主要科研情况:
近五年发表的一作和通讯作者的文章
- Zhang K#, Li S#, Wang Y#, Wang Z, Mulvenna N, Yang H, Zhang P, Chen H, Li Y, Wang H, Gao Y, Wigneshweraraj S, Matthews S, Zhang K, Liu B. Bacteriophage protein peip is a potent bacillus subtilis enolase inhibitor. Cell Rep 2022;40:111026. (IF: 9.995)
- Li Y, Zhu F, Li Y, Pan S, Wang H, Yang Z, Wang Z, Hu Z, Yu J, Barritt JD, Li T, Liu X, Wang Y*, Ma X*, Liu B*. Bacteriophages allow selective depletion of gut bacteria to produce a targeted-bacterium-depleted mouse model. Cell Reports Methods 2022:100324.
- Guo R, Gao J, Hui L, Li Y, Liu J, Fu Y, Shi L, Wang Y*, Liu B*. An improved method for quick quantification of unsaturated transferrin. Biosensors (Basel) 2022;12. (IF: 5.743)
- Shi X, Hu Z, Gan B, He Y, Zhang L, Chen M, Wang Y*, Li X*. Multivariate evaluation of DNA quality differences in different preanalytical procedures in mouse livers. Biopreserv Biobank 2022. (IF:2.256)
- Peipei Zhang#, Xiaohui Zhao#, Yawen Wang#, Ke Du, Zhihao Wang, Jianfeng Yu, Gang Chang, Steve Matthews , Hongliang Wang* , Bing Liu*.(2022). Bacteriophage protein Gp46 is a cross-species inhibitor of nucleoid-associated HU proteins. Proc Natl Acad Sci U S A. 119(9):e2116278119.
- Bing Liu #*,, Shanshan Li #, Yang Liu #, Huan Chen, Zhenyue Hu, Zhihao Wang, Yimin Zhao, Lei Zhang, Biyun Ma, Hongliang Wang, Steve Matthews, Yawen Wang*,, Kaiming Zhang*,. Bacteriophage Twort protein Gp168 is a β-clamp inhibitor by occupying the DNA sliding channel. Nucleic Acids Research, 2021 Oct 6;gkab875.
- Li J. #, Gao J.,# Li N., Wang,Y.* (2021). Distribution of human papillomavirus genotypes in western China and their association with cervical cancer and precancerous lesions. Archives of Virology, 166:853–862.
- Wang, F., Wang, X., Li, N., Liu, J., Zhang, L., Hui, L., Feng, A., Wang, Z., & Wang, Y.* (2021). Prolonged unfolded protein reaction is involved in the induction of chronic myeloid leukemia cell death upon oprozomib treatment. Cancer science, 112(1), 133–143.
- Zhang, K., Wang, Z., Chang, G., Wang, H., Wang, Y.*, & Liu, B*. (2020). Resonance assignments of bacteriophage T4 Y04L protein. Biomolecular NMR assignments, 14(1), 51–54. (IF:0.765)
- Hu, Y., Chen, T., Liu, M., Zhang, L., Wang, F., Zhao, S., Liu, H., Xia, H., Wang, Y.*, & Li, L*. (2020). Positive detection of SARS-CoV-2 combined HSV1 and HHV6B virus nucleic acid in tear and conjunctival secretions of a non-conjunctivitis COVID-19 patient with obstruction of common lacrimal duct. Acta ophthalmologica, 98(8), 859–863.
- Zhao, S., Zhang, K., Jiang, S., Liu,Zhi., Wang Zhi., Wang, Y.*, & Liu, B*. (2019). Resonance assignments of sigma factor S binding protein Crl from Escherichia coli.. Biomolecular NMR assignments, 13(1), 223-226.
- Li, Y., Liu, Z., Hui, L., Liu, X., Feng, A., Wang, W., Zhang, L., Li, N., Zhou, G., Wang, Q., Han, Q., Lv, Y., Wang, Q., Yang, G., & Wang, Y. * (2017). Transbody against virus core protein potently inhibits hepadnavirus replication in vivo: evidence from a duck model of hepatitis B virus. British journal of pharmacology, 174(14), 2261–2272.
