研究方向：
1．心血管病：动脉粥样硬化及血管再狭窄分子病理机制研究；
2．糖尿病防治：糖尿病血管病变的分子机制研究；
3．受体与基因表达的调控：血管分子机械-生物信号转导研究;
4．免疫炎症性皮肤病机制。
主持科研项目：
1. 国家自然科学基金重点项目（批准号82230012），合作主持
2. 国家自然科学基金重大研究计划培育项目（批准号91939108），主持
3. 国家自然科学基金面上项目（批准号81770497），主持
4. 西安交通大学医学“基础-临床”融合创新项目（批准号YXJLRH2022024），合作主持
5. “医学攀登人才计划”﹣医学部首批国家级后备人选支持计划（No.217），主持
发表论文情况（#第一作者，*通讯作者）：
1. Cui Q, Jiang T, Xie X, Wang, H, Qian L, Cheng Y, Li Q, Lu T, Yao Q, Liu J, Lai B, Chen C, Xiao L*, Wang N*: S-nitrosylation Attenuates Pregnane X Receptor Hyperactivity and Acetaminophen-induced Liver Injury. JCI Insight 2024, 9(2):e172632.
2. Xie X#, Cui Q#, Jiang T, Zhao Z, Liu Z, Liu J, Yao Q, Wang Y, Dang E, Wang G, Xiao L*, Wang N: A Critical Role of Endothelial Skp2/PTEN Axis in Angiogenesis and Psoriasis. Br J Dermatol. 2024;190(2):244-257.
3. 崔琪，杜雄，校蕾*，汪南平*. 转录因子的巯基亚硝基化修饰及其生理学意义，《生理科学进展》，2023:54, 26-32.
4. Xiao L, Wang N*: PPAR-δ: A key nuclear receptor in vascular function and remodeling. Journal of molecular and cellular cardiology 2022, 169:1-9.
5. Liu J#, Du X#, Yao Q, Jiang T, Cui Q, Xie X, Zhao Z, Lai B, Wang N, Xiao L*, Procyanidin B2 ameliorates endothelial dysfunction induced by nicotine via the induction of tetrahydrobiopterin synthesis, J Funct Foods., 2022; 99, 105306.
6. Liu J, Yao Q, Xie X, Cui Q, Jiang T, Zhao Z, Du X, Lai B, Xiao L, Wang N*: Procyanidin B2 Attenuates Nicotine-Induced Hepatocyte Pyroptosis through a PPARγ-Dependent Mechanism. Nutrients 2022, 14(9).
7. Xiao L, Nie X, Cheng Y, Wang N*: Sodium-Glucose Cotransporter-2 Inhibitors in Vascular Biology: Cellular and Molecular Mechanisms. Cardiovascular drugs and therapy 2021, 35(6):1253-1267.
8. Lai B#, Xie X#, Li F#, Cui Q, Dang E, Luo W, Wang N, Zheng Y, Wang G, Xiao L*,Wang N*: Xenobiotic Receptor CAR Is Highly Induced in Psoriasis and Promotes Keratinocyte Proliferation. The Journal of investigative dermatology 2021, 141(12):2895-2907.e2897.
9. Nie X#, Tang W#, Zhang Z, Yang C, Qian L, Xie X, Qiang E, Zhao J, Zhao W, Xiao L*,Wang N*: Procyanidin B2 mitigates endothelial endoplasmic reticulum stress through a PPARδ-Dependent mechanism. Redox biology 2020, 37:101728.
10. Liu J, Yao Q, Xiao L, Ma W, Li F, Lai B, Wang N*: PPARγ induces NEDD4 gene expression to promote autophagy and insulin action. The FEBS journal 2020, 287(3):529-545.
11. Liu J, Yao Q, Xiao L, Li F, Ma W, Zhang Z, Xie X, Yang C, Cui Q, Tian Y, Zhang C, Lai B, Wang N*: APC/Cdh1 targets PECAM-1 for ubiquitination and degradation in endothelial cells. Journal of cellular physiology 2020, 235(3):2521-2531.
12. Zhang Z, Xie X, Yao Q, Liu J, Tian Y, Yang C, Xiao L*, Wang N*: PPARδ agonist prevents endothelial dysfunction via induction of dihydrofolate reductase gene and activation of tetrahydrobiopterin salvage pathway. British journal of pharmacology 2019, 176(16):2945-2961.
