基本信息

个人简介:

 

 

 

校蕾 副教授,博士生导师

2019年起任基础医学院心血管研究所 PI、病理生理学博士生导师。在血管生物学领域的工作已以第一、通讯(含共同)作者在Redox Biol., Br J Pharmacol., J Invest Dermatol.,Adv Drug Deliv Rev., Mol Immunol., Mol Pharmacol., Am J Physiol., Front Immunol.,中国科学等杂志发表论文20余篇;作为参与作者在 Proc Natl Acad Sci U S A., Circ Res., Arterioscler Thromb Vasc Biol.,J Biol Chem.等杂志发表 SCI论文10余篇。并应邀撰写《血管生物学(第2版)》核受体与血管病变章节(北京大学医学出版社,2014,董尔丹等)。

 

任中国病理生理学会理事、中国生物化学与分子生物学会脂质与脂蛋白专业委员会青年委员、中国病理生理学会血管医学专业委员会及受体专业委员会青年委员、中华医学会心血管病学分会代谢性心血管疾病学组委员。

 

教育经历:

(1) 2007.09–2012.07,北京师范大学,生理学,博士

(2) 2003.09–2007.07,西北大学,生物技术,学士

 

科研与学术工作经历:

(1) 2018.01-至今,西安交通大学医学部,心血管研究中心,副教授

(2) 2015.04-2016.06,美国佐治亚州立大学,分子转化医学研究中心,博士后

(3) 2014.04-2015.04,美国俄克拉荷马大学,分子医学中心,博士后

(4) 2012.07-2017.12,西安交通大学医学部,心血管研究中心,讲师

联系方式

电子邮箱:xiaolei0122@xjtu.edu.cn

联系电话:18609284536

微信号:lei0439

联系地址:西安交通大学创新港校区21号楼4

站点计数器

研究领域

研究方向:

1.心血管病:动脉粥样硬化及血管再狭窄分子病理机制研究;

2.糖尿病防治:糖尿病血管病变的分子机制研究;

3.受体与基因表达的调控:血管分子机械-生物信号转导研究。

 

主持科研项目:

1.国家自然科学基金重大研究计划培育项目1项;

2.国家自然科学基金面上项目1项;

3.医学部国家级后备人选支持计划:医学攀登人才计划;

4.国家自然科学基金青年科学基金项目1

 

发表论文情况(#第一作者,*通讯作者):

1.   Xiao L, Wang N*: PPAR-δ: A key nuclear receptor in vascular function and remodeling. Journal of molecular and cellular cardiology 2022, 169:1-9.

2.   Liu J, Yao Q, Xie X, Cui Q, Jiang T, Zhao Z, Du X, Lai B, Xiao L, Wang N*: Procyanidin B2 Attenuates Nicotine-Induced Hepatocyte Pyroptosis through a PPARγ-Dependent Mechanism. Nutrients 2022, 14(9).

3.   Xiao L, Nie X, Cheng Y, Wang N*: Sodium-Glucose Cotransporter-2 Inhibitors in Vascular Biology: Cellular and Molecular Mechanisms. Cardiovascular drugs and therapy 2021, 35(6):1253-1267.

4.  Lai B#, Xie X#, Li F#, Cui Q, Dang E, Luo W, Wang N, Zheng Y, Wang G, Xiao L*,Wang N*: Xenobiotic Receptor CAR Is Highly Induced in Psoriasis and Promotes Keratinocyte Proliferation. The Journal of investigative dermatology 2021, 141(12):2895-2907.e2897.

5.  Nie X#, Tang W#, Zhang Z, Yang C, Qian L, Xie X, Qiang E, Zhao J, Zhao W, Xiao L*,Wang N*: Procyanidin B2 mitigates endothelial endoplasmic reticulum stress through a PPARδ-Dependent mechanism. Redox biology 2020, 37:101728.

6.  Liu J, Yao Q, Xiao L, Ma W, Li F, Lai B, Wang N*: PPARγ induces NEDD4 gene expression to promote autophagy and insulin action. The FEBS journal 2020, 287(3):529-545.

7.  Liu J, Yao Q, Xiao L, Li F, Ma W, Zhang Z, Xie X, Yang C, Cui Q, Tian Y, Zhang C, Lai B, Wang N*: APC/Cdh1 targets PECAM-1 for ubiquitination and degradation in endothelial cells. Journal of cellular physiology 2020, 235(3):2521-2531.