近五年参与发表的文章:
- Kaining Zhang, Shanshan Li, Yawen Wang, Zhihao Wang, Nancy Mulvenna, Hang Yang, Peipei Zhang, Huan Chen, Yan Li, Hongliang Wang , Yongxiang Gao, Sivaramesh Wigneshweraraj, Steve Matthews, Kaiming Zhang, Bing Liu. (2022).Bacteriophage protein PEIP is a potent Bacillus subtilis enolase inhibitor. Cell Rep. 5;40(1):111026.
- Wang, Z., Zhao, S., Li, Y., Zhang, K., Mo, F., Zhang, J., Hou, Y., He, L., Liu, Z., Wang, Y., Xu, Y., Wang, H., Buck, M., Matthews, S. J., & Liu, B. (2021). RssB-mediated σS Activation is Regulated by a Two-Tier Mechanism via Phosphorylation and Adaptor Protein - IraD. Journal of molecular biology, 433(3), 166757.
- Ren, Y., Liu, W., Zhang, L., Zhang, J., Bi, J., Wang, T., Wang, M., Du, Z., Wang, Y., Zhang, L., Wu, Z., Lv, Y., Meng, L., & Wu, R. (2021). Milk fat globule EGF factor 8 restores mitochondrial function via integrin-medicated activation of the FAK-STAT3 signaling pathway in acute pancreatitis. Clinical and translational medicine, 11(2), e295.
- Zhang, D., Guo, R., Lei, L., Liu, H., Wang, Y., Wang, Y., Qian, H., Dai, T., Zhang, T., Lai, Y., Wang, J., Liu, Z., Chen, T., He, A., O'Dwyer, M., & Hu, J. (2021). Frontline Science: COVID-19 infection induces readily detectable morphologic and inflammation-related phenotypic changes in peripheral blood monocytes. Journal of leukocyte biology, 109(1), 13–22.
- Li, Y., Li, G., Wang, Z., Chen, W., Wang, H., Wang, Y., & Liu, B. (2021). Resonance assignments of the cytoplasmic domain of ECF sigma factor W pathway protein YsdB from Bacillus subtilis. Biomolecular NMR assignments, 15(1), 103–106.
- Yang, Y., Ke, Z., Wang, Z., Li, Y., Li, Y., Wang, Y., & Liu, B. (2020). 1H, 13C and 15 N NMR assignments of solubility tag protein Msyb of Escherichia coli. Biomolecular NMR assignments, 14(2), 251–254.
- Wei, S., Bi, J., Yang, L., Zhang, J., Wan, Y., Chen, X., Wang, Y., Wu, Z., Lv, Y., & Wu, R. (2020). Serum irisin levels are decreased in patients with sepsis, and exogenous irisin suppresses ferroptosis in the liver of septic mice. Clinical and translational medicine, 10(5), e173.
- Bi, J., Zhang, J., Ren, Y., Du, Z., Zhang, Y., Liu, C., Wang, Y., Zhang, L., Shi, Z., Wu, Z., Lv, Y., & Wu, R. (2020). Exercise hormone irisin mitigates endothelial barrier dysfunction and microvascular leakage-related diseases. JCI insight, 5(13), e136277.
- Wang, Z., Liang, Y., Liu, H., Wang, Y., Wang, H., & Liu, B. (2020). Resonance assignments of bacteriophage SPO1 Gp49 protein. Biomolecular NMR assignments, 14(1), 111–114.
- Zhang, J., Ke, M., Ren, Y., Bi, J., Du, Z., Zhang, M., Wang, Y., Zhang, L., Wu, Z., Lv, Y., & Wu, R. (2019). Serum Irisin Predicts Posthepatectomy Complications in Patients with Hepatocellular Carcinoma. Disease markers, 2019, 9850191.
- Wang, Z., Zhao, S., Jiang, S., Wang, Y., Buck, M., Matthews, S., & Liu, B. (2019). Resonance assignments of N-terminal receiver domain of sigma factor S regulator RssB from Escherichia coli. Biomolecular NMR assignments, 13(2), 333–337.