13. Zhang M, Zhang Z, Xie X, Yao Q, Liu J, Lai B, Xiao L*, Wang N*: Xenobiotic pregnane X receptor promotes neointimal formation in balloon-injured rat carotid arteries. Journal of cellular physiology 2019, 234(4):4342-4351.
14. Yao Q, Liu J, Xiao L, Wang N*: Sonic hedgehog signaling instigates high-fat diet-induced insulin resistance by targeting PPARγ stability. The Journal of biological chemistry 2019, 294(9):3284-3293.
15. Xie X, Yang C, Cui Q, Ma W, Liu J, Yao Q, Zhang Z, Xiao L*, Wang N*: Stachydrine Mediates Rapid Vascular Relaxation: Activation of Endothelial Nitric Oxide Synthase Involving AMP-Activated Protein Kinase and Akt Phosphorylation in Vascular Endothelial Cells. Journal of agricultural and food chemistry 2019, 67(35):9805-9811.
16. Tian Y, Yang C, Yao Q, Qian L, Liu J, Xie X, Ma W, Nie X, Lai B, Xiao L*, Wang N*: Procyanidin B2 Activates PPARγ to Induce M2 Polarization in Mouse Macrophages. Frontiers in immunology 2019, 10:1895.
17. Li C#, Xiao L#, Jia J, Li F, Wang X, Duan Q, Jing H, Yang P, Chen C, Wang Q, Liu J, Shao Y, Wang N*, Zheng Y*: Cornulin Is Induced in Psoriasis Lesions and Promotes Keratinocyte Proliferation via Phosphoinositide 3-Kinase/Akt Pathways. The Journal of investigative dermatology 2019, 139(1):71-80.
18. Ban Y#, Liu Y#, Li Y, Zhang Y, Xiao L, Gu Y, Chen S, Zhao B, Chen C*, Wang N*: S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension. Redox biology 2019, 21:101099.
19. Zhang C, Deng J, Liu D, Tuo X, Xiao L, Lai B, Yao Q, Liu J, Yang H*, Wang N*: Nuciferine ameliorates hepatic steatosis in high-fat diet/streptozocin-induced diabetic mice through a PPARα/PPARγ coactivator-1α pathway. British journal of pharmacology 2018, 175(22):4218-4228.
20. Yao Q, Liu J, Zhang Z, Li F, Zhang C, Lai B, Xiao L, Wang N*: Peroxisome proliferator-activated receptor γ (PPARγ) induces the gene expression of integrin α(V)β(5) to promote macrophage M2 polarization. The Journal of biological chemistry 2018, 293(43):16572-16582.
21. 李帆，张子绘，谢新雅，校蕾*，汪南平*。增塑剂邻苯二甲酸二丁酯致血管内皮功能损伤及其机制，中国科学 生命科学 2018;48(5):535-543.
22. Xie X, Zhang Z, Wang X, Luo Z, Lai B, Xiao L*, Wang N*: Stachydrine protects eNOS uncoupling and ameliorates endothelial dysfunction induced by homocysteine. Molecular medicine (Cambridge, Mass) 2018, 24(1):10.
23. Zhang Z#, Jiang M#, Xie X, Yang H, Wang X, Xiao L*, Wang N*: Oleanolic acid ameliorates high glucose-induced endothelial dysfunction via PPARδ activation. Scientific reports 2017, 7:40237.
24. Yang H, Xiao L, Wang N*: Peroxisome proliferator-activated receptor α ligands and modulators from dietary compounds: Types, screening methods and functions. Journal of diabetes 2017, 9(4):341-352.
25. Wang S, Xie X, Lei T, Zhang K, Lai B, Zhang Z, Guan Y, Mao G, Xiao L*, Wang N*: Statins Attenuate Activation of the NLRP3 Inflammasome by Oxidized LDL or TNFα in Vascular Endothelial Cells through a PXR-Dependent Mechanism. Molecular pharmacology 2017, 92(3):256-264.