8.  Zhang Z, Xie X, Yao Q, Liu J, Tian Y, Yang C, Xiao L*, Wang N*: PPARδ agonist prevents endothelial dysfunction via induction of dihydrofolate reductase gene and activation of tetrahydrobiopterin salvage pathway. British journal of pharmacology 2019, 176(16):2945-2961.

9. Zhang M, Zhang Z, Xie X, Yao Q, Liu J, Lai B, Xiao L*, Wang N*: Xenobiotic pregnane X receptor promotes neointimal formation in balloon-injured rat carotid arteries. Journal of cellular physiology 2019, 234(4):4342-4351.

10. Yao Q, Liu J, Xiao L, Wang N*: Sonic hedgehog signaling instigates high-fat diet-induced insulin resistance by targeting PPARγ stability. The Journal of biological chemistry 2019, 294(9):3284-3293.

11. Xie X, Yang C, Cui Q, Ma W, Liu J, Yao Q, Zhang Z, Xiao L*, Wang N*: Stachydrine Mediates Rapid Vascular Relaxation: Activation of Endothelial Nitric Oxide Synthase Involving AMP-Activated Protein Kinase and Akt Phosphorylation in Vascular Endothelial Cells. Journal of agricultural and food chemistry 2019, 67(35):9805-9811.

12. Tian Y, Yang C, Yao Q, Qian L, Liu J, Xie X, Ma W, Nie X, Lai B, Xiao L*, Wang N*: Procyanidin B2 Activates PPARγ to Induce M2 Polarization in Mouse Macrophages. Frontiers in immunology 2019, 10:1895.

13. Li C#, Xiao L#, Jia J, Li F, Wang X, Duan Q, Jing H, Yang P, Chen C, Wang Q, Liu J, Shao Y, Wang N*, Zheng Y*: Cornulin Is Induced in Psoriasis Lesions and Promotes Keratinocyte Proliferation via Phosphoinositide 3-Kinase/Akt Pathways. The Journal of investigative dermatology 2019, 139(1):71-80.

14. Ban Y#, Liu Y#, Li Y, Zhang Y, Xiao L, Gu Y, Chen S, Zhao B, Chen C*, Wang N*: S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension. Redox biology 2019, 21:101099.

15. Zhang C, Deng J, Liu D, Tuo X, Xiao L, Lai B, Yao Q, Liu J, Yang H*, Wang N*: Nuciferine ameliorates hepatic steatosis in high-fat diet/streptozocin-induced diabetic mice through a PPARα/PPARγ coactivator-1α pathway. British journal of pharmacology 2018, 175(22):4218-4228.

16. Yao Q, Liu J, Zhang Z, Li F, Zhang C, Lai B, Xiao L, Wang N*: Peroxisome proliferator-activated receptor γ (PPARγ) induces the gene expression of integrin α(V)β(5) to promote macrophage M2 polarization. The Journal of biological chemistry 2018, 293(43):16572-16582.

17.  李帆,张子绘,谢新雅,校蕾*汪南平*。增塑剂邻苯二甲酸二丁酯致血管内皮功能损伤及其机制,中国科学 生命科学  2018;48(5):535-543.

18.  Xie X, Zhang Z, Wang X, Luo Z, Lai B, Xiao L*, Wang N*: Stachydrine protects eNOS uncoupling and ameliorates endothelial dysfunction induced by homocysteine. Molecular medicine (Cambridge, Mass) 2018, 24(1):10.

19. Zhang Z#, Jiang M#, Xie X, Yang H, Wang X, Xiao L*, Wang N*: Oleanolic acid ameliorates high glucose-induced endothelial dysfunction via PPARδ activation. Scientific reports 2017, 7:40237.

20. Yang H, Xiao L, Wang N*: Peroxisome proliferator-activated receptor α ligands and modulators from dietary compounds: Types, screening methods and functions. Journal of diabetes 2017, 9(4):341-352.

21. Wang S, Xie X, Lei T, Zhang K, Lai B, Zhang Z, Guan Y, Mao G, Xiao L*, Wang N*: Statins Attenuate Activation of the NLRP3 Inflammasome by Oxidized LDL or TNFα in Vascular Endothelial Cells through a PXR-Dependent Mechanism. Molecular pharmacology 2017, 92(3):256-264.