- Zhang, P., Wang, Z., Zhao, S., Wang, Y., Matthews, S., & Liu, B. (2019). 1H, 13C and 15N NMR assignments of Bacillus subtilis bacteriophage SPO1 protein Gp46. Biomolecular NMR assignments, 13(1), 245–247.
- Liu, B., Wang, Z., Lan, L., Yang, Q., Zhang, P., Shi, L., Lang, Y., Tabib-Salazar, A., Wigneshweraraj, S., Zhang, J., Wang, Y., Tang, Y., Matthews, S., & Zhang, X. (2018). A Rapid Colorimetric Method to Visualize Protein Interactions. Chemistry (Weinheim an der Bergstrasse, Germany), 24(26), 6727–6731.
- Wang, W., Li, Y., Wang, Y., Ren, S., Li, Y., & Wang, B. (2018). Polyactin A is a novel and potent immunological adjuvant for peptide-based cancer vaccine. International immunopharmacology, 54, 95–102.
- Wang, X., Li, Y., Chen, W., Wang, Y., Hui, L., Liu, J., Li, N., Zhang, L., Zou, Y., & Wang, F. (2017). Nrf-2/Gst-α mediated imatinib resistance through rapid 4-HNE clearance. Experimental cell research, 353(2), 72–78.
- Sun, Y., Mo, L., Feng, X., Yang, D., Tan, T., Zeng, L., Hui, L., Wang, Y., Liu, C., & He, L. (2017). Association of Fcgamma receptor type 2A and 3A genotypes with rheumatoid arthritis in Chinese population. Pharmacogenomics, 18(3), 255–264.
主持或参加科研项目
[1] 国家自然科学基金青年基金项目《融合蛋白质转导域的抗HBV核心蛋白穿膜抗体细胞内靶向抗病毒作用研究》,主持.(22万元)
[2] 生物安全关键技术研发重点专项《中国人类遗传资源样本库建设》子课题1项负责人。(65万元)
[3] 陕西省科技攻关项目,《同型半胱氨酸酶联免疫检测试剂盒的研制》,主持。(3万元)
[4] 国家“重大新药创制”科技重大专项,《GoldMag金磁微粒标记CYP2C19基因分型试纸条开发及其在硫酸氯吡格雷个体化临床用药中的应用》(356.97万元),参与。
[5] 国家“863”计划课题《脑血栓治疗新方法——多态脂质纳米微泡》(319万元),参与。
[6] 陕西省科技统筹创新工程计划项目《α-甘露聚糖肽佐剂的乳腺癌治疗性疫苗关键技术的研究》(50万元),参与。
[7] 国家自然科学基金面上项目《以JC病毒VLP为载体探讨中枢神经系统定向基因传递》,参与。
[8] 国家自然科学基金面上项目《HCV核心蛋白对肝脏干细胞的转分化作用研究》,参与。
[9] 国家自然科学基金面上项目《MRI、磁共振波谱及多种生物学指标在Alzheimer病早期诊断中联合应用的研究》,参与。
[10] 国家自然科学基金面上项目《贫困山区巨细胞病毒UL97和UL54基因突变与宫内感染的关系研究》,参与。
奖励
[1]《肾综合征出血热β整合素相关发病机理和疾病严重程度临床评价研究》,陕西省人民政府,陕西省科学技术进步奖,三等奖,2012年.
[2]《肾综合征出血热β整合素相关发病机理和疾病严重程度临床评价研究》,西安市人民政府,西安市科学技术进步奖,二等奖,2011年.
专利
[1] 专利名称:一种鸭乙型肝炎病毒的荧光定量PCR检测方法及试剂.发明专利号:201310046253.8(第一发明人)
[2] 专利名称:一种靶向病毒核心蛋白的穿膜抗体及其制备方法.专利受理号:201310418409.0(第一发明人)
[3] 专利名称:血栓诊断和或治疗用含气干粉活性剂及其制备工艺.发明专利号:2005100442767.1(第五发明人)