26. 张子绘#，汤伟琦#，李帆，校蕾*，汪南平。异源物代谢核受体 PXR 和 CAR 在血管疾病中的作用。生理科学进展 2017;48:(5) pp.341-346
27. Xiao L#, Zhang Z#, Luo X, Yang H, Li F, Wang N*: Retinoid acid receptor-related orphan receptor alpha (RORα) regulates macrophage M2 polarization via activation of AMPKα. Molecular immunology 2016, 80:17-23.
28. Ni J, Zhang Z, Luo X, Xiao L*, Wang N*: Plasticizer DBP Activates NLRP3 Inflammasome through the P2X7 Receptor in HepG2 and L02 Cells. Journal of biochemical and molecular toxicology 2016, 30(4):178-185.
29. Luo X, Luo Z, Zhang Z, Yang H, Lai B, Yao Q, Xiao L, Wang N*: Homocysteine upregulates hepcidin expression through BMP6/SMAD signaling pathway in hepatocytes. Biochemical and biophysical research communications 2016, 471(2):303-308.
30. Xiao L#, Wang J#, Li J, Chen X, Xu P, Sun S, He D, Cong Y, Zhai Y*: RORα inhibits adipocyte-conditioned medium-induced colorectal cancer cell proliferation and migration and chick embryo chorioallantoic membrane angiopoiesis. American journal of physiology Cell physiology 2015, 308(5):C385-396.
31. Wang X#, Cheang WS#, Yang H, Xiao L, Lai B, Zhang M, Ni J, Luo Z, Zhang Z, Huang Y, Wang N*: Nuciferine relaxes rat mesenteric arteries through endothelium-dependent and -independent mechanisms. British journal of pharmacology 2015, 172(23):5609-5618.
32. Yang H, Xiao L, Yuan Y, Luo X, Jiang M, Ni J, Wang N*: Procyanidin B2 inhibits NLRP3 inflammasome activation in human vascular endothelial cells. Biochemical pharmacology 2014, 92(4):599-606.
33. Xiao L*, Zhang Z, Luo X: Roles of xenobiotic receptors in vascular pathophysiology. Circulation journal : official journal of the Japanese Circulation Society 2014, 78(7):1520-1530.
34. Xiao L, Liu Y, Wang N*: New paradigms in inflammatory signaling in vascular endothelial cells. American journal of physiology Heart and circulatory physiology 2014, 306(3):H317-325.
35. Wang S, Lei T, Zhang K, Zhao W, Fang L, Lai B, Han J, Xiao L, Wang N*: Xenobiotic pregnane X receptor (PXR) regulates innate immunity via activation of NLRP3 inflammasome in vascular endothelial cells. The Journal of biological chemistry 2014, 289(43):30075-30081.
36. Luo X, Xiao L, Yang H, Zhang R, Jiang M, Ni J, Lei T, Wang N*: Homocysteine downregulates gene expression of heme oxygenase-1 in hepatocytes. Nutrition & metabolism 2014, 11(1):55.
37. Xie X, Wang S, Xiao L, Zhang J, Wang J, Liu J, Shen X, He D, Zheng X, Zhai Y*: DBZ blocks LPS-induced monocyte activation and foam cell formation via inhibiting nuclear factor-ĸB. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2011, 28(4):649-662.
38. Xiao L, Zhang J, Li H, Liu J, He L, Zhang J, Zhai Y*: Inhibition of adipocyte differentiation and adipogenesis by the traditional Chinese herb Sibiraea angustata. Experimental biology and medicine (Maywood, NJ) 2010, 235(12):1442-1449.
39. Xiao L, Xie X, Zhai Y*: Functional crosstalk of CAR-LXR and ROR-LXR in drug metabolism and lipid metabolism. Advanced drug delivery reviews 2010, 62(13):1316-1321.
40. Li HX#, Xiao L#, Wang C, Gao JL, Zhai YG*: Review: Epigenetic regulation of adipocyte differentiation and adipogenesis. Journal of Zhejiang University Science B 2010, 11(10):784-791.
著作章节列表：
1. Xiao L, Wang J, Jiang M, Xie W, Zhai Y*. The emerging role of Constitutive Androstane Receptor and its cross talk with Liver X Receptors and Peroxisome Proliferator-Activated Receptors in lipid metabolism. Vitamins and Hormones, edited by Gerald Litwack, Academic Press, 2013.
2. 汪南平、校蕾，核受体与血管病变 章节，血管生物学，北京大学医学出版社，2014.