22.  张子绘#,汤伟琦#,李帆,校蕾*汪南平。异源物代谢核受体 PXR CAR 在血管疾病中的作用。生理科学进展 2017;48:(5) pp.341-346

23. Xiao L#, Zhang Z#, Luo X, Yang H, Li F, Wang N*: Retinoid acid receptor-related orphan receptor alpha (RORα) regulates macrophage M2 polarization via activation of AMPKα. Molecular immunology 2016, 80:17-23.

24. Ni J, Zhang Z, Luo X, Xiao L*, Wang N*: Plasticizer DBP Activates NLRP3 Inflammasome through the P2X7 Receptor in HepG2 and L02 Cells. Journal of biochemical and molecular toxicology 2016, 30(4):178-185.

25. Luo X, Luo Z, Zhang Z, Yang H, Lai B, Yao Q, Xiao L, Wang N*: Homocysteine upregulates hepcidin expression through BMP6/SMAD signaling pathway in hepatocytes. Biochemical and biophysical research communications 2016, 471(2):303-308.

26. Xiao L#, Wang J#, Li J, Chen X, Xu P, Sun S, He D, Cong Y, Zhai Y*: RORα inhibits adipocyte-conditioned medium-induced colorectal cancer cell proliferation and migration and chick embryo chorioallantoic membrane angiopoiesis. American journal of physiology Cell physiology 2015, 308(5):C385-396.

27. Wang X#, Cheang WS#, Yang H, Xiao L, Lai B, Zhang M, Ni J, Luo Z, Zhang Z, Huang Y, Wang N*: Nuciferine relaxes rat mesenteric arteries through endothelium-dependent and -independent mechanisms. British journal of pharmacology 2015, 172(23):5609-5618.

28. Yang H, Xiao L, Yuan Y, Luo X, Jiang M, Ni J, Wang N*: Procyanidin B2 inhibits NLRP3 inflammasome activation in human vascular endothelial cells. Biochemical pharmacology 2014, 92(4):599-606.

29. Xiao L*, Zhang Z, Luo X: Roles of xenobiotic receptors in vascular pathophysiology. Circulation journal : official journal of the Japanese Circulation Society 2014, 78(7):1520-1530.

30. Xiao L, Liu Y, Wang N*: New paradigms in inflammatory signaling in vascular endothelial cells. American journal of physiology Heart and circulatory physiology 2014, 306(3):H317-325.

31. Wang S, Lei T, Zhang K, Zhao W, Fang L, Lai B, Han J, Xiao L, Wang N*: Xenobiotic pregnane X receptor (PXR) regulates innate immunity via activation of NLRP3 inflammasome in vascular endothelial cells. The Journal of biological chemistry 2014, 289(43):30075-30081.

32. Luo X, Xiao L, Yang H, Zhang R, Jiang M, Ni J, Lei T, Wang N*: Homocysteine downregulates gene expression of heme oxygenase-1 in hepatocytes. Nutrition & metabolism 2014, 11(1):55.

33. Xie X, Wang S, Xiao L, Zhang J, Wang J, Liu J, Shen X, He D, Zheng X, Zhai Y*: DBZ blocks LPS-induced monocyte activation and foam cell formation via inhibiting nuclear factor-ĸB. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2011, 28(4):649-662.

34. Xiao L, Zhang J, Li H, Liu J, He L, Zhang J, Zhai Y*: Inhibition of adipocyte differentiation and adipogenesis by the traditional Chinese herb Sibiraea angustata. Experimental biology and medicine (Maywood, NJ) 2010, 235(12):1442-1449.

35. Xiao L, Xie X, Zhai Y*: Functional crosstalk of CAR-LXR and ROR-LXR in drug metabolism and lipid metabolism. Advanced drug delivery reviews 2010, 62(13):1316-1321.

36. Li HX#, Xiao L#, Wang C, Gao JL, Zhai YG*: Review: Epigenetic regulation of adipocyte differentiation and adipogenesis. Journal of Zhejiang University Science B 2010, 11(10):784-791.

 

著作章节列表:

1. Xiao L, Wang J, Jiang M, Xie W, Zhai Y*. The emerging role of Constitutive Androstane Receptor and its cross talk with Liver X Receptors and Peroxisome Proliferator-Activated Receptors in lipid metabolism. Vitamins and Hormones, edited by Gerald Litwack, Academic Press, 2013.

2. 汪南平、校蕾,核受体与血管病变 章节,血管生物学,北京大学医学出版社,2014.