liu, Z., Wang, Y., Xu, Y., Wang, H., Buck, M., Matthews, S. J., & Liu, B. (2021). RssB-mediated σS Activation is Regulated by a Two-Tier Mechanism via Phosphorylation and Adaptor Protein - IraD. Journal of molecular biology433(3), 166757.
  3. Ren, Y., Liu, W., Zhang, L., Zhang, J., Bi, J., Wang, T., Wang, M., Du, Z., Wang, Y., Zhang, L., Wu, Z., Lv, Y., Meng, L., & Wu, R. (2021). Milk fat globule EGF factor 8 restores mitochondrial function via integrin-medicated activation of the FAK-STAT3 signaling pathway in acute pancreatitis. Clinical and translational medicine11(2), e295.
  4. Zhang, D., Guo, R., Lei, L., Liu, H., Wang, Y., Wang, Y., Qian, H., Dai, T., Zhang, T., Lai, Y., Wang, J., Liu, Z., Chen, T., He, A., O'Dwyer, M., & Hu, J. (2021). Frontline Science: COVID-19 infection induces readily detectable morphologic and inflammation-related phenotypic changes in peripheral blood monocytes. Journal of leukocyte biology109(1), 13–22.
  5. Li, Y., Li, G., Wang, Z., Chen, W., Wang, H., Wang, Y., & Liu, B. (2021). Resonance assignments of the cytoplasmic domain of ECF sigma factor W pathway protein YsdB from Bacillus subtilis. Biomolecular NMR assignments15(1), 103–106.
  6. Yang, Y., Ke, Z., Wang, Z., Li, Y., Li, Y., Wang, Y., & Liu, B. (2020). 1H, 13C and 15 N NMR assignments of solubility tag protein Msyb of Escherichia coli. Biomolecular NMR assignments14(2), 251–254.
  7. Wei, S., Bi, J., Yang, L., Zhang, J., Wan, Y., Chen, X., Wang, Y., Wu, Z., Lv, Y., & Wu, R. (2020). Serum irisin levels are decreased in patients with sepsis, and exogenous irisin suppresses ferroptosis in the liver of septic mice. Clinical and translational medicine10(5), e173.
  8. Bi, J., Zhang, J., Ren, Y., Du, Z., Zhang, Y., Liu, C., Wang, Y., Zhang, L., Shi, Z., Wu, Z., Lv, Y., & Wu, R. (2020). Exercise hormone irisin mitigates endothelial barrier dysfunction and microvascular leakage-related diseases. JCI insight5(13), e136277.
  9. Wang, Z., Liang, Y., Liu, H., Wang, Y., Wang, H., & Liu, B. (2020). Resonance assignments of bacteriophage SPO1 Gp49 protein. Biomolecular NMR assignments14(1), 111–114.
  10. Zhang, J., Ke, M., Ren, Y., Bi, J., Du, Z., Zhang, M., Wang, Y., Zhang, L., Wu, Z., Lv, Y., & Wu, R. (2019). Serum Irisin Predicts Posthepatectomy Complications in Patients with Hepatocellular Carcinoma. Disease markers2019, 9850191.
  11. Wang, Z., Zhao, S., Jiang, S., Wang, Y., Buck, M., Matthews, S., & Liu, B. (2019). Resonance assignments of N-terminal receiver domain of sigma factor S regulator RssB from Escherichia coli. Biomolecular NMR assignments13(2), 333–337.
  12. Zhang, P., Wang, Z., Zhao, S., Wang, Y., Matthews, S., & Liu, B. (2019). 1H, 13C and 15N NMR assignments of Bacillus subtilis bacteriophage SPO1 protein Gp46. Biomolecular NMR assignments13(1), 245–247.
  13. Liu, B., Wang, Z., Lan, L., Yang, Q., Zhang, P., Shi, L., Lang, Y., Tabib-Salazar, A., Wigneshweraraj, S., Zhang, J., Wang, Y., Tang, Y., Matthews, S., & Zhang, X. (2018). A Rapid Colorimetric Method to Visualize Protein Interactions. Chemistry (Weinheim an der Bergstrasse, Germany)24(26), 6727–6731.
  14. Wang, W., Li, Y., Wang, Y., Ren, S., Li, Y., & Wang, B. (2018). Polyactin A is a novel and potent immunological adjuvant for peptide-based cancer vaccine. International immunopharmacology54, 95–102.
  15. Wang, X., Li, Y., Chen, W., Wang, Y., Hui, L., Liu, J., Li, N., Zhang, L., Zou, Y., & Wang, F. (2017). Nrf-2/Gst-α mediated imatinib resistance through rapid 4-HNE clearance. Experimental cell research353(2), 72–78.
  16. Sun, Y., Mo, L., Feng, X., Yang, D., Tan, T., Zeng, L., Hui, L., Wang, Y., Liu, C., & He, L. (2017). Association of Fcgamma receptor type 2A and 3A genotypes with rheumatoid arthritis in Chinese population. Pharmacogenomics18(3), 255–264.

主持或参加科研项目

[1] 国家自然科学基金青年基金项目《融合蛋白质转导域的抗HBV核心蛋白穿膜抗体细胞内靶向抗病毒作用研究》,主持.(22万元)

[2] 生物安全关键技术研发重点专项中国人类遗传资源样本库建设子课题1项负责人。(65万元)

[3] 陕西省科技攻关项目,《同型半胱氨酸酶联免疫检测试剂盒的研制》,主持。(3万元)

[4] 国家重大新药创制科技重大专项,《GoldMag金磁微粒标记CYP2C19基因分型试纸条开发及其在硫酸氯吡格雷个体化临床用药中的应用》(356.97万元),参与。

[5] 国家863计划课题《脑血栓治疗新方法——多态脂质纳米微泡》(319万元),参与。

[6] 陕西省科技统筹创新工程计划项目《α-甘露聚糖肽佐剂的乳腺癌治疗性疫苗关键技术的研究》(50万元),参与。

[7] 国家自然科学基金面上项目《以JC病毒VLP为载体探讨中枢神经系统定向基因传递》,参与。

[8] 国家自然科学基金面上项目《HCV核心蛋白对肝脏干细胞的转分化作用研究》,参与。

[9] 国家自然科学基金面上项目《MRI、磁共振波谱及多种生物学指标在Alzheimer病早期诊断中联合应用的研究》,参与。

[10] 国家自然科学基金面上项目《贫困山区巨细胞病毒UL97UL54基因突变与宫内感染的关系研究》,参与。

奖励

[1]《肾综合征出血热β整合素相关发病机理和疾病严重程度临床评价研究》,陕西省人民政府,陕西省科学技术进步奖,三等奖,2012年.

[2]《肾综合征出血热β整合素相关发病机理和疾病严重程度临床评价研究》,西安市人民政府,西安市科学技术进步奖,二等奖,2011年.

专利

[1] 专利名称:一种鸭乙型肝炎病毒的荧光定量PCR检测方法及试剂.发明专利号:201310046253.8(第一发明人)

[2] 专利名称:一种靶向病毒核心蛋白的穿膜抗体及其制备方法.专利受理号:201310418409.0(第一发明人)

[3] 专利名称:血栓诊断和或治疗用含气干粉活性剂及其制备工艺.发明专利号:2005100442767.1(第五发明人